Science 8 November 1991: Vol. 254. no. 5033, pp. 847 - 850 DOI: 10.1126/science.1658934

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Articles

{alpha}-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption.

L. Torielli, S. Tivodar, R. C. Montella, R. Iacone, G. Padoani, P. Tarsini, O. Russo, D. Sarnataro, P. Strazzullo, P. Ferrari, et al. (2008)
Am J Physiol Renal Physiol 295, F478-F487
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Apical Sorting Motif and Mechanism of Targeting of the M2 Muscarinic Acetylcholine Receptor.

R. S. Chmelar and N. M. Nathanson (2006)
J. Biol. Chem. 281, 35381-35396
 |  Abstract »  |  Full Text »  |  PDF »

The Polarized Expression of Na+,K+-ATPase in Epithelia Depends on the Association between {beta}-Subunits Located in Neighboring Cells.

L. Shoshani, R. G. Contreras, M. L. Roldan, J. Moreno, A. Lazaro, M. S. Balda, K. Matter, and M. Cereijido (2005)
Mol. Biol. Cell 16, 1071-1081
 |  Abstract »  |  Full Text »  |  PDF »

Cell Adhesion, Polarity, and Epithelia in the Dawn of Metazoans.

M. Cereijido, R. G. Contreras, and L. Shoshani (2004)
Physiol Rev 84, 1229-1262
 |  Abstract »  |  Full Text »  |  PDF »

EFA6, Exchange Factor for ARF6, Regulates the Actin Cytoskeleton and Associated Tight Junction in Response to E-Cadherin Engagement.

F. Luton, S. Klein, J.-P. Chauvin, A. Le Bivic, S. Bourgoin, M. Franco, and P. Chardin (2004)
Mol. Biol. Cell 15, 1134-1145
 |  Abstract »  |  Full Text »  |  PDF »

The C-terminal domain of Drosophila {beta}Heavy-spectrin exhibits autonomous membrane association and modulates membrane area.

J. A. Williams, B. MacIver, E. A. Klipfell, and G. H. Thomas (2004)
J. Cell Sci. 117, 771-782
 |  Abstract »  |  Full Text »  |  PDF »

Transcytosis: Crossing Cellular Barriers.

P. L. TUMA and A. L. HUBBARD (2003)
Physiol Rev 83, 871-932
 |  Abstract »  |  Full Text »  |  PDF »

Inversin Forms a Complex with Catenins and N-Cadherin in Polarized Epithelial Cells.

J. Nurnberger, R. L. Bacallao, and C. L. Phillips (2002)
Mol. Biol. Cell 13, 3096-3106
 |  Abstract »  |  Full Text »  |  PDF »

Quality Control in the Yeast Secretory Pathway. A MISFOLDED PMA1 H+-ATPase REVEALS TWO CHECKPOINTS.

T. Ferreira, A. B. Mason, M. Pypaert, K. E. Allen, and C. W. Slayman (2002)
J. Biol. Chem. 277, 21027-21040
 |  Abstract »  |  Full Text »  |  PDF »

Dynamics of Ankyrin-containing Complexes in Chicken Embryonic Erythroid Cells: Role of Phosphorylation.

S. Ghosh and J. V. Cox (2001)
Mol. Biol. Cell 12, 3864-3874
 |  Abstract »  |  Full Text »  |  PDF »

Posttranslational Processing of PH-20 During Epididymal Sperm Maturation in the Horse.

J. Rutllant and S. A. Meyers (2001)
Biol Reprod 65, 1324-1331
 |  Abstract »  |  Full Text »  |  PDF »

Progressive Changes in Adherens Junction Structure during Intestinal Adenoma Formation in Apc Mutant Mice.

A. M. Carothers, K. A. Melstrom Jr., J. D. Mueller, M. J. Weyant, and M. M. Bertagnolli (2001)
J. Biol. Chem. 276, 39094-39102
 |  Abstract »  |  Full Text »  |  PDF »

A mutant plasma membrane ATPase, Pma1-10, is defective in stability at the yeast cell surface.

