Science 22 November 1991: Vol. 254. no. 5035, pp. 1146 - 1153 DOI: 10.1126/science.1659742

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Articles

Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways.

K. Gross, I. Karagiannides, T. Thomou, H. W. Koon, C. Bowe, H. Kim, N. Giorgadze, T. Tchkonia, T. Pirtskhalava, J. L. Kirkland, et al. (2009)
Am J Physiol Gastrointest Liver Physiol 296, G1012-G1019
 |  Abstract »  |  Full Text »  |  PDF »

Case-control analysis of nucleotide excision repair pathway and the risk of renal cell carcinoma.

J. Lin, X. Pu, W. Wang, S. Matin, N. M. Tannir, C. G. Wood, and X. Wu (2008)
Carcinogenesis 29, 2112-2119
 |  Abstract »  |  Full Text »  |  PDF »

Phase I Trial of Erlotinib Combined with Cisplatin and Radiotherapy for Patients with Locally Advanced Cervical Squamous Cell Cancer.

A. Nogueira-Rodrigues, C. C. do Carmo, C. Viegas, F. Erlich, C. Camisao, K. Fontao, R. Lima, D. Herchenhorn, R. G. Martins, G. M. Moralez, et al. (2008)
Clin. Cancer Res. 14, 6324-6329
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-like Growth Factor 1, Insulin-like Growth Factor-Binding Protein 3, and Testicular Germ-Cell Tumor Risk.

V. M. Chia, S. M. Quraishi, B. I. Graubard, M. V. Rubertone, R. L. Erickson, F. Z. Stanczyk, and K. A. McGlynn (2008)
Am. J. Epidemiol. 167, 1438-1445
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Polymorphism in EGF Is Associated with Prostate Cancer Aggressiveness and Progression-Free Interval in Androgen Blockade-Treated Patients.

A. L. Teixeira, R. Ribeiro, D. Cardoso, D. Pinto, F. Lobo, A. Fraga, F. Pina, F. Calais-da-Silva, and R. Medeiros (2008)
Clin. Cancer Res. 14, 3367-3371
 |  Abstract »  |  Full Text »  |  PDF »

Targeting Growth Factors in Lung Cancer.

P. S. Hodkinson, A. MacKinnon, and T. Sethi (2008)
Chest 133, 1209-1216
 |  Abstract »  |  Full Text »  |  PDF »

Evaluation of serum HER2 extracellular domain in early breast cancer patients: correlation with clinicopathological parameters and survival.

V. Ludovini, S. Gori, M. Colozza, L. Pistola, E. Rulli, I. Floriani, E. Pacifico, F. R. Tofanetti, A. Sidoni, C. Basurto, et al. (2008)
Ann. Onc. 19, 883-890
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II.

J.-S. Wang, F.-B. Wang, Q.-G. Zhang, Z.-Z. Shen, and Z.-M. Shao (2008)
Mol. Cancer Res. 6, 372-382
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase.

T. Okabe, I. Okamoto, S. Tsukioka, J. Uchida, T. Iwasa, T. Yoshida, E. Hatashita, Y. Yamada, T. Satoh, K. Tamura, et al. (2008)
Mol. Cancer Ther. 7, 599-606
 |  Abstract »  |  Full Text »  |  PDF »

Biology of Interactions: Antiepidermal Growth Factor Receptor Agents.

P. M. Harari, G. W. Allen, and J. A. Bonner (2007)
J. Clin. Oncol. 25, 4057-4065
 |  Abstract »  |  Full Text »  |  PDF »

Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: A Pediatric Brain Tumor Consortium report.

I. F. Pollack, R. I. Jakacki, S. M. Blaney, M. L. Hancock, M. W. Kieran, P. Phillips, L. E. Kun, H. Friedman, R. Packer, A. Banerjee, et al. (2007)
Neuro-oncol 9, 145-160
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Polymorphisms of the Epidermal Growth Factor and Related Receptor in Non-Small Cell Lung Cancer--A Review of the Literature.

A. Araujo, R. Ribeiro, I. Azevedo, A. Coelho, M. Soares, B. Sousa, D. Pinto, C. Lopes, R. Medeiros, and G. V. Scagliotti (2007)
Oncologist 12, 201-210
 |  Abstract »  |  Full Text »  |  PDF »

Body Size and Risk of Colon and Rectal Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)..

