Science 1 November 1991: Vol. 254. no. 5032, pp. 713 - 716 DOI: 10.1126/science.1948050

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Articles

PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.

X. Lu, R. Malumbres, B. Shields, X. Jiang, K. A. Sarosiek, Y. Natkunam, T. Tiganis, and I. S. Lossos (2008)
Blood 112, 4098-4108
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Cancer Gene Therapy Using a Hypoxia Inducible Factor Dependent Oncolytic Adenovirus Armed with Interleukin-4.

D. E. Post, E. M. Sandberg, M. M. Kyle, N. S. Devi, D. J. Brat, Z. Xu, M. Tighiouart, and E. G. Van Meir (2007)
Cancer Res. 67, 6872-6881
 |  Abstract »  |  Full Text »  |  PDF »

T-Cell Protein Tyrosine Phosphatase, Distinctively Expressed in Activated-B-Cell-Like Diffuse Large B-Cell Lymphomas, Is the Nuclear Phosphatase of STAT6.

X. Lu, J. Chen, R. T. Sasmono, E. D. Hsi, K. A. Sarosiek, T. Tiganis, and I. S. Lossos (2007)
Mol. Cell. Biol. 27, 2166-2179
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Th1 cell adjuvant therapy combined with tumor vaccination: a novel strategy for promoting CTL responses while avoiding the accumulation of Tregs.

Y. Zhang, D. Wakita, K. Chamoto, Y. Narita, N. Matsubara, H. Kitamura, and T. Nishimura (2007)
Int. Immunol. 19, 151-161
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Tumor-Derived Interleukin-4 Reduces Tumor Clearance and Deviates the Cytokine and Granzyme Profile of Tumor-Induced CD8+ T Cells.

S. Olver, P. Groves, K. Buttigieg, E. S. Morris, M. L. Janas, A. Kelso, and N. Kienzle (2006)
Cancer Res. 66, 571-580
 |  Abstract »  |  Full Text »  |  PDF »

Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells.

K. Liu, J. Idoyaga, A. Charalambous, S.-i. Fujii, A. Bonito, J. Mordoh, R. Wainstok, X.-F. Bai, Y. Liu, and R. M. Steinman (2005)
J. Exp. Med. 202, 1507-1516
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Delivery of Dendritic Cells Engineered to Secrete IFN-{alpha} into Central Nervous System Tumors Enhances the Efficacy of Peripheral Tumor Cell Vaccines: Dependence on Apoptotic Pathways.

N. Kuwashima, F. Nishimura, J. Eguchi, H. Sato, M. Hatano, T. Tsugawa, T. Sakaida, J. E. Dusak, W. K. Fellows-Mayle, G. D. Papworth, et al. (2005)
J. Immunol. 175, 2730-2740
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Allergies and the Risk of Pancreatic Cancer: A Meta-analysis with Review of Epidemiology and Biological Mechanisms.

S. Gandini, A. B. Lowenfels, E. M. Jaffee, T. D. Armstrong, and P. Maisonneuve (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 1908-1916
 |  Abstract »  |  Full Text »  |  PDF »

Distinct IL-4-induced gene expression, proliferation, and intracellular signaling in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas.

X. Lu, H. Nechushtan, F. Ding, M. F. Rosado, R. Singal, A. A. Alizadeh, and I. S. Lossos (2005)
Blood 105, 2924-2932
 |  Abstract »  |  Full Text »  |  PDF »

Allogeneic Hematopoietic Cell Transplantation for Metastatic Renal Cell Carcinoma after Nonmyeloablative Conditioning: Toxicity, Clinical Response, and Immunological Response to Minor Histocompatibility Antigens.

S. S. Tykodi, E. H. Warren, J. A. Thompson, S. R. Riddell, R. W. Childs, B. E. Otterud, M. F. Leppert, R. Storb, and B. M. Sandmaier (2004)
Clin. Cancer Res. 10, 7799-7811
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 Protects Tumor Cells from Anti-CD95 and Chemotherapeutic Agents via Up-Regulation of Antiapoptotic Proteins.

C. Conticello, F. Pedini, A. Zeuner, M. Patti, M. Zerilli, G. Stassi, A. Messina, C. Peschle, and R. De Maria (2004)
J. Immunol. 172, 5467-5477
 |  Abstract »  |  Full Text »  |  PDF »

Granulocyte-Macrophage Colony-Stimulating Factor Gene-Modified Autologous Tumor Vaccines in Non-Small-Cell Lung Cancer.

