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Science 11 October 1991:
Vol. 254. no. 5029, pp. 279 - 282
DOI: 10.1126/science.1681588
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Articles

Science, Vol 254, Issue 5029, 279-282
Copyright © 1991 by American Association for the Advancement of Science

articles

Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

P Salgame, JS Abrams, C Clayberger, H Goldstein, J Convit, RL Modlin, and BR Bloom

Howard Hughes Medical Institute, Albert Einstein College of Medicine, New York, NY 10461.

Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-gamma, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-gamma. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.


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   Abstract »    Full Text »    PDF »
T-Cell Recognition of Mycobacterial GroES Peptides in Thai Leprosy Patients and Contacts.
B. Chua-Intra, S. Peerapakorn, N. Davey, S. Jurcevic, M. Busson, H. M. Vordermeier, C. Pirayavaraporn, and J. Ivanyi (1998)
Infect. Immun. 66, 4903-4909
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Gene-Modified Tumor Vaccine with Therapeutic Potential Shifts Tumor-Specific T Cell Response from a Type 2 to a Type 1 Cytokine Profile.
H.-M. Hu, W. J. Urba, and B. A. Fox (1998)
J. Immunol. 161, 3033-3041
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B7-1, But Not CD28, Is Crucial for the Maintenance of the CD4+ T Cell Responses in Human Leprosy.
K. Schlienger, K. Uyemura, D. Jullien, P. A. Sieling, T. H. Rea, P. S. Linsley3, and R. L. Modlin (1998)
J. Immunol. 161, 2407-2413
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Th2-Specific Protein/DNA Interactions at the Proximal Nuclear Factor-AT Site Contribute to the Functional Activity of the Human IL-4 Promoter.
M. Li-Weber, P. Salgame, C. Hu, I. V. Davydov, O. Laur, S. Klevenz, and P. H. Krammer (1998)
J. Immunol. 161, 1380-1389
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T Cells and T-Cell Cytokine Transcripts in the Synovial Membrane in Patients with Osteoarthritis.
L. I. Sakkas, C. Scanzello, N. Johanson, J. Burkholder, A. Mitra, P. Salgame, C. D. Katsetos, and C. D. Platsoucas (1998)
Clin. Vaccine Immunol. 5, 430-437
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In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines.
A. Cerwenka, L. L. Carter, J. B. Reome, S. L. Swain, and R. W. Dutton (1998)
J. Immunol. 161, 97-105
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Serum interleukin 12 concentration in juvenile chronic arthritis.
M Gattorno, P Picco, S Vignola, F Stalla, A Buoncompagni, and V Pistoia (1998)
Ann Rheum Dis 57, 425-428
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The Th1-Th2 model---what relevance to inflammatory arthritis?.
P. D W KIELY (1998)
Ann Rheum Dis 57, 328-330
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Functional Diversity of the CD8+ T-Cell Response to Epstein-Barr Virus (EBV): Implications for the Pathogenesis of EBV-Associated Lymphoproliferative Disorders.
R. A. Nazaruk, R. Rochford, M. V. Hobbs, and M. J. Cannon (1998)
Blood 91, 3875-3883
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Activation Requirements, Lytic Mechanism, and Development of a Novel Anti-CD8-Resistant CTL Population.
S. A. McCarthy, M. S. Mainwaring, D. S. Dougall, and E. S. Lamouse-Smith (1998)
J. Immunol. 160, 2715-2724
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The Host Immune Response to Tuberculosis.
N. W. SCHLUGER and W. N. ROM (1998)
Am. J. Respir. Crit. Care Med. 157, 679-691
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Type 1- and Type 2-Like Lesional Skin-Derived Mycobacterium leprae-Responsive T Cell Clones Are Characterized by Coexpression of IFN-{gamma}/TNF-{alpha} and IL-4/IL-5/IL-13, Respectively.
C. E. Verhagen, T. C. T. M. van der Pouw Kraan, A. A. M. Buffing, M. A. Chand, W. R. Faber, L. A. Aarden, and P. K. Das (1998)
J. Immunol. 160, 2380-2387
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