Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 7 February 1992:
Vol. 255. no. 5045, pp. 733 - 736
DOI: 10.1126/science.1738848
Prev | Table of Contents | Next

Articles

Science, Vol 255, Issue 5045, 733-736
Copyright © 1992 by American Association for the Advancement of Science

articles

Chondroitin sulfate as a regulator of neuronal patterning in the retina

PA Brittis, DR Canning, and J Silver

Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106.

Highly sulfated proteoglycans are correlated with axon boundaries in the developing central nervous system which suggests that these molecules affect neural pattern formation. In the developing mammalian retina, gradual regression of chondroitin sulfate may help control the onset of ganglion cell differentiation and initial direction of their axons. Changes induced by the removal of chondroitin sulfate from intact retinas in culture confirm the function of chondroitin sulfate in retinal histogenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Oversulfated Chondroitin Sulfate Plays Critical Roles in the Neuronal Migration in the Cerebral Cortex.
M. Ishii and N. Maeda (2008)
J. Biol. Chem. 283, 32610-32620
   Abstract »    Full Text »    PDF »
Molecular regulation of visual system development: more than meets the eye.
T. Harada, C. Harada, and L. F. Parada (2007)
Genes & Dev. 21, 367-378
   Abstract »    Full Text »    PDF »
Slit Proteins Regulate Distinct Aspects of Retinal Ganglion Cell Axon Guidance within Dorsal and Ventral Retina.
H. Thompson, O. Camand, D. Barker, and L. Erskine (2006)
J. Neurosci. 26, 8082-8091
   Abstract »    Full Text »    PDF »
Molecular Cloning and Characterization of Chick SPACRCAN.
Y. Inoue, M. Yoneda, J. Zhao, O. Miyaishi, A. Ohno-Jinno, T. Kataoka, Z. Isogai, K. Kimata, M. Iwaki, and M. Zako (2006)
J. Biol. Chem. 281, 10381-10388
   Abstract »    Full Text »    PDF »
NG2 glial cells provide a favorable substrate for growing axons..
Z. Yang, R. Suzuki, S. B. Daniels, C. B. Brunquell, C. J. Sala, and A. Nishiyama (2006)
J. Neurosci. 26, 3829-3839
   Abstract »    Full Text »    PDF »
The cell adhesion molecule NrCAM is crucial for growth cone behaviour and pathfinding of retinal ganglion cell axons.
P. Zelina, H. X. Avci, K. Thelen, and G. E. Pollerberg (2005)
Development 132, 3609-3618
   Abstract »    Full Text »    PDF »
Degradation of Chondroitin Sulfate Proteoglycans Induces Sprouting of Intact Purkinje Axons in the Cerebellum of the Adult Rat.
L. Corvetti and F. Rossi (2005)
J. Neurosci. 25, 7150-7158
   Abstract »    Full Text »    PDF »
Disruption of gradient expression of Zic3 resulted in abnormal intra-retinal axon projection.
J. Zhang, Z. Jin, and Z.-Z. Bao (2004)
Development 131, 1553-1562
   Abstract »    Full Text »    PDF »
Keratan Sulfate Proteoglycan Phosphacan Regulates Mossy Fiber Outgrowth and Regeneration.
C. D. Butler, S. A. Schnetz, E. Y. Yu, J. B. Davis, K. Temple, J. Silver, and A. T. Malouf (2004)
J. Neurosci. 24, 462-473
   Abstract »    Full Text »    PDF »
Connecting the eye to the brain: the molecular basis of ganglion cell axon guidance.
S F Oster and D W Sretavan (2003)
Br J Ophthalmol 87, 639-645
   Abstract »    Full Text »    PDF »