T. Pischon, P. H. Lahmann, H. Boeing, C. Friedenreich, T. Norat, A. Tjonneland, J. Halkjaer, K. Overvad, F. Clavel-Chapelon, M.-C. Boutron-Ruault, et al. (2006)
J Natl Cancer Inst 98, 920-931
 |  Abstract »  |  Full Text »  |  PDF »

Doxorubicin-Conjugated Anti-Midkine Monoclonal Antibody as a Potential Anti-Tumor Drug.

K. Inoh, H. Muramatsu, S. Torii, S. Ikematsu, M. Oda, H. Kumai, S. Sakuma, T. Inui, T. Kimura, and T. Muramatsu (2006)
Jpn. J. Clin. Oncol. 36, 207-211
 |  Abstract »  |  Full Text »  |  PDF »

The Smaller Isoforms of Ankyrin 3 Bind to the p85 Subunit of Phosphatidylinositol 3'-Kinase and Enhance Platelet-derived Growth Factor Receptor Down-regulation.

A. Ignatiuk, J. P. Quickfall, A. D. Hawrysh, M. D. Chamberlain, and D. H. Anderson (2006)
J. Biol. Chem. 281, 5956-5964
 |  Abstract »  |  Full Text »  |  PDF »

Anti-CD3 x Anti-Epidermal Growth Factor Receptor (EGFR) Bispecific Antibody Redirects T-Cell Cytolytic Activity to EGFR-Positive Cancers In vitro and in an Animal Model.

U. Reusch, M. Sundaram, P. A. Davol, S. D. Olson, J. B. Davis, K. Demel, J. Nissim, R. Rathore, P. Y. Liu, and L. G. Lum (2006)
Clin. Cancer Res. 12, 183-190
 |  Abstract »  |  Full Text »  |  PDF »

Proliferation of Human Neuroblastomas Mediated by the Epidermal Growth Factor Receptor.

R. Ho, J. E. Minturn, T. Hishiki, H. Zhao, Q. Wang, A. Cnaan, J. Maris, A. E. Evans, and G. M. Brodeur (2005)
Cancer Res. 65, 9868-9875
 |  Abstract »  |  Full Text »  |  PDF »

c-Fos-Dependent Induction of the Small Ras-Related GTPase Rab11a in Skin Carcinogenesis.

C. Gebhardt, U. Breitenbach, K. H. Richter, G. Furstenberger, C. Mauch, P. Angel, and J. Hess (2005)
Am. J. Pathol. 167, 243-253
 |  Abstract »  |  Full Text »  |  PDF »

Gefitinib ("Iressa", ZD1839), an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Reverses Breast Cancer Resistance Protein/ABCG2-Mediated Drug Resistance.

Y. Nakamura, M. Oka, H. Soda, K. Shiozawa, M. Yoshikawa, A. Itoh, Y. Ikegami, J. Tsurutani, K. Nakatomi, T. Kitazaki, et al. (2005)
Cancer Res. 65, 1541-1546
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Receptor (EGFR) Is Overexpressed in Anaplastic Thyroid Cancer, and the EGFR Inhibitor Gefitinib Inhibits the Growth of Anaplastic Thyroid Cancer.

B. A. Schiff, A. B. McMurphy, S. A. Jasser, M. N. Younes, D. Doan, O. G. Yigitbasi, S. Kim, G. Zhou, M. Mandal, B. N. Bekele, et al. (2004)
Clin. Cancer Res. 10, 8594-8602
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Epidermal growth factor receptor inhibition strategies in oncology.

P M Harari (2004)
Endocr. Relat. Cancer 11, 689-708
 |  Abstract »  |  Full Text »  |  PDF »

Cooperative Autocrine and Paracrine Functions of Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor in the Progression of Skin Carcinoma Cells.

E. Obermueller, S. Vosseler, N. E. Fusenig, and M. M. Mueller (2004)
Cancer Res. 64, 7801-7812
 |  Abstract »  |  Full Text »  |  PDF »

CIN85 Associates with Multiple Effectors Controlling Intracellular Trafficking of Epidermal Growth Factor Receptors.

K. Kowanetz, K. Husnjak, D. Holler, M. Kowanetz, P. Soubeyran, D. Hirsch, M. H.H Schmidt, K. Pavelic, P. De Camilli, P. A. Randazzo, et al. (2004)
Mol. Biol. Cell 15, 3155-3166
 |  Abstract »  |  Full Text »  |  PDF »

IL-1{beta} Suppresses Prolonged Akt Activation and Expression of E2F-1 and Cyclin A in Breast Cancer Cells.

