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Science 6 March 1992:
Vol. 255. no. 5049, pp. 1243 - 1245
DOI: 10.1126/science.1546322
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Articles

Science, Vol 255, Issue 5049, 1243-1245
Copyright © 1992 by American Association for the Advancement of Science

articles

Effect of sodium salicylate on the human heat shock response

DA Jurivich, L Sistonen, RA Kroes, and RI Morimoto

Department of Medicine and Biochemistry, Northwestern University, Evanston, IL 60208.

Sodium salicylate, an anti-inflammatory agent, was examined for its effects on the heat shock response in cultured human cells. Salicylate activation of DNA binding by the heat shock transcription factor (HSF) was comparable to activation attained during heat shock. However, sodium salicylate did not induce heat shock gene transcription even though the HSF was bound in vivo to the heat shock elements upstream of the heat shock protein 70 (Hsp 70) gene. These results reveal that activation of the heat shock transcriptional response is a multistep process. Modulation of extracellular pH augments sensitivity to salicylate-induced activation of HSF.


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HSF1 granules: a novel stress-induced nuclear compartment of human cells.
J Cotto, S Fox, and R Morimoto (1997)
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   Abstract »    PDF »
Salicylate Is a Transcriptional Inhibitor of the Inducible Nitric Oxide Synthase in Cultured Cardiac Fibroblasts.
R. S. Farivar and P. Brecher (1996)
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   Abstract »    Full Text »    PDF »
Sodium Salicylate Decreases Intracellular ATP, Induces Both Heat Shock Factor Binding and Chromosomal Puffing, but Does Not Induce hsp 70Gene Transcription in Drosophila.
N. A. Winegarden, K. S. Wong, M. Sopta, and J. T. Westwood (1996)
J. Biol. Chem. 271, 26971-26980
   Abstract »    Full Text »    PDF »
Inhibition of HSP70 Expression by Calcium Ionophore A23187 in Human Cells. AN EFFECT INDEPENDENT OF THE ACQUISITION OF DNA-BINDING ACTIVITY BY THE HEAT SHOCK TRANSCRIPTION FACTOR.
G. Elia, A. De Marco, A. Rossi, and M. G. Santoro (1996)
J. Biol. Chem. 271, 16111-16118
   Abstract »    Full Text »    PDF »
Salicylate or Aspirin Inhibits the Induction of the Inducible Nitric Oxide Synthase in Rat Cardiac Fibroblasts.
R. Saeid Farivar, A. V. Chobanian, and P. Brecher (1996)
Circ. Res. 78, 759-768
   Abstract »    Full Text »
Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate.
P. Schwenger, E. Y. Skolnik, and J. Vilcek (1996)
J. Biol. Chem. 271, 8089-8094
   Abstract »    Full Text »    PDF »
Oxidative stress induced heat shock factor phosphorylation and HSF-dependent activation of yeast metallothionein gene transcription..
X D Liu and D J Thiele (1996)
Genes & Dev. 10, 592-603
   Abstract »    PDF »
Activation of Heat Shock Factor 1 DNA Binding Precedes Stress-induced Serine Phosphorylation.
J. J. Cotto, M. Kline, and R. I. Morimoto (1996)
J. Biol. Chem. 271, 3355-3358
   Abstract »    Full Text »    PDF »
Transcription regulation of alpha B-crystallin in astrocytes: analysis of HSF and AP1 activation by different types of physiological stress.
M. Head, L Hurwitz, and J. Goldman (1996)
J. Cell Sci. 109, 1029-1039
   Abstract »    PDF »
Pharmacological Induction of Heat Shock Protein 68 Synthesis in Cultured Rat Astrocytes.
R. N. Nishimura and B. E. Dwyer (1995)
J. Biol. Chem. 270, 29967-29970
   Abstract »    Full Text »    PDF »
Salicylate Triggers Heat Shock Factor Differently than Heat.
D. A. Jurivich, C. Pachetti, L. Qiu, and J. F. Welk (1995)
J. Biol. Chem. 270, 24489-24495
   Abstract »    Full Text »    PDF »
Sodium Salicylate and Yeast Heat Shock Gene Transcription.
C. Giardina and J. T. Lis (1995)
J. Biol. Chem. 270, 10369-10372
   Abstract »    Full Text »    PDF »
Inhibition of NF-kappa B by sodium salicylate and aspirin.
E Kopp and S Ghosh (1994)
Science 265, 956-959
   Abstract »    PDF »
Regulation of chemical stress-induced hsp70 gene expression in murine L929 cells.
R. Liu, P. Corry, and Y. Lee (1994)
J. Cell Sci. 107, 2209-2214
   Abstract »    PDF »
Cells in stress: transcriptional activation of heat shock genes.
R. Morimoto (1993)
Science 259, 1409-1410
   PDF »
Analysis of chromatin structure by ligation-mediated PCR..
G P Pfeifer (1992)
Genome Res. 2, 107-111
   PDF »
The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression..
K Abravaya, M P Myers, S P Murphy, and R I Morimoto (1992)
Genes & Dev. 6, 1153-1164
   Abstract »    PDF »
Glycogen Synthase Kinase 3beta Negatively Regulates Both DNA-binding and Transcriptional Activities of Heat Shock Factor 1.
I. J. Xavier, P. A. Mercier, C. M. McLoughlin, A. Ali, J. R. Woodgett, and N. Ovsenek (2000)
J. Biol. Chem. 275, 29147-29152
   Abstract »    Full Text »    PDF »
Geldanamycin Restores a Defective Heat Shock Response in Vivo.
K. F. Winklhofer, A. Reintjes, M. C. Hoener, R. Voellmy, and J. Tatzelt (2001)
J. Biol. Chem. 276, 45160-45167
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)