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Science 29 November 1991: Vol. 254. no. 5036, pp. 1388 - 1390 DOI: 10.1126/science.1962198
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Articles
Science, Vol 254, Issue 5036, 1388-1390
Copyright © 1991 by American Association for the Advancement of Science
Prevention of apoptosis by a baculovirus gene during infection of insect cells
RJ Clem,
M Fechheimer,
and
LK Miller
Department of Genetics, University of Georgia, Athens 30602.
Programmed cell death is an active process of self destruction that is important in both the development and maintenance of multicellular animals. The molecular mechanisms controlling activation or suppression of programmed cell death are largely unknown. Apoptosis, a morphologically and biochemically defined type of programmed cell death commonly seen in vertebrates, was found to be initiated during baculovirus replication in insect cells. A specific viral gene product, p35, was identified as being responsible for blocking the apoptotic response. Identification of the function of this gene will allow further definition of the molecular pathways involved in the regulation of programmed cell death and may identify the role of apoptosis in invertebrate viral defense systems.
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