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Science 15 November 1991:
Vol. 254. no. 5034, pp. 1016 - 1019
DOI: 10.1126/science.1719635

Articles

Science, Vol 254, Issue 5034, 1016-1019
Copyright © 1991 by American Association for the Advancement of Science


articles

GPI-anchored cell-surface molecules complexed to protein tyrosine kinases

I Stefanova, V Horejsi, IJ Ansotegui, W Knapp, and H Stockinger

Institute of Immunology-Vienna International Research Cooperation Center, University of Vienna, Austria.

Binding of ligand or antibody to certain cell-surface proteins that are anchored to the membrane by glycophosphatidylinositol (GPI) can cause activation of leukocytes. However, it is not known how these molecules, which lack intracellular domains, can transduce signals. The GPI-linked human molecules CD59, CD55, CD48, CD24, and CD14 as well as the mouse molecules Thy-1 and Ly-6 were found to associate with protein tyrosine kinases, key regulators of cell activation and signal transduction. A protein tyrosine kinase associated with the GPI-linked proteins CD59, CD55, and CD48 in human T cells, and with Thy-1 in mouse T cells was identified as p56lck, a protein tyrosine kinase related to Src. This interaction of GPI-linked molecules with protein tyrosine kinases suggests a potential mechanism of signal transduction in cells.


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N. Funatsu, S. Miyata, H. Kumanogoh, M. Shigeta, K. Hamada, Y. Endo, Y. Sokawa, and S. Maekawa (1999)
J. Biol. Chem. 274, 8224-8230
   Abstract »    Full Text »    PDF »
Resistance of Paroxysmal Nocturnal Hemoglobinuria Cells to the Glycosylphosphatidylinositol-Binding Toxin Aerolysin.
R. A. Brodsky, G. L. Mukhina, K. L. Nelson, T. S. Lawrence, R. J. Jones, and J. T. Buckley (1999)
Blood 93, 1749-1756
   Abstract »    Full Text »    PDF »
Function of CD14 as a peptidoglycan receptor: differences and similarities with LPS.
R. Dziarski and D. Gupta (1999)
Innate Immunity 5, 56-61
   Abstract »    PDF »
Endocytosis at the apical plasma membrane of pancreatic acinar cells is regulated by tyrosine kinases.
S. D. Freedman, M. H. Katz, E. M. Parker, and A. Gelrud (1999)
Am J Physiol Cell Physiol 276, C306-C311
   Abstract »    Full Text »    PDF »
The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research.
M. Ferguson (1999)
J. Cell Sci. 112, 2799-2809
   Abstract »    PDF »
High Level Transcription of the Complement Regulatory Protein CD59 Requires an Enhancer Located in Intron 1.
M. Tone, L. E. Diamond, L. A. Walsh, Y. Tone, S. A. J. Thompson, E. M. Shanahan, J. S. Logan, and H. Waldmann (1999)
J. Biol. Chem. 274, 710-716
   Abstract »    Full Text »    PDF »
Polyunsaturated Fatty Acids Inhibit T Cell Signal Transduction by Modification of Detergent-insoluble Membrane Domains.
T. M. Stulnig, M. Berger, T. Sigmund, D. Raederstorff, H. Stockinger, and W. Waldhausl (1998)
J. Cell Biol. 143, 637-644
   Abstract »    Full Text »    PDF »
Role of plasmalemmal caveolae in signal transduction.
P. W. Shaul and R. G. W. Anderson (1998)
Am J Physiol Lung Cell Mol Physiol 275, L843-L851
   Abstract »    Full Text »    PDF »
Calcium Source Diversity in Canine Lower Esophageal Sphincter Muscle.
A. M. F. Salapatek, A. Lam, and E. E. Daniel (1998)
J. Pharmacol. Exp. Ther. 287, 98-106
   Abstract »    Full Text »
Distinct Regulatory Mechanisms for Interferon-alpha /beta (IFN-alpha /beta )- and IFN-gamma -Mediated Induction of Ly-6E Gene in B Cells.
M. M. Khodadoust, K. D. Khan, E.-h. Park, and A. L.M. Bothwell (1998)
Blood 92, 2399-2409
   Abstract »    Full Text »    PDF »
Antibody Cross-linking of the Glycosylphosphatidylinositol-linked Protein CD59 on Hematopoietic Cells Induces Signaling Pathways Resembling Activation by Complement.
E. W. Murray and S. M. Robbins (1998)
J. Biol. Chem. 273, 25279-25284
   Abstract »    Full Text »    PDF »
Piracy of Decay-Accelerating Factor (CD55) Signal Transduction by the Diffusely Adhering Strain Escherichia coli C1845 Promotes Cytoskeletal F-Actin Rearrangements in Cultured Human Intestinal INT407 Cells.
I. Peiffer, A. L. Servin, and M.-F. Bernet-Camard (1998)
Infect. Immun. 66, 4036-4042
   Abstract »    Full Text »    PDF »
A Functional Interaction between the Neuronal Adhesion Molecules TAG-1 and F3 Modulates Neurite Outgrowth and Fasciculation of Cerebellar Granule Cells.
M. Buttiglione, J.-M. Revest, O. Pavlou, D. Karagogeos, A. Furley, G. Rougon, and C. Faivre-Sarrailh (1998)
J. Neurosci. 18, 6853-6870
   Abstract »    Full Text »    PDF »
The Urokinase-type Plasminogen Activator Receptor Mediates Tyrosine Phosphorylation of Focal Adhesion Proteins and Activation of Mitogen-activated Protein Kinase in Cultured Endothelial Cells.
H. Tang, D. M. Kerins, Q. Hao, T. Inagami, and D. E. Vaughan (1998)
J. Biol. Chem. 273, 18268-18272
   Abstract »    Full Text »    PDF »
Distribution of a Glycosylphosphatidylinositol-anchored Protein at the Apical Surface of MDCK Cells Examined at a Resolution of <100 A Using Imaging Fluorescence Resonance Energy Transfer.
A.K. Kenworthy and M. Edidin (1998)
J. Cell Biol. 142, 69-84
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CD4+ T Cells Mature in the Absence of MHC Class I and Class II Expression in Ly-6A.2 Transgenic Mice.
S. C. Henderson, A. Berezovskaya, A. English, D. Palliser, K. L. Rock, and A. Bamezai (1998)
J. Immunol. 161, 175-182
   Abstract »    Full Text »    PDF »
CD44 Selectively Associates With Active Src Family Protein Tyrosine Kinases Lck and Fyn in Glycosphingolipid-Rich Plasma Membrane Domains of Human Peripheral Blood Lymphocytes.
S. Ilangumaran, A. Briol, and D. C. Hoessli (1998)
Blood 91, 3901-3908
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The Glycosylphosphatidylinositol-Anchored Form and the Transmembrane Form of CD58 Associate with Protein Kinases.
D. Itzhaky, N. Raz, and N. Hollander (1998)
J. Immunol. 160, 4361-4366
   Abstract »    Full Text »    PDF »



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