Science 6 March 1992: Vol. 255. no. 5049, pp. 1243 - 1245 DOI: 10.1126/science.1546322

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Articles

Increased temperature and protein oxidation lead to HSP72 mRNA and protein accumulation in the in vivo exercised rat heart.

J. L. Staib, N. Tumer, and S. K. Powers (2009)
Exp Physiol 94, 71-80
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Heat Shock Co-Activates Interleukin-8 Transcription.

I. S. Singh, A. Gupta, A. Nagarsekar, Z. Cooper, C. Manka, L. Hester, I. J. Benjamin, J.-r. He, and J. D. Hasday (2008)
Am. J. Respir. Cell Mol. Biol. 39, 235-242
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Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging.

R. I. Morimoto (2008)
Genes & Dev. 22, 1427-1438
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Modulation of heat shock factors accompanies salicylic acid-mediated potentiation of Hsp70 in tomato seedlings.

M. Snyman and M. J. Cronje (2008)
J. Exp. Bot.
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Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule.

A. Trott, J. D. West, L. Klaic, S. D. Westerheide, R. B. Silverman, R. I. Morimoto, and K. A. Morano (2008)
Mol. Biol. Cell 19, 1104-1112
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DNMT1 as a Molecular Target in a Multimodality-Resistant Phenotype in Tumor Cells.

M. V. Mishra, K. S. Bisht, L. Sun, K. Muldoon-Jacobs, R. Awwad, A. Kaushal, P. Nguyen, L. Huang, J. D. Pennington, S. Markovina, et al. (2008)
Mol. Cancer Res. 6, 243-249
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Investigation of the Mechanisms Involved in the High-Dose and Long-Term Acetyl Salicylic Acid Therapy of Type I Diabetic Rats.

A. Jafarnejad, S. Z. Bathaie, M. Nakhjavani, and M. Z. Hassan (2008)
J. Pharmacol. Exp. Ther. 324, 850-857
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Increased temperature, not cardiac load, activates heat shock transcription factor 1 and heat shock protein 72 expression in the heart.

J. L. Staib, J. C. Quindry, J. P. French, D. S. Criswell, and S. K. Powers (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R432-R439
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Testosterone Is Required for Delayed Cardioprotection and Enhanced Heat Shock Protein 70 Expression Induced by Preconditioning.

J. Liu, S. Tsang, and T. M. Wong (2006)
Endocrinology 147, 4569-4577
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Reciprocal activation of HSF1 and HSF3 in brain and blood tissues: is redundancy developmentally related?.

A. Shabtay and Z. Arad (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R566-R572
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Triptolide, an Inhibitor of the Human Heat Shock Response That Enhances Stress-induced Cell Death.

S. D. Westerheide, T. L. A. Kawahara, K. Orton, and R. I. Morimoto (2006)
J. Biol. Chem. 281, 9616-9622
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Heat Shock-Independent Induction of Multidrug Resistance by Heat Shock Factor 1.

T. Tchenio, M. Havard, L. A. Martinez, and F. Dautry (2006)
Mol. Cell. Biol. 26, 580-591
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Phosphorylation of HSF1 by MAPK-Activated Protein Kinase 2 on Serine 121, Inhibits Transcriptional Activity and Promotes HSP90 Binding.

X. Wang, M. A. Khaleque, M. J. Zhao, R. Zhong, M. Gaestel, and S. K. Calderwood (2006)
J. Biol. Chem. 281, 782-791
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Heat Shock Response Modulators as Therapeutic Tools for Diseases of Protein Conformation.

S. D. Westerheide and R. I. Morimoto (2005)
J. Biol. Chem. 280, 33097-33100
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Protein Phosphatase 5 Is a Negative Modulator of Heat Shock Factor 1.

R. Conde, J. Xavier, C. McLoughlin, M. Chinkers, and N. Ovsenek (2005)
J. Biol. Chem. 280, 28989-28996
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Celastrols as Inducers of the Heat Shock Response and Cytoprotection.

S. D. Westerheide, J. D. Bosman, B. N. A. Mbadugha, T. L. A. Kawahara, G. Matsumoto, S. Kim, W. Gu, J. P. Devlin, R. B. Silverman, and R. I. Morimoto (2004)
J. Biol. Chem. 279, 56053-56060
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DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity.

F. Boellmann, T. Guettouche, Y. Guo, M. Fenna, L. Mnayer, and R. Voellmy (2004)
PNAS 101, 4100-4105
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Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model.

