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Science 28 February 1992:
Vol. 255. no. 5048, pp. 1134 - 1137
DOI: 10.1126/science.1546316

Articles

Science, Vol 255, Issue 5048, 1134-1137
Copyright © 1992 by American Association for the Advancement of Science


articles

Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants

SM Wolinsky, CM Wike, BT Korber, C Hutto, WP Parks, LL Rosenblum, KJ Kunstman, MR Furtado, and JL Munoz

Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.

Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother predominated in her infant. A conserved N-linked glycosylation site within the V3 region, present in each mother's sequence set, was absent in all of the infants' sequence sets. These findings demonstrate that a minor subset of maternal virus is transmitted to the infant.


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