W. H. Shen, S. T. Jackson, S. R. Broussard, R. H. McCusker, K. Strle, G. G. Freund, R. W. Johnson, R. Dantzer, and K. W. Kelley (2004)
J. Immunol. 172, 7272-7281
 |  Abstract »  |  Full Text »  |  PDF »

Combination therapy with gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, gemcitabine and cisplatin in patients with advanced solid tumors.

G. Giaccone, J. L. Gonzalez-Larriba, A. T. van Oosterom, R. Alfonso, E. F. Smit, M. Martens, G. J. Peters, W. J. F. van der Vijgh, R. Smith, S. Averbuch, et al. (2004)
Ann. Onc. 15, 831-838
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Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells.

A. Solhaug, M. Refsnes, M. Lag, P. E. Schwarze, T. Husoy, and J. A. Holme (2004)
Carcinogenesis 25, 809-819
 |  Abstract »  |  Full Text »  |  PDF »

Phase II Trial of Cetuximab in Patients With Refractory Colorectal Cancer That Expresses the Epidermal Growth Factor Receptor.

L. B. Saltz, N. J. Meropol, P. J. Loehrer Sr, M. N. Needle, J. Kopit, and R. J. Mayer (2004)
J. Clin. Oncol. 22, 1201-1208
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Tumor Necrosis Factor {alpha} Inhibits Cyclin A Expression and Retinoblastoma Hyperphosphorylation Triggered by Insulin-like Growth Factor-I Induction of New E2F-1 Synthesis.

W. H. Shen, Y. Yin, S. R. Broussard, R. H. McCusker, G. G. Freund, R. Dantzer, and K. W. Kelley (2004)
J. Biol. Chem. 279, 7438-7446
 |  Abstract »  |  Full Text »  |  PDF »

Height, predictors of C-peptide and cancer risk in men.

E. Giovannucci, E. B Rimm, Y. Liu, and W. C Willett (2004)
Int. J. Epidemiol. 33, 217-225
 |  Abstract »  |  Full Text »  |  PDF »

Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation.

M. J. Marinissen, J.-M. Servitja, S. Offermanns, M. I. Simon, and J. S. Gutkind (2003)
J. Biol. Chem. 278, 46814-46825
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Anti-Interleukin-6 Monoclonal Antibody Therapy for Cancer: A Review of the Rationale and Clinical Evidence.

M. Trikha, R. Corringham, B. Klein, and J.-F. Rossi (2003)
Clin. Cancer Res. 9, 4653-4665
 |  Abstract »  |  Full Text »  |  PDF »

Potential Clinical Utility of Serum HER-2/neu Oncoprotein Concentrations in Patients with Breast Cancer.

W. P. Carney, R. Neumann, A. Lipton, K. Leitzel, S. Ali, and C. P. Price (2003)
Clin. Chem. 49, 1579-1598
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Distinct Mechanisms Mediate the Initial and Sustained Phases of Cell Migration in Epidermal Growth Factor Receptor-Overexpressing Cells.

J. S. Kruger and K. B. Reddy (2003)
Mol. Cancer Res. 1, 801-809
 |  Abstract »  |  Full Text »  |  PDF »

Naamidine A Intensifies the Phosphotransferase Activity of Extracellular Signal-regulated Kinases Causing A-431 Cells to Arrest in G1.

R. D. James, D. A. Jones, W. Aalbersberg, and C. M. Ireland (2003)
Mol. Cancer Ther. 2, 747-751
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Ku70 and Ku80 Mediated by NF-kappa B and Cyclooxygenase-2 Is Related to Proliferation of Human Gastric Cancer Cells.

J. W. Lim, H. Kim, and K. H. Kim (2002)
J. Biol. Chem. 277, 46093-46100
 |  Abstract »  |  Full Text »  |  PDF »

Selective Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 Is Generally Well-Tolerated and Has Activity in Non-Small-Cell Lung Cancer and Other Solid Tumors: Results of a Phase I Trial.

R. S. Herbst, A.-M. Maddox, M. L. Rothenberg, E. J. Small, E. H. Rubin, J. Baselga, F. Rojo, W. K. Hong, H. Swaisland, S. D. Averbuch, et al. (2002)
J. Clin. Oncol. 20, 3815-3825
 |  Abstract »  |  Full Text »  |  PDF »

Proinflammatory Cytokines Block Growth of Breast Cancer Cells by Impairing Signals from a Growth Factor Receptor.

