Science 4 October 1991: Vol. 254. no. 5028, pp. 97 - 99 DOI: 10.1126/science.1925564

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Articles

Neuronal Migration and Neurodegeneration: 2 Sides of the Same Coin.

O. Reiner, A. Shmueli, and T. Sapir (2009)
Cereb Cortex 19, i42-i48
 |  Abstract »  |  Full Text »  |  PDF »

Clinical and Neuropathological Features of the Arctic APP Gene Mutation Causing Early-Onset Alzheimer Disease.

H. Basun, N. Bogdanovic, M. Ingelsson, O. Almkvist, J. Naslund, K. Axelman, T. D. Bird, D. Nochlin, G. D. Schellenberg, L.-O. Wahlund, et al. (2008)
Arch Neurol 65, 499-505
 |  Abstract »  |  Full Text »  |  PDF »

The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family.

S. Spina, M. R. Farlow, F. W. Unverzagt, D. A. Kareken, J. R. Murrell, G. Fraser, F. Epperson, R. A. Crowther, M. G. Spillantini, M. Goedert, et al. (2008)
Brain 131, 72-89
 |  Abstract »  |  Full Text »  |  PDF »

A Critical Function for -Amyloid Precursor Protein in Neuronal Migration Revealed by In Utero RNA Interference.

T. L. Young-Pearse, J. Bai, R. Chang, J. B. Zheng, J. J. LoTurco, and D. J. Selkoe (2007)
J. Neurosci. 27, 14459-14469
 |  Abstract »  |  Full Text »  |  PDF »

Clinicopathologic features of frontotemporal dementia with Progranulin sequence variation.

S. Spina, J. R. Murrell, E. D. Huey, E. M. Wassermann, P. Pietrini, M. A. Baraibar, A. G. Barbeito, J. C. Troncoso, R. Vidal, B. Ghetti, et al. (2007)
Neurology 68, 820-827
 |  Abstract »  |  Full Text »  |  PDF »

A Century of Alzheimer's Disease.

M. Goedert and M. G. Spillantini (2006)
Science 314, 777-781
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic approaches to Alzheimer's disease.

H.-W. Klafki, M. Staufenbiel, J. Kornhuber, and J. Wiltfang (2006)
Brain 129, 2840-2855
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{beta}-Secretase-Cleaved Amyloid Precursor Protein Accumulates at Actin Inclusions Induced in Neurons by Stress or Amyloid {beta}: A Feedforward Mechanism for Alzheimer's Disease.

M. T. Maloney, L. S. Minamide, A. W. Kinley, J. A. Boyle, and J. R. Bamburg (2005)
J. Neurosci. 25, 11313-11321
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Estrogen Therapy Fails to Alter Amyloid Deposition in the PDAPP Model of Alzheimer's Disease.

P. S. Green, K. Bales, S. Paul, and G. Bu (2005)
Endocrinology 146, 2774-2781
 |  Abstract »  |  Full Text »  |  PDF »

Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease.

Y Wakutani, K Watanabe, Y Adachi, K Wada-Isoe, K Urakami, H Ninomiya, T C Saido, T Hashimoto, T Iwatsubo, and K Nakashima (2004)
J. Neurol. Neurosurg. Psychiatry 75, 1039-1042
 |  Abstract »  |  Full Text »  |  PDF »

Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: Digital morphometric analyses.

C.-C. Wu, F. Chawla, D. Games, R. E. Rydel, S. Freedman, D. Schenk, W. G. Young, J. H. Morrison, and F. E. Bloom (2004)
PNAS 101, 7141-7146
 |  Abstract »  |  Full Text »  |  PDF »

The Human Amyloid-{beta} Precursor Protein770 Mutation V717F Generates Peptides Longer Than Amyloid-{beta}-(40-42) and Flocculent Amyloid Aggregates.