X. Gong and A. Chang (2001)
PNAS 98, 9104-9109
 |  Abstract »  |  Full Text »  |  PDF »

Dynamics of Glycine Receptor Insertion in the Neuronal Plasma Membrane.

M. Rosenberg, J. Meier, A. Triller, and C. Vannier (2001)
J. Neurosci. 21, 5036-5044
 |  Abstract »  |  Full Text »  |  PDF »

Tetraspanins in intercellular adhesion of polarized epithelial cells: spatial and functional relationship to integrins and cadherins.

M Yanez-Mo, R Tejedor, P Rousselle, and F Sanchez -Madrid (2001)
J. Cell Sci. 114, 577-587
 |  Abstract »  |  PDF »

Intracellular Redirection of Plasma Membrane Trafficking after Loss of Epithelial Cell Polarity.

S. H. Low, M. Miura, P. A. Roche, A. C. Valdez, K. E. Mostov, and T. Weimbs (2000)
Mol. Biol. Cell 11, 3045-3060
 |  Abstract »  |  Full Text »

High Levels of E-/P-Cadherin: Correlation with Decreased Apical Polarity of Na/K ATPase in Bovine RPE Cells In Situ.

J. M. Burke, F. Cao, and P. E. Irving (2000)
Invest. Ophthalmol. Vis. Sci. 41, 1945-1952
 |  Abstract »  |  Full Text »

Drosophila {beta} Spectrin Functions Independently of {alpha} Spectrin to Polarize the Na,k Atpase in Epithelial Cells.

R. R. Dubreuil, P. Wang, S. Dahl, J. Lee, and L. S.B. Goldstein (2000)
J. Cell Biol. 149, 647-656
 |  Abstract »  |  Full Text »  |  PDF »

The Extracellular Domain of Herpes Simplex Virus gE Is Sufficient for Accumulation at Cell Junctions but Not for Cell-to-Cell Spread.

T. Wisner, C. Brunetti, K. Dingwell, and D. C. Johnson (2000)
J. Virol. 74, 2278-2287
 |  Abstract »  |  Full Text »

A Transmembrane Segment Determines the Steady-State Localization of an Ion-Transporting Adenosine Triphosphatase.

L. A. Dunbar, P. Aronson, and M. J. Caplan (2000)
J. Cell Biol. 148, 769-778
 |  Abstract »  |  Full Text »  |  PDF »

Targeting of membrane transporters in renal epithelia: when cell biology meets physiology.

D. Brown (2000)
Am J Physiol Renal Physiol 278, F192-F201
 |  Abstract »  |  Full Text »  |  PDF »

Apical Plasma Membrane Mispolarization of NaK-ATPase in Polycystic Kidney Disease Epithelia Is Associated with Aberrant Expression of the {beta}2 Isoform.

P. D. Wilson, O. Devuyst, X. Li, L. Gatti, D. Falkenstein, S. Robinson, D. Fambrough, and C. R. Burrow (2000)
Am. J. Pathol. 156, 253-268
 |  Abstract »  |  Full Text »  |  PDF »

Establishment of the Circumferential Actin Filament Network Is a Prerequisite for Localization of the Cadherin-Catenin Complex in Epithelial Cells.

M. P. Quinlan and J. L. Hyatt (1999)
Cell Growth Differ. 10, 839-854
 |  Abstract »  |  Full Text »

Evidence for an interaction between adducin and Na+-K+-ATPase: relation to genetic hypertension.

M. Ferrandi, S. Salardi, G. Tripodi, P. Barassi, R. Rivera, P. Manunta, R. Goldshleger, P. Ferrari, G. Bianchi, and S. J. D. Karlish (1999)
Am J Physiol Heart Circ Physiol 277, H1338-H1349
 |  Abstract »  |  Full Text »  |  PDF »

Apical Spectrin Is Essential for Epithelial Morphogenesis but Not Apicobasal Polarity in Drosophila.