W.-H. Shen, J.-H. Zhou, S. R. Broussard, G. G. Freund, R. Dantzer, and K. W. Kelley (2002)
Cancer Res. 62, 4746-4756
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Molecular Therapy for Oral Cancer With Epidermal Growth Factor Receptor Blockade: A Preliminary Report.

J. N. Myers, F. C. Holsinger, B. N. Bekele, E. Li, S. A. Jasser, J. J. Killion, and I. J. Fidler (2002)
Arch Otolaryngol Head Neck Surg 128, 875-879
 |  Abstract »  |  Full Text »  |  PDF »

Rodent Carcinogenicity with the Thiazolidinedione Antidiabetic Agent Troglitazone.

J. R. Herman, L. A. Dethloff, E. J. McGuire, R. F. Parker, K. M. Walsh, A. W. Gough, H. Masuda, and F. A. de la Iglesia (2002)
Toxicol. Sci. 68, 226-236
 |  Abstract »  |  Full Text »  |  PDF »

A Ligand-inducible Epidermal Growth Factor Receptor/Anaplastic Lymphoma Kinase Chimera Promotes Mitogenesis and Transforming Properties in 3T3 Cells.

G. Piccinini, R. Bacchiocchi, M. Serresi, C. Vivani, S. Rossetti, C. Gennaretti, D. Carbonari, and F. Fazioli (2002)
J. Biol. Chem. 277, 22231-22239
 |  Abstract »  |  Full Text »  |  PDF »

Neutralization of Adrenomedullin Inhibits the Growth of Human Glioblastoma Cell Lines in Vitro and Suppresses Tumor Xenograft Growth in Vivo.

L'H. Ouafik, S. Sauze, F. Boudouresque, O. Chinot, C. Delfino, F. Fina, V. Vuaroqueaux, C. Dussert, J. Palmari, H. Dufour, et al. (2002)
Am. J. Pathol. 160, 1279-1292
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New Directions in the Treatment of Cancer: Inhibition of Signal Transduction.

R. S. Finley (2002)
Journal of Pharmacy Practice 15, 5-16
 |  Abstract »  |  PDF »

Antisense Oligodeoxynucleotide Targeted to Midkine, a Heparin-binding Growth Factor, Suppresses Tumorigenicity of Mouse Rectal Carcinoma Cells.

Y. Takei, K. Kadomatsu, S. Matsuo, H. Itoh, K. Nakazawa, S. Kubota, and T. Muramatsu (2001)
Cancer Res. 61, 8486-8491
 |  Abstract »  |  Full Text »  |  PDF »

Alcohol and Breast Cancer: Review of Epidemiologic and Experimental Evidence and Potential Mechanisms.

K. W. Singletary and S. M. Gapstur (2001)
JAMA 286, 2143-2151
 |  Abstract »  |  Full Text »  |  PDF »

A Case with HER2-overexpressing Breast Cancer Completely Responded to Humanized anti-HER2 Monoclonal Antibody.

M. Ohta, Y. Tokuda, Y. Suzuki, M. Kubota, T. Watanabe, H. Fujii, Y. Sasaki, T. Niwa, H. Makuuchi, and T. Tajima (2001)
Jpn. J. Clin. Oncol. 31, 553-556
 |  Abstract »  |  Full Text »  |  PDF »

Cytostatic effects of 3,3'-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-{alpha} expression.

H. Leong, G. L. Firestone, and L. F. Bjeldanes (2001)
Carcinogenesis 22, 1809-1817
 |  Abstract »  |  Full Text »  |  PDF »

Insulin, Insulin-Like Growth Factors and Colon Cancer: A Review of the Evidence.

E. Giovannucci (2001)
J. Nutr. 131, 3109S-3120
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Gab1 Lacking the Pleckstrin Homology Domain Is Associated with Neoplastic Progression.

H. Kameda, J. I. Risinger, B.-B. Han, S. J. Baek, J. C. Barrett, T. Abe, T. Takeuchi, W. C. Glasgow, and T. E. Eling (2001)
Mol. Cell. Biol. 21, 6895-6905
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophins and Neurotrophin Receptors in Human Lung Cancer.