Irx4-mediated regulation of Slit1 expression contributes to the definition of early axonal paths inside the retina.
Z. Jin, J. Zhang, A. Klar, A. Chedotal, Y. Rao, C. L. Cepko, and Z.-Z. Bao (2003)
Development 130, 1037-1048
   Abstract »    Full Text »    PDF »
Accumulation of Neurocan, a Brain Chondroitin Sulfate Proteoglycan, in Association with the Retinal Vasculature in RCS Rats.
Y. Zhang, U. Rauch, and M.-T. R. Perez (2003)
Invest. Ophthalmol. Vis. Sci. 44, 1252-1261
   Abstract »    Full Text »    PDF »
Versican Is Upregulated in CNS Injury and Is a Product of Oligodendrocyte Lineage Cells.
R. A. Asher, D. A. Morgenstern, M. C. Shearer, K. H. Adcock, P. Pesheva, and J. W. Fawcett (2002)
J. Neurosci. 22, 2225-2236
   Abstract »    Full Text »    PDF »
Repellent Guidance of Regenerating Optic Axons by Chondroitin Sulfate Glycosaminoglycans in Zebrafish.
C. G. Becker and T. Becker (2002)
J. Neurosci. 22, 842-853
   Abstract »    Full Text »    PDF »
Roles of the Telencephalic Cells and their Chondroitin Sulfate Proteoglycans in Delimiting an Anterior Border of the Retinal Pathway.
H. Ichijo and I. Kawabata (2001)
J. Neurosci. 21, 9304-9314
   Abstract »    Full Text »    PDF »
Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog.
F. Trousse, E. Marti, P. Gruss, M. Torres, and P. Bovolenta (2001)
Development 128, 3927-3936
   Abstract »    Full Text »    PDF »
Axonal Regeneration into Acellular Nerve Grafts Is Enhanced by Degradation of Chondroitin Sulfate Proteoglycan.
C. A. Krekoski, D. Neubauer, J. Zuo, and D. Muir (2001)
J. Neurosci. 21, 6206-6213
   Abstract »    Full Text »    PDF »
Inhibitory Effects of Neurocan and Phosphacan on Neurite Outgrowth from Retinal Ganglion Cells in Culture.
M. Inatani, M. Honjo, Y. Otori, A. Oohira, N. Kido, Y. Tano, Y. Honda, and H. Tanihara (2001)
Invest. Ophthalmol. Vis. Sci. 42, 1930-1938
   Abstract »    Full Text »    PDF »
Intact Aggrecan and Fragments Generated by Both Aggrecanse and Metalloproteinase-Like Activities Are Present in the Developing and Adult Rat Spinal Cord and Their Relative Abundance Is Altered by Injury.
M. L. Lemons, J. D. Sandy, D. K. Anderson, and D. R. Howland (2001)
J. Neurosci. 21, 4772-4781
   Abstract »    Full Text »    PDF »
Effect of ADCON-L on adjustable strabismus surgery in rabbits.
M. Y. Choi, S.-J. Auh, D. G. Choi, and B. L. Chang (2001)
Br J Ophthalmol 85, 80-84
   Abstract »    Full Text »
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins.
C. E. Bandtlow and D. R. Zimmermann (2000)
Physiol Rev 80, 1267-1290
   Abstract »    Full Text »    PDF »
Slit2 Is a Repellent for Retinal Ganglion Cell Axons.
S. P. Niclou, L. Jia, and J. A. Raper (2000)
J. Neurosci. 20, 4962-4974
   Abstract »    Full Text »    PDF »
Neurocan Is Upregulated in Injured Brain and in Cytokine-Treated Astrocytes.
R. A. Asher, D. A. Morgenstern, P. S. Fidler, K. H. Adcock, A. Oohira, J. E. Braistead, J. M. Levine, R. U. Margolis, J. H. Rogers, and J. W. Fawcett (2000)
J. Neurosci. 20, 2427-2438
   Abstract »    Full Text »    PDF »
Identification of cis-Elements Regulating Exon 15 Splicing of the Amyloid Precursor Protein Pre-mRNA.
C. Bergsdorf, K. Paliga, S. Kreger, C. L. Masters, and K. Beyreuther (2000)
J. Biol. Chem. 275, 2046-2056