A. E. Roher, T. A. Kokjohn, C. Esh, N. Weiss, J. Childress, W. Kalback, D. C. Luehrs, J. Lopez, D. Brune, Y.-M. Kuo, et al. (2004)
J. Biol. Chem. 279, 5829-5836
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Markedly Facilitates Age-Dependent Cerebral Amyloid Angiopathy and Spontaneous Hemorrhage in Amyloid Precursor Protein Transgenic Mice.

J. D. Fryer, J. W. Taylor, R. B. DeMattos, K. R. Bales, S. M. Paul, M. Parsadanian, and D. M. Holtzman (2003)
J. Neurosci. 23, 7889-7896
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid deposition in the hippocampus and entorhinal cortex: Quantitative analysis of a transgenic mouse model.

J. F. Reilly, D. Games, R. E. Rydel, S. Freedman, D. Schenk, W. G. Young, J. H. Morrison, and F. E. Bloom (2003)
PNAS 100, 4837-4842
 |  Abstract »  |  Full Text »  |  PDF »

gamma -Secretase Cleavage Site Specificity Differs for Intracellular and Secretory Amyloid beta.

H. S. Grimm, D. Beher, S. F. Lichtenthaler, M. S. Shearman, K. Beyreuther, and T. Hartmann (2003)
J. Biol. Chem. 278, 13077-13085
 |  Abstract »  |  Full Text »  |  PDF »

Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis.

J. M. Redwine, B. Kosofsky, R. E. Jacobs, D. Games, J. F. Reilly, J. H. Morrison, W. G. Young, and F. E. Bloom (2003)
PNAS 100, 1381-1386
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Precursor Protein, Presenilins, and alpha -Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer's Disease.

Y.-H. Suh and F. Checler (2002)
Pharmacol. Rev. 54, 469-525
 |  Abstract »  |  Full Text »  |  PDF »

A Portrait of Alzheimer Secretases--New Features and Familiar Faces.

W. P. Esler and M. S. Wolfe (2001)
Science 293, 1449-1454
 |  Abstract »  |  Full Text »  |  PDF »

Pathogenic APP mutations near the {gamma}-secretase cleavage site differentially affect A{beta} secretion and APP C-terminal fragment stability.

C. De Jonghe, C. Esselens, S. Kumar-Singh, K. Craessaerts, S. Serneels, F. Checler, W. Annaert, C. Van Broeckhoven, and B. De Strooper (2001)
Hum. Mol. Genet. 10, 1665-1671
 |  Abstract »  |  Full Text »  |  PDF »

Early-onset Alzheimer's disease in Scotland: environmental and familial factors.

L. J. WHALLEY (2001)
The British Journal of Psychiatry 178 , s53-s59
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Age-Dependent Changes in Brain, CSF, and Plasma Amyloid {beta} Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease.

T. Kawarabayashi, L. H. Younkin, T. C. Saido, M. Shoji, K. H. Ashe, and S. G. Younkin (2001)
J. Neurosci. 21, 372-381
 |  Abstract »  |  Full Text »  |  PDF »

High-Level Neuronal Expression of Abeta 1-42 in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation.

L. Mucke, E. Masliah, G.-Q. Yu, M. Mallory, E. M. Rockenstein, G. Tatsuno, K. Hu, D. Kholodenko, K. Johnson-Wood, and L. McConlogue (2000)
J. Neurosci. 20, 4050-4058
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease, {beta}-Amyloid Protein and Zinc.

X. Huang, M. P. Cuajungco, C. S. Atwood, R. D. Moir, R. E. Tanzi, and A. I. Bush (2000)
J. Nutr. 130, 1488S-1492
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Toxicity of Dutch (E22Q) and Flemish (A21G) Mutant Amyloid {beta} Proteins to Human Cerebral Microvessel and Aortic Smooth Muscle Cells • Editorial Comment.