D. C. Zarnescu and G. H. Thomas (1999)
J. Cell Biol. 146, 1075-1086
 |  Abstract »  |  Full Text »  |  PDF »

Development of an endogenous epithelial Na+/H+ exchanger (NHE3) in three clones of Caco-2 cells.

A. J. Janecki, M. H. Montrose, C. M. Tse, F. S. de Medina, A. Zweibaum, and M. Donowitz (1999)
Am J Physiol Gastrointest Liver Physiol 277, G292-G305
 |  Abstract »  |  Full Text »  |  PDF »

PST 2238: A New Antihypertensive Compound that Modulates Na,K-ATPase in Genetic Hypertension.

P. Ferrari, M. Ferrandi, G. Tripodi, L. Torielli, G. Padoani, E. Minotti, P. Melloni, and G. Bianchi (1999)
J. Pharmacol. Exp. Ther. 288, 1074-1083
 |  Abstract »  |  Full Text »

Coupling Assembly of the E-Cadherin/{beta}-Catenin Complex to Efficient Endoplasmic Reticulum Exit and Basal-lateral Membrane Targeting of E-Cadherin in Polarized MDCK Cells.

Y.-T. Chen, D. B. Stewart, and W. J. Nelson (1999)
J. Cell Biol. 144, 687-699
 |  Abstract »  |  Full Text »  |  PDF »

Cadherin function in junctional complex rearrangement and posttranslational control of cadherin expression.

M. L. Troxell, Y.-T. Chen, N. Cobb, W. J. Nelson, and J. A. Marrs (1999)
Am J Physiol Cell Physiol 276, C404-C418
 |  Abstract »  |  Full Text »  |  PDF »

Neural Cell Adhesion Molecule (N-CAM) Is Required for Cell Type Segregation and Normal Ultrastructure in Pancreatic Islets.

F. Esni, I.-B. Taljedal, A.-K. Perl, H. Cremer, G. Christofori, and H. Semb (1999)
J. Cell Biol. 144, 325-337
 |  Abstract »  |  Full Text »  |  PDF »

Selective localization of the polytopic membrane protein prominin in microvilli of epithelial cells - a combination of apical sorting and retention in plasma membrane protrusions.

D Corbeil, K Roper, M. Hannah, A Hellwig, and W. Huttner (1999)
J. Cell Sci. 112, 1023-1033
 |  Abstract »  |  PDF »

New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity.

C. YEAMAN, K. K. GRINDSTAFF, and W. J. NELSON (1999)
Physiol Rev 79, 73-98
 |  Abstract »  |  Full Text »  |  PDF »

The Saccharomyces cerevisiae SOP1 and SOP2 Genes, Which Act in Cation Homeostasis, Can Be Functionally Substituted by the Drosophila lethal(2)giant larvae Tumor Suppressor Gene.

K. Larsson, F. Bohl, I. Sjostrom, N. Akhtar, D. Strand, B. M. Mechler, R. Grabowski, and L. Adler (1998)
J. Biol. Chem. 273, 33610-33618
 |  Abstract »  |  Full Text »  |  PDF »

The Cytoplasmic Domains of a beta 1 Integrin Mediate Polarization in Madin-Darby Canine Kidney Cells by Selective Basolateral Stabilization.

A. Gut, M. S. Balda, and K. Matter (1998)
J. Biol. Chem. 273, 29381-29388
 |  Abstract »  |  Full Text »  |  PDF »

The Herpes Simplex Virus gE-gI Complex Facilitates Cell-to-Cell Spread and Binds to Components of Cell Junctions.

K. S. Dingwell and D. C. Johnson (1998)
J. Virol. 72, 8933-8942
 |  Abstract »  |  Full Text »  |  PDF »

Biogenesis of Polarized Epithelial Cells During Kidney Development In Situ: Roles of E-Cadherin-mediated Cell-Cell Adhesion and Membrane Cytoskeleton Organization.

P. A. Piepenhagen and W. J. Nelson (1998)
Mol. Biol. Cell 9, 3161-3177
 |  Abstract »  |  Full Text »

The Cytoplasmic Tail of Rhodopsin Acts as a Novel Apical Sorting Signal in Polarized MDCK Cells.

