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Science 8 November 1991:
Vol. 254. no. 5033, pp. 815 - 820
DOI: 10.1126/science.1658933
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Articles

Science, Vol 254, Issue 5033, 815-820
Copyright © 1991 by American Association for the Advancement of Science

articles

Molecular basis of latency in pathogenic human viruses

MA Garcia-Blanco and BR Cullen

Section of Cell Growth, Regulation, and Oncogenesis, Duke University Medical Center, Durham, NC 27710.

Several human viruses are able to latently infect specific target cell populations in vivo. Analysis of the replication cycles of herpes simplex virus, Epstein-Barr virus, and human immunodeficiency virus suggests that the latent infections established by these human pathogens primarily result from a lack of host factors critical for the expression of viral early gene products. The subsequent activation of specific cellular transcription factors in response to extracellular stimuli can induce the expression of these viral regulatory proteins and lead to a burst of lytic viral replication. Latency in these eukaryotic viruses therefore contrasts with latency in bacteriophage, which is maintained primarily by the expression of virally encoded repressors of lytic replication.


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