Z. Wang, R. Natte, J. A. Berliner, S. G. van Duinen, H. V. Vinters, and W. I. Rosenblum (2000)
Stroke 31, 534-538
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Proteolytic processing and cell biological functions of the amyloid precursor protein.

B De Strooper and W Annaert (2000)
J. Cell Sci. 113, 1857-1870
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Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects.

D. B. Donoviel, A.-K. Hadjantonakis, M. Ikeda, H. Zheng, P. S. G. Hyslop, and A. Bernstein (1999)
Genes & Dev. 13, 2801-2810
 |  Abstract »  |  Full Text »

Cellular Cofactors for Amyloid {beta}-Peptide-Induced Cell Stress : Moving from Cell Culture to in Vivo.

S. D. Yan, A. Roher, A. M. Schmidt, and D. M. Stern (1999)
Am. J. Pathol. 155, 1403-1411
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Elimination of the Class A Scavenger Receptor Does Not Affect Amyloid Plaque Formation or Neurodegeneration in Transgenic Mice Expressing Human Amyloid Protein Precursors.

F. Huang, M. Buttini, T. Wyss-Coray, L. McConlogue, T. Kodama, R. E. Pitas, and L. Mucke (1999)
Am. J. Pathol. 155, 1741-1747
 |  Abstract »  |  Full Text »  |  PDF »

Glycosylphosphatidylinositol-anchored Proteins Play an Important Role in the Biogenesis of the Alzheimer's Amyloid beta -Protein.

K. Sambamurti, D. Sevlever, T. Koothan, L. M. Refolo, I. Pinnix, S. Gandhi, L. Onstead, L. Younkin, C. M. Prada, D. Yager, et al. (1999)
J. Biol. Chem. 274, 26810-26814
 |  Abstract »  |  Full Text »  |  PDF »

The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: Evidence for other phenotype-modifying factors.

T. Gomez-Isla, W. B. Growdon, M. J. McNamara, D. Nochlin, T. D. Bird, J. C. Arango, F. Lopera, K. S. Kosik, P. L. Lantos, N. J. Cairns, et al. (1999)
Brain 122, 1709-1719
 |  Abstract »  |  Full Text »  |  PDF »

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis.

X. Xu, D. Yang, T. Wyss-Coray, J. Yan, L. Gan, Y. Sun, and L. Mucke (1999)
PNAS 96, 7547-7552
 |  Abstract »  |  Full Text »  |  PDF »

Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer's disease.

R. B. Knowles, C. Wyart, S. V. Buldyrev, L. Cruz, B. Urbanc, M. E. Hasselmo, H. E. Stanley, and B. T. Hyman (1999)
PNAS 96, 5274-5279
 |  Abstract »  |  Full Text »  |  PDF »

Unusual phenotypic alteration of beta  amyloid precursor protein (beta APP) maturation by a new Val-715 right-arrow Met beta APP-770 mutation responsible for probable early-onset Alzheimer's disease.

K. Ancolio, C. Dumanchin, H. Barelli, J. M. Warter, A. Brice, D. Campion, T. Frebourg, and F. Checler (1999)
PNAS 96, 4119-4124
 |  Abstract »  |  Full Text »  |  PDF »

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.

A. Y. Hsia, E. Masliah, L. McConlogue, G.-Q. Yu, G. Tatsuno, K. Hu, D. Kholodenko, R. C. Malenka, R. A. Nicoll, and L. Mucke (1999)
PNAS 96, 3228-3233
 |  Abstract »  |  Full Text »  |  PDF »

The Neurobiology and Pharmacotherapy of Alzheimer's Disease.

O. Felician and T. A. Sandson (1999)
J Neuropsychiatry Clin Neurosci 11, 19-31
 |  Abstract »  |  Full Text »

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta -amyloid peptides.