A. Ricci, S. Greco, S. Mariotta, L. Felici, E. Bronzetti, A. Cavazzana, G. Cardillo, F. Amenta, A. Bisetti, and G. Barbolini (2001)
Am. J. Respir. Cell Mol. Biol. 25, 439-446
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Progression of Skin Carcinoma Cells in Vivo Promoted by Clonal Selection, Mutagenesis, and Autocrine Growth Regulation by Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor.

M. M. Mueller, W. Peter, M. Mappes, A. Huelsen, H. Steinbauer, P. Boukamp, M. Vaccariello, J. Garlick, and N. E. Fusenig (2001)
Am. J. Pathol. 159, 1567-1579
 |  Abstract »  |  Full Text »

A Novel Approach in the Treatment of Cancer: Targeting the Epidermal Growth Factor Receptor.

F. Ciardiello and G. Tortora (2001)
Clin. Cancer Res. 7, 2958-2970
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Receptor Signaling and the Invasive Phenotype of Ovarian Carcinoma Cells.

O. Alper, E. S. Bergmann-Leitner, T. A. Bennett, N. F. Hacker, K. Stromberg, and W. G. Stetler-Stevenson (2001)
J Natl Cancer Inst 93, 1375-1384
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Receptor Expression and Activation in Nonseminomatous Germ Cell Tumors.

M. Moroni, S. Veronese, R. Schiavo, O. Carminati, B. S. Sorensen, M. Gambacorta, and S. Siena (2001)
Clin. Cancer Res. 7, 2770-2775
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Epidermal Growth Factor Receptor- Grb2-associated Binder-1-SHP-2 Complex Formation and Its Functional Loss during Neoplastic Cell Progression.

H. Kameda, J. I. Risinger, B.-B. Han, S. J. Baek, J. C. Barrett, W. C. Glasgow, and T. E. Eling (2001)
Cell Growth Differ. 12, 307-318
 |  Abstract »  |  Full Text »  |  PDF »

Tamoxifen Inhibits Nerve Growth Factor-induced Proliferation of the Human Breast Cancerous Cell Line MCF-7.

A. Chiarenza, P. Lazarovici, L. Lempereur, G. Cantarella, A. Bianchi, and R. Bernardini (2001)
Cancer Res. 61, 3002-3008
 |  Abstract »  |  Full Text »

Transient vs. prolonged histone hyperacetylation: effects on colon cancer cell growth, differentiation, and apoptosis.

J. T. Wu, S. Y. Archer, B. Hinnebusch, S. Meng, and R. A. Hodin (2001)
Am J Physiol Gastrointest Liver Physiol 280, G482-G490
 |  Abstract »  |  Full Text »  |  PDF »

Establishment of a Novel Species- and Tissue-specific Metastasis Model of Human Prostate Cancer in Humanized Non-Obese Diabetic/Severe Combined Immunodeficient Mice Engrafted with Human Adult Lung and Bone.

H. Yonou, T. Yokose, T. Kamijo, N. Kanomata, T. Hasebe, K. Nagai, T. Hatano, Y. Ogawa, and A. Ochiai (2001)
Cancer Res. 61, 2177-2182
 |  Abstract »  |  Full Text »

Overexpression of Dihydrodiol Dehydrogenase as a Prognostic Marker of Non-Small Cell Lung Cancer.

N.-Y. Hsu, H.-C. Ho, K.-C. Chow, T.-Y. Lin, C.-S. Shih, L.-S. Wang, and C.-M. Tsai (2001)
Cancer Res. 61, 2727-2731
 |  Abstract »  |  Full Text »

High Level Class II trans-Activator Induction Does Not Occur with Transient Activation of the IFN-{{gamma}} Signaling Pathway.

D. D. Eason and G. Blanck (2001)
J. Immunol. 166, 1041-1048
 |  Abstract »  |  Full Text »  |  PDF »

The Nature of the Heterozygous Trp53 Knockout Model for Identifi cation of Mutagenic Carcinogens.

J. French, R. D. Storer, and L. A. Donehower (2001)
Toxicol Pathol 29, 24-29
 |  Abstract »  |  PDF »

Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression.

A. E. Marjou, A. Delouvee, J. P. Thiery, and F. Radvanyi (2000)
Carcinogenesis 21, 2211-2218
 |  Abstract »  |  Full Text »  |  PDF »

The mRNA of L-Type Calcium Channel Elevated in Colon Cancer : Protein Distribution in Normal and Cancerous Colon.

