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Science 29 November 1991: Vol. 254. no. 5036, pp. 1359 - 1361 DOI: 10.1126/science.1962194
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Articles
Science, Vol 254, Issue 5036, 1359-1361
Copyright © 1991 by American Association for the Advancement of Science
A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin
PD McCrea,
CW Turck,
and
B Gumbiner
Department of Pharmacology, University of California, San Francisco 94143.
Three cytoplasmic proteins, called catenins, bind to the cytoplasmic tail of the epithelial cell-cell adhesion molecule E-cadherin. The complementary DNA sequence was determined for the 92-kilodalton beta catenin of Xenopus laevis. The sequence is homologous to mammalian plakoglobin, a protein of desmosomal and zonula adherens cell junctions, and to the plakoglobin homolog in Drosophila melanogaster, the product of the segment polarity gene armadillo. A monoclonal antibody to bovine plakoglobin recognizes the analogous beta catenin in the Madin-Darby canine kidney (MDCK) cell line. Armadillo plakoglobin may link E-cadherin to the underlying actin cytoskeleton at cell-cell junctions; the E-cadherin-catenin protein complex may also participate in the transmission of developmental information.
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