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Science 17 January 1992:
Vol. 255. no. 5042, pp. 339 - 342
DOI: 10.1126/science.1347957
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Articles
Science, Vol 255, Issue 5042, 339-342
Copyright © 1992 by American Association for the Advancement of Science
Gz-mediated hormonal inhibition of cyclic AMP accumulation
YH Wong,
BR Conklin,
and
HR Bourne
Department of Pharmacology, University of California, San Francisco 94143.
Hormones inhibit synthesis of adenosine 3',5'-monophosphate (cAMP) in most cells via receptors coupled to pertussis toxin (PTX)-sensitive guanine nucleotide-binding (G) proteins. Mutationally activated alpha subunits of Gi2 (alpha i2) constitutively inhibit cAMP accumulation when transfected into cells. Cells have now been transfected with mutant alpha subunits of four other G proteins--Gz, a PTX-insensitive G protein of unknown function, and Gi1, Gi3, and G(o), which are PTX-sensitive. Mutant alpha z, alpha i1, and alpha i3 inhibited cAMP accumulation but alpha o did not. Moreover, expression of wild-type alpha z produced cells in which PTX did not block hormonal inhibition of cAMP accumulation. Thus, Gz can trigger an effector pathway in response to hormone receptors that ordinarily interact with PTX-sensitive Gi proteins.
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| Full Text »
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J. Biol. Chem.
272, 32979-32987
| Abstract »
| Full Text »
| PDF »
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17, 1830-1836
| Abstract »
| Full Text »
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- L. R. Shekter, R. Taussig, S. E. Gillard, and R. J. Miller (1997)
Mol. Pharmacol.
52, 282-291
| Abstract »
| Full Text »
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- R. C. Tsu, M. K.C. Ho, L. Y. Yung, S. Joshi, and Y. H. Wong (1997)
Mol. Pharmacol.
52, 38-45
| Abstract »
| Full Text »
- A GTPase-activating Protein for the G Protein Galpha z. IDENTIFICATION, PURIFICATION, AND MECHANISM OF ACTION.
- J. Wang, Y. Tu, J. Woodson, X. Song, and E. M. Ross (1997)
J. Biol. Chem.
272, 5732-5740
| Abstract »
| Full Text »
| PDF »
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28, 83-90
| Abstract »
| Full Text »
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- J. Glick, G. Santoyo, and P. J. Casey (1996)
J. Biol. Chem.
271, 2949-2954
| Abstract »
| Full Text »
| PDF »
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- T. A. Fields and P. J. Casey (1995)
J. Biol. Chem.
270, 23119-23125
| Abstract »
| Full Text »
| PDF »
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- P. Butkerait, Y. Zheng, H. Hallak, T. E. Graham, H. A. Miller, K. D. Burris, P. B. Molinoff, and D. R. Manning (1995)
J. Biol. Chem.
270, 18691-18699
| Abstract »
| Full Text »
| PDF »
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- D. Wu, Y. Kuang, Y. Wu, and H. Jiang (1995)
J. Biol. Chem.
270, 16008-16010
| Abstract »
| Full Text »
| PDF »
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- P. T. Wilson and H. R. Bourne (1995)
J. Biol. Chem.
270, 9667-9675
| Abstract »
| Full Text »
| PDF »
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- A. M. Lew and H. P. Elsholtz (1995)
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270, 7156-7160
| Abstract »
| Full Text »
| PDF »
- Purification of Recombinant G Proteins from Sf9 Cells by Hexahistidine Tagging of Associated Subunits.
- T. Kozasa and A. G. Gilman (1995)
J. Biol. Chem.
270, 1734-1741
| Abstract »
| Full Text »
| PDF »
- Separate GTP binding and GTPase activating domains of a G alpha subunit.
- D. Markby, R Onrust, and H. Bourne (1993)
Science
262, 1895-1901
| Abstract »
| PDF »
- Inhibition of adenylyl cyclase by Gi alpha.
- R Taussig, J. Iniguez-Lluhi, and A. Gilman (1993)
Science
261, 218-221
| Abstract »
| PDF »
- Detection of Coincident Signals by G Proteins and Adenylyl Cyclase.
- H.R. Bourne, K.D. Lustig, Y.H. Wong, and B.R. Conklin (1992)
Cold Spring Harb Symp Quant Biol
57, 145-148
| Abstract »
| PDF »
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- X. Fan, L. F. Brass, M. Poncz, F. Spitz, P. Maire, and D. R. Manning (2000)
J. Biol. Chem.
275, 32129-32134
| Abstract »
| Full Text »
| PDF »
- Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs.
- J. Yang, J. Wu, M. A. Kowalska, A. Dalvi, N. Prevost, P. J. O'Brien, D. Manning, M. Poncz, I. Lucki, J. A. Blendy, et al. (2000)
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97, 9984-9989
| Abstract »
| Full Text »
| PDF »
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