Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 18 October 1991:
Vol. 254. no. 5030, pp. 432 - 437
DOI: 10.1126/science.1718042
Prev | Table of Contents | Next

Articles

Science, Vol 254, Issue 5030, 432-437
Copyright © 1991 by American Association for the Advancement of Science

articles

Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel

AV Maricq, AS Peterson, AJ Brake, RM Myers, and D Julius

Department of Pharmacology, University of California, San Francisco 94143-0450.

The neurotransmitter serotonin (5HT) activates a variety of second messenger signaling systems and through them indirectly regulates the function of ion channels. Serotonin also activates ion channels directly, suggesting that it may also mediate rapid, excitatory responses. A complementary DNA clone containing the coding sequence of one of these rapidly responding channels, a 5HT3 subtype of the serotonin receptor, has been isolated by screening a neuroblastoma expression library for functional expression of serotonin-gated currents in Xenopus oocytes. The predicted protein product has many of the features shared by other members of the ligand-gated ion channel family. The pharmacological and electrophysiological characteristics of the cloned receptor are largely consistent with the properties of native 5HT3 receptors. Messenger RNA encoding this receptor is found in the brain, spinal cord, and heart. This receptor defines a new class of excitatory ligand-gated channels.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ligand-Gated Chloride Channels Are Receptors for Biogenic Amines in C. elegans.
N. Ringstad, N. Abe, and H. R. Horvitz (2009)
Science 325, 96-100
   Abstract »    Full Text »    PDF »
Chromogranin A Regulates Renal Function by Triggering Weibel-Palade Body Exocytosis.
Y. Chen, M. Mahata, F. Rao, S. Khandrika, M. Courel, M. M. Fung, K. Zhang, M. Stridsberg, M. G. Ziegler, B. A. Hamilton, et al. (2009)
J. Am. Soc. Nephrol. 20, 1623-1632
   Abstract »    Full Text »    PDF »
Colchicine: A Novel Positive Allosteric Modulator of the Human 5-Hydroxytryptamine3A Receptor.
A. N. de Oliveira-Pierce, R. Zhang, and T. K. Machu (2009)
J. Pharmacol. Exp. Ther. 329, 838-847
   Abstract »    Full Text »    PDF »
Acute Alcohol Action and Desensitization of Ligand-Gated Ion Channels.
A. M. Dopico and D. M. Lovinger (2009)
Pharmacol. Rev. 61, 98-114
   Abstract »    Full Text »    PDF »
Potentiation of {alpha}7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
G. T. Young, R. Zwart, A. S. Walker, E. Sher, and N. S. Millar (2008)
PNAS 105, 14686-14691
   Abstract »    Full Text »    PDF »
On the voltage-dependent Ca2+ block of serotonin 5-HT3 receptors: a critical role of intracellular phosphates.
Y. Noam, W. J. Wadman, and J. A. van Hooft (2008)
J. Physiol. 586, 3629-3638
   Abstract »    Full Text »    PDF »
Structural Determinants of Ca2+ Permeability and Conduction in the Human 5-Hydroxytryptamine Type 3A Receptor.
M. R. Livesey, M. A. Cooper, T. Z. Deeb, J. E. Carland, J. Kozuska, Tim. G. Hales, J. J. Lambert, and J. A. Peters (2008)
J. Biol. Chem. 283, 19301-19313
   Abstract »    Full Text »    PDF »
High Affinity Binding of Epibatidine to Serotonin Type 3 Receptors.
R. C. Drisdel, D. Sharp, T. Henderson, T. G. Hales, and W. N. Green (2008)
J. Biol. Chem. 283, 9659-9665
   Abstract »    Full Text »    PDF »
Arginine 246 of the Pretransmembrane Domain 1 Region Alters 2,2,2-Trichloroethanol Action in the 5-Hydroxytryptamine3A Receptor.
X.-Q. Hu and R. W. Peoples (2008)
J. Pharmacol. Exp. Ther. 324, 1011-1018
   Abstract »    Full Text »    PDF »
Modulation of 5-HT3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells.