J. P. Greenfield, J. Tsai, G. K. Gouras, B. Hai, G. Thinakaran, F. Checler, S. S. Sisodia, P. Greengard, and H. Xu (1999)
PNAS 96, 742-747
 |  Abstract »  |  Full Text »  |  PDF »

Prospective Study of Risk Factors for Alzheimer's Disease: Results at 7.5 Years.

G. S. Zubenko, E. Winwood, B. Jacobs, I. Teply, J. S. Stiffler, H. B. Hughes III, F. J. Huff, T. Sunderland, and A. J. Martinez (1999)
Am J Psychiatry 156, 50-57
 |  Abstract »  |  Full Text »

Hereditary Amyloid Cardiomyopathy Caused by a Variant Apolipoprotein A1.

L. Hamidi Asl, J. J. Liepnieks, K. Hamidi Asl, T. Uemichi, G. Moulin, E. Desjoyaux, R. Loire, M. Delpech, G. Grateau, and M. D. Benson (1999)
Am. J. Pathol. 154, 221-227
 |  Abstract »  |  Full Text »  |  PDF »

Propagating structure of Alzheimer's beta -amyloid(10-35) is parallel beta -sheet with residues in exact register.

T. L. S. Benzinger, D. M. Gregory, T. S. Burkoth, H. Miller-Auer, D. G. Lynn, R. E. Botto, and S. C. Meredith (1998)
PNAS 95, 13407-13412
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Neurodegenerative Diseases: The Human Illness and Transgenic Models.

D. L. Price, S. S. Sisodia, and D. R. Borchelt (1998)
Science 282, 1079-1083
 |  Abstract »  |  Full Text »

Lewy Bodies Contain Altered {alpha}-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes.

C. F. Lippa, H. Fujiwara, D. M.A. Mann, B. Giasson, M. Baba, M. L. Schmidt, L. E. Nee, B. O'Connell, D. A. Pollen, P. St. George-Hyslop, et al. (1998)
Am. J. Pathol. 153, 1365-1370
 |  Abstract »  |  Full Text »  |  PDF »

A Basic Amino Acid in the Cytoplasmic Domain of Alzheimer's beta -Amyloid Precursor Protein (APP) Is Essential for Cleavage of APP at the alpha -Site.

S. Tomita, Y. Kirino, and T. Suzuki (1998)
J. Biol. Chem. 273, 19304-19310
 |  Abstract »  |  Full Text »  |  PDF »

Wide Range of Disease Onset in a Family With Alzheimer Disease and a His163Tyr Mutation in the Presenilin-1 Gene.

K. Axelman, H. Basun, and L. Lannfelt (1998)
Arch Neurol 55, 698-702
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Syndrome and not Alzheimer's disease: The historical struggle to define the disease.

J. R. Shua-Haim and J. S. Ross (1998)
American Journal of Alzheimer's Disease and Other Dementias 13, 92-95
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Enhanced Production and Oligomerization of the 42-residue Amyloid beta -Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins.

W. Xia, J. Zhang, D. Kholodenko, M. Citron, M. B. Podlisny, D. B. Teplow, C. Haass, P. Seubert, E. H. Koo, and D. J. Selkoe (1997)
J. Biol. Chem. 272, 7977-7982
 |  Abstract »  |  Full Text »  |  PDF »

Light and Electron Microscopic Localization of Presenilin-1 in Primate Brain.

J. J. Lah, C. J. Heilman, N. R. Nash, H. D. Rees, H. Yi, S. E. Counts, and A. I. Levey (1997)
J. Neurosci. 17, 1971-1980
 |  Abstract »  |  Full Text »  |  PDF »

Exploring the Etiology of Alzheimer Disease Using Molecular Genetics.

C. L. Lendon, F. Ashall, and A. M. Goate (1997)
JAMA 277, 825-831
 |  Abstract »  |  PDF »

Amyloid precursor protein processing and Abeta 42 deposition in a transgenic mouse model of Alzheimer disease.

