Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Signaling - Call For Papers

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 13 March 1992:
Vol. 255. no. 5050, pp. 1419 - 1421
DOI: 10.1126/science.1542789
Prev | Table of Contents | Next

Articles

Science, Vol 255, Issue 5050, 1419-1421
Copyright © 1992 by American Association for the Advancement of Science

articles

Long-range attraction and molecular rearrangements in receptor-ligand interactions

DE Leckband, JN Israelachvili, FJ Schmitt, and W Knoll

Department of Chemical and Nuclear Engineering, University of California, Santa Barbara 93106.

A surface force apparatus was used to measure a long-range attractive protein-ligand force at separations D less than 85 angstroms. This force may effectively "steer" ligand trajectories, resulting in a greater than 27-fold enhancement of the association rate. A much stronger specific attraction is measured at contact (D less than 4 angstroms). A sevenfold increase in intermembrane adhesion resulted from increased lateral mobility of the receptors and molecular rearrangements in membranes above the solid-fluid transition temperature.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Multi-Step Fibrinogen Binding to the Integrin {alpha}IIb{beta}3 Detected Using Force Spectroscopy.
R. I. Litvinov, J. S. Bennett, J. W. Weisel, and H. Shuman (2005)
Biophys. J. 89, 2824-2834
   Abstract »    Full Text »    PDF »
Neural Cell Adhesion Molecule (N-CAM) Homophilic Binding Mediated by the Two N-terminal Ig Domains Is Influenced by Intramolecular Domain-Domain Interactions.
A. R. Atkins, W. J. Gallin, G. C. Owens, G. M. Edelman, and B. A. Cunningham (2004)
J. Biol. Chem. 279, 49633-49643
   Abstract »    Full Text »    PDF »
Designing Human m1 Muscarinic Receptor-Targeted Hydrophobic Eigenmode Matched Peptides as Functional Modulators.
K. A. Selz, A. J. Mandell, M. F. Shlesinger, V. Arcuragi, and M. J. Owens (2004)
Biophys. J. 86, 1308-1331
   Abstract »    Full Text »    PDF »
Binding strength between cell adhesion proteoglycans measured by atomic force microscopy.
U Dammer, O Popescu, P Wagner, D Anselmetti, H. Guntherodt, and G. Misevic (1995)
Science 267, 1173-1175
   Abstract »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)