H. Sun, X.-Q. Hu, M. B. Emerit, J. C. Schoenebeck, C. E. Kimmel, R. W. Peoples, A. Miko, and L. Zhang (2008)
J. Physiol. 586, 751-762
   Abstract »    Full Text »    PDF »
Modular Design of Cys-loop Ligand-gated Ion Channels: Functional 5-HT3 and GABA {rho}1 Receptors Lacking the Large Cytoplasmic M3M4 Loop.
M. Jansen, M. Bali, and M. H. Akabas (2008)
J. Gen. Physiol. 131, 137-146
   Abstract »    Full Text »    PDF »
5-HT Receptor Regulation of Neurotransmitter Release.
K. B. Fink and M. Gothert (2007)
Pharmacol. Rev. 59, 360-417
   Abstract »    Full Text »    PDF »
Subunit-Dependent Modulation of the 5-Hydroxytryptamine Type 3 Receptor Open-Close Equilibrium by n-Alcohols.
D. Rusch, B. Musset, H. Wulf, A. Schuster, and D. E. Raines (2007)
J. Pharmacol. Exp. Ther. 321, 1069-1074
   Abstract »    Full Text »    PDF »
An Interaction Involving an Arginine Residue in the Cytoplasmic Domain of the 5-HT3A Receptor Contributes to Receptor Desensitization Mechanism.
X.-Q. Hu, H. Sun, R. W. Peoples, R. Hong, and L. Zhang (2006)
J. Biol. Chem. 281, 21781-21788
   Abstract »    Full Text »    PDF »
N-Terminal Domains in Mouse and Human 5-Hydroxytryptamine3A Receptors Confer Partial Agonist and Antagonist Properties to Benzylidene Analogs of Anabaseine.
R. Zhang, N. A. White, F. S. Soti, W. R. Kem, and T. K. Machu (2006)
J. Pharmacol. Exp. Ther. 317, 1276-1284
   Abstract »    Full Text »    PDF »
Ionotropic 5-HT3 Receptor Agonist-Induced Motor Responses in the Hindlimbs of Paraplegic Mice.
P. A. Guertin and I. Steuer (2005)
J Neurophysiol 94, 3397-3405
   Abstract »    Full Text »    PDF »
General Anesthetic-Induced Channel Gating Enhancement of 5-Hydroxytryptamine Type 3 Receptors Depends on Receptor Subunit Composition.
K. Solt, R. J. Stevens, P. A. Davies, and D. E. Raines (2005)
J. Pharmacol. Exp. Ther. 315, 771-776
   Abstract »    Full Text »    PDF »
Role of aspartate 298 in mouse 5-HT3A receptor gating and modulation by extracellular Ca2+.
X.-Q. Hu and D. M Lovinger (2005)
J. Physiol. 568, 381-396
   Abstract »    Full Text »    PDF »
Antiemetics of the 5-Hydroxytryptamine 3A Antagonist Class Inhibit Muscle Nicotinic Acetylcholine Receptors.
M. Paul, R. Callahan, J. Au, C. H. Kindler, and C. S. Yost (2005)
Anesth. Analg. 101, 715-721
   Abstract »    Full Text »    PDF »
Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors.
N. P. Barrera, P. Herbert, R. M. Henderson, I. L. Martin, and J. M. Edwardson (2005)
PNAS 102, 12595-12600
   Abstract »    Full Text »    PDF »
A Variant C178T in the Regulatory Region of the Serotonin Receptor Gene HTR3A Modulates Neural Activation in the Human Amygdala.
T. Iidaka, N. Ozaki, A. Matsumoto, J. Nogawa, Y. Kinoshita, T. Suzuki, N. Iwata, Y. Yamamoto, T. Okada, and N. Sadato (2005)
J. Neurosci. 25, 6460-6466
   Abstract »    Full Text »    PDF »
Molecular Determinants of Picrotoxin Inhibition of 5-Hydroxytryptamine Type 3 Receptors.
P. Das and G. H. Dillon (2005)
J. Pharmacol. Exp. Ther. 314, 320-328
   Abstract »    Full Text »    PDF »
Synthesis and Biodistribution of Radiolabeled {alpha}7 Nicotinic Acetylcholine Receptor Ligands.