J. Nemunaitis, D. Sterman, D. Jablons, J. W. Smith II, B. Fox, P. Maples, S. Hamilton, F. Borellini, A. Lin, S. Morali, et al. (2004)
J Natl Cancer Inst 96, 326-331
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Rejection by Modulation of Tumor Stromal Fibroblasts.

T. Schuler, S. Kornig, and T. Blankenstein (2003)
J. Exp. Med. 198, 1487-1493
 |  Abstract »  |  Full Text »  |  PDF »

Retrovirus-mediated IL-7 expression in leukemic dendritic cells generated from primary acute myelogenous leukemias enhances their functional properties.

C. Bello-Fernandez, J. Stasakova, A. Renner, N. Carballido-Perrig, M. Koening, M. Waclavicek, O. Madjic, L. Oehler, O. Haas, J. M. Carballido, et al. (2003)
Blood 101, 2184-2190
 |  Abstract »  |  Full Text »  |  PDF »

CD4+ T Lymphocytes Play a Critical Role in Antibody Production and Tumor Immunity against Simian Virus 40 Large Tumor Antigen.

R. C. Kennedy, M. H. Shearer, A. M. Watts, and R. K. Bright (2003)
Cancer Res. 63, 1040-1045
 |  Abstract »  |  Full Text »  |  PDF »

Cancer Vaccines.

I. Espinoza-Delgado (2002)
Oncologist 7, 20-33
 |  Abstract »  |  Full Text »  |  PDF »

A Clonal Culture System Demonstrates That IL-4 Induces a Subpopulation of Noncytolytic T Cells with Low CD8, Perforin, and Granzyme Expression.

N. Kienzle, K. Buttigieg, P. Groves, T. Kawula, and A. Kelso (2002)
J. Immunol. 168, 1672-1681
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Immunity in Peripheral Tissues Combined with Intracerebral Transplantation of Interleukin-2-producing Cells Eliminates Established Brain Tumors.

Y. Iwadate, A. Yamaura, Y. Sato, S. Sakiyama, and M. Tagawa (2001)
Cancer Res. 61, 8769-8774
 |  Abstract »  |  Full Text »  |  PDF »

Vaccines in oncology: background and clinical potential.

A C Armstrong and R E Hawkins (2001)
Br. J. Radiol. 74, 991-1002
 |  Abstract »  |  Full Text »  |  PDF »

Effective Particle-mediated Vaccination against Mouse Melanoma by Coadministration of Plasmid DNA Encoding Gp100 and Granulocyte-Macrophage Colony-Stimulating Factor.

A. L. Rakhmilevich, M. Imboden, Z. Hao, M. D. Macklin, T. Roberts, K. M. Wright, M. R. Albertini, N.-S. Yang, and P. M. Sondel (2001)
Clin. Cancer Res. 7, 952-961
 |  Abstract »  |  Full Text »

Immunization with an Antigen Identified by Cytokine Tumor Vaccine-assisted SEREX (CAS) Suppressed Growth of the Rat 9L Glioma in Vivo.

H. Okada, J. Attanucci, K. M. Giezeman-Smits, C. Brissette-Storkus, W. K. Fellows, A. Gambotto, I. F. Pollack, K. Pogue-Geile, M. T. Lotze, M. E. Bozik, et al. (2001)
Cancer Res. 61, 2625-2631
 |  Abstract »  |  Full Text »

IL-6 Secretion by a Rat T9 Glioma Clone Induces a Neutrophil-Dependent Antitumor Response with Resultant Cellular, Antiglioma Immunity.

M. R. Graf, R. M. Prins, and R. E. Merchant (2001)
J. Immunol. 166, 121-129
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Antitumor Immunity with Combination of HER2/neu DNA Vaccine and Interleukin 2 Gene-modified Tumor Vaccine.

S.-A. Chen, M.-H. T. F.-T. Wu, A. Hsiang, Y.-L. Chen, H.-Y. Lei, T.-S. Tzai, H. W. C. Leung, Y.-T. Jin, C.-L. Hsieh, L.-H. Hwang, et al. (2000)
Clin. Cancer Res. 6, 4381-4388
 |  Abstract »  |  Full Text »  |  PDF »

Impact of genomics on drug discovery and clinical medicine.

G. Emilien, M. Ponchon, C. Caldas, O. Isacson, and J.-M. Maloteaux (2000)
QJM 93, 391-423
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Analysis of Genetically Modified Dendritic Cells and Tumor Cells as Therapeutic Cancer Vaccines.