J.-Z. Chuang and C.-H. Sung (1998)
J. Cell Biol. 142, 1245-1256
 |  Abstract »  |  Full Text »  |  PDF »

Rotavirus Infection Reduces Sucrase-Isomaltase Expression in Human Intestinal Epithelial Cells by Perturbing Protein Targeting and Organization of Microvillar Cytoskeleton.

N. Jourdan, J. P. Brunet, C. Sapin, A. Blais, J. Cotte-Laffitte, F. Forestier, A.-M. Quero, G. Trugnan, and A. L. Servin (1998)
J. Virol. 72, 7228-7236
 |  Abstract »  |  Full Text »  |  PDF »

Apical Plasma Membrane Proteins and Endolyn-78 Travel through a Subapical Compartment in Polarized WIF-B Hepatocytes.

G. Ihrke, G. V. Martin, M. R. Shanks, M. Schrader, T. A. Schroer, and A. L. Hubbard (1998)
J. Cell Biol. 141, 115-133
 |  Abstract »  |  Full Text »  |  PDF »

Apiconuclear Organization of Microtubules Does Not Specify Protein Delivery from the Trans-Golgi Network to Different Membrane Domains in Polarized Epithelial Cells.

K. K. Grindstaff, R. L. Bacallao, and W. J. Nelson (1998)
Mol. Biol. Cell 9, 685-699
 |  Abstract »  |  Full Text »

Distribution of epithelial ankyrin (Ank3) spliceoforms in renal proximal and distal tubules.

R. B. Doctor, J. Chen, L. L. Peters, S. E. Lux, and L. J. Mandel (1998)
Am J Physiol Renal Physiol 274, F129-F138
 |  Abstract »  |  Full Text »  |  PDF »

Embryonic Expression of the Putative {gamma} Subunit of the Sodium Pump Is Required for Acquisition of Fluid Transport Capacity during Mouse Blastocyst Development.

D. H. Jones, T. C. Davies, and G. M. Kidder (1997)
J. Cell Biol. 139, 1545-1552
 |  Abstract »  |  Full Text »  |  PDF »

The Effect of Apical and Basolateral Lipids on the Function of the Band 3 Anion Exchange Protein.

W. v. Hof, A. Malik, S. Vijayakumar, J. Qiao, J. v. Adelsberg, and Q. Al-Awqati (1997)
J. Cell Biol. 139, 941-949
 |  Abstract »  |  Full Text »  |  PDF »

Targeting of the Synaptic Vesicle Protein Synaptobrevin in the Axon of Cultured Hippocampal Neurons: Evidence for Two Distinct Sorting Steps.

A. E. West, R. L. Neve, and K. M. Buckley (1997)
J. Cell Biol. 139, 917-927
 |  Abstract »  |  Full Text »  |  PDF »

Segregation of Two Spectrin Isoforms: Polarized Membrane-binding Sites Direct Polarized Membrane Skeleton Assembly.

R. R. Dubreuil, P. B. Maddux, T. A. Grushko, and G. R. Macvicar (1997)
Mol. Biol. Cell 8, 1933-1942
 |  Abstract »  |  Full Text »

Apical Enrichment of Human EGF Precursor in Madin-Darby Canine Kidney Cells Involves Preferential Basolateral Ectodomain Cleavage Sensitive to a Metalloprotease Inhibitor.

P. J. Dempsey, K. S. Meise, Y. Yoshitake, K. Nishikawa, and R. J. Coffey (1997)
J. Cell Biol. 138, 747-758
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of Microtubules Reveals Two Independent Apical Targeting Mechanisms for G-protein-coupled Receptors in Polarized Renal Epithelial Cells.

C. Saunders and L. E. Limbird (1997)
J. Biol. Chem. 272, 19035-19045
 |  Abstract »  |  Full Text »  |  PDF »

Glucose transporter GLUT3: Ontogeny, targeting, and role in the mouse blastocyst.