M. G. Pomper, E. Phillips, H. Fan, D. J. McCarthy, R. A. Keith, J. C. Gordon, U. Scheffel, R. F. Dannals, and J. L. Musachio (2005)
J. Nucl. Med. 46, 326-334
   Abstract »    Full Text »    PDF »
Noninvasive Imaging of 5-HT3 Receptor Trafficking in Live Cells: FROM BIOSYNTHESIS TO ENDOCYTOSIS.
E. Ilegems, H. M. Pick, C. Deluz, S. Kellenberger, and H. Vogel (2004)
J. Biol. Chem. 279, 53346-53352
   Abstract »    Full Text »    PDF »
In Vivo Excitation of GABA Interneurons in the Medial Prefrontal Cortex through 5-HT3 Receptors.
M. V. Puig, N. Santana, P. Celada, G. Mengod, and F. Artigas (2004)
Cereb Cortex 14, 1365-1375
   Abstract »    Full Text »    PDF »
The Role of Palmitoylation in Functional Expression of Nicotinic {alpha}7 Receptors.
R. C. Drisdel, E. Manzana, and W. N. Green (2004)
J. Neurosci. 24, 10502-10510
   Abstract »    Full Text »    PDF »
Acetaminophen: A Central Analgesic Drug That Involves a Spinal Tropisetron-Sensitive, Non-5-HT3 Receptor-Mediated Effect.
F. Libert, J. Bonnefont, E. Bourinet, E. Doucet, A. Alloui, M. Hamon, J. Nargeot, and A. Eschalier (2004)
Mol. Pharmacol. 66, 728-734
   Abstract »    Full Text »    PDF »
Minimal Structural Rearrangement of the Cytoplasmic Pore during Activation of the 5-HT3A Receptor.
S. Panicker, H. Cruz, C. Arrabit, K. F. Suen, and P. A. Slesinger (2004)
J. Biol. Chem. 279, 28149-28158
   Abstract »    Full Text »    PDF »
Uropathic Observations in Mice Expressing a Constitutively Active Point Mutation in the 5-HT3A Receptor Subunit.
A. Bhattacharya, H. Dang, Q.-M. Zhu, B. Schnegelsberg, N. Rozengurt, G. Cain, R. Prantil, D. A. Vorp, N. Guy, D. Julius, et al. (2004)
J. Neurosci. 24, 5537-5548
   Abstract »    Full Text »    PDF »
A TM2 Residue in the {beta}1 Subunit Determines Spontaneous Opening of Homomeric and Heteromeric {gamma}-Aminobutyric Acid-gated Ion Channels.
A. Miko, E. Werby, H. Sun, J. Healey, and L. Zhang (2004)
J. Biol. Chem. 279, 22833-22840
   Abstract »    Full Text »    PDF »
Evidence that the TM1-TM2 Loop Contributes to the {rho}1 GABA Receptor Pore.
N. Filippova, V. E. Wotring, and D. S. Weiss (2004)
J. Biol. Chem. 279, 20906-20914
   Abstract »    Full Text »    PDF »
Pharmacological Properties of {alpha}9{alpha}10 Nicotinic Acetylcholine Receptors Revealed by Heterologous Expression of Subunit Chimeras.
E. R. Baker, R. Zwart, E. Sher, and N. S. Millar (2004)
Mol. Pharmacol. 65, 453-460
   Abstract »    Full Text »    PDF »
Arginine 222 in the Pre-transmembrane Domain 1 of 5-HT3A Receptors Links Agonist Binding to Channel Gating.
X.-Q. Hu, L. Zhang, R. R. Stewart, and F. F. Weight (2003)
J. Biol. Chem. 278, 46583-46589
   Abstract »    Full Text »    PDF »
Modulation of 5-HT3 Receptor-mediated Response and Trafficking by Activation of Protein Kinase C.
H. Sun, X.-Q. Hu, E. M. Moradel, F. F. Weight, and L. Zhang (2003)
J. Biol. Chem. 278, 34150-34157
   Abstract »    Full Text »    PDF »
Improvements in Hippocampal-Dependent Learning and Decremental Attention in 5-HT3 Receptor Overexpressing Mice.
