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Science 25 October 1991:
Vol. 254. no. 5031, pp. 529 - 533
DOI: 10.1126/science.1948028
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Articles

Science, Vol 254, Issue 5031, 529-533
Copyright © 1991 by American Association for the Advancement of Science

articles

Control of granulocytes and macrophages: molecular, cellular, and clinical aspects

D Metcalf

Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia.

The production and functional activity of two important white blood cells, the granulocytes and macrophages, are regulated mainly by a group of glycoprotein colony-stimulating factors. The colony-stimulating factors have been mass-produced with recombinant technology and are now proving of value in preventing or suppressing infections in a variety of individuals with subnormal or defective formation of blood cells.


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