M. Ren, V. V. Senatorov, R.-W. Chen, and D.-M. Chuang (2003)
PNAS 100, 6210-6215
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Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress.

S.-G. Ahn and D. J. Thiele (2003)
Genes & Dev. 17, 516-528
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Effect of Hyaluronan Oligosaccharides on the Expression of Heat Shock Protein 72.

H. Xu, T. Ito, A. Tawada, H. Maeda, H. Yamanokuchi, K. Isahara, K. Yoshida, Y. Uchiyama, and A. Asari (2002)
J. Biol. Chem. 277, 17308-17314
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Protection against Heat Stress-Induced Oxidative Damage in Arabidopsis Involves Calcium, Abscisic Acid, Ethylene, and Salicylic Acid.

J. Larkindale and M. R. Knight (2002)
Plant Physiology 128, 682-695
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Evidence for a Mechanism of Repression of Heat Shock Factor 1 Transcriptional Activity by a Multichaperone Complex.

Y. Guo, T. Guettouche, M. Fenna, F. Boellmann, W. B. Pratt, D. O. Toft, D. F. Smith, and R. Voellmy (2001)
J. Biol. Chem. 276, 45791-45799
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Cyclooxygenase-independent actions of cyclooxygenase inhibitors.

I. TEGEDER, J. PFEILSCHIFTER, and G. GEISSLINGER (2001)
FASEB J 15, 2057-2072
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Heat Shock Proteins and Cardiovascular Pathophysiology.

L. H. E. H. Snoeckx, R. N. Cornelussen, F. A. Van Nieuwenhoven, R. S. Reneman, and G. J. Van der Vusse (2001)
Physiol Rev 81, 1461-1497
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Salicylates Inhibit Flavivirus Replication Independently of Blocking Nuclear Factor Kappa B Activation.

C.-L. Liao, Y.-L. Lin, B.-C. Wu, C.-H. Tsao, M.-C. Wang, C.-I Liu, Y.-L. Huang, J.-H. Chen, J.-P. Wang, and L.-K. Chen (2001)
J. Virol. 75, 7828-7839
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Roles of the heat shock transcription factors in regulation of the heat shock response and beyond.

L. PIRKKALA, P. NYKANEN, and L. SISTONEN (2001)
FASEB J 15, 1118-1131
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Increased Activator Protein 1 Activity as Well as Resistance to Heat-induced Radiosensitization, Hydrogen Peroxide, and Cisplatin Are Inhibited by Indomethacin in Oxidative Stress-resistant Cells.

C. M. Bradbury, J. E. Locke, S. J. Wei, L. M. Rene, S. Karimpour, C. Hunt, D. R. Spitz, and D. Gius (2001)
Cancer Res. 61, 3486-3492
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Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.

M. Minuzzo, S. Marchini, M. Broggini, G. Faircloth, M. D'Incalci, and R. Mantovani (2000)
PNAS 97, 6780-6784
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Resistance to apoptosis is a mechanism of adaptation of rat stomach to aspirin.

B. M. Alderman, G. A. Cook, M. Familari, N. D. Yeomans, and A. S. Giraud (2000)
Am J Physiol Gastrointest Liver Physiol 278, G839-G846
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The Yeast Heat Shock Transcription Factor Changes Conformation in Response to Superoxide and Temperature.

S. Lee, T. Carlson, N. Christian, K. Lea, J. Kedzie, J. P. Reilly, and J. J. Bonner (2000)
Mol. Biol. Cell 11, 1753-1764
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Aspirin Reduces Apolipoprotein(a) (Apo(a)) Production in Human Hepatocytes by Suppression of Apo(a) Gene Transcription.

A. Kagawa, H. Azuma, M. Akaike, Y. Kanagawa, and T. Matsumoto (1999)
J. Biol. Chem. 274, 34111-34115
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Salicylic Acid and Aspirin Inhibit the Activity of RSK2 Kinase and Repress RSK2-Dependent Transcription of Cyclic AMP Response Element Binding Protein- and NF-{kappa}B-Responsive Genes.

M. A. Stevenson, M.-J. Zhao, A. Asea, C. N. Coleman, and S. K. Calderwood (1999)
J. Immunol. 163, 5608-5616
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The Mammalian HSF4 Gene Generates Both an Activator and a Repressor of Heat Shock Genes by Alternative Splicing.

M. Tanabe, N. Sasai, K. Nagata, X.-D. Liu, P. C. C. Liu, D. J. Thiele, and A. Nakai (1999)
J. Biol. Chem. 274, 27845-27856
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Ku Autoantigen Affects the Susceptibility to Anticancer Drugs.

