Science 18 October 1991: Vol. 254. no. 5030, pp. 415 - 418 DOI: 10.1126/science.1925598

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Articles

Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling.

G. Biswas, S. Srinivasan, H. K. Anandatheerthavarada, and N. G. Avadhani (2008)
PNAS 105, 186-191
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RelB, a New Partner of Aryl Hydrocarbon Receptor-Mediated Transcription.

C. F. A. Vogel, E. Sciullo, W. Li, P. Wong, G. Lazennec, and F. Matsumura (2007)
Mol. Endocrinol. 21, 2941-2955
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Carcinogen-induced histone alteration in normal human mammary epithelial cells.

C. Bradley, R. van der Meer, N. Roodi, H. Yan, M. B. Chandrasekharan, Z.-W. Sun, R. L. Mernaugh, and F. F. Parl (2007)
Carcinogenesis 28, 2184-2192
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Ligand-Independent Regulation of Transforming Growth Factor {beta}1 Expression and Cell Cycle Progression by the Aryl Hydrocarbon Receptor.

X. Chang, Y. Fan, S. Karyala, S. Schwemberger, C. R. Tomlinson, M. A. Sartor, and A. Puga (2007)
Mol. Cell. Biol. 27, 6127-6139
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An Aryl Hydrocarbon Receptor Odyssey to the Shores of Toxicology: The Deichmann Lecture, International Congress of Toxicology-XI.

A. B. Okey (2007)
Toxicol. Sci. 98, 5-38
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Unraveling the Complexities of the Mechanism of Action of Dioxins.

N. J. Walker (2007)
Toxicol. Sci. 95, 297-299
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Inhibition of Follicular Development, Vitellogenesis, and Serum 17{beta}-Estradiol Concentrations in Zebrafish Following Chronic, Sublethal Dietary Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.

T. King Heiden, M. J. Carvan III, and R. J. Hutz (2006)
Toxicol. Sci. 90, 490-499
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A Weight-of-Evidence Analysis of the Cancer Dose-Response Characteristics of 2,3,7,8-Tetrachlorodibenzodioxin (TCDD).

J. A. Popp, E. Crouch, and E. E. McConnell (2006)
Toxicol. Sci. 89, 361-369
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MODULATION OF HUMAN CYTOCHROME P450 1B1 EXPRESSION BY 2,4,3',5'-TETRAMETHOXYSTILBENE.

Y.-J. Chun, S.-K. Lee, and M. Y. Kim (2005)
Drug Metab. Dispos. 33, 1771-1776
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Transforming Growth Factor-{beta}3 Restores Fusion in Palatal Shelves Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

T. L. Thomae, E. A. Stevens, and C. A. Bradfield (2005)
J. Biol. Chem. 280, 12742-12746
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Interaction between the Aryl Hydrocarbon Receptor and Retinoic Acid Pathways Increases Matrix Metalloproteinase-1 Expression in Keratinocytes.

K. A. Murphy, C. M. Villano, R. Dorn, and L. A. White (2004)
J. Biol. Chem. 279, 25284-25293
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Cell Density Regulates Intracellular Localization of Aryl Hydrocarbon Receptor.

T. Ikuta, Y. Kobayashi, and K. Kawajiri (2004)
J. Biol. Chem. 279, 19209-19216
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Multiple Comparisons Model-based Clustering and Ternary Pattern Tree Numerical Display of Gene Response to Treatment: Procedure and Application to the Preclinical Evaluation of Chemopreventive Agents.

T. R. Sutter, X.-R. He, P. Dimitrov, L. Xu, G. Narasimhan, E. O. George, C. H. Sutter, C. Grubbs, R. Savory, M. Stephan-Gueldner, et al. (2002)
Mol. Cancer Ther. 1, 1283-1292
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Differential Toxicogenomic Responses to 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Malignant and Nonmalignant Human Airway Epithelial Cells.

J. M. Martinez, C. A. Afshari, P. R. Bushel, A. Masuda, T. Takahashi, and N. J. Walker (2002)
Toxicol. Sci. 69, 409-423
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Dioxin stimulates RANTES expression in an in-vitro model of endometriosis.

D. Zhao, E. A. Pritts, V. A. Chao, J.-F. Savouret, and R. N. Taylor (2002)
Mol. Hum. Reprod. 8, 849-854
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Tissue-Specific Expression of AHR2, ARNT2, and CYP1A in Zebrafish Embryos and Larvae: Effects of Developmental Stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure.

E. A. Andreasen, J. M. Spitsbergen, R. L. Tanguay, J. J. Stegeman, W. Heideman, and R. E. Peterson (2002)
Toxicol. Sci. 68, 403-419
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Environmental Contaminants and Dietary Factors in Endometriosis.

W. G. FOSTER and S. K. AGARWAL (2002)
Ann. N.Y. Acad. Sci. 955, 213-229
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Novel Target Genes of the Ah (Dioxin) Receptor: Transcriptional Induction of N-Myristoyltransferase 2.

S. K. Kolluri, C. Balduf, M. Hofmann, and M. Gottlicher (2001)
Cancer Res. 61, 8534-8539
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Prevention of Apoptosis by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A Cell Line: Correlation with Increased Transforming GrowthFactor {{alpha}} Production.

