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Science 22 November 1991:
Vol. 254. no. 5035, pp. 1161 - 1167
DOI: 10.1126/science.1957168
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Articles

Science, Vol 254, Issue 5035, 1161-1167
Copyright © 1991 by American Association for the Advancement of Science

articles

Transgenic models of tumor development

JM Adams and S Cory

Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

Numerous cancer-prone strains of mice have been created by the introduction of candidate tumor-promoting genes into fertilized eggs. Each transgenic strain is predisposed to develop specific types of tumors, but they usually arise stochastically because of the need for spontaneous mutation of genes that collaborate with the introduced oncogene. These mice are providing insights into the effects of individual oncogenes on cellular proliferation, differentiation, and viability, as well as on oncogene cooperativity. Their predisposed state imposes sensitivity to viral and chemical carcinogenesis, and the mice should prove valuable in tests of potential carcinogens, therapies, and preventive measures.


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