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Science 11 October 1991: Vol. 254. no. 5029, pp. 277 - 279 DOI: 10.1126/science.1925582
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Articles
Science, Vol 254, Issue 5029, 277-279
Copyright © 1991 by American Association for the Advancement of Science
Defining protective responses to pathogens: cytokine profiles in leprosy lesions
M Yamamura,
K Uyemura,
RJ Deans,
K Weinberg,
TH Rea,
BR Bloom,
and
RL Modlin
Division of Dermatology, UCLA School of Medicine 90024.
The immunological mechanisms required to engender resistance have been defined in few infectious diseases of man, and the role of specific cytokines is unclear. Leprosy presents clinically as a spectrum in which resistance correlates with cell-mediated immunity to the pathogen. To assess in situ cytokine patterns, messenger RNA extracted from leprosy skin biopsy specimens was amplified by the polymerase chain reaction with 14 cytokine-specific primers. In lesions of the resistant form of the disease, messenger RNAs coding for interleukin-2 and interferon-gamma were most evident. In contrast, messenger RNAs for interleukin-4, interleukin-5, and interleukin-10 predominated in the multibacillary form. Thus, resistance and susceptibility were correlated with distinct patterns of cytokine production.
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