X.-T. Wang, Y. Nagaba, H. S. Cross, F. Wrba, L. Zhang, and S. E. Guggino (2000)
Am. J. Pathol. 157, 1549-1562
 |  Abstract »  |  Full Text »  |  PDF »

Antiangiogenic and Antitumor Activity of Anti-Epidermal Growth Factor Receptor C225 Monoclonal Antibody in Combination with Vascular Endothelial Growth Factor Antisense Oligonucleotide in Human GEO Colon Cancer Cells.

F. Ciardiello, R. Bianco, V. Damiano, G. Fontanini, R. Caputo, G. Pomatico, Sabino De Placido, A. R. Bianco, J. Mendelsohn, and G. Tortora (2000)
Clin. Cancer Res. 6, 3739-3747
 |  Abstract »  |  Full Text »

Multiple Growth Factor Induction of a Murine Early Response Gene That Complements a Lethal Defect in Yeast Ribosome Biogenesis.

S. A. Nelson, J. P. Aris, B. K. R. Patel, and W. J. LaRochelle (2000)
J. Biol. Chem. 275, 13835-13841
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468.

R. Lu and G. Serrero (2000)
PNAS 97, 3993-3998
 |  Abstract »  |  Full Text »  |  PDF »

A Prospective Study of Plasma Insulin-like Growth Factor-1 and Binding Protein-3 and Risk of Colorectal Neoplasia in Women.

E. Giovannucci, M. N. Pollak, E. A. Platz, W. C. Willett, M. J. Stampfer, N. Majeed, G. A. Colditz, F. E. Speizer, and S. E. Hankinson (2000)
Cancer Epidemiol. Biomarkers Prev. 9, 345-349
 |  Abstract »  |  Full Text »

Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice.

J. DiGiovanni, K. Kiguchi, A. Frijhoff, E. Wilker, D. K. Bol, L. Beltran, S. Moats, A. Ramirez, J. Jorcano, and C. Conti (2000)
PNAS 97, 3455-3460
 |  Abstract »  |  Full Text »  |  PDF »

Reversible G1 Arrest Induced by Inhibition of the Epidermal Growth Factor Receptor Tyrosine Kinase Requires Up-regulation of p27KIP1 Independent of MAPK Activity.

D. Busse, R. S. Doughty, T. T. Ramsey, W. E. Russell, J. O. Price, W. M. Flanagan, L. K. Shawver, and C. L. Arteaga (2000)
J. Biol. Chem. 275, 6987-6995
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Expression of Insulin-like Growth Factor-1 in Epidermal Basal Cells of Transgenic Mice Leads to Spontaneous Tumor Promotion.

J. DiGiovanni, D. K. Bol, E. Wilker, L. Beltrán, S. Carbajal, S. Moats, A. Ramirez, J. Jorcano, and K. Kiguchi (2000)
Cancer Res. 60, 1561-1570
 |  Abstract »  |  Full Text »

Phase I Studies of Anti-Epidermal Growth Factor Receptor Chimeric Antibody C225 Alone and in Combination With Cisplatin.

J. Baselga, D. Pfister, M. R. Cooper, R. Cohen, B. Burtness, M. Bos, G. D’Andrea, A. Seidman, L. Norton, K. Gunnett, et al. (2000)
J. Clin. Oncol. 18, 904
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Benzo[a]pyrene Partitioning and Cellular Homeostasis in a Rat Liver Cell Line.

R. Barhoumi, Y. Mouneimne, K. S. Ramos, S. H. Safe, T. D. Phillips, V. E. Centonze, C. Ainley, M. S. Gupta, and R. C. Burghardt (2000)
Toxicol. Sci. 53, 264-270
 |  Abstract »  |  Full Text »  |  PDF »

EGF Receptor and p21WAF1 Expression are Reciprocally Altered as ME-180 Cervical Carcinoma Cells Progress from High to Low Cisplatin Sensitivity.

N. J. Donato, M. Perez, H. Kang, Z. H. Siddik, Y.-H. Ling, and R. Perez-Soler (2000)
Clin. Cancer Res. 6, 193-202
 |  Abstract »  |  Full Text »

Autocrine Growth Regulation by Granulocyte Colony-Stimulating Factor and Granulocyte Macrophage Colony-Stimulating Factor in Human Gliomas with Tumor Progression.

M. M. Mueller, C. C. Herold-Mende, D. Riede, M. Lange, H.-H. Steiner, and N. E. Fusenig (1999)
Am. J. Pathol. 155, 1557-1567
 |  Abstract »  |  Full Text »  |  PDF »

Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease.