S. H. Kim, D. Kim, J. S. Han, C. S. Jeong, B. S. Chung, C. D. Kang, and G. C. Li (1999)
Cancer Res. 59, 4012-4017
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Inhibition of Cytokine Gene Expression by Sodium Salicylate in a Macrophage Cell Line through an NF-kappa B-Independent Mechanism.

S. Lemay, T. V. Lebedeva, and A. K. Singh (1999)
Clin. Vaccine Immunol. 6, 567-572
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Modulation of Human Heat Shock Factor Trimerization by the Linker Domain.

P. C. C. Liu and D. J. Thiele (1999)
J. Biol. Chem. 274, 17219-17225
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Glycogen Synthase Phosphatase Interacts with Heat Shock Factor To Activate CUP1 Gene Transcription in Saccharomyces cerevisiae.

J. T. Lin and J. T. Lis (1999)
Mol. Cell. Biol. 19, 3237-3245
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Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.

R. I. Morimoto (1998)
Genes & Dev. 12, 3788-3796
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Molecular Chaperones: Biology and Prospects for Pharmacological Intervention.

D. F. Smith, L. Whitesell, and E. Katsanis (1998)
Pharmacol. Rev. 50, 493-514
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Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion.

M. H. Pillinger, C. Capodici, P. Rosenthal, N. Kheterpal, S. Hanft, M. R. Philips, and G. Weissmann (1998)
PNAS 95, 14540-14545
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Metabolic Oxidative Stress-induced HSP70 Gene Expression Is Mediated through SAPK Pathway. ROLE OF Bcl-2 AND c-Jun NH2-TERMINAL KINASE.

Y. J. Lee and P. M. Corry (1998)
J. Biol. Chem. 273, 29857-29863
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Heat Shock Factor 1 Mediates Hemin-induced hsp70 Gene Transcription in K562 Erythroleukemia Cells.

T. Yoshima, T. Yura, and H. Yanagi (1998)
J. Biol. Chem. 273, 25466-25471
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Negative regulation of the heat shock transcriptional response by HSBP1.

S. H. Satyal, D. Chen, S. G. Fox, J. M. Kramer, and R. I. Morimoto (1998)
Genes & Dev. 12, 1962-1974
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Transcriptional Activation of Heat Shock Factor HSF1 Probed by Phosphopeptide Analysis of Factor 32P-labeled in Vivo.

W. Xia, Y. Guo, N. Vilaboa, J. Zuo, and R. Voellmy (1998)
J. Biol. Chem. 273, 8749-8755
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Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation.

K. Kaarniranta, M. Elo, R. Sironen, M. J. Lammi, M. B. Goldring, J. E. Eriksson, L. Sistonen, and H. J. Helminen (1998)
PNAS 95, 2319-2324
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Molecularchaperones as HSF1-specific transcriptional repressors.

Y. Shi, D. D. Mosser, and R. I. Morimoto (1998)
Genes & Dev. 12, 654-666
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Intramolecular Repression of Mouse Heat Shock Factor 1.

T. Farkas, Y. A. Kutskova, and V. Zimarino (1998)
Mol. Cell. Biol. 18, 906-918
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Conventional and novel PKC isoenzymes modify the heat-induced stress response but are not activated by heat shock.

C. Holmberg, P. Roos, J. Lord, J. Eriksson, and L Sistonen (1998)
J. Cell Sci. 111, 3357-3365
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Inhibition of Activator Protein 1Activity and Neoplastic Transformation by Aspirin.

Z. Dong, C. Huang, R. E. Brown, and W.-Y. Ma (1997)
J. Biol. Chem. 272, 9962-9970
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The Phorbol Ester 12-O-Tetradecanoylphorbol 13-Acetate Enhances the Heat-induced Stress Response.

C. I. Holmberg, S. Leppa, J. E. Eriksson, and L. Sistonen (1997)
J. Biol. Chem. 272, 6792-6798
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Hyperphosphorylation of Heat Shock Transcription Factor 1Is Correlated with Transcriptional Competence and Slow Dissociation of Active Factor Trimers.

W. Xia and R. Voellmy (1997)
J. Biol. Chem. 272, 4094-4102
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HSF1 granules: a novel stress-induced nuclear compartment of human cells.

J Cotto, S Fox, and R Morimoto (1997)
J. Cell Sci. 110, 2925-2934
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Salicylate Is a Transcriptional Inhibitor of the Inducible Nitric Oxide Synthase in Cultured Cardiac Fibroblasts.

