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Science 25 October 1991:
Vol. 254. no. 5031, pp. 562 - 565
DOI: 10.1126/science.1948031
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Articles

Science, Vol 254, Issue 5031, 562-565
Copyright © 1991 by American Association for the Advancement of Science

articles

Establishment of cell type by compartmentalized activation of a transcription factor

P Margolis, A Driks, and R Losick

Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138.

Early in the process of spore formation in Bacillus subtilis a septum is formed that partitions the sporangium into daughter cells called the forespore and the mother cell. The daughter cells each have their own chromosome but follow dissimilar programs of gene expression. Differential gene expression in the forespore is now shown to be established by the compartmentalized activity of the transcription factor sigma F. The sigma F factor is produced prior to septation, but is active only in the forespore compartment of the post-septation sporangium. The sigma F factor is controlled by the products of sporulation operons spoIIA and spoIIE, which may be responsible for confining its activity to one of the daughter cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Compartmentalization of Gene Expression during Bacillus subtilis Spore Formation.
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Prespore-specific gene expression in Bacillus subtilis is driven by sequestration of SpoIIE phosphatase to the prespore side of the asymmetric septum.
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A L Decatur and R Losick (1996)
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A Feucht, T Magnin, M D Yudkin, and J Errington (1996)
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P A Levin and R Losick (1996)
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Developmental Biology: Defining the First Steps on the Path Toward Cell Specialization.
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Localization of Protein Implicated in Establishment of Cell Type to Sites of Asymmetric Division.
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Activation of Cell-Specific Transcription by a Serine Phosphatase at the Site of Asymmetric Division.
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A conjugation-like mechanism for prespore chromosome partitioning during sporulation in Bacillus subtilis..
L J Wu, P J Lewis, R Allmansberger, P M Hauser, and J Errington (1995)
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J A Londono-Vallejo and P Stragier (1995)
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Role of interactions between SpoIIAA and SpoIIAB in regulating cell-specific transcription factor sigma F of Bacillus subtilis..
B Diederich, J F Wilkinson, T Magnin, M Najafi, J Erringston, and M D Yudkin (1994)
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Bacillus subtilis spoIIIE protein required for DNA segregation during asymmetric cell division.
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Subcellular localization of proteins involved in the assembly of the spore coat of Bacillus subtilis..
A Driks, S Roels, B Beall, C P Moran, and R Losick (1994)
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