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Science 10 January 1992:
Vol. 255. no. 5041, pp. 212 - 215
DOI: 10.1126/science.1313186
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Articles

Science, Vol 255, Issue 5041, 212-215
Copyright © 1992 by American Association for the Advancement of Science

articles

Requirements for phosphorylation of MAP kinase during meiosis in Xenopus oocytes

J Posada and JA Cooper

Fred Hutchinson Cancer Research Center, Seattle, WA 98104.

Mitogen-activated protein (MAP) kinases are activated in response to a variety of extracellular stimuli by phosphorylation on tyrosine and threonine residues. Xp42 is a Xenopus laevis MAP kinase that is activated during oocyte maturation. Modified forms of Xp42 that lacked enzymatic activity or either of the phosphorylation sites were expressed in Xenopus oocytes. When meiotic maturation was induced with progesterone, each mutant Xp42 was phosphorylated, indicating that at least one kinase was activated that can phosphorylate Xp42 on tyrosine and threonine. Phosphorylation of one residue is not strictly dependent on phosphorylation of the other.


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