Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 October 1991:
Vol. 254. no. 5028, pp. 112 - 114
DOI: 10.1126/science.1681587
Prev | Table of Contents | Next

Articles

Science, Vol 254, Issue 5028, 112-114
Copyright © 1991 by American Association for the Advancement of Science

articles

Molecular cloning of an invertebrate glutamate receptor subunit expressed in Drosophila muscle

CM Schuster, A Ultsch, P Schloss, JA Cox, B Schmitt, and H Betz

Zentrum fur Molekulare Biologie, Universitat Heidelberg, Federal Republic of Germany.

Insects and other invertebrates use glutamate as a neurotransmitter in the central nervous system and at the neuromuscular junction. A complementary DNA from Drosophila melanogaster, designated DGluR-II, has been isolated that encodes a distant homolog of the cloned mammalian ionotropic glutamate receptor family and is expressed in somatic muscle tissue of Drosophila embryos. Electrophysiological recordings made in Xenopus oocytes that express DGluR-II revealed depolarizing responses to L-glutamate and L-aspartate but low sensitivity to quisqualate, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and kainate. The DGluR-II protein may represent a distinct glutamate receptor subtype, which shares its structural design with other members of the ionotropic glutamate receptor family.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Importin 13 Regulates Neurotransmitter Release at the Drosophila Neuromuscular Junction.
N. Giagtzoglou, Y. Q. Lin, C. Haueter, and H. J. Bellen (2009)
J. Neurosci. 29, 5628-5639
   Abstract »    Full Text »    PDF »
Novel Roles for the NF-{kappa}B Signaling Pathway in Regulating Neuronal Function.
M. C. Boersma and M. K. Meffert (2008)
Science Signaling 1, pe7
   Abstract »    Full Text »    PDF »
hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the neuromuscular junction.
A. Chai, J. Withers, Y. H. Koh, K. Parry, H. Bao, B. Zhang, V. Budnik, and G. Pennetta (2008)
Hum. Mol. Genet. 17, 266-280
   Abstract »    Full Text »    PDF »
Drosophila Fragile X Mental Retardation Protein and Metabotropic Glutamate Receptor A Convergently Regulate the Synaptic Ratio of Ionotropic Glutamate Receptor Subclasses.
L. Pan and K. S. Broadie (2007)
J. Neurosci. 27, 12378-12389
   Abstract »    Full Text »    PDF »
Dystrophin Is Required for Appropriate Retrograde Control of Neurotransmitter Release at the Drosophila Neuromuscular Junction.
M. C. van der Plas, G. S. K. Pilgram, J. J. Plomp, A. de Jong, L. G. Fradkin, and J. N. Noordermeer (2006)
J. Neurosci. 26, 333-344
   Abstract »    Full Text »    PDF »
Retrograde Signaling by Syt 4 Induces Presynaptic Release and Synapse-Specific Growth.
M. Yoshihara, B. Adolfsen, K. T. Galle, and J. T. Littleton (2005)
Science 310, 858-863
   Abstract »    Full Text »    PDF »
An Essential Drosophila Glutamate Receptor Subunit That Functions in Both Central Neuropil and Neuromuscular Junction.
D. E. Featherstone, E. Rushton, J. Rohrbough, F. Liebl, J. Karr, Q. Sheng, C. K. Rodesch, and K. Broadie (2005)
J. Neurosci. 25, 3199-3208
   Abstract »    Full Text »    PDF »
Four Different Subunits Are Essential for Expressing the Synaptic Glutamate Receptor at Neuromuscular Junctions of Drosophila.
G. Qin, T. Schwarz, R. J. Kittel, A. Schmid, T. M. Rasse, D. Kappei, E. Ponimaskin, M. Heckmann, and S. J. Sigrist (2005)
J. Neurosci. 25, 3209-3218
   Abstract »    Full Text »    PDF »
d-Glutamic Acid-Induced Muscle Contraction in the Silkworm, Bombyx mori.
K. Sekimizu, J. Larranaga, H. Hamamoto, M. Sekine, T. Furuchi, M. Katane, H. Homma, and N. Matsuki (2005)
J. Biochem. 137, 199-203
   Abstract »    Full Text »    PDF »
Glutamatergic Innervation of the Heart Initiates Retrograde Contractions in Adult Drosophila melanogaster.
D. Dulcis and R. B. Levine (2005)
J. Neurosci. 25, 271-280
   Abstract »    Full Text »    PDF »
The Drosophila Metabotropic Glutamate Receptor DmGluRA Regulates Activity-Dependent Synaptic Facilitation and Fine Synaptic Morphology.
L. Bogdanik, R. Mohrmann, A. Ramaekers, J. Bockaert, Y. Grau, K. Broadie, and M.-L. Parmentier (2004)
J. Neurosci. 24, 9105-9116
   Abstract »    Full Text »    PDF »
Differential Localization of Glutamate Receptor Subunits at the Drosophila Neuromuscular Junction.
S. B. Marrus, S. L. Portman, M. J. Allen, K. G. Moffat, and A. DiAntonio (2004)
J. Neurosci. 24, 1406-1415
   Abstract »    Full Text »    PDF »
Experience-Dependent Strengthening of Drosophila Neuromuscular Junctions.
S. J. Sigrist, D. F. Reiff, P. R. Thiel, J. R. Steinert, and C. M. Schuster (2003)
J. Neurosci. 23, 6546-6556
   Abstract »    Full Text »    PDF »
The Postsynaptic Glutamate Receptor Subunit DGluR-IIA Mediates Long-Term Plasticity in Drosophila.
S. J. Sigrist, P. R. Thiel, D. F. Reiff, and C. M. Schuster (2002)
J. Neurosci. 22, 7362-7372
   Abstract »    Full Text »    PDF »
Partitioning of N-Ethylmaleimide-Sensitive Fusion (NSF) Protein Function in Drosophila melanogaster: dNSF1 Is Required in the Nervous System, and dNSF2 Is Required in Mesoderm.
J. A. Golby, L. A. Tolar, and L. Pallanck (2001)
Genetics 158, 265-278
   Abstract »    Full Text »
Glutamate Receptor Expression Regulates Quantal Size and Quantal Content at the Drosophila Neuromuscular Junction.
A. DiAntonio, S. A. Petersen, M. Heckmann, and C. S. Goodman (1999)
J. Neurosci. 19, 3023-3032
   Abstract »    Full Text »    PDF »
Insertional Mutation of the Drosophila Nuclear Lamin Dm0 Gene Results in Defective Nuclear Envelopes, Clustering of Nuclear Pore Complexes, and Accumulation of Annulate Lamellae.
B. Lenz-Bohme, J. Wismar, S. Fuchs, R. Reifegerste, E. Buchner, H. Betz, and B. Schmitt (1997)
J. Cell Biol. 137, 1001-1016
   Abstract »    Full Text »    PDF »
Cloning and Functional Expression of a Drosophila Metabotropic Glutamate Receptor Expressed in the Embryonic CNS.
M.-L. Parmentier, J.-P. Pin, J. Bockaert, and Y. Grau (1996)
J. Neurosci. 16, 6687-6694
   Abstract »    Full Text »    PDF »
Structure and Pharmacological Properties of a Molluscan Glutamate-Gated Cation Channel and its Likely Role in Feeding Behavior.
T. Stuhmer, M. Amar, R. J. Harvey, I. Bermudez, J. van Minnen, and M. G. Darlison (1996)
J. Neurosci. 16, 2869-2880
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)