K. Johnson-Wood, M. Lee, R. Motter, K. Hu, G. Gordon, R. Barbour, K. Khan, M. Gordon, H. Tan, D. Games, et al. (1997)
PNAS 94, 1550-1555
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F beta -Amyloid Precursor Protein and Alzheimer's Disease.

E. Masliah, A. Sisk, M. Mallory, L. Mucke, D. Schenk, and D. Games (1996)
J. Neurosci. 16, 5795-5811
 |  Abstract »  |  Full Text »  |  PDF »

beta -Amyloid Precursor Protein. LOCATION OF TRANSMEMBRANE DOMAIN AND SPECIFICITY OF gamma -SECRETASE CLEAVAGE.

E. Tischer and B. Cordell (1996)
J. Biol. Chem. 271, 21914-21919
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta -Protein and the Genetics of Alzheimer's Disease.

D. J. Selkoe and D. J. Selkoe (1996)
J. Biol. Chem. 271, 18295-18298
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Amyloids beta[IMAGE] and beta[IMAGE] Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation.

R. S. Turner, N. Suzuki, A. S. C. Chyung, S. G. Younkin, and V. M.-Y. Lee (1996)
J. Biol. Chem. 271, 8966-8970
 |  Abstract »  |  Full Text »  |  PDF »

Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization.

T Yamazaki, E. Koo, and D. Selkoe (1996)
J. Cell Sci. 109, 999-1008
 |  Abstract »  |  PDF »

The Role of Presenilin 1 in the Genetics of Alzheimer's Disease.

R.F. Clark, M. Hutton, C. Talbot, M. Wragg, C. Lendon, F. Busfield, S.W. Han, J. Perez-Tur, M. Adams, R. Fuldner, et al. (1996)
Cold Spring Harb Symp Quant Biol 61, 551-558
 |  Abstract »  |  PDF »

Two Homologous Genes Causing Early-onset Familial Alzheimer's Disease.

P.H. St. George-Hyslop, G. Levesque, L. Levesque, J. Rommens, D. Westaway, and P.E. Fraser (1996)
Cold Spring Harb Symp Quant Biol 61, 559-564
 |  Abstract »  |  PDF »

Levels and Alternative Splicing of Amyloid beta Protein Precursor (APP) Transcripts in Brains of APP Transgenic Mice and Humans with Alzheimer's Disease.

E. M. Rockenstein, L. McConlogue, H. Tan, M. Power, E. Masliah, and L. Mucke (1995)
J. Biol. Chem. 270, 28257-28267
 |  Abstract »  |  Full Text »  |  PDF »

Candidate gene for the chromosome 1 familial Alzheimer's disease locus.

E Levy-Lahad, W Wasco, P Poorkaj, D. Romano, J Oshima, W. Pettingell, C. Yu, P. Jondro, S. Schmidt, K Wang, et al. (1995)
Science 269, 973-977
 |  Abstract »  |  PDF »

Proteoglycan-mediated Inhibition of Abeta Proteolysis.

R. Gupta-Bansal, R. C. A. Frederickson, and K. R. Brunden (1995)
J. Biol. Chem. 270, 18666-18671
 |  Abstract »  |  Full Text »  |  PDF »

A Promising Animal Model of Alzheimer's Disease.

R. E. Tanzi (1995)
N. Engl. J. Med. 332, 1512-1513
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The Chondroitin Sulfate Attachment Site of Appican Is Formed by Splicing Out Exon 15 of the Amyloid Precursor Gene.

M. N. Pangalos, S. Efthimiopoulos, J. Shioi, and N. K. Robakis (1995)
J. Biol. Chem. 270, 10388-10391
 |  Abstract »  |  Full Text »  |  PDF »

The Prevention of Neurogenetic Disease.

R. N. Rosenberg and S. T. Iannaccone (1995)
Arch Neurol 52, 356-362
 |  Abstract »  |  PDF »

Ligand-dependent G Protein Coupling Function of Amyloid Transmembrane Precursor.

