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Science 11 October 1991:
Vol. 254. no. 5029, pp. 277 - 279
DOI: 10.1126/science.1925582

Articles

Science, Vol 254, Issue 5029, 277-279
Copyright © 1991 by American Association for the Advancement of Science


articles

Defining protective responses to pathogens: cytokine profiles in leprosy lesions

M Yamamura, K Uyemura, RJ Deans, K Weinberg, TH Rea, BR Bloom, and RL Modlin

Division of Dermatology, UCLA School of Medicine 90024.

The immunological mechanisms required to engender resistance have been defined in few infectious diseases of man, and the role of specific cytokines is unclear. Leprosy presents clinically as a spectrum in which resistance correlates with cell-mediated immunity to the pathogen. To assess in situ cytokine patterns, messenger RNA extracted from leprosy skin biopsy specimens was amplified by the polymerase chain reaction with 14 cytokine-specific primers. In lesions of the resistant form of the disease, messenger RNAs coding for interleukin-2 and interferon-gamma were most evident. In contrast, messenger RNAs for interleukin-4, interleukin-5, and interleukin-10 predominated in the multibacillary form. Thus, resistance and susceptibility were correlated with distinct patterns of cytokine production.


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J. Fierer, L. Walls, L. Eckmann, T. Yamamoto, and T. N. Kirkland (1998)
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Local Immune Responses Correlate with Presentation and Outcome in Tuberculosis.
R. CONDOS, W. N. ROM, Y. M. LIU, and N. W. SCHLUGER (1998)
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Changes in Expression of Signal Transduction Proteins in T Lymphocytes of Patients with Leprosy.
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Infect. Immun. 66, 499-504
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Cytokine Profiles for Peripheral Blood Lymphocytes from Patients with Active Pulmonary Tuberculosis and Healthy Household Contacts in Response to the 30-Kilodalton Antigen of Mycobacterium tuberculosis.
M. Torres, T. Herrera, H. Villareal, E. A. Rich, and E. Sada (1998)
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Cytokine Expression in Periodontal Health and Disease.
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An epidemic of tuberculosis with a high rate of tuberculin anergy among a population previously unexposed to tuberculosis, the Yanomami Indians of the Brazilian Amazon.
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PNAS 94, 13227-13232
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A J G Swaak, H G van den Brink, and L A Aarden (1997)
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The Tat Protein of HIV-1 Induces Tumor Necrosis Factor-alpha Production. IMPLICATIONS FOR HIV-1-ASSOCIATED NEUROLOGICAL DISEASES.
P. Chen, M. Mayne, C. Power, and A. Nath (1997)
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In Vitro Generation of Allospecific Human CD8+ T Cells of Tc1 and Tc2 Phenotype.
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Blood 90, 2089-2096
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A. S. Varadhachary, S. N. Perdow, C. Hu, M. Ramanarayanan, and P. Salgame (1997)
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The Broad Spectrum of Cytokine Gene Expression by Myoid Cells from the Human Marrow Microenvironment.
L. Sensebe, M. Deschaseaux, J. Li, P. Herve, and P. Charbord (1997)
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Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma.
R. Masood, J. Cai, T. Zheng, D. L. Smith, Y. Naidu, and P. S. Gill (1997)
PNAS 94, 979-984
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Antigen organization regulates cluster formation and induction of cytotoxic T lymphocytes by helper T cell subsets.
G. Stuhler and S. F. Schlossman (1997)
PNAS 94, 622-627
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Interleukin-15 Triggers the Proliferation and Cytotoxicity of Granular Lymphocytes in Patients With Lymphoproliferative Disease of Granular Lymphocytes.
R. Zambello, M. Facco, L. Trentin, R. Sancetta, C. Tassinari, A. Perin, A. Milani, G. Pizzolo, F. Rodeghiero, C. Agostini, et al. (1997)
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A comparison of methods for RNA extraction from lymphocytes for RT-PCR..
W Liedtke, L Battistini, C F Brosnan, and C S Raine (1994)
Genome Res. 4, 185-187
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Cytokine Gene Profile in Circulating Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus: Increased Interleukin-2 but not Interleukin-4 mRNA.
D. A. Horwitz, Hua Wang, and J. D. Gray (1994)
Lupus 3, 423-428
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Cytokine patterns during the progression to AIDS.
T. Mosmann (1994)
Science 265, 193-194
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Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals.
C Graziosi, G Pantaleo, K. Gantt, J. Fortin, J. Demarest, O. Cohen, R. Sekaly, and A. Fauci (1994)
Science 265, 248-252
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Recent advances in tropical medicine.
D N J Lockwood and G Pasvol (1994)
BMJ 308, 1559-1562
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The use of the PCR to quantitate gene expression..
W C Gause and J Adamovicz (1994)
Genome Res. 3, S123-S135
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TH1 and TH2 cell antigen receptors in experimental leishmaniasis.
S. Reiner, Z. Wang, F Hatam, P Scott, and R. Locksley (1993)
Science 259, 1457-1460
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Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones.
P Salgame, J. Abrams, C Clayberger, H Goldstein, J Convit, R. Modlin, and B. Bloom (1991)
Science 254, 279-282
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