   Abstract »    Full Text »    PDF »
Axon routing at the optic chiasm after enzymatic removal of chondroitin sulfate in mouse embryos.
K. Chung, J. Taylor, D. Shum, and S. Chan (2000)
Development 127, 2673-2683
   Abstract »    PDF »
Embryonic Neurons Adapt to the Inhibitory Proteoglycan Aggrecan by Increasing Integrin Expression.
M. L. Condic, D. M. Snow, and P. C. Letourneau (1999)
J. Neurosci. 19, 10036-10043
   Abstract »    Full Text »    PDF »
The Receptor Tyrosine Phosphatase Cryp{alpha} Promotes Intraretinal Axon Growth.
M. M. Ledig, F. Haj, J. L. Bixby, A. W. Stoker, and B. K. Mueller (1999)
J. Cell Biol. 147, 375-388
   Abstract »    Full Text »    PDF »
DSD-1-Proteoglycan Is the Mouse Homolog of Phosphacan and Displays Opposing Effects on Neurite Outgrowth Dependent on Neuronal Lineage.
J. Garwood, O. Schnadelbach, A. Clement, K. Schutte, A. Bach, and A. Faissner (1999)
J. Neurosci. 19, 3888-3899
   Abstract »    Full Text »    PDF »
Neurolin Ig Domain 2 Participates in Retinal Axon Guidance and Ig Domains 1 and 3 in Fasciculation.
C. A. Leppert, H. Diekmann, C. Paul, U. Laessing, M. Marx, M. Bastmeyer, and C. A.O. Stuermer (1999)
J. Cell Biol. 144, 339-349
   Abstract »    Full Text »    PDF »
The DSD-1 Carbohydrate Epitope Depends on Sulfation, Correlates with Chondroitin Sulfate D Motifs, and Is Sufficient to Promote Neurite Outgrowth.
A. M. Clement, S. Nadanaka, K. Masayama, C. Mandl, K. Sugahara, and A. Faissner (1998)
J. Biol. Chem. 273, 28444-28453
   Abstract »    Full Text »    PDF »
Retinal Ganglion Cell Axon Progression from the Optic Chiasm to Initiate Optic Tract Development Requires Cell Autonomous Function of GAP-43.
K. Kruger, A. S. Tam, C. Lu, and D. W. Sretavan (1998)
J. Neurosci. 18, 5692-5705
   Abstract »    Full Text »    PDF »
Patterns of Chondroitin Sulfate Immunoreactivity in the Developing Tectum Reflect Regional Differences in Glycosaminoglycan Biosynthesis.
D. Hoffman-Kim, A. D. Lander, and S. Jhaveri (1998)
J. Neurosci. 18, 5881-5890
   Abstract »    Full Text »    PDF »
Neuronal Matrix Metalloproteinase-2 Degrades and Inactivates a Neurite-Inhibiting Chondroitin Sulfate Proteoglycan.
J. Zuo, T. A. Ferguson, Y. J. Hernandez, W. G. Stetler-Stevenson, and D. Muir (1998)
J. Neurosci. 18, 5203-5211
   Abstract »    Full Text »    PDF »
Axonal Versus Dendritic Outgrowth Is Differentially Affected by Radial Glia in Discrete Layers of the Retina.
H. Bauch, H. Stier, and B. Schlosshauer (1998)
J. Neurosci. 18, 1774-1785
   Abstract »    Full Text »    PDF »
Isolation of a Tenascin-R Binding Protein from Mouse Brain Membranes. A PHOSPHACAN-RELATED CHONDROITIN SULFATE PROTEOGLYCAN.
Z.-C. Xiao, U. Bartsch, R. K. Margolis, G. Rougon, D. Montag, and M. Schachner (1997)
J. Biol. Chem. 272, 32092-32101
   Abstract »    Full Text »    PDF »
Alternative Splicing of the Unique "PLUS" Domain of Chicken PG-M/Versican Is Developmentally Regulated.
M. Zako, T. Shinomura, and K. Kimata (1997)
J. Biol. Chem. 272, 9325-9331
   Abstract »    Full Text »    PDF »
Directed Growth of Early Cortical Axons Is Influenced by a Chemoattractant Released from an Intermediate Target.
L. J. Richards, S. E. Koester, R. Tuttle, and D. D. M. O'Leary (1997)
J. Neurosci. 17, 2445-2458