T. Okamoto, S. Takeda, Y. Murayama, E. Ogata, and I. Nishimoto (1995)
J. Biol. Chem. 270, 4205-4208
 |  Abstract »  |  Full Text »  |  PDF »

A Large Swedish Family With Alzheimer's Disease With a Codon 670/671 Amyloid Precursor Protein Mutation: A Clinical and Genealogical Investigation.

K. Axelman, H. Basun, B. Winblad, and L. Lannfelt (1994)
Arch Neurol 51, 1193-1197
 |  Abstract »  |  PDF »

Rapid induction of Alzheimer A beta amyloid formation by zinc.

A. Bush, W. Pettingell, G Multhaup, M d Paradis, J. Vonsattel, J. Gusella, K Beyreuther, C. Masters, and R. Tanzi (1994)
Science 265, 1464-1467
 |  Abstract »  |  PDF »

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

N Suzuki, T. Cheung, X. Cai, A Odaka, L Otvos Jr, C Eckman, T. Golde, and S. Younkin (1994)
Science 264, 1336-1340
 |  Abstract »  |  PDF »

Tomorrow's Prenatal Genetic Testing: Should We Test for 'Minor' Diseases?.

C. Strong (1993)
Arch Fam Med 2, 1187-1193
 |  Abstract »  |  PDF »

An Introduction to the Molecular Genetics of Neurological Disease: Recent Advances.

R. N. Rosenberg (1993)
Arch Neurol 50, 1123-1128
 |  Abstract »  |  PDF »

Molecular Genetics of Alzheimer's Disease.

R. F. Clark and A. M. Goate (1993)
Arch Neurol 50, 1164-1172
 |  Abstract »  |  PDF »

Molecular genetics of neurological diseases.

J. Martin (1993)
Science 262, 674-676
 |  PDF »

A Linkage Study of Chromosome 11q in Schizophrenia.

Z. W. Wang, D. Black, N. C. Andreasen, and R. R. Crowe (1993)
Arch Gen Psychiatry 50, 212-216
 |  Abstract »  |  PDF »

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

X. Cai, T. Golde, and S. Younkin (1993)
Science 259, 514-516
 |  Abstract »  |  PDF »

Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism.

L. Goldfarb, R. Petersen, M Tabaton, P Brown, A. LeBlanc, P Montagna, P Cortelli, J Julien, C Vital, W. Pendelbury, et al. (1992)
Science 258, 806-808
 |  Abstract »  |  PDF »

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14.

G. Schellenberg, T. Bird, E. Wijsman, H. Orr, L Anderson, E Nemens, J. White, L Bonnycastle, J. Weber, M. Alonso, et al. (1992)
Science 258, 668-671
 |  Abstract »  |  PDF »

Alzheimer's disease: a cell biological perspective.

K. Kosik (1992)
Science 256, 780-783
 |  Abstract »  |  PDF »

Alzheimer's disease: the amyloid cascade hypothesis.

J. Hardy and G. Higgins (1992)
Science 256, 184-185
 |  PDF »

Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.

T. Golde, S Estus, L. Younkin, D. Selkoe, and S. Younkin (1992)
Science 255, 728-730
 |  Abstract »  |  PDF »

Substitutions at Codon 22 of Alzheimer's Abeta Peptide Induce Diverse Conformational Changes and Apoptotic Effects in Human Cerebral Endothelial Cells.

L. Miravalle, T. Tokuda, R. Chiarle, G. Giaccone, O. Bugiani, F. Tagliavini, B. Frangione, and J. Ghiso (2000)
J. Biol. Chem. 275, 27110-27116
 |  Abstract »  |  Full Text »  |  PDF »

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.

M. Farzan, C. E. Schnitzler, N. Vasilieva, D. Leung, and H. Choe (2000)
PNAS 97, 9712-9717
 |  Abstract »  |  Full Text »  |  PDF »

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