A. V. Harrell and A. M. Allan (2003)
Learn. Mem. 10, 410-419
   Abstract »    Full Text »    PDF »
Cell Surface Expression of 5-Hydroxytryptamine Type 3 Receptors Is Controlled by an Endoplasmic Reticulum Retention Signal.
G. W. Boyd, A. I. Doward, E. F. Kirkness, N. S. Millar, and C. N. Connolly (2003)
J. Biol. Chem. 278, 27681-27687
   Abstract »    Full Text »    PDF »
Nongenomic Steroid Action: Controversies, Questions, and Answers.
R. M. LOSEL, E. FALKENSTEIN, M. FEURING, A. SCHULTZ, H.-C. TILLMANN, K. ROSSOL-HASEROTH, and M. WEHLING (2003)
Physiol Rev 83, 965-1016
   Abstract »    Full Text »    PDF »
Characterization of the Ligand-binding Site of the Serotonin 5-HT3 Receptor: THE ROLE OF GLUTAMATE RESIDUES 97, 224, AND 235.
C. Schreiter, R. Hovius, M. Costioli, H. Pick, S. Kellenberger, L. Schild, and H. Vogel (2003)
J. Biol. Chem. 278, 22709-22716
   Abstract »    Full Text »    PDF »
Variations in the 5-Hydroxytryptamine Type 3B Receptor Gene as Predictors of the Efficacy of Antiemetic Treatment in Cancer Patients.
P.-B. Tremblay, R. Kaiser, O. Sezer, N. Rosler, C. Schelenz, K. Possinger, I. Roots, and J. Brockmoller (2003)
J. Clin. Oncol. 21, 2147-2155
   Abstract »    Full Text »    PDF »
Direct Interaction of Serotonin Type 3 Receptor Ligands with Recombinant and Native alpha 9alpha 10-Containing Nicotinic Cholinergic Receptors.
C. V. Rothlin, M. I. Lioudyno, A. F. Silbering, P. V. Plazas, M. E. G. Casati, E. Katz, P. S. Guth, and A. B. Elgoyhen (2003)
Mol. Pharmacol. 63, 1067-1074
   Abstract »    Full Text »    PDF »
Ca2+ Ions Block and Permeate Serotonin 5-HT3 Receptor Channels in Rat Hippocampal Interneurons.
J. A. van Hooft and W. J. Wadman (2003)
J Neurophysiol 89, 1864-1869
   Abstract »    Full Text »    PDF »
Intracellular Cross Talk and Physical Interaction between Two Classes of Neurotransmitter-Gated Channels.
E. Boue-Grabot, C. Barajas-Lopez, Y. Chakfe, D. Blais, D. Belanger, M. B. Emerit, and P. Seguela (2003)
J. Neurosci. 23, 1246-1253
   Abstract »    Full Text »    PDF »
Changes in Conformation and Subcellular Distribution of alpha 4beta 2 Nicotinic Acetylcholine Receptors Revealed by Chronic Nicotine Treatment and Expression of Subunit Chimeras.
P. C. Harkness and N. S. Millar (2002)
J. Neurosci. 22, 10172-10181
   Abstract »    Full Text »    PDF »
Inhibitory interactions between 5-HT3 and P2X channels in submucosal neurons.
C. Barajas-Lopez, L. M. Montano, and R. Espinosa-Luna (2002)
Am J Physiol Gastrointest Liver Physiol 283, G1238-G1248
   Abstract »    Full Text »    PDF »
Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter.
M.-T. Liu, S. Rayport, Y. Jiang, D. L. Murphy, and M. D. Gershon (2002)
Am J Physiol Gastrointest Liver Physiol 283, G1398-G1411
   Abstract »    Full Text »    PDF »
Distinct Molecular Basis for Differential Sensitivity of the Serotonin Type 3A Receptor to Ethanol in the Absence and Presence of Agonist.
L. Zhang, M. Hosoi, M. Fukuzawa, H. Sun, R. R. Rawlings, and F. F. Weight (2002)
J. Biol. Chem. 277, 46256-46264
   Abstract »    Full Text »    PDF »
Serotonin 5-HT3 receptors in rat CA1 hippocampal interneurons: functional and molecular characterization.