C. Klein, H. Bueler, and R. C. Mulligan (2000)
J. Exp. Med. 191, 1699-1708
 |  Abstract »  |  Full Text »  |  PDF »

Immunity to Murine Breast Cancer Cells Modified to Express MUC-1, a Human Breast Cancer Antigen, in Transgenic Mice Tolerant to Human MUC-1.

V. Carr-Brendel, D. Markovic, K. Ferrer, M. Smith, J. Taylor-Papadimitriou, and E. P. Cohen (2000)
Cancer Res. 60, 2435-2443
 |  Abstract »  |  Full Text »

Cytokine Gene Therapy of Gliomas: Induction of Reactive CD4+ T Cells by Interleukin-4-transfected 9L Gliosarcoma Is Essential for Protective Immunity.

K. M. Giezeman-Smits, H. Okada, C. S. Brissette-Storkus, L. A. Villa, J. Attanucci, M. T. Lotze, I. F. Pollack, M. E. Bozik, and W. H. Chambers (2000)
Cancer Res. 60, 2449-2457
 |  Abstract »  |  Full Text »

The CC Chemokine CK{beta}-11/MIP-3{beta}/ELC/Exodus 3 Mediates Tumor Rejection of Murine Breast Cancer Cells Through NK Cells.

S. E. Braun, K. Chen, R. G. Foster, C. H. Kim, R. Hromas, M. H. Kaplan, H. E. Broxmeyer, and K. Cornetta (2000)
J. Immunol. 164, 4025-4031
 |  Abstract »  |  Full Text »  |  PDF »

Viral Vector Delivery in Solid-State Vehicles: Gene Expression in a Murine Prostate Cancer Model.

D. R. Siemens, J. C. Austin, S. P. Hedican, J. Tartaglia, and T. L. Ratliff (2000)
J Natl Cancer Inst 92, 403-412
 |  Abstract »  |  Full Text »  |  PDF »

Preclinical Evaluation of "Whole" Cell Vaccines for Prophylaxis and Therapy Using a Disabled Infectious Single Cycle-Herpes Simplex Virus Vector to Transduce Cytokine Genes.

S. A. Ali, C. S. McLean, M. E. G. Boursnell, G. Martin, C. L. Holmes, S. Reeder, C. Entwisle, D. M. Blakeley, J. G. Shields, S. Todryk, et al. (2000)
Cancer Res. 60, 1663-1670
 |  Abstract »  |  Full Text »

Interleukin-7/B7.1-encoding Adenoviruses Induce Rejection of Transplanted but not Nontransplanted Tumors.

G. Willimsky and T. Blankenstein (2000)
Cancer Res. 60, 685-692
 |  Abstract »  |  Full Text »

Type 1 and Type 2 CD8+ Effector T Cell Subpopulations Promote Long-Term Tumor Immunity and Protection to Progressively Growing Tumor.

M. J. Dobrzanski, J. B. Reome, and R. W. Dutton (2000)
J. Immunol. 164, 916-925
 |  Abstract »  |  Full Text »  |  PDF »

Immunotherapy of Advanced Malignancy by Direct Gene Transfer of an Interleukin-2 DNA/DMRIE/DOPE Lipid Complex: Phase I/II Experience.

E. Galanis, E. M. Hersh, A. T. Stopeck, R. Gonzalez, P. Burch, C. Spier, E. T. Akporiaye, J. J. Rinehart, J. Edmonson, R. E. Sobol, et al. (1999)
J. Clin. Oncol. 17, 3313-3323
 |  Abstract »  |  Full Text »  |  PDF »

IL-4-Transduced Tumor Cell Vaccine Induces Immunoregulatory Type 2 CD8 T Lymphocytes That Cure Lung Metastases Upon Adoptive Transfer.

M. Rodolfo, C. Zilocchi, P. Accornero, B. Cappetti, I. Arioli, and M. P. Colombo (1999)
J. Immunol. 163, 1923-1928
 |  Abstract »  |  Full Text »  |  PDF »

Combination Surgery and Nonviral Interleukin 2 Gene Therapy for Head and Neck Cancer.

D. Li, W. Jiang, J. S. Bishop, R. Ralston, and B. W. O'Malley Jr. (1999)
Clin. Cancer Res. 5, 1551-1556
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic Effects of Tumor-Reactive Type 1 and Type 2 CD8+ T Cell Subpopulations in Established Pulmonary Metastases.

