Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 27 September 1991:
Vol. 253. no. 5027, pp. 1553 - 1557
DOI: 10.1126/science.1716787

Articles

Science, Vol 253, Issue 5027, 1553-1557
Copyright © 1991 by American Association for the Advancement of Science


articles

The roles of the subunits in the function of the calcium channel

D Singer, M Biel, I Lotan, V Flockerzi, F Hofmann, and N Dascal

Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.

Dihydropyridine-sensitive voltage-dependent L-type calcium channels are critical to excitation-secretion and excitation-contraction coupling. The channel molecule is a complex of the main, pore-forming subunit alpha 1 and four additional subunits: alpha 2, delta, beta, and gamma (alpha 2 and delta are encoded by a single messenger RNA). The alpha 1 subunit messenger RNA alone directs expression of functional calcium channels in Xenopus oocytes, and coexpression of the alpha 2/delta and beta subunits enhances the amplitude of the current. The alpha 2, delta, and gamma subunits also have pronounced effects on its macroscopic characteristics, such as kinetics, voltage dependence of activation and inactivation, and enhancement by a dihydropyridine agonist. In some cases, specific modulatory functions can be assigned to individual subunits, whereas in other cases the different subunits appear to act in concert to modulate the properties of the channel.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Targeted disruption of the voltage-dependent calcium channel {alpha}2/{delta}-1-subunit.
G. A. Fuller-Bicer, G. Varadi, S. E. Koch, M. Ishii, I. Bodi, N. Kadeer, J. N. Muth, G. Mikala, N. N. Petrashevskaya, M. A. Jordan, et al. (2009)
Am J Physiol Heart Circ Physiol 297, H117-H124
   Abstract »    Full Text »    PDF »
Arachidonic acid inhibition of L-type calcium (CaV1.3b) channels varies with accessory CaV{beta} subunits.
M. L. Roberts-Crowley and A. R. Rittenhouse (2009)
J. Gen. Physiol. 133, 387-403
   Abstract »    Full Text »    PDF »
A critical GxxxA motif in the {gamma}6 calcium channel subunit mediates its inhibitory effect on Cav3.1 calcium current.
Z. Lin, K. Witschas, T. Garcia, R.-S. Chen, J. P. Hansen, Z. M. Sellers, E. Kuzmenkina, S. Herzig, and P. M. Best (2008)
J. Physiol. 586, 5349-5366
   Abstract »    Full Text »    PDF »
straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel {alpha}1 subunit.
C. V. Ly, C.-K. Yao, P. Verstreken, T. Ohyama, and H. J. Bellen (2008)
J. Cell Biol. 181, 157-170
   Abstract »    Full Text »    PDF »
Calcium and Arrhythmogenesis.
H. E. D. J. ter Keurs and P. A. Boyden (2007)
Physiol Rev 87, 457-506
   Abstract »    Full Text »    PDF »
Chronic verapamil treatment remodels ICa,L in mouse ventricle.
E. Schroder, J. Magyar, D. Burgess, D. Andres, and J. Satin (2007)
Am J Physiol Heart Circ Physiol 292, H1906-H1916
   Abstract »    Full Text »    PDF »
Dose-dependent and Isoform-specific Modulation of Ca2+ Channels by RGK GTPases.
L. Seu and G. S. Pitt (2006)
J. Gen. Physiol. 128, 605-613
   Abstract »    Full Text »    PDF »
Alternative Splicing of the CaV1.3 Channel IQ Domain, a Molecular Switch for Ca2+-Dependent Inactivation within Auditory Hair Cells..
Y. Shen, D. Yu, H. Hiel, P. Liao, D. T. Yue, P. A. Fuchs, and T. W. Soong (2006)
J. Neurosci. 26, 10690-10699
   Abstract »    Full Text »    PDF »
The Role of Voltage-Gated Calcium Channels in Pancreatic {beta}-Cell Physiology and Pathophysiology.
