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Science 1 November 1991:
Vol. 254. no. 5032, pp. 707 - 710
DOI: 10.1126/science.1948049
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Articles

Science, Vol 254, Issue 5032, 707-710
Copyright © 1991 by American Association for the Advancement of Science

articles

Generation and analysis of interleukin-4 deficient mice

R Kuhn, K Rajewsky, and W Muller

Institute for Genetics, University of Cologne, Germany.

Interleukin-4 (IL-4) promotes the growth and differentiation of many hematopoietic cells in vitro; in particular, it directs the immunoglobulin (Ig) class switch to IgG1 and IgE. Mice homozygous for a mutation that inactivates the IL-4 gene were generated to test the requirement for IL-4 in vivo. In the mutant mice T and B cell development was normal, but the serum levels of IgG1 and IgE were strongly reduced. The IgG1 dominance in a T cell-dependent immune response was lost, and IgE was not detectable upon nematode infection. Thus, some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo.


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Hum. Mol. Genet. 11, 1129-1135
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Toll-Like Receptor 4 Is Required for Optimal Development of Th2 Immune Responses: Role of Dendritic Cells.
K. Dabbagh, M. E. Dahl, P. Stepick-Biek, and D. B. Lewis (2002)
J. Immunol. 168, 4524-4530
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Analysis of Sequence Upstream of the Endogenous H19 Gene Reveals Elements Both Essential and Dispensable for Imprinting.
J. L. Thorvaldsen, M. R. W. Mann, O. Nwoko, K. L. Duran, and M. S. Bartolomei (2002)
Mol. Cell. Biol. 22, 2450-2462
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Specificity of Interleukin-2 Receptor gamma Chain Superfamily Cytokines Is Mediated by Insulin Receptor Substrate-dependent Pathway.
H. Xiao, T. Yin, X.-Y. Wang, T. Uchida, J. Chung, M. F. White, and Y.-C. Yang (2002)
J. Biol. Chem. 277, 8091-8098
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Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells.
G. Schratt, U. Philippar, J. Berger, H. Schwarz, O. Heidenreich, and A. Nordheim (2002)
J. Cell Biol. 156, 737-750
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Indirect IL-4 Pathway in Type 1 Immunity.
A. Y. Karulin, M. D. Hesse, H. C. Yip, and P. V. Lehmann (2002)
J. Immunol. 168, 545-553
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Persistent Ehrlichia chaffeensis Infection Occurs in the Absence of Functional Major Histocompatibility Complex Class II Genes.
R. R. Ganta, M. J. Wilkerson, C. Cheng, A. M. Rokey, and S. K. Chapes (2002)
Infect. Immun. 70, 380-388
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The IL-4 production capability of different strains of naive CD4+ T cells controls the direction of the Th cell response.
R. Yagi, W. Suzuki, N. Seki, M. Kohyama, T. Inoue, T. Arai, and M. Kubo (2002)
Int. Immunol. 14, 1-11
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Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes"".
M. A. C. de Lafaille, S. Muriglan, M.-J. Sunshine, Y. Lei, N. Kutchukhidze, G. C. Furtado, A. K. Wensky, D. Olivares-Villagomez, and J. J. Lafaille (2001)
J. Exp. Med. 194, 1349-1360
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