S. N Sudweeks, J. A van Hooft, and J. L Yakel (2002)
J. Physiol. 544, 715-726
   Abstract »    Full Text »    PDF »
The beta Subunit Determines the Ion Selectivity of the GABAA Receptor.
M. L. Jensen, D. B. Timmermann, T. H. Johansen, A. Schousboe, T. Varming, and P. K. Ahring (2002)
J. Biol. Chem. 277, 41438-41447
   Abstract »    Full Text »    PDF »
Electrophysiological Evidence for Expression of Glycine Receptors in Freshly Isolated Neurons from Nucleus Accumbens.
G. Martin and G. R. Siggins (2002)
J. Pharmacol. Exp. Ther. 302, 1135-1145
   Abstract »    Full Text »    PDF »
5-HT3 Receptors Mediate Serotonergic Fast Synaptic Excitation of Neocortical Vasoactive Intestinal Peptide/Cholecystokinin Interneurons.
I. Ferezou, B. Cauli, E. L. Hill, J. Rossier, E. Hamel, and B. Lambolez (2002)
J. Neurosci. 22, 7389-7397
   Abstract »    Full Text »    PDF »
Differential Composition of 5-Hydroxytryptamine3 Receptors Synthesized in the Rat CNS and Peripheral Nervous System.
M. Morales and S.-D. Wang (2002)
J. Neurosci. 22, 6732-6741
   Abstract »    Full Text »    PDF »
Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1.
S. Sato, M. Nakamura, D. H. Cho, S. J. Tapscott, H. Ozaki, and K. Kawakami (2002)
Hum. Mol. Genet. 11, 1045-1058
   Abstract »    Full Text »    PDF »
Serotonin 5-HT3 receptors on mechanosensitive neurons with cardiac afferents.
P. Linz and R. Veelken (2002)
Am J Physiol Heart Circ Physiol 282, H1828-H1835
   Abstract »    Full Text »    PDF »
Cation-selective Mutations in the M2 Domain of the Inhibitory Glycine Receptor Channel Reveal Determinants of Ion-Charge Selectivity.
A. Keramidas, A. J. Moorhouse, K. D. Pierce, P. R. Schofield, and P. H. Barry (2002)
J. Gen. Physiol. 119, 393-410
   Abstract »    Full Text »    PDF »
Molecular Structure and Physiological Function of Chloride Channels.
T. J. Jentsch, V. Stein, F. Weinreich, and A. A. Zdebik (2002)
Physiol Rev 82, 503-568
   Abstract »    Full Text »    PDF »
Evidence for a Centrally Located Gate in the Pore of a Serotonin-Gated Ion Channel.
S. Panicker, H. Cruz, C. Arrabit, and P. A. Slesinger (2002)
J. Neurosci. 22, 1629-1639
   Abstract »    Full Text »    PDF »
The 5-HT3 Subtype of Serotonin Receptor Contributes to Nociceptive Processing via a Novel Subset of Myelinated and Unmyelinated Nociceptors.
K. P. Zeitz, N. Guy, A. B. Malmberg, S. Dirajlal, W. J. Martin, L. Sun, D. W. Bonhaus, C. L. Stucky, D. Julius, and A. I. Basbaum (2002)
J. Neurosci. 22, 1010-1019
   Abstract »    Full Text »    PDF »
Benzylidene Analogs of Anabaseine Display Partial Agonist and Antagonist Properties at the Mouse 5-Hydroxytryptamine3A Receptor.
T. K. Machu, M. E. Hamilton, T. F. Frye, C. L. Shanklin, M. C. Harris, H. Sun, T. E. Tenner Jr., F. S. Soti, and W. R. Kem (2001)
J. Pharmacol. Exp. Ther. 299, 1112-1119
   Abstract »    Full Text »    PDF »
Structural and Electrostatic Properties of the 5-HT3 Receptor Pore Revealed by Substituted Cysteine Accessibility Mutagenesis.
D. C. Reeves, E. N. Goren, M. H. Akabas, and S. C. R. Lummis (2001)
J. Biol. Chem. 276, 42035-42042
   Abstract »    Full Text »    PDF »
Mutations in the Caenorhabditis elegans Serotonin Reuptake Transporter MOD-5 Reveal Serotonin-Dependent and -Independent Activities of Fluoxetine.