J. W. Davis II, F. T. Lauer, A. D. Burdick, L. G. Hudson, and S. W. Burchiel (2001)
Cancer Res. 61, 3314-3320
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Putative Link between Transcriptional Regulation of IgM Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and the Aryl Hydrocarbon Receptor/Dioxin-Responsive Enhancer Signaling Pathway.

C. E. W. Sulentic, M. P. Holsapple, and N. E. Kaminski (2000)
J. Pharmacol. Exp. Ther. 295, 705-716
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Subchronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Modulates the Pathophysiology of Endometriosis in the Cynomolgus Monkey.

J. Z. Yang, S. K. Agarwal, and W. G. Foster (2000)
Toxicol. Sci. 56, 374-381
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Effect of chlorinated hydrocarbons on expression of cytochrome P450 1A1, 1A2 and 1B1 and 2- and 4-hydroxylation of 17{beta}-estradiol in female Sprague-Dawley rats.

A. F. Badawi, E. L. Cavalieri, and E. G. Rogan (2000)
Carcinogenesis 21, 1593-1599
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Chapter 5: Tissue-Specific Synthesis and Oxidative Metabolism of Estrogens.

C. R. Jefcoate, J. G. Liehr, R. J. Santen, T. R. Sutter, J. D. Yager, W. Yue, S. J. Santner, R. Tekmal, L. Demers, R. Pauley, et al. (2000)
J Natl Cancer Inst Monographs 2000, 95-112
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits growth factor withdrawal-induced apoptosis in the human mammary epithelial cell line, MCF-10A.

J. W. Davis II, K. Melendez, V. M. Salas, F. T. Lauer, and S. W. Burchiel (2000)
Carcinogenesis 21, 881-886
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Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the Expression of Follicle-Stimulating Hormone Receptors during Cell Differentiation in Cultured Granulosa Cells.

T. Hirakawa, T. Minegishi, K. Abe, H. Kishi, K. Inoue, Y. Ibuki, and K. Miyamoto (2000)
Endocrinology 141, 1470-1476
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p27Kip1 induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells.

S. K. Kolluri, C. Weiss, A. Koff, and M. Göttlicher (1999)
Genes & Dev. 13, 1742-1753
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Cancer, Heart Disease, and Diabetes in Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

K. Steenland, L. Piacitelli, J. Deddens, M. Fingerhut, and L. I. Chang (1999)
J Natl Cancer Inst 91, 779-786
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Induction of Human UDP Glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-Butylhydroquinone and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Caco-2 Cells.

P. A. Münzel, S. Schmohl, H. Heel, K. Kälberer, B. S. Bock-Hennig, and K. W. Bock (1999)
Drug Metab. Dispos. 27, 569-573
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Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[a]anthracene-induced lymphomas.

J. T. M. Buters, S. Sakai, T. Richter, T. Pineau, D. L. Alexander, U. Savas, J. Doehmer, J. M. Ward, C. R. Jefcoate, and F. J. Gonzalez (1999)
PNAS 96, 1977-1982
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Quantitative Analysis of Constitutive and 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced Cytochrome P450 1B1 Expression in Human Lymphocytes.

D. L. Spencer, S. A. Masten, K. M. Lanier, X. Yang, J. A. Grassman, C. R. Miller, T. R. Sutter, G. W. Lucier, and N. J. Walker (1999)
Cancer Epidemiol. Biomarkers Prev. 8, 139-146
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Aryl Hydrocarbon Receptor-Dependent Suppression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin of IgM Secretion in Activated B Cells.

C. E. W. Sulentic, M. P. Holsapple, and N. E. Kaminski (1998)
Mol. Pharmacol. 53, 623-629
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Characterization of the Mouse Cyp1B1 Gene. IDENTIFICATION OF AN ENHANCER REGION THAT DIRECTS ARYL HYDROCARBON RECEPTOR-MEDIATED CONSTITUTIVE AND INDUCED EXPRESSION.

L. Zhang, U. Savas, D. L. Alexander, and C. R. Jefcoate (1998)
J. Biol. Chem. 273, 5174-5183
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Constitutive Activation of the Aromatic Hydrocarbon Receptor.

C.-Y. C. a. A. Puga (1998)
Mol. Cell. Biol. 18, 525-535
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Functional Analysis of the Promoter for the Human CYP1B1 Gene.

Y.-Y. P. Wo, J. Stewart, and W. F. Greenlee (1997)
J. Biol. Chem. 272, 26702-26707
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Cytokine Gene Expression during Ontogeny in Murine Thymus on Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Z.-W. Lai, C. Hundeiker, E. Gleichmann, and C. Esser (1997)
Mol. Pharmacol. 52, 30-37
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Isolation and Characterization of the Human Cytochrome P450 CYP1B1 Gene.

Y. M. Tang, Y.-Y. P. Wo, J. Stewart, A. L. Hawkins, C. A. Griffin, T. R. Sutter, and W. F. Greenlee (1996)
J. Biol. Chem. 271, 28324-28330
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Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor.

P Fernandez-Salguero, T Pineau, D. Hilbert, T McPhail, S. Lee, S Kimura, D. Nebert, S Rudikoff, J. Ward, and F. Gonzalez (1995)
Science 268, 722-726
 |  Abstract »  |  PDF »

Toxicology goes molecular.

E Marshall (1993)
Science 259, 1394-1398
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