M. A. Cobleigh, C. L. Vogel, D. Tripathy, N. J. Robert, S. Scholl, L. Fehrenbacher, J. M. Wolter, V. Paton, S. Shak, G. Lieberman, et al. (1999)
J. Clin. Oncol. 17, 2639
 |  Abstract »  |  Full Text »  |  PDF »

Elevated Cyclin E Levels, Inactive Retinoblastoma Protein, and Suppression of the p27KIP1 Inhibitor Characterize Early Development of Promyeloid Cells into Macrophages.

Q. Liu, R. W. VanHoy, J. H. Zhou, R. Dantzer, G. G. Freund, and K. W. Kelley (1999)
Mol. Cell. Biol. 19, 6229-6239
 |  Abstract »  |  Full Text »  |  PDF »

Human Colon Cancer Cell Proliferation Mediated by the M3 Muscarinic Cholinergic Receptor.

H. Frucht, R. T. Jensen, D. Dexter, W.-L. Yang, and Y. Xiao (1999)
Clin. Cancer Res. 5, 2532-2539
 |  Abstract »  |  Full Text »  |  PDF »

Serine Phosphorylation of the Ligand-activated beta -Platelet-derived Growth Factor Receptor by Casein Kinase I-gamma 2 Inhibits the Receptor's Autophosphorylating Activity.

E. B. Bioukar, N. C. Marricco, D. Zuo, and L. Larose (1999)
J. Biol. Chem. 274, 21457-21463
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Receptor Expression and Gene Amplification in High-Grade Non-Brainstem Gliomas of Childhood.

M. Bredel, I. F. Pollack, R. L. Hamilton, and C. D. James (1999)
Clin. Cancer Res. 5, 1786-1792
 |  Abstract »  |  Full Text »  |  PDF »

Antitumor Activity of Sequential Treatment with Topotecan and Anti-Epidermal Growth Factor Receptor Monoclonal Antibody C225.

F. Ciardiello, R. Bianco, V. Damiano, S. De Lorenzo, S. Pepe, S. De Placido, Z. Fan, J. Mendelsohn, A. R. Bianco, and G. Tortora (1999)
Clin. Cancer Res. 5, 909-916
 |  Abstract »  |  Full Text »  |  PDF »

Emergent Properties of Networks of Biological Signaling Pathways.

U. S. Bhalla and Ravi Iyengar (1999)
Science 283, 381-387
 |  Abstract »  |  Full Text »

An Activating Mutation in the Kit Receptor Abolishes the Stroma Requirement for Growth of ELM Erythroleukemia Cells, But Does Not Prevent Their Differentiation in Response to Erythropoietin.

N. R. Leslie, J. O'Prey, C. Bartholomew, and P. R. Harrison (1998)
Blood 92, 4798-4807
 |  Abstract »  |  Full Text »  |  PDF »

Potato Carboxypeptidase Inhibitor, a T-knot Protein, Is an Epidermal Growth Factor Antagonist That Inhibits Tumor Cell Growth.

C. Blanco-Aparicio, M. A. Molina, E. Fernandez-Salas, M. L. Frazier, J. M. Mas, E. Querol, F. X. Aviles, and R. de Llorens (1998)
J. Biol. Chem. 273, 12370-12377
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Protein Kinase C-{zeta} and Phosphatidylinositol 3'-Kinase and Promotion of Macrophage Differentiation by Insulin-Like Growth Factor-I.

Q. Liu, W. Ning, R. Dantzer, G. G. Freund, and K. W. Kelley (1998)
J. Immunol. 160, 1393-1401
 |  Abstract »  |  Full Text »  |  PDF »

Physical Interaction between Epidermal Growth Factor Receptor and DNA-dependent Protein Kinase in Mammalian Cells.

D. Bandyopadhyay, M. Mandal, L. Adam, J. Mendelsohn, and R. Kumar (1998)
J. Biol. Chem. 273, 1568-1573
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal growth factor alters fibroblast migration speed and directional persistence reciprocally and in a matrix-dependent manner.

M. Ware, A Wells, and D. Lauffenburger (1998)
J. Cell Sci. 111, 2423-2432
 |  Abstract »  |  PDF »

Inosine-5'-Monophosphate Dehydrogenase Is a Rate-determining Factor for p53-dependent Growth Regulation.