R. S. Farivar and P. Brecher (1996)
J. Biol. Chem. 271, 31585-31592
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Sodium Salicylate Decreases Intracellular ATP, Induces Both Heat Shock Factor Binding and Chromosomal Puffing, but Does Not Induce hsp 70Gene Transcription in Drosophila.

N. A. Winegarden, K. S. Wong, M. Sopta, and J. T. Westwood (1996)
J. Biol. Chem. 271, 26971-26980
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of HSP70 Expression by Calcium Ionophore A23187 in Human Cells. AN EFFECT INDEPENDENT OF THE ACQUISITION OF DNA-BINDING ACTIVITY BY THE HEAT SHOCK TRANSCRIPTION FACTOR.

G. Elia, A. De Marco, A. Rossi, and M. G. Santoro (1996)
J. Biol. Chem. 271, 16111-16118
 |  Abstract »  |  Full Text »  |  PDF »

Salicylate or Aspirin Inhibits the Induction of the Inducible Nitric Oxide Synthase in Rat Cardiac Fibroblasts.

R. Saeid Farivar, A. V. Chobanian, and P. Brecher (1996)
Circ. Res. 78, 759-768
 |  Abstract »  |  Full Text »

Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate.

P. Schwenger, E. Y. Skolnik, and J. Vilcek (1996)
J. Biol. Chem. 271, 8089-8094
 |  Abstract »  |  Full Text »  |  PDF »

Oxidative stress induced heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription..

X D Liu and D J Thiele (1996)
Genes & Dev. 10, 592-603
 |  Abstract »  |  PDF »

Activation of Heat Shock Factor 1 DNA Binding Precedes Stress-induced Serine Phosphorylation.

J. J. Cotto, M. Kline, and R. I. Morimoto (1996)
J. Biol. Chem. 271, 3355-3358
 |  Abstract »  |  Full Text »  |  PDF »

Transcription regulation of alpha B-crystallin in astrocytes: analysis of HSF and AP1 activation by different types of physiological stress.

M. Head, L Hurwitz, and J. Goldman (1996)
J. Cell Sci. 109, 1029-1039
 |  Abstract »  |  PDF »

Pharmacological Induction of Heat Shock Protein 68 Synthesis in Cultured Rat Astrocytes.

R. N. Nishimura and B. E. Dwyer (1995)
J. Biol. Chem. 270, 29967-29970
 |  Abstract »  |  Full Text »  |  PDF »

Salicylate Triggers Heat Shock Factor Differently than Heat.

D. A. Jurivich, C. Pachetti, L. Qiu, and J. F. Welk (1995)
J. Biol. Chem. 270, 24489-24495
 |  Abstract »  |  Full Text »  |  PDF »

Sodium Salicylate and Yeast Heat Shock Gene Transcription.

C. Giardina and J. T. Lis (1995)
J. Biol. Chem. 270, 10369-10372
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of NF-kappa B by sodium salicylate and aspirin.

E Kopp and S Ghosh (1994)
Science 265, 956-959
 |  Abstract »  |  PDF »

Regulation of chemical stress-induced hsp70 gene expression in murine L929 cells.

R. Liu, P. Corry, and Y. Lee (1994)
J. Cell Sci. 107, 2209-2214
 |  Abstract »  |  PDF »

Cells in stress: transcriptional activation of heat shock genes.

R. Morimoto (1993)
Science 259, 1409-1410
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Analysis of chromatin structure by ligation-mediated PCR..

G P Pfeifer (1992)
Genome Res. 2, 107-111
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The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression..

K Abravaya, M P Myers, S P Murphy, and R I Morimoto (1992)
Genes & Dev. 6, 1153-1164
 |  Abstract »  |  PDF »

Glycogen Synthase Kinase 3beta Negatively Regulates Both DNA-binding and Transcriptional Activities of Heat Shock Factor 1.

I. J. Xavier, P. A. Mercier, C. M. McLoughlin, A. Ali, J. R. Woodgett, and N. Ovsenek (2000)
J. Biol. Chem. 275, 29147-29152
 |  Abstract »  |  Full Text »  |  PDF »

Geldanamycin Restores a Defective Heat Shock Response in Vivo.

K. F. Winklhofer, A. Reintjes, M. C. Hoener, R. Voellmy, and J. Tatzelt (2001)
J. Biol. Chem. 276, 45160-45167
 |  Abstract »  |  Full Text »  |  PDF »

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