M. Pantaleon, M. B. Harvey, W. S. Pascoe, D. E. James, and P. L. Kaye (1997)
PNAS 94, 3795-3800
 |  Abstract »  |  Full Text »  |  PDF »

Basolateral Localization and Transcytosis of Gonadotropin and Thyrotropin Receptors Expressed in Madin-Darby Canine Kidney Cells.

I. Beau, M. Misrahi, B. Gross, B. Vannier, H. Loosfelt, M. T. V. Hai, C. Pichon, and E. Milgrom (1997)
J. Biol. Chem. 272, 5241-5248
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms for de novo biogenesis of an apical membrane compartment in groups of simple epithelial cells surrounded by extracellular matrix.

G. Ojakian, W. Nelson, and K. Beck (1997)
J. Cell Sci. 110, 2781-2794
 |  Abstract »  |  PDF »

Sorting of MHC class II molecules and the associated invariant chain (Ii) in polarized MDCK cells.

A Simonsen, E Stang, B Bremnes, M Roe, K Prydz, and O Bakke (1997)
J. Cell Sci. 110, 597-609
 |  Abstract »  |  PDF »

alpha-Spectrin is required for ovarian follicle monolayer integrity in Drosophila melanogaster.

J. Lee, E Brandin, D Branton, and L. Goldstein (1997)
Development 124, 353-362
 |  Abstract »  |  PDF »

Renal Na,K-ATPase in Genetic Hypertension.

M. Ferrandi, G. Tripodi, S. Salardi, M. Florio, R. Modica, P. Barassi, P. Parenti, A. Shainskaya, S. Karlish, G. Bianchi, et al. (1996)
Hypertension 28, 1018-1025
 |  Abstract »  |  Full Text »

Translational Regulation of Na,K-ATPase alpha 1 and beta 1 Polypeptide Expression in Epithelial Cells.

K. K. Grindstaff, G. Blanco, and R. W. Mercer (1996)
J. Biol. Chem. 271, 23211-23221
 |  Abstract »  |  Full Text »  |  PDF »

Immortalised mouse submandibular epithelial cell lines retain polarised structural and functional properties.

B. Laoide, Y Courty, I Gastinne, C Thibaut, O Kellermann, and F Rougeon (1996)
J. Cell Sci. 109, 2789-2800
 |  Abstract »  |  PDF »

The polarity of the plasma membrane protein RET-PE2 in retinal pigment epithelium is developmentally regulated.

A. Marmorstein, V. Bonilha, S Chiflet, J. Neill, and E Rodriguez-Boulan (1996)
J. Cell Sci. 109, 3025-3034
 |  Abstract »  |  PDF »

Differential localization of Na+/H+ exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines.

J Noel, D Roux, and J Pouyssegur (1996)
J. Cell Sci. 109, 929-939
 |  Abstract »  |  PDF »

Identification of a Binding Motif for Ankyrin on the alpha-Subunit of Na[IMAGE],K[IMAGE]-ATPase.

C. Jordan, B. Püschel, R. Koob, and D. Drenckhahn (1995)
J. Biol. Chem. 270, 29971-29975
 |  Abstract »  |  Full Text »  |  PDF »

MOP2 (SLA2) Affects the Abundance of the Plasma Membrane H[IMAGE]-ATPase of Saccharomyces cerevisiae.

S. Na, M. Hincapie, J. H. McCusker, and J. E. Haber (1995)
J. Biol. Chem. 270, 6815-6823
 |  Abstract »  |  Full Text »  |  PDF »

Polarized Distribution and Delivery of Plasma Membrane Proteins in Thyroid Follicular Epithelial Cells.

R. Kuliawat, M. P. Lisanti, and P. Arvan (1995)
J. Biol. Chem. 270, 2478-2482
 |  Abstract »  |  Full Text »  |  PDF »

Galectin-3 expression and effects on cyst enlargement and tubulogenesis in kidney epithelial MDCK cells cultured in three-dimensional matrices in vitro.

