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Science 18 October 1991:
Vol. 254. no. 5030, pp. 418 - 421
DOI: 10.1126/science.1925599
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Articles

Science, Vol 254, Issue 5030, 418-421
Copyright © 1991 by American Association for the Advancement of Science

articles

Dual role of the Drosophila pattern gene tailless in embryonic termini

E Steingrimsson, F Pignoni, GJ Liaw, and JA Lengyel

Department of Biology, University of California, Los Angeles 90024.

One of the first zygotically active genes required for formation of the terminal domains of the Drosophila embryo is tailless (tll). Expression of the tll gene is activated ectopically in gain-of-function mutants of the maternal terminal gene torso (tor); this suggests that tor normally activates the tll gene in the termini. Ectopic expression of tll under the control of an inducible promoter results in differentiation of ectopic terminal-specific structures, the Filzkorper, and leads to the activation of at least one gene, hunchback, that is required to form these structures. Ectopic expression of the tll gene also represses segmentation by repressing the gap genes Kruppel and knirps and probably also pair rule genes.


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