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Science 25 October 1991:
Vol. 254. no. 5031, pp. 539 - 544
DOI: 10.1126/science.1948029
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Articles

Science, Vol 254, Issue 5031, 539-544
Copyright © 1991 by American Association for the Advancement of Science

articles

X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil

EK O'Shea, JD Klemm, PS Kim, and T Alber

Howard Hughes Medical Institute, Cambridge, MA 02142.

The x-ray crystal structure of a peptide corresponding to the leucine zipper of the yeast transcriptional activator GCN4 has been determined at 1.8 angstrom resolution. The peptide forms a parallel, two-stranded coiled coil of alpha helices packed as in the "knobs-into-holes" model proposed by Crick in 1953. Contacts between the helices include ion pairs and an extensive hydrophobic interface that contains a distinctive hydrogen bond. The conserved leucines, like the residues in the alternate hydrophobic repeat, make side-to-side interactions (as in a handshake) in every other layer of the dimer interface. The crystal structure of the GCN4 leucine zipper suggests a key role for the leucine repeat, but also shows how other features of the coiled coil contribute to dimer formation.


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Direct in Vivo Screening of Intrabody Libraries Constructed on a Highly Stable Single-chain Framework.
A. A. d. Maur, C. Zahnd, F. Fischer, S. Spinelli, A. Honegger, C. Cambillau, D. Escher, A. Pluckthun, and A. Barberis (2002)
J. Biol. Chem. 277, 45075-45085
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Numerical Study of the Entropy Loss of Dimerization and the Folding Thermodynamics of the GCN4 Leucine Zipper.
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Classification of Human B-ZIP Proteins Based on Dimerization Properties.
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Redox Regulation of Plant Homeodomain Transcription Factors.
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J. Fassler, D. Landsman, A. Acharya, J. R. Moll, M. Bonovich, and C. Vinson (2002)
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W. Fan and X. Dong (2002)
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Y. Li, S. Mui, J. H. Brown, J. Strand, L. Reshetnikova, L. S. Tobacman, and C. Cohen (2002)
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NEMO Trimerizes through Its Coiled-coil C-terminal Domain.
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J. Biol. Chem. 277, 17464-17475
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C. Beloin, S. McKenna, and C. J. Dorman (2002)
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M. Stewart (2001)
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DNA-binding specificity and dimerization of the DNA-binding domain of the PEND protein in the chloroplast envelope membrane.
N. Sato and N. Ohta (2001)
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K. P. McGrath, M. M. Butler, C. M. DiGirolamo, D. L. Kaplan, W. A. Petka, and T. M. Laue (2000)
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Structural hierarchy in erythrocruorin, the giant respiratory assemblage of annelids.
W. E. Royer Jr., K. Strand, M. van Heel, and W. A. Hendrickson (2000)
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Regulation of alpha -Helical Coiled-coil Dimerization in Chicken Skeletal Muscle Light Meromyosin.
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