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Science 3 January 1992: Vol. 255. no. 5040, pp. 79 - 82 DOI: 10.1126/science.1532456
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Articles
Science, Vol 255, Issue 5040, 79-82
Copyright © 1992 by American Association for the Advancement of Science
Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon
F Letourneur
and
RD Klausner
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
The multichain T cell antigen receptor functions by interacting with and activating one or more nonreceptor tyrosine kinases. The cytoplasmic tail of the zeta chain can activate T cells independently of the rest of the receptor complex. The function of the remaining invariant CD3 chains remains unknown. A 22-amino acid region of the cytoplasmic tail of CD3 epsilon was also able to independently activate T cells. Stimulation of T cells by means of the cytoplasmic tails of either zeta or CD3 epsilon resulted in quantitatively distinct patterns of tyrosine phosphorylation, suggesting activation of different biochemical pathways.
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