M. J. Dobrzanski, J. B. Reome, and R. W. Dutton (1999)
J. Immunol. 162, 6671-6680
 |  Abstract »  |  Full Text »  |  PDF »

Treatment of Breast Cancer with Fibroblasts Transfected with DNA from Breast Cancer Cells.

E. de Zoeten, V. Carr-Brendel, D. Markovic, J. Taylor-Papadimitriou, and E. P. Cohen (1999)
J. Immunol. 162, 6934-6941
 |  Abstract »  |  Full Text »  |  PDF »

Successful Adoptive Immunotherapy of Murine Poorly Immunogenic Tumor with Specific Effector Cells Generated from Gene-Modified Tumor-Primed Lymph Node Cells.

H. Tanaka, H. Yoshizawa, Y. Yamaguchi, K. Ito, H. Kagamu, E. Suzuki, F. Gejyo, H. Hamada, and M. Arakawa (1999)
J. Immunol. 162, 3574-3582
 |  Abstract »  |  Full Text »  |  PDF »

Effect of In Situ Retroviral Interleukin-4 Transfer on Established Intracranial Tumors.

M. Saleh, A. Wiegmans, Q. Malone, S. S. Stylli, and A. H. Kaye (1999)
J Natl Cancer Inst 91, 438-445
 |  Abstract »  |  Full Text »  |  PDF »

Cancer Vaccines.

T. F. Greten and E. M. Jaffee (1999)
J. Clin. Oncol. 17, 1047
 |  Abstract »  |  Full Text »  |  PDF »

The Central Role of CD4+ T Cells in the Antitumor Immune Response.

K. Hung, R. Hayashi, A. Lafond-Walker, C. Lowenstein, D. Pardoll, and H. Levitsky (1998)
J. Exp. Med. 188, 2357-2368
 |  Abstract »  |  Full Text »  |  PDF »

Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice.

X.-Q. Qin, N. Tao, A. Dergay, P. Moy, S. Fawell, A. Davis, J. M. Wilson, and J. Barsoum (1998)
PNAS 95, 14411-14416
 |  Abstract »  |  Full Text »  |  PDF »

Eliciting T Cell Immunity Against Poorly Immunogenic Tumors by Immunization with Dendritic Cell-Tumor Fusion Vaccines.

J. Wang, S. Saffold, X. Cao, J. Krauss, and W. Chen (1998)
J. Immunol. 161, 5516-5524
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Angiogenesis by Interleukin 4.

O. V. Volpert, T. Fong, A. E. Koch, J. D. Peterson, C. Waltenbaugh, R. I. Tepper, and N. P. Bouck (1998)
J. Exp. Med. 188, 1039-1046
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 Adenovector-Transduced Autologous Tumor Cells Induce Antitumor Immune Responses in Patients With Neuroblastoma.

L. Bowman, M. Grossmann, D. Rill, M. Brown, W.-y. Zhong, B. Alexander, T. Leimig, E. Coustan-Smith, D. Campana, J. Jenkins, et al. (1998)
Blood 92, 1941-1949
 |  Abstract »  |  Full Text »  |  PDF »

CTLA-4 blockade synergizes with tumor-derived granulocyte- macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma.

A. A. Hurwitz, T. F.-Y. Yu, D. R. Leach, and J. P. Allison (1998)
PNAS 95, 10067-10071
 |  Abstract »  |  Full Text »  |  PDF »

Papillomaviruses and Cervical Cancer: Pathogenesis and Vaccine Development.

D. R. Lowy and J. T. Schiller (1998)
J Natl Cancer Inst Monographs 1998, 27-30
 |  Abstract »  |  Full Text »

Resistance to Melanoma in Mice Immunized with Semiallogeneic Fibroblasts Transfected with DNA from Mouse Melanoma Cells.

E. F. de Zoeten, V. Carr-Brendel, and E. P. Cohen (1998)
J. Immunol. 160, 2915-2922
 |  Abstract »  |  Full Text »  |  PDF »

MHC Class II-Transfected Tumor Cells Directly Present Antigen to Tumor-Specific CD4+ T Lymphocytes1.

T. D. Armstrong, V. K. Clements, and S. Ostrand-Rosenberg (1998)
J. Immunol. 160, 661-666
 |  Abstract »  |  Full Text »  |  PDF »

Neutrophils but Not Eosinophils Are Involved in Growth Suppression of IL-4-Secreting Tumors.

G. Noffz, Z. Qin, M. Kopf, and T. Blankenstein (1998)
J. Immunol. 160, 345-350
 |  Abstract »  |  Full Text »  |  PDF »

Vaccine Trials for the Clinician: Prospects for Tumor Antigens.

