Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 21 February 1992:
Vol. 255. no. 5047, pp. 991 - 994
DOI: 10.1126/science.1546297
Prev | Table of Contents | Next

Articles

Science, Vol 255, Issue 5047, 991-994
Copyright © 1992 by American Association for the Advancement of Science

articles

Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes

KL Mowry and DA Melton

Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.

Contained within a single cell, the fertilized egg, is information that will ultimately specify the entire organism. During early embryonic cleavages, cells acquire distinct fates and their differences in developmental potential might be explained by localization of informational molecules in the egg. The mechanisms by which Vg1 RNA, a maternal mRNA, is translocated to the vegetal pole of Xenopus oocytes may indicate how developmental signals are localized. Data presented here show that a 340-nucleotide localization signal present in the 3' untranslated region of Vg1 RNA is sufficient to direct RNA localization to the vegetal pole.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A bioinformatics search pipeline, RNA2DSearch, identifies RNA localization elements in Drosophila retrotransposons.
R. S. Hamilton, E. Hartswood, G. Vendra, C. Jones, V. Van De Bor, D. Finnegan, and I. Davis (2009)
RNA 15, 200-207
   Abstract »    Full Text »    PDF »
A manganese-dependent ribozyme in the 3'-untranslated region of Xenopus Vg1 mRNA.
N. G. Kolev, E. I. Hartland, and P. W. Huber (2008)
Nucleic Acids Res. 36, 5530-5539
   Abstract »    Full Text »    PDF »
PTB/hnRNP I Is Required for RNP Remodeling during RNA Localization in Xenopus Oocytes.
R. A. Lewis, J. A. Gagnon, and K. L. Mowry (2008)
Mol. Cell. Biol. 28, 678-686
   Abstract »    Full Text »    PDF »
Cis-acting determinants of asymmetric, cytoplasmic RNA transport.
A. Jambhekar and J. L. DeRisi (2007)
RNA 13, 625-642
   Abstract »    Full Text »    PDF »
RAP55, a Cytoplasmic mRNP Component, Represses Translation in Xenopus Oocytes.
K. J. Tanaka, K. Ogawa, M. Takagi, N. Imamoto, K. Matsumoto, and M. Tsujimoto (2006)
J. Biol. Chem. 281, 40096-40106
   Abstract »    Full Text »    PDF »
40LoVe interacts with Vg1RBP/Vera and hnRNP I in binding the Vg1-Localization Element.
K. CZAPLINSKI and I. W. MATTAJ (2006)
RNA 12, 213-222
   Abstract »    Full Text »    PDF »
The Xenopus ELAV Protein ElrB Represses Vg1 mRNA Translation during Oogenesis.
L. J. Colegrove-Otero, A. Devaux, and N. Standart (2005)
Mol. Cell. Biol. 25, 9028-9039
   Abstract »    Full Text »    PDF »
RNA localization.
Y. Shav-Tal and R. H. Singer (2005)
J. Cell Sci. 118, 4077-4081
   Full Text »    PDF »
RNA localization mechanisms in oocytes.
M. Kloc and L. D. Etkin (2005)
J. Cell Sci. 118, 269-282
   Abstract »    Full Text »    PDF »
The RNA ligands for mouse proline-rich RNA-binding protein (mouse Prrp) contain two consensus sequences in separate loop structure.
T. Hori, Y. Taguchi, S. Uesugi, and Y. Kurihara (2005)
Nucleic Acids Res. 33, 190-200
   Abstract »    Full Text »    PDF »
Localization of RNAs to the Mitochondrial Cloud in Xenopus Oocytes through Entrapment and Association with Endoplasmic Reticulum.
P. Chang, J. Torres, R. A. Lewis, K. L. Mowry, E. Houliston, and M. L. King (2004)
Mol. Biol. Cell 15, 4669-4681
   Abstract »    Full Text »    PDF »
Evidence for overlapping, but not identical, protein machineries operating in vegetal RNA localization along early and late pathways in Xenopus oocytes.
M. Claussen, K. Horvay, and T. Pieler (2004)
Development 131, 4263-4273
   Abstract »    Full Text »    PDF »
Xenopus Staufen is a component of a ribonucleoprotein complex containing Vg1 RNA and kinesin.