R. Ranganathan, E. R. Sawin, C. Trent, and H. R. Horvitz (2001)
J. Neurosci. 21, 5871-5884
   Abstract »    Full Text »    PDF »
A Single Amino-Acid in the TM1 Domain Is an Important Determinant of the Desensitization Kinetics of Recombinant Human and Guinea Pig {alpha}-Homomeric 5-Hydroxytryptamine Type 3 Receptors.
N. Lobitz, G. Gisselmann, H. Hatt, and C. H. Wetzel (2001)
Mol. Pharmacol. 59, 844-851
   Abstract »    Full Text »
Presynaptic 5-HT3 receptor-mediated modulation of synaptic GABA release in the mechanically dissociated rat amygdala neurons.
S. Koyama, N. Matsumoto, C. Kubo, and N. Akaike (2000)
J. Physiol. 529, 373-383
   Abstract »    Full Text »    PDF »
The Multiplicity of Serotonin Receptors: Uselessly Diverse Molecules or an Embarrassment of Riches?.
B. L. Roth, E. Lopez, S. Patel, and W. K. Kroeze (2000)
Neuroscientist 6, 252-262
   Abstract »    PDF »
Probing the Role of a Conserved M1 Proline Residue in 5-Hydroxytryptamine3 Receptor Gating.
H. Dang, P. M. England, S. S. Farivar, D. A. Dougherty, and H. A. Lester (2000)
Mol. Pharmacol. 57, 1114-1122
   Abstract »    Full Text »
Importance of Phenylalanine 107 in Agonist Recognition by the 5-Hydroxytryptamine3A Receptor.
L. J. Steward, F. G. Boess, J. A. Steele, D. Liu, N. Wong, and I. L. Martin (2000)
Mol. Pharmacol. 57, 1249-1255
   Abstract »    Full Text »
The Role of Tryptophan Residues in the 5-Hydroxytryptamine3 Receptor Ligand Binding Domain.
A. D. Spier and S. C. R. Lummis (2000)
J. Biol. Chem. 275, 5620-5625
   Abstract »    Full Text »    PDF »
Nondepolarizing Neuromuscular Blockers Inhibit the Serotonin-Type 3A Receptor Expressed in Xenopus Oocytes.
K. T. Min, C. L. Wu, and J. Yang (2000)
Anesth. Analg. 90, 476
   Abstract »    Full Text »    PDF »
The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors.
M. J Gunthorpe, J. A Peters, C. H Gill, J. J Lambert, and S. C R Lummis (2000)
J. Physiol. 522, 187-198
   Abstract »    Full Text »    PDF »
Activation of Serotonin Receptors Modulates Synaptic Transmission in Rat Cerebral Cortex.
F.-M. Zhou and J. J. Hablitz (1999)
J Neurophysiol 82, 2989-2999
   Abstract »    Full Text »    PDF »
The Pharmacological and Functional Characteristics of the Serotonin 5-HT3A Receptor Are Specifically Modified by a 5-HT3B Receptor Subunit.
A. E. Dubin, R. Huvar, M. R. D'Andrea, J. Pyati, J. Y. Zhu, K. C. Joy, S. J. Wilson, J. E. Galindo, C. A. Glass, L. Luo, et al. (1999)
J. Biol. Chem. 274, 30799-30810
   Abstract »    Full Text »    PDF »
Inward Currents in Neurons from Newborn Guinea Pig Intestine: Mediation by 5-Hydroxytryptamine Type 3 Receptors.
J. Zhai, M. D. Gershon, J. H. Walsh, H. C. Wong, and A. L. Kirchgessner (1999)
J. Pharmacol. Exp. Ther. 291, 374-382
   Abstract »    Full Text »
Up-regulation of Cell-surface alpha 4beta 2 Neuronal Nicotinic Receptors by Lower Temperature and Expression of Chimeric Subunits.
S. T. Cooper, P. C. Harkness, E. R. Baker, and N. S. Millar (1999)
J. Biol. Chem. 274, 27145-27152
   Abstract »    Full Text »    PDF »
Diltiazem causes open channel block of recombinant 5-HT3 receptors.
