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Science 6 March 1992:
Vol. 255. no. 5049, pp. 1264 - 1266
DOI: 10.1126/science.1546329
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Articles

Science, Vol 255, Issue 5049, 1264-1266
Copyright © 1992 by American Association for the Advancement of Science

articles

HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation

RA Henderson, H Michel, K Sakaguchi, J Shabanowitz, E Appella, DF Hunt, and VH Engelhard

Department of Microbiology, University of Virginia School of Medicine, Charlottesville 22908.

Peptides extracted from HLA-A2.1 class I major histocompatibility complex (MHC) molecules expressed on the antigen processing mutant CEMx721.174.T2 were characterized by electrospray ionization-tandem mass spectrometry. Only seven dominant peptides were found, in contrast to over 200 associated with HLA-A2.1 on normal cells. These peptides were derived from the signal peptide domains of normal cellular proteins, were usually larger than nine residues, and were also associated with HLA-A2.1 in normal cells. These results suggest that proteolysis of signal peptide domains in the endoplasmic reticulum is a second mechanism for processing and presentation of peptides for association with class I molecules.


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P. J. Lehner, J. T. Karttunen, G. W. G. Wilkinson, and P. Cresswell (1997)
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F. Zappacosta, F. Borrego, A. G. Brooks, K. C. Parker, and J. E. Coligan (1997)
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P. A. Smith, A. Brunmark, M. R. Jackson, and T. A. Potter (1997)
J. Exp. Med. 185, 1023-1034
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M. P. Davenport, K. J. Smith, D. Barouch, S. W. Reid, W. M. Bodnar, A. C. Willis, D. F. Hunt, and A. V.S. Hill (1997)
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G. Russ, F. Esquivel, J. W. Yewdell, P. Cresswell, T. Spies, and J. R. Bennink (1995)
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Signal Sequence Processing in Rough Microsomes.
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D. Buchholz, P. Scott, and N. Shastri (1995)
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B. Martoglio and B. Dobberstein (1995)
Cold Spring Harb Symp Quant Biol 60, 41-45
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Assembly, Peptide Loading, and Transport of MHC Class I Molecules in a Calnexin-negative Cell Line.
B.K. Sadasivan, A. Cariappa, G.L. Waneck, and P. Cresswell (1995)
Cold Spring Harb Symp Quant Biol 60, 267-275
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Interaction of MHC class I molecules with the transporter associated with antigen processing.
W. Suh, M. Cohen-Doyle, K Fruh, K Wang, P. Peterson, and D. Williams (1994)
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Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines.
A. Cox, J Skipper, Y Chen, R. Henderson, T. Darrow, J Shabanowitz, V. Engelhard, D. Hunt, and C. Slingluff Jr (1994)
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Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant.
A Sette, S Ceman, R. Kubo, K Sakaguchi, E Appella, D. Hunt, T. Davis, H Michel, J Shabanowitz, R Rudersdorf, et al. (1992)
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Emerging principles for the recognition of peptide antigens by MHC class I molecules.
M Matsumura, D. Fremont, P. Peterson, and I. Wilson (1992)
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Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry.
D. Hunt, R. Henderson, J Shabanowitz, K Sakaguchi, H Michel, N Sevilir, A. Cox, E Appella, and V. Engelhard (1992)
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E.-M. Click, K.S. Anderson, M.J. Androlewicz, M.L. Wei, and P. Cresswell (1992)
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Peptide Specificity of RT1-A1c, an Inhibitory Rat Major Histocompatibility Complex Class I Natural Killer Cell Ligand.
J. Stevens, R. C. Jones, R. S. Bordoli, J. Trowsdale, S. J. Gaskell, G. W. Butcher, and E. Joly (2000)
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