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Science 22 November 1991:
Vol. 254. no. 5035, pp. 1178 - 1181
DOI: 10.1126/science.1957169
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Articles

Science, Vol 254, Issue 5035, 1178-1181
Copyright © 1991 by American Association for the Advancement of Science

articles

Optical coherence tomography

D Huang, EA Swanson, CP Lin, JS Schuman, WG Stinson, W Chang, MR Hee, T Flotte, K Gregory, CA Puliafito, and al. et

Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139.

A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.


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Development and Comparison of Automated Classifiers for Glaucoma Diagnosis Using Stratus Optical Coherence Tomography.
M.-L. Huang and H.-Y. Chen (2005)
Invest. Ophthalmol. Vis. Sci. 46, 4121-4129
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Optical Coherence Tomography Machine Learning Classifiers for Glaucoma Detection: A Preliminary Study.
Z. Burgansky-Eliash, G. Wollstein, T. Chu, J. D. Ramsey, C. Glymour, R. J. Noecker, H. Ishikawa, and J. S. Schuman (2005)
Invest. Ophthalmol. Vis. Sci. 46, 4147-4152
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Comparative Study of Retinal Nerve Fiber Layer Measurement by StratusOCT and GDx VCC, II: Structure/Function Regression Analysis in Glaucoma.
C.