Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 13 December 1991:
Vol. 254. no. 5038, pp. 1654 - 1656
DOI: 10.1126/science.1749937
Prev | Table of Contents | Next

Articles

Science, Vol 254, Issue 5038, 1654-1656
Copyright © 1991 by American Association for the Advancement of Science

articles

Intracellular signaling by 14-hydroxy-4,14-retro-retinol

J Buck, F Derguini, E Levi, K Nakanishi, and U Hammerling

Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.

In mammals, retinol is the precursor for retinoids, which affect various aspects of morphogenesis and development. However, B lymphocytes, although retinol-dependent, do not use retinoic acid as mediator. Retinol is metabolized by B lymphocytes and other cell lines to optically active 14-hydroxy-4,14-retro-retinol; it is this compound that mediates the growth control. Thus another second messenger molecule, in addition to retinoic acid and retinal, is derived from retinol.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation.
H.-J. Chiu, D. A. Fischman, and U. Hammerling (2008)
FASEB J 22, 3878-3887
   Abstract »    Full Text »    PDF »
UVA photoirradiation of anhydroretinol - formation of singlet oxygen and superoxide.
J. Yin, Q Xia, and P. Fu (2007)
Toxicology and Industrial Health 23, 625-631
   Abstract »    PDF »
Metabolism and Transactivation Activity of 13,14-Dihydroretinoic Acid.
A. R. Moise, V. Kuksa, W. S. Blaner, W. Baehr, and K. Palczewski (2005)
J. Biol. Chem. 280, 27815-27825
   Abstract »    Full Text »    PDF »
Identification of All-trans-Retinol:All-trans-13,14-dihydroretinol Saturase.
A. R. Moise, V. Kuksa, Y. Imanishi, and K. Palczewski (2004)
J. Biol. Chem. 279, 50230-50242
   Abstract »    Full Text »    PDF »
Expression of the Aldehyde Dehydrogenase 2-like Gene Is Controlled by BOB.1/OBF.1 in B Lymphocytes.
C. Brunner, H. Laumen, P. J. Nielsen, N. Kraut, and T. Wirth (2003)
J. Biol. Chem. 278, 45231-45239
   Abstract »    Full Text »    PDF »
Retinoids Regulate Survival and Antigen Presentation by Immature Dendritic Cells.
F. Geissmann, P. Revy, N. Brousse, Y. Lepelletier, C. Folli, A. Durandy, P. Chambon, and M. Dy (2003)
J. Exp. Med. 198, 623-634
   Abstract »    Full Text »    PDF »
Activation of c-Raf Kinase by Ultraviolet Light. REGULATION BY RETINOIDS.
B. Hoyos, A. Imam, I. Korichneva, E. Levi, R. Chua, and U. Hammerling (2002)
J. Biol. Chem. 277, 23949-23957
   Abstract »    Full Text »    PDF »
Alveolar Proliferation, Retinoid Synthesizing Enzymes, and Endogenous Retinoids in the Postnatal Mouse Lung . Different Roles for Aldh-1 and Raldh-2.
M. Hind, J. Corcoran, and M. Maden (2002)
Am. J. Respir. Cell Mol. Biol. 26, 67-73
   Abstract »    Full Text »    PDF »
Free Radicals in the Physiological Control of Cell Function.
W. Droge (2002)
Physiol Rev 82, 47-95
   Abstract »    Full Text »    PDF »
Reduced Levels of Retinyl Esters and Vitamin A in Human Renal Cancers.
X. Guo, D. M Nanus, A. Ruiz, R. R Rando, D. Bok, and L. J Gudas (2001)
Cancer Res. 61, 2774-2781
   Abstract »    Full Text »
Esterification of all-trans-retinol in normal human epithelial cell strains and carcinoma lines from oral cavity, skin and breast: reduced expression of lecithin:retinol acyltransferase in carcinoma lines.
X. Guo, A. Ruiz, R. R. Rando, D. Bok, and L. J. Gudas (2000)
Carcinogenesis 21, 1925-1933
   Abstract »    Full Text »    PDF »
The Cysteine-rich Regions of the Regulatory Domains of Raf and Protein Kinase C as Retinoid.