Y. J. Yoon and K. L. Mowry (2004)
Development 131, 3035-3045
   Abstract »    Full Text »    PDF »
Nuclear RNP complex assembly initiates cytoplasmic RNA localization.
T. L. Kress, Y. J. Yoon, and K. L. Mowry (2004)
J. Cell Biol. 165, 203-211
   Abstract »    Full Text »    PDF »
A homolog of FBP2/KSRP binds to localized mRNAs in Xenopus oocytes.
T. T. Kroll, W.-m. Zhao, C. Jiang, and P. W. Huber (2003)
Development 129, 5609-5619
   Abstract »    Full Text »    PDF »
Deleted in Azoospermia Associated Protein 1 Shuttles Between Nucleus and Cytoplasm During Normal Germ Cell Maturation.
Y. Vera, T. Dai, A. P. S. Hikim, Y. Lue, E. C. Salido, R. S. Swerdloff, and P. H. Yen (2002)
J Androl 23, 622-628
   Abstract »    Full Text »    PDF »
Effects of Elevated Intraocular Pressure on Outflow Facility and TIGR/MYOC Expression in Perfused Human Anterior Segments.
T. Borras, L. L. S. Rowlette, E. R. Tamm, J. Gottanka, and D. L. Epstein (2002)
Invest. Ophthalmol. Vis. Sci. 43, 33-40
   Abstract »    Full Text »    PDF »
Asymmetric Subcellular mRNA Distribution Correlates with Carbonic Anhydrase Activity in Acetabularia acetabulum.
K. A. Serikawa, D. M. Porterfield, and D. F. Mandoli (2001)
Plant Physiology 125, 900-911
   Abstract »    Full Text »
Coordinate control of translation and localization of Vg1 mRNA in Xenopus oocytes.
J. E. Wilhelm, R. D. Vale, and R. S. Hegde (2000)
PNAS 97, 13132-13137
   Abstract »    Full Text »    PDF »
Subcellular Localization of Expansin mRNA in Xylem Cells.
K.-H. Im, D. J. Cosgrove, and A. M. Jones (2000)
Plant Physiology 123, 463-470
   Abstract »    Full Text »
The Cis-Acting RNA Trafficking Signal from Myelin Basic Protein mRNA and Its Cognate Trans-Acting Ligand Hnrnp A2 Enhance CaP-Dependent Translation.
S. Kwon, E. Barbarese, and J. H. Carson (1999)
J. Cell Biol. 147, 247-256
   Abstract »    Full Text »    PDF »
fatvg encodes a new localized RNA that uses a 25-nucleotide element (FVLE1) to localize to the vegetal cortex of Xenopus oocytes.
A. Chan, M Kloc, and L. Etkin (1999)
Development 126, 4943-4953
   Abstract »    PDF »
Microtubule Involvement in Translational Regulation of Fibronectin Expression by Light Chain 3 of Microtubule-Associated Protein 1 in Vascular Smooth Muscle Cells.
B. Zhou and M. Rabinovitch (1998)
Circ. Res. 83, 481-489
   Abstract »    Full Text »    PDF »
RNA-binding protein conserved in both microtubule- and microfilament-based RNA localization.
L. Havin, A. Git, Z. Elisha, F. Oberman, K. Yaniv, S. P. Schwartz, N. Standart, and J. K. Yisraeli (1998)
Genes & Dev. 12, 1593-1598
   Abstract »    Full Text »
Differential Intracellular Sorting of Immediate Early Gene mRNAs Depends on Signals in the mRNA Sequence.
C. S. Wallace, G. L. Lyford, P. F. Worley, and O. Steward (1998)
J. Neurosci. 18, 26-35
   Abstract »    Full Text »    PDF »
Transport and Localization Elements in Myelin Basic Protein mRNA.
K. Ainger, D. Avossa, A. S. Diana, C. Barry, E. Barbarese, and J. H. Carson (1997)
J. Cell Biol. 138, 1077-1087
   Abstract »    Full Text »    PDF »
Two copies of a subelement from the Vg1 RNA localization sequence are sufficient to direct vegetal localization in Xenopus oocytes.
D Gautreau, C. Cote, and K. Mowry (1997)
Development 124, 5013-5020
   Abstract »    PDF »
Complex formation between stage-specific oocyte factors and a Xenopus mRNA localization element.
K. L. Mowry (1996)
PNAS 93, 14608-14613
   Abstract »    Full Text »    PDF »
Ultrastructural Localization of Dendritic Messenger RNA in Adult Rat Hippocampus.
M. E. Martone, J. A. Pollock, Y. Z. Jones, and M. H. Ellisman (1996)
J. Neurosci. 16, 7437-7446
   Abstract »    Full Text »    PDF »
