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Science 29 November 1991:
Vol. 254. no. 5036, pp. 1359 - 1361
DOI: 10.1126/science.1962194

Articles

Science, Vol 254, Issue 5036, 1359-1361
Copyright © 1991 by American Association for the Advancement of Science


articles

A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin

PD McCrea, CW Turck, and B Gumbiner

Department of Pharmacology, University of California, San Francisco 94143.

Three cytoplasmic proteins, called catenins, bind to the cytoplasmic tail of the epithelial cell-cell adhesion molecule E-cadherin. The complementary DNA sequence was determined for the 92-kilodalton beta catenin of Xenopus laevis. The sequence is homologous to mammalian plakoglobin, a protein of desmosomal and zonula adherens cell junctions, and to the plakoglobin homolog in Drosophila melanogaster, the product of the segment polarity gene armadillo. A monoclonal antibody to bovine plakoglobin recognizes the analogous beta catenin in the Madin-Darby canine kidney (MDCK) cell line. Armadillo plakoglobin may link E-cadherin to the underlying actin cytoskeleton at cell-cell junctions; the E-cadherin-catenin protein complex may also participate in the transmission of developmental information.


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A Gonzalez-Reyes and D St Johnston (1998)
Development 125, 3635-3644
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X Pan and D. Goldfarb (1998)
J. Cell Sci. 111, 2137-2147
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Wnt signaling: a common theme in animal development.
K. M. Cadigan and R. Nusse (1997)
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beta -Catenin mutations in cell lines established from human colorectal cancers.
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   Abstract »    Full Text »    PDF »
An alpha -E-catenin gene trap mutation defines its function in preimplantation development.
M. Torres, A. Stoykova, O. Huber, K. Chowdhury, P. Bonaldo, A. Mansouri, S. Butz, R. Kemler, and P. Gruss (1997)
PNAS 94, 901-906
   Abstract »    Full Text »    PDF »
Mutations of Ros Differentially Effecting Signal Transduction Pathways Leading to Cell Growth Versus Transformation.
C. S. Zong, J. L.-K. Chan, S.-K. Yang, and L.-H. Wang (1997)
J. Biol. Chem. 272, 1500-1506
   Abstract »    Full Text »    PDF »
A role for Siamois in Spemann organizer formation.
M. Fan and S. Sokol (1997)
Development 124, 2581-2589
   Abstract »    PDF »
Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling.
R. Binari, B. Staveley, W. Johnson, R Godavarti, R Sasisekharan, and A. Manoukian (1997)
Development 124, 2623-2632
   Abstract »    PDF »
Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin.
J. Nieset, A. Redfield, F Jin, K. Knudsen, K. Johnson, and M. Wheelock (1997)
J. Cell Sci. 110, 1013-1022
   Abstract »    PDF »
Drosophila alpha -Catenin and E-cadherin Bind to Distinct Regions of Drosophila Armadillo.
L.-M. Pai, C. Kirkpatrick, J. Blanton, H. Oda, M. Takeichi, and M. Peifer (1996)
J. Biol. Chem. 271, 32411-32420
   Abstract »    Full Text »    PDF »
Signal transduction through beta-catenin and specification of cell fate during embryogenesis..
J R Miller and R T Moon (1996)
Genes & Dev. 10, 2527-2539
   PDF »
Association of Human Protein-tyrosine Phosphatase kappa with Members of the Armadillo Family.
M. Fuchs, T. Muller, M. M. Lerch, and A. Ullrich (1996)
J. Biol. Chem. 271, 16712-16719
   Abstract »    Full Text »    PDF »
Molecular Cloning and Characterization of a Newly Identified Member of the Cadherin Family, PB-cadherin.
K. Sugimoto, S. Honda, T. Yamamoto, T. Ueki, M. Monden, A. Kaji, K. Matsumoto, and T. Nakamura (1996)
J. Biol. Chem. 271, 11548-11556
   Abstract »    Full Text »    PDF »
Zygotic Drosophila E-cadherin expression is required for processes of dynamic epithelial cell rearrangement in the Drosophila embryo..
T Uemura, H Oda, R Kraut, S Hayashi, Y Kotaoka, and M Takeichi (1996)
Genes & Dev. 10, 659-671
   Abstract »    PDF »
Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes.
A. Zhu and F. Watt (1996)
J. Cell Sci. 109, 3013-3023
   Abstract »    PDF »



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