, , , , , , , and (2000)
J. Exp. Med. 192, 835-846
   Abstract »    Full Text »    PDF »
Vitamin A in pregnancy: requirements and safety limits.
V. Azais-Braesco and G. Pascal (2000)
Am. J. Clinical Nutrition 71, 1325S-1333
   Abstract »    Full Text »    PDF »
The role of retinoic acid receptors in neurite outgrowth from different populations of embryonic mouse dorsal root ganglia.
J Corcoran, B Shroot, J Pizzey, and M Maden (2000)
J. Cell Sci. 113, 2567-2574
   Abstract »    PDF »
Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells.
M. A. Lane, A. C. Chen, S. D. Roman, F. Derguini, and L. J. Gudas (1999)
PNAS 96, 13524-13529
   Abstract »    Full Text »    PDF »
Anhydroretinol Induces Oxidative Stress and Cell Death.
Y. Chen, J. Buck, and F. Derguini (1999)
Cancer Res. 59, 3985-3990
   Abstract »    Full Text »    PDF »
Post-Transcriptional Regulation of MyD118 and GADD45 in Human Lung Carcinoma Cells During 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid-Induced Apoptosis.
M. Sakaue, H. Adachi, and A. M. Jetten (1999)
Mol. Pharmacol. 55, 668-676
   Abstract »    Full Text »
F-actin as a functional target for retro-retinoids: a potential role in anhydroretinol-triggered cell death.
I Korichneva and U Hammerling (1999)
J. Cell Sci. 112, 2521-2528
   Abstract »    PDF »
Substrate Specificity and Kinetic Mechanism of the Insect Sulfotransferase, Retinol Dehydratase.
E. Vakiani, J. G. Luz, and J. Buck (1998)
J. Biol. Chem. 273, 35381-35387
   Abstract »    Full Text »    PDF »
Retinoid Metabolism in the Skin.
T. C. Roos, F. K. Jugert, H. F. Merk, and D. R. Bickers (1998)
Pharmacol. Rev. 50, 315-333
   Abstract »    Full Text »    PDF »
Mouse P450RAI (CYP26) Expression and Retinoic Acid-inducible Retinoic Acid Metabolism in F9 Cells Are Regulated by Retinoic Acid Receptor gamma  and Retinoid X Receptor alpha.
S. S. Abu-Abed, B. R. Beckett, H. Chiba, J. V. Chithalen, G. Jones, D. Metzger, P. Chambon, and M. Petkovich (1998)
J. Biol. Chem. 273, 2409-2415
   Abstract »    Full Text »    PDF »
Vitamin A in serum is a survival factor for fibroblasts.
Y. Chen, F. Derguini, and J. Buck (1997)
PNAS 94, 10205-10208
   Abstract »    Full Text »    PDF »
Purification, Cloning, and Bacterial Expression of Retinol Dehydratase from Spodoptera frugiperda.
F. Grun, N. Noy, U. Hammerling, and J. Buck (1996)
J. Biol. Chem. 271, 16135-16138
   Abstract »    Full Text »    PDF »
Auto-regulation of Retinoic Acid Biosynthesis through Regulation of Retinol Esterification in Human Keratinocytes.
S. B. Kurlandsky, E. A. Duell, S. Kang, J. J. Voorhees, and G. J. Fisher (1996)
J. Biol. Chem. 271, 15346-15352
   Abstract »    Full Text »    PDF »
13,14-Dihydroxy-retinol, a New Bioactive Retinol Metabolite.
F. Derguini, K. Nakanishi, U. Hämmerling, R. Chua, T. Eppinger, E. Levi, and J. Buck (1995)
J. Biol. Chem. 270, 18875-18880
   Abstract »    Full Text »    PDF »
Retinoid Receptors and Keratinocytes.
C. Fisher, M. Blumenberg, and M. Tomic-Canic (1995)
Critical Reviews in Oral Biology & Medicine 6, 284-301
   Abstract »    Full Text »    PDF »
Acute Promyelocytic Leukemia.
R. P. Warrell, H. de The, Z.-Y. Wang, and L. Degos (1993)
N. Engl. J. Med. 329, 177-189
   Full Text »
The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies.
S. L. Friedman (1993)
N. Engl. J. Med. 328, 1828-1835
   Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)