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Science 22 November 1991:
Vol. 254. no. 5035, pp. 1153 - 1160
DOI: 10.1126/science.1957167
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Articles
Science, Vol 254, Issue 5035, 1153-1160
Copyright © 1991 by American Association for the Advancement of Science
Chromosome aberrations and cancer
E Solomon,
J Borrow,
and
AD Goddard
Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom.
Cancer may be defined as a progressive series of genetic events that occur in a single clone of cells because of alterations in a limited number of specific genes: the oncogenes and tumor suppressor genes. The association of consistent chromosome aberrations with particular types of cancer has led to the identification of some of these genes and the elucidation of their mechanisms of action. Consistent chromosome aberrations are observed not only in rare tumor types but also in the relatively common lung, colon, and breast cancers. Identification of additional mutated genes through other chromosomal abnormalities will lead to a more complete molecular description of oncogenesis.
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