M. J Gunthorpe and S. C R Lummis (1999)
J. Physiol. 519, 713-722
   Abstract »    Full Text »    PDF »
Competitive Antagonism of the Mouse 5-Hydroxytryptamine3 Receptor by Bisindolylmaleimide I, a "Selective" Protein Kinase C Inhibitor.
S. J. Coultrap, H. Sun, T. E. Tenner Jr., and T. K. Machu (1999)
J. Pharmacol. Exp. Ther. 290, 76-82
   Abstract »    Full Text »
Inhibitory Effect of Ondansetron on Glycine Response of Dissociated Rat Hippocampal Neurons.
J. H. Ye, R. Schaefer, W.-H. Wu, P. L. Liu, V. K. Zbuzek, and J. J. Mcardle (1999)
J. Pharmacol. Exp. Ther. 290, 104-111
   Abstract »    Full Text »
Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release.
A. Meir, S. Ginsburg, A. Butkevich, S. G. Kachalsky, I. Kaiserman, R. Ahdut, S. Demirgoren, and R. Rahamimoff (1999)
Physiol Rev 79, 1019-1088
   Abstract »    Full Text »    PDF »
Molecular Determinants of (+)-Tubocurarine Binding at Recombinant 5-Hydroxytryptamine3A Receptor Subunits.
A. G. Hope, D. Belelli, I. D. Mair, J. J. Lambert, and J. A. Peters (1999)
Mol. Pharmacol. 55, 1037-1043
   Abstract »    Full Text »
Acid-Evoked Currents in Cardiac Sensory Neurons : A Possible Mediator of Myocardial Ischemic Sensation.
C. J. Benson, S. P. Eckert, and E. W. McCleskey (1999)
Circ. Res. 84, 921-928
   Abstract »    Full Text »    PDF »
Structural Features of the Ligand-binding Domain of the Serotonin 5HT3 Receptor.
D. Yan, M. K. Schulte, K. E. Bloom, and M. M. White (1999)
J. Biol. Chem. 274, 5537-5541
   Abstract »    Full Text »    PDF »
The Nicotinic alpha 4 Receptor Subunit Contributes to the Lining of the Ion Channel Pore When Expressed with the 5-HT3 Receptor Subunit.
S. Kriegler, S. Sudweeks, and J. L. Yakel (1999)
J. Biol. Chem. 274, 3934-3936
   Abstract »    Full Text »    PDF »
The alpha 9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A gamma -Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors.
C. V. Rothlin, E. Katz, M. Verbitsky, and A. B. Elgoyhen (1999)
Mol. Pharmacol. 55, 248-254
   Abstract »    Full Text »
Promiscuous coassembly of serotonin 5-HT3 and nicotinic alpha 4 receptor subunits into Ca2+-permeable ion channels.
J. A. van Hooft, A. D. Spier, J. L. Yakel, S. C. R. Lummis, and H. P. M. Vijverberg (1998)
PNAS 95, 11456-11461
   Abstract »    Full Text »    PDF »
Functional Antagonism of Gonadal Steroids at the 5-Hydroxytryptamine Type 3 Receptor.
C. H. R. Wetzel, B. Hermann, C. Behl, E. Pestel, G. Rammes, W. Zieglgänsberger, F. Holsboer, and R. Rupprecht (1998)
Mol. Endocrinol. 12, 1441-1451
   Abstract »    Full Text »
Neuronal Expression of the 5HT3 Serotonin Receptor Gene Requires Nuclear Factor 1 Complexes.
F. K. Bedford, D. Julius, and H. A. Ingraham (1998)
J. Neurosci. 18, 6186-6194
   Abstract »    Full Text »    PDF »
Inactivation of a Serotonin-Gated Ion Channel by a Polypeptide Toxin from Marine Snails.
L. J. England, J. Imperial, R. Jacobsen, A. G. Craig, J. Gulyas, M. Akhtar, J. Rivier, D. Julius, and B. M. Olivera (1998)
Science 281, 575-578
   Abstract »    Full Text »
A Mutation Affecting Dihydropyridine-Sensitive Current Levels and Activation Kinetics in Drosophila Muscle and Mammalian Heart Calcium Channels.