Q Bao and R. Hughes (1995)
J. Cell Sci. 108, 2791-2800
 |  Abstract »  |  PDF »

Generation of Epithelial Cell Polarity: Roles for Protein Trafficking, Membrane-Cytoskeleton, and E-Cadherin-mediated Cell Adhesion.

R.W. Mays, W.J. Nelson, and J.A. Marrs (1995)
Cold Spring Harb Symp Quant Biol 60, 763-773
 |  Abstract »  |  PDF »

Regulation of Protein Traffic in Polarized Epithelial Cells: The Polymeric Immunoglobulin Receptor Model.

K.E. Mostov, Y. Altschuler, S.J. Chapin, C. Enrich, S.-H. Low, F. Luton, J. Richman-Eisenstat, K.L. Singer, K. Tang, and T. Weimbs (1995)
Cold Spring Harb Symp Quant Biol 60, 775-781
 |  Abstract »  |  PDF »

Alterations in Epithelial Polarity and the Pathogenesis of Disease States.

E. M. Fish and B. A. Molitoris (1994)
N. Engl. J. Med. 330, 1580-1588
 |  Full Text »

Delivery of Na+,K(+)-ATPase in polarized epithelial cells.

C Zurzolo and E Rodriguez-Boulan (1993)
Science 260, 550-552
 |  PDF »

Delivery of Na+,K(+)-ATPase in polarized epithelial cells.

C. Gottardi and M. Caplan (1993)
Science 260, 552-554
 |  PDF »

Response.

K. A. Siemers (Krzeminski), R. Wilson (Hammerton), R. W. Mays, T. A. Ryan, D. A. Wollner, and W. J. Nelson (1993)
Science 260, 554-556
 |  PDF »

Requirement of the carboxyl terminus of a bacterial chemoreceptor for its targeted proteolysis.

M. Alley, Maddock JR, and L Shapiro (1993)
Science 259, 1754-1757
 |  Abstract »  |  PDF »

Immortalization of polarized rat retinal pigment epithelium.

I. Nabi, A. Mathews, L Cohen-Gould, D Gundersen, and E Rodriguez-Boulan (1993)
J. Cell Sci. 104, 37-49
 |  Abstract »  |  PDF »

Regulation of cell surface polarity from bacteria to mammals.

W. Nelson (1992)
Science 258, 948-955
 |  Abstract »  |  PDF »

Biogenesis of Cell-surface Polarity in Epithelial Cells and Neurons.

K. Simons, P. Dupree, K. Fiedler, L.A. Huber, T. Kobayashi, T. Kurzchalia, V. Olkkonen, S. Pimplikar, R. Parton, and C. Dotti (1992)
Cold Spring Harb Symp Quant Biol 57, 611-619
 |  Abstract »  |  PDF »

Regulation of Epithelial Cell Polarity: A View from the Cell Surface.

W.J. Nelson, R. Wilson, D. Wollner, R. Mays, H. McNeill, and K. Siemers (1992)
Cold Spring Harb Symp Quant Biol 57, 621-630
 |  Abstract »  |  PDF »

Distinctive Cyclic AMP-dependent Protein Kinase Subunit Localization Is Associated with Cyst Formation and Loss of Tubulogenic Capacity in Madin-Darby Canine Kidney Cell Clones.

S. A. Orellana and C. Marfella-Scivittaro (2000)
J. Biol. Chem. 275, 21233-21240
 |  Abstract »  |  Full Text »  |  PDF »

Ion Pumps in Polarized Cells: Sorting and Regulation of the Na+,K+- and H+,K+-ATPases.

L. A. Dunbar and M. J. Caplan (2001)
J. Biol. Chem. 276, 29617-29620
 |  Abstract »  |  Full Text »  |  PDF »

Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex.

O. Olsen, H. Liu, J. B. Wade, J. Merot, and P. A. Welling (2002)
Am J Physiol Cell Physiol 282, C183-C195
 |  Abstract »  |  Full Text »  |  PDF »

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