S. Osanto (1997)
Oncologist 2, 284-299
 |  Abstract »  |  Full Text »  |  PDF »

Vaccine Trials for the Clinician: Prospects for Viral and Non-Viral Vectors.

P. S. Goedegebuure and T. J. Eberlein (1997)
Oncologist 2, 300-310
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Interleukin-2 in Combination Adenovirus Gene Therapy for Head and Neck Cancer.

B. W. O’Malley Jr., D. A. Sewell, D. Li, K.-i. Kosai, S.-H. Chen, S. L.C. Woo, and L. Duan (1997)
Mol. Endocrinol. 11, 667-673
 |  Abstract »  |  Full Text »

Fibroblasts as efficient antigen-presenting cells in lymphoid organs.

T. Kundig, M. Bachmann, C DiPaolo, J. Simard, M Battegay, H Lother, A Gessner, K Kuhlcke, P. Ohashi, H Hengartner, et al. (1995)
Science 268, 1343-1347
 |  Abstract »  |  PDF »

Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens.

A. Huang, P Golumbek, M Ahmadzadeh, E Jaffee, D Pardoll, and H Levitsky (1994)
Science 264, 961-965
 |  Abstract »  |  PDF »

Current Issues in Cancer: Genes dreams and cancer.

K Sikora (1994)
BMJ 308, 1217-1221
 |  Full Text »

Molecular Genetic Interventions for Cancer.

G.J. Nabel, E.G. Nabel, Z. Yang, B.A. Fox, G.E. Plautz, X. Gao, L. Huang, S. Shu, D. Gordon, and A.E. Chang (1994)
Cold Spring Harb Symp Quant Biol 59, 699-707
 |  Abstract »  |  PDF »

Immunobiologic Effects of Cytokine Gene Transfer of the B16-BL6 Melanoma.

S. E. Strome, J. C. Krauss, M. J. Cameron, K. Forslund, S. Shu, and A. E. Chang (1993)
Arch Otolaryngol Head Neck Surg 119, 1289-1295
 |  Abstract »  |  PDF »

Transfer of Interleukin 2 Receptor Genes Into Squamous Cell Carcinoma: Modification of Tumor Cell Growth.

W.-c. Lin, S. Yasumura, and T. L. Whiteside (1993)
Arch Otolaryngol Head Neck Surg 119, 1229-1235
 |  Abstract »  |  PDF »

Gene Therapy.

F. Levine and T. Friedmann (1993)
Arch Pediatr Adolesc Med 147, 1167-1174
 |  Abstract »  |  PDF »

Adoptive Cellular Therapy of Malignancy.

A. E. Chang, J. D. Geiger, V. K Sondak, and S. Shu (1993)
Arch Surg 128, 1281-1290
 |  Abstract »  |  PDF »

Identifying strategies for immune intervention.

A Lanzavecchia (1993)
Science 260, 937-944
 |  Abstract »  |  PDF »

Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells.

S. Townsend and J. Allison (1993)
Science 259, 368-370
 |  Abstract »  |  PDF »

Human Gene Therapy: A Role for the Primary Care Physician.

C. J. Schmeichel and J. M. Loeb (1992)
Arch Fam Med 1, 113-120
 |  Abstract »  |  PDF »

An eosinophil-dependent mechanism for the antitumor effect of interleukin-4.

R. Tepper, R. Coffman, and P Leder (1992)
Science 257, 548-551
 |  Abstract »  |  PDF »

Oncology.

J. E. Karp and S. Broder (1992)
JAMA 268, 391-393
 |  Abstract »  |  PDF »

Three-Dimensional Solution Structure of Human Interleukin-4 by Multidimensional Heteronuclear Magnetic Resonance Spectroscopy.

R. Powers, D. S. Garrett, C. J. March, E. A. Frieden, A. M. Gronenborn, and G. M. Clore (1992)
Science 256, 1673-1677
 |  Abstract »  |  PDF »

A NEW APPROACH TO CANCER IMMUNOTHERAPY.

(1991)
Journal Watch (General) 1991, 11
 |  Full Text »

Potent induction of long-term CD8+ T cell memory by short-term IL-4 exposure during T cell receptor stimulation.

L.-R. Huang, F.-L. Chen, Y.-T. Chen, Y.-M. Lin, and J. T. Kung (2000)
PNAS 97, 3406-3411
 |  Abstract »  |  Full Text »  |  PDF »

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