D. Ren, H. Xu, D. F. Eberl, M. Chopra, and L. M. Hall (1998)
J. Neurosci. 18, 2335-2341
   Abstract »    Full Text »    PDF »
Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A).
A M Brown, A G Hope, J J Lambert, and J A Peters (1998)
J. Physiol. 507, 653-665
   Abstract »    Full Text »    PDF »
Substitutions of the Highly Conserved M2 Leucine Create Spontaneously Opening rho 1 gamma -Aminobutyric Acid Receptors.
Y. Chang and D. S. Weiss (1998)
Mol. Pharmacol. 53, 511-523
   Abstract »    Full Text »
Two mechanisms for inward rectification of current flow through the purinoceptor P2X2 class of ATP-gated channels.
Z. Zhou and R. I Hume (1998)
J. Physiol. 507, 353-364
   Abstract »    Full Text »    PDF »
Molecular Cloning, Functional Expression, and Pharmacological Characterization of 5-Hydroxytryptamine3 Receptor cDNA and Its Splice Variants from Guinea Pig.
S. Lankiewicz, N. Lobitz, C. H. R. Wetzel, R. Rupprecht, G. Gisselmann, and H. Hatt (1998)
Mol. Pharmacol. 53, 202-212
   Abstract »    Full Text »
Hippocampal Interneurons Are Excited Via Serotonin-Gated Ion Channels.
L. L. McMahon and J. A. Kauer (1997)
J Neurophysiol 78, 2493-2502
   Abstract »    Full Text »    PDF »
Developing Neonatal Rat Sympathetic and Sensory Neurons Differ in Their Regulation of 5-HT3 Receptor Expression.
M. Rosenberg, B. Pie, and E. Cooper (1997)
J. Neurosci. 17, 6629-6638
   Abstract »    Full Text »    PDF »
The Role of the Cystine Loop in Acetylcholine Receptor Assembly.
W. N. Green and C. P. Wanamaker (1997)
J. Biol. Chem. 272, 20945-20953
   Abstract »    Full Text »    PDF »
Agonist-induced closure of constitutively open gamma -aminobutyric acid channels with mutated M2 domains.
Z.-H. Pan, D. Zhang, X. Zhang, and S. A. Lipton (1997)
PNAS 94, 6490-6495
   Abstract »    Full Text »    PDF »
Electrophysiological Analysis of Dorsal Root Ganglion Neurons Pre- and Post-Coexpression of Green Fluorescent Protein and Functional 5-HT3 Receptor.
G. M. Smith, R. L. Berry, J. Yang, and D. Tanelian (1997)
J Neurophysiol 77, 3115-3121
   Abstract »    Full Text »    PDF »
The 5-HT3 Receptor Is Present in Different Subpopulations of GABAergic Neurons in the Rat Telencephalon.
M. Morales and F. E. Bloom (1997)
J. Neurosci. 17, 3157-3167
   Abstract »    Full Text »    PDF »
Formation of Oligomers Containing the beta 3 and beta 4 Subunits of the Rat Nicotinic Receptor.
J. R. Forsayeth and E. Kobrin (1997)
J. Neurosci. 17, 1531-1538
   Abstract »    Full Text »    PDF »
Platelet Activation in Carotid Sinuses Triggers Reflex Sympathoinhibition and Hypotension.
H. Z. Mao, Z. Li, and M. W. Chapleau (1996)
Hypertension 27, 584-590
   Abstract »    Full Text »
Molecular and Genetic Insights into Ligand Binding and Signal Transduction at the Inhibitory Glycine Receptor.
P.R. Schofield, J.W. Lynch, S. Rajendra, K.D. Pierce, C.A. Handford, and P.H. Barry (1996)
Cold Spring Harb Symp Quant Biol 61, 333-342
   Abstract »    PDF »
Mutations Affecting the Glycine Receptor Agonist Transduction Mechanism Convert the Competitive Antagonist, Picrotoxin, into an Allosteric Potentiator.
J. W. Lynch, S. Rajendra, P. H. Barry, and P. R. Schofield (1995)
J. Biol. Chem. 270, 13799-13806
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)