   Abstract »    Full Text »    PDF »
Integrated interactions between chondroitin sulphate proteoglycans and weak dc electric fields regulate nerve growth cone guidance in vitro.
L Erskine and C. McCaig (1997)
J. Cell Sci. 110, 1957-1965
   Abstract »    PDF »
The Behavior of Optic Axons on Substrate Gradients of Retinal Basal Lamina Proteins and Merosin.
W. Halfter (1996)
J. Neurosci. 16, 4389-4401
   Abstract »    Full Text »    PDF »
Actin filament bundles are required for microtubule reorientation during growth cone turning to avoid an inhibitory guidance cue.
J. Challacombe, D. Snow, and P. Letourneau (1996)
J. Cell Sci. 109, 2031-2040
   Abstract »    PDF »
The Alzheimer Amyloid Precursor Proteoglycan (Appican) Is Present in Brain and Is Produced by Astrocytes but Not by Neurons in Primary Neural Cultures.
J. Shioi, M. N. Pangalos, J. A. Ripellino, D. Vassilacopoulou, C. Mytilineou, R. U. Margolis, and N. K. Robakis (1995)
J. Biol. Chem. 270, 11839-11844
   Abstract »    Full Text »    PDF »
The Chondroitin Sulfate Attachment Site of Appican Is Formed by Splicing Out Exon 15 of the Amyloid Precursor Gene.
M. N. Pangalos, S. Efthimiopoulos, J. Shioi, and N. K. Robakis (1995)
J. Biol. Chem. 270, 10388-10391
   Abstract »    Full Text »    PDF »
Expression of PG-M(V3), an Alternatively Spliced Form of PG-M without a Chondroitin Sulfate Attachment Region in Mouse and Human Tissues.
M. Zako, T. Shinomura, M. Ujita, K. Ito, and K. Kimata (1995)
J. Biol. Chem. 270, 3914-3918
   Abstract »    Full Text »    PDF »
Axonal guidance in the chicken retina.
H Stier and B Schlosshauer (1995)
Development 121, 1443-1454
   Abstract »    PDF »
Laminar specific attachment and neurite outgrowth of thalamic neurons on cultured slices of developing cerebral neocortex.
D. Emerling and A. Lander (1994)
Development 120, 2811-2822
   Abstract »    PDF »
Differential effects of glycosaminoglycans on neurite outgrowth from hippocampal and thalamic neurones.
I Fernaud-Espinosa, M Nieto-Sampedro, and P Bovolenta (1994)
J. Cell Sci. 107, 1437-1448
   Abstract »    PDF »
An inhibitor of neurite outgrowth produced by astrocytes.
L. Smith-Thomas, J Fok-Seang, J Stevens, J. Du, E Muir, A Faissner, H. Geller, J. Rogers, and J. Fawcett (1994)
J. Cell Sci. 107, 1687-1695
   Abstract »    PDF »
Glycoconjugates mark a transient barrier to neural crest migration in the chicken embryo.
R. Oakley, C. Lasky, C. Erickson, and K. Tosney (1994)
Development 120, 103-114
   Abstract »    PDF »
Neuronal Cell Adhesion, Mediated by the Heparin-binding Neuroregulatory Factor Midkine, Is Specifically Inhibited by Chondroitin Sulfate E. STRUCTURAL AND FUNCTIONAL IMPLICATIONS OF THE OVER-SULFATED CHONDROITIN SULFATE.
C. Ueoka, N. Kaneda, I. Okazaki, S. Nadanaka, T. Muramatsu, and K. Sugahara (2000)
J. Biol. Chem. 275, 37407-37413
   Abstract »    Full Text »    PDF »
Appican, the Proteoglycan Form of the Amyloid Precursor Protein, Contains Chondroitin Sulfate E in the Repeating Disaccharide Region and 4-O-Sulfated Galactose in the Linkage Region.
K. Tsuchida, J. Shioi, S. Yamada, G. Boghosian, A. Wu, H. Cai, K. Sugahara, and N. K. Robakis (2001)
J. Biol. Chem. 276, 37155-37160
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)