Y. Liu, S. A. Bohn, and J. L. Sherley (1998)
Mol. Biol. Cell 9, 15-28
 |  Abstract »  |  Full Text »

Modulation of Commitment, Proliferation, and Differentiation of Chondrogenic Cells in Defined Culture Medium.

R. Quarto, G. Campanile, R. Cancedda, and B. Dozin (1997)
Endocrinology 138, 4966-4976
 |  Abstract »  |  Full Text »  |  PDF »

The 66-kDa Shc Isoform Is a Negative Regulator of the Epidermal Growth Factor-stimulated Mitogen-activated Protein Kinase Pathway.

S. Okada, A. W. Kao, B. P. Ceresa, P. Blaikie, B. Margolis, and J. E. Pessin (1997)
J. Biol. Chem. 272, 28042-28049
 |  Abstract »  |  Full Text »  |  PDF »

The Linoleic Acid Metabolite, (13S)-Hydroperoxyoctadecadienoic Acid, Augments the Epidermal Growth Factor Receptor Signaling Pathway by Attenuation of Receptor Dephosphorylation. DIFFERENTIAL RESPONSE IN SYRIAN HAMSTER EMBRYO TUMOR SUPPRESSOR PHENOTYPES.

W. C. Glasgow, R. Hui, A. L. Everhart, S. P. Jayawickreme, J. Angerman-Stewart, B.-B. Han, and T. E. Eling (1997)
J. Biol. Chem. 272, 19269-19276
 |  Abstract »  |  Full Text »  |  PDF »

Cell-surface perturbations of the epidermal growth factor and vascular endothelial growth factor receptors by phosphorothioate oligodeoxynucleotides.

P. Rockwell, W. J. O'Connor, K. King, N. I. Goldstein, L. M. Zhang, and C. A. Stein (1997)
PNAS 94, 6523-6528
 |  Abstract »  |  Full Text »  |  PDF »

Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors. INVOLVEMENT OF SPHINGOSINE 1-PHOSPHATE IN PDGF BUT NOT EGF SIGNALING.

C. S.S. Rani, F. Wang, E. Fuior, A. Berger, J. Wu, T. W. Sturgill, D. Beitner-Johnson, D. LeRoith, L. Varticovski, and S. Spiegel (1997)
J. Biol. Chem. 272, 10777-10783
 |  Abstract »  |  Full Text »  |  PDF »

The cell cycle and cancer.

K. Collins, T. Jacks, and N. P. Pavletich (1997)
PNAS 94, 2776-2778
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The combination of epidermal growth factor and transforming growth factor-beta induces novel phenotypic changes in mouse liver stem cell lines.

R. Isfort, D. Cody, S. Stuard, C. Randall, C Miller, G. Ridder, C. Doersen, W. Richards, B. Yoder, J. Wilkinson, et al. (1997)
J. Cell Sci. 110, 3117-3129
 |  Abstract »  |  PDF »

The Drosophila TGF alpha homolog Spitz acts in photoreceptor recruitment in the developing retina.

M Tio and K Moses (1997)
Development 124, 343-351
 |  Abstract »  |  PDF »

Rho Is Required for Galpha q and alpha 1-Adrenergic Receptor Signaling in Cardiomyocytes. DISSOCIATION OF Ras AND Rho PATHWAYS.

V. P. Sah, M. Hoshijima, K. R. Chien, and J. H. Brown (1996)
J. Biol. Chem. 271, 31185-31190
 |  Abstract »  |  Full Text »  |  PDF »

Stat6 and Jak1 Are Common Elements in Platelet-derived Growth Factor and Interleukin-4 Signal Transduction Pathways in NIH 3T3 Fibroblasts.

B. K.R. Patel, L.-M. Wang, C.-C. Lee, W. G. Taylor, J. H. Pierce, and W. J. LaRochelle (1996)
J. Biol. Chem. 271, 22175-22182
 |  Abstract »  |  Full Text »  |  PDF »

An Immunological Approach Reveals Biological Differences between the Two NDF/Heregulin Receptors, ErbB-3 and ErbB-4.

X. Chen, G. Levkowitz, E. Tzahar, D. Karunagaran, S. Lavi, N. Ben-Baruch, O. Leitner, B. J. Ratzkin, S. S. Bacus, and Y. Yarden (1996)
J. Biol. Chem. 271, 7620-7629
 |  Abstract »  |  Full Text »  |  PDF »

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