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Science 20 December 1991:
Vol. 254. no. 5039, pp. 1785 - 1788
DOI: 10.1126/science.1837175
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Articles
Science, Vol 254, Issue 5039, 1785-1788
Copyright © 1991 by American Association for the Advancement of Science
Regulation of phagocytosis and [Ca2+]i flux by distinct regions of an Fc receptor
JA Odin,
JC Edberg,
CJ Painter,
RP Kimberly,
and
JC Unkeless
Department of Biochemistry, Mount Sinai Medical Center, New York, NY 10029.
The binding of multivalent immunoglobulin G complexes to Fc receptors (Fc gamma Rs) on macrophages activates multiple immune functions. A murine macrophage cell line, but not a fibroblast cell line, that was transfected with human Fc gamma RIIA mediated phagocytosis and an intracellular Ca2+ concentration ([Ca2+]i) flux upon cross-linking of human Fc gamma RIIA. Transfected macrophages that expressed a truncated receptor lacking 17 carboxy-terminal amino acids phagocytosed small antibody complexes. However, only wild-type transfectants phagocytosed labeled erythrocytes and fluxed [Ca2+]i. Thus, the cytoplasmic domain of human Fc gamma RIIA contains distinct functional regions.
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