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Science 22 November 1991:
Vol. 254. no. 5035, pp. 1178 - 1181
DOI: 10.1126/science.1957169
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Articles

Science, Vol 254, Issue 5035, 1178-1181
Copyright © 1991 by American Association for the Advancement of Science

articles

Optical coherence tomography

D Huang, EA Swanson, CP Lin, JS Schuman, WG Stinson, W Chang, MR Hee, T Flotte, K Gregory, CA Puliafito, and al. et

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139.

A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.


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   Abstract »    Full Text »    PDF »
Analysis of bleb morphology after trabeculectomy with Visante anterior segment optical coherence tomography.
C. K.-s. Leung, D. W.-f. Yick, Y. Y.-y. Kwong, F. C.-h. Li, D. Y.-l. Leung, S. Mohamed, C. C.-y. Tham, C. Chung-chai, and D. S.-C. Lam (2007)
Br. J. Ophthalmol. 91, 340-344
   Abstract »    Full Text »    PDF »
In situ Assessment of Intraepithelial Neoplasia in Hamster Trachea Epithelium Using Angle-Resolved Low-Coherence Interferometry.
K. J. Chalut, L. A. Kresty, J. W. Pyhtila, R. Nines, M. Baird, V. E. Steele, and A. Wax (2007)
Cancer Epidemiol. Biomarkers Prev. 16, 223-227
   Abstract »    Full Text »    PDF »
Error Correction and Quantitative Subanalysis of Optical Coherence Tomography Data Using Computer-Assisted Grading.
S. R. Sadda, S. Joeres, Z. Wu, P. Updike, P. Romano, A. T. Collins, and A. C. Walsh (2007)
Invest. Ophthalmol. Vis. Sci. 48, 839-848
   Abstract »    Full Text »    PDF »
Optical coherence tomography of the anterior segment in secondary glaucoma with corneal opacity after penetrating keratoplasty.
F. Memarzadeh, Y. Li, B. A Francis, R. E Smith, J. Gutmark, and D. Huang (2007)
Br. J. Ophthalmol. 91, 189-192
   Abstract »    Full Text »    PDF »
Rule Extraction for Glaucoma Detection with Summary Data from StratusOCT.
M.-L. Huang, H.-Y. Chen, and J.-C. Lin (2007)
Invest. Ophthalmol. Vis. Sci. 48, 244-250
   Abstract »    Full Text »    PDF »
RDH12 and RPE65, Visual Cycle Genes Causing Leber Congenital Amaurosis, Differ in Disease Expression.
S. G. Jacobson, A. V. Cideciyan, T. S. Aleman, A. Sumaroka, S. B. Schwartz, E. A. M. Windsor, A. J. Roman, E. Heon, E. M. Stone, and D. A. Thompson (2007)
Invest. Ophthalmol. Vis. Sci. 48, 332-338
   Abstract »    Full Text »    PDF »
Microtubule Contribution to the Reflectance of the Retinal Nerve Fiber Layer.
X.-R. Huang, R. W. Knighton, and L. N. Cavuoto (2006)
Invest. Ophthalmol. Vis. Sci. 47, 5363-5367
   Abstract »    Full Text »    PDF »
Dynamic and Quantitative Analysis of Choroidal Neovascularization by Fluorescein Angiography.
S. M. Shah, S. Tatlipinar, E. Quinlan, J. U. Sung, H. Tabandeh, Q. D. Nguyen, A. S. Fahmy, I. Zimmer-Galler, R. C. A. Symons, J. M. Cedarbaum, et al. (2006)
Invest. Ophthalmol. Vis. Sci. 47, 5460-5468
   Abstract »    Full Text »    PDF »
Human Macula Investigated In Vivo with Polarization-Sensitive Optical Coherence Tomography.
M. Pircher, E. Gotzinger, O. Findl, S. Michels, W. Geitzenauer, C. Leydolt, U. Schmidt-Erfurth, and C. K. Hitzenberger (2006)
Invest. Ophthalmol. Vis. Sci. 47, 5487-5494
   Abstract »    Full Text »    PDF »
Noninvasive Volumetric Imaging and Morphometry of the Rodent Retina with High-Speed, Ultrahigh-Resolution Optical Coherence Tomography.
V. J. Srinivasan, T. H. Ko, M. Wojtkowski, M. Carvalho, A. Clermont, S.-E. Bursell, Q. H. Song, J. Lem, J. S. Duker, J. S. Schuman, et al. (2006)
Invest. Ophthalmol. Vis. Sci. 47, 5522-5528
   Abstract »    Full Text »    PDF »


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