The 3'-untranslated region of CaMKIIalpha is a cis-acting signal for the localization and translation of mRNA in dendrites.
M. Mayford, D. Baranes, K. Podsypanina, and E. R. Kandel (1996)
PNAS 93, 13250-13255
   Abstract »    Full Text »    PDF »
Localization of Xcat-2 RNA, a putative germ plasm component, to the mitochondrial cloud in Xenopus stage I oocytes.
Y Zhou and M. King (1996)
Development 122, 2947-2953
   Abstract »    PDF »
A localisation signal in the 3' untranslated region of c-myc mRNA targets c-myc mRNA and beta-globin reporter sequences to the perinuclear cytoplasm and cytoskeletal-bound polysomes.
J. Veyrune, G. Campbell, J Wiseman, J. Blanchard, and J. Hesketh (1996)
J. Cell Sci. 109, 1185-1194
   Abstract »    PDF »
Review : Single-Cell mRNA Amplification: Implications for Basic and Clinical Neuroscience.
J. Eberwine, P. Crino, and M. Dichter (1995)
Neuroscientist 1, 200-211
   Abstract »    PDF »
Induction of dorsal mesoderm by soluble, mature Vg1 protein.
D. Kessler and D. Melton (1995)
Development 121, 2155-2164
   Abstract »    PDF »
Temporal regulation of the Xenopus FGF receptor in development: a translation inhibitory element in the 3' untranslated region.
E. Robbie, M Peterson, E Amaya, and T. Musci (1995)
Development 121, 1775-1785
   Abstract »    PDF »
Two distinct pathways for the localization of RNAs at the vegetal cortex in Xenopus oocytes.
M Kloc and L. Etkin (1995)
Development 121, 287-297
   Abstract »    PDF »
RNA localization along the anteroposterior axis of the Drosophila oocyte requires PKA-mediated signal transduction to direct normal microtubule organization..
M E Lane and D Kalderon (1994)
Genes & Dev. 8, 2986-2995
   Abstract »    PDF »
Vertebrate embryonic induction: mesodermal and neural patterning.
D. Kessler and D. Melton (1994)
Science 266, 596-604
   Abstract »    PDF »
The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation..
M D Sheets, C A Fox, T Hunt, G Vande Woude, and M Wickens (1994)
Genes & Dev. 8, 926-938
   Abstract »    PDF »
Intracellular distribution of beta-actin mRNA is polarized in embryonic corneal epithelia.
B Yeh and K. Svoboda (1994)
J. Cell Sci. 107, 105-115
   Abstract »    PDF »
Translocation of repetitive RNA sequences with the germ plasm in Xenopus oocytes.
M Kloc, G Spohr, and L. Etkin (1993)
Science 262, 1712-1714
   Abstract »    PDF »
Xwnt-11: a maternally expressed Xenopus wnt gene.
M. Ku and D. A. Melton (1993)
Development 119, 1161-1173
   Abstract »    PDF »
Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene..
R L Kelley (1993)
Genes & Dev. 7, 948-960
   Abstract »    PDF »
Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA.
J Kim-Ha, P. Webster, J. Smith, and P. Macdonald (1993)
Development 119, 169-178
   Abstract »    PDF »
RNA regulatory element BLE1 directs the early steps of bicoid mRNA localization.
P. Macdonald, K Kerr, J. Smith, and A Leask (1993)
Development 118, 1233-1243
   Abstract »    PDF »
A mRNA localized to the vegetal cortex of Xenopus oocytes encodes a protein with a nanos-like zinc finger domain.
L. Mosquera, C. Forristall, Y. Zhou, and M. L. King (1993)
Development 117, 377-386
   Abstract »    PDF »
Translational control by poly(A) elongation during Xenopus development: differential repression and enhancement by a novel cytoplasmic polyadenylation element..
R Simon, J P Tassan, and J D Richter (1992)
Genes & Dev. 6, 2580-2591
   Abstract »    PDF »
Regulation of Induction by GLP1, a Localized Cell Surface Receptor in Caenorhabditis elegans.
J. Kimble, S. Crittenden, E. Lambie, V. Kodoyianni, S. Mango, and E. Troemel (1992)
Cold Spring Harb Symp Quant Biol 57, 401-407
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)