S.-N. Yang and P.-O. Berggren (2006)
Endocr. Rev. 27, 621-676
   Abstract »    Full Text »    PDF »
Regulation of Maximal Open Probability Is a Separable Function of Cav{beta} Subunit in L-type Ca2+ Channel, Dependent on NH2 Terminus of {alpha}1C (Cav1.2{alpha}).
N. Kanevsky and N. Dascal (2006)
J. Gen. Physiol. 128, 15-36
   Abstract »    Full Text »    PDF »
Molecular Physiology of Cardiac Repolarization.
J. M. Nerbonne and R. S. Kass (2005)
Physiol Rev 85, 1205-1253
   Abstract »    Full Text »    PDF »
A CaV{beta} SH3/Guanylate Kinase Domain Interaction Regulates Multiple Properties of Voltage-gated Ca2+ Channels.
S. X. Takahashi, J. Miriyala, L. H. Tay, D. T. Yue, and H. M. Colecraft (2005)
J. Gen. Physiol. 126, 365-377
   Abstract »    Full Text »    PDF »
A single CaV{beta} can reconstitute both trafficking and macroscopic conductance of voltage-dependent calcium channels.
S. Dalton, S. X Takahashi, J. Miriyala, and H. M Colecraft (2005)
J. Physiol. 567, 757-769
   Abstract »    Full Text »    PDF »
The {alpha}-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionate Receptor Trafficking Regulator "Stargazin" Is Related to the Claudin Family of Proteins by Its Ability to Mediate Cell-Cell Adhesion.
M. G. Price, C. F. Davis, F. Deng, and D. L. Burgess (2005)
J. Biol. Chem. 280, 19711-19720
   Abstract »    Full Text »    PDF »
Unique modulation of L-type Ca2+ channels by short auxiliary {beta}1d subunit present in cardiac muscle.
R. M. Cohen, J. D. Foell, R. C. Balijepalli, V. Shah, J. W. Hell, and T. J. Kamp (2005)
Am J Physiol Heart Circ Physiol 288, H2363-H2374
   Abstract »    Full Text »    PDF »
Direct Inhibition of the Interaction between {alpha}-Interaction Domain and {beta}-Interaction Domain of Voltage-dependent Ca2+ Channels by Gem.
T. Sasaki, T. Shibasaki, P. Beguin, K. Nagashima, M. Miyazaki, and S. Seino (2005)
J. Biol. Chem. 280, 9308-9312
   Abstract »    Full Text »    PDF »
Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells.
S. L Johnson, W. Marcotti, and C. J Kros (2005)
J. Physiol. 563, 177-191
   Abstract »    Full Text »    PDF »
The Ca2+ Channel {alpha}2{delta}-1 Subunit Determines Ca2+ Current Kinetics in Skeletal Muscle but Not Targeting of {alpha}1S or Excitation-Contraction Coupling.
G. J. Obermair, G. Kugler, S. Baumgartner, P. Tuluc, M. Grabner, and B. E. Flucher (2005)
J. Biol. Chem. 280, 2229-2237
   Abstract »    Full Text »    PDF »
The C-terminal Residues in the Alpha-interacting Domain (AID) Helix Anchor CaV{beta} Subunit Interaction and Modulation of CaV2.3 Channels.
L. Berrou, Y. Dodier, A. Raybaud, A. Tousignant, O. Dafi, J. N. Pelletier, and L. Parent (2005)
J. Biol. Chem. 280, 494-505
   Abstract »    Full Text »    PDF »
Calcium Absorption Across Epithelia.
J. G. J. Hoenderop, B. Nilius, and R. J. M. Bindels (2005)
Physiol Rev 85, 373-422
   Abstract »    Full Text »    PDF »
Altered Inactivation of Ca2+ Current and Ca2+ Release in Mouse Muscle Fibers Deficient in the DHP receptor {gamma}1 subunit.
D. Ursu, R. P. Schuhmeier, M. Freichel, V. Flockerzi, and W. Melzer (2004)
J. Gen. Physiol. 124, 605-618
   Abstract »    Full Text »    PDF »
Conductance-Based Model of the Voltage-Dependent Generation of a Plateau Potential in Subthalamic Neurons.
T. Otsuka, T. Abe, T. Tsukagawa, and W.-J. Song (2004)
J Neurophysiol 92, 255-264
   Abstract »    Full Text »    PDF »
Membrane-associated guanylate kinase-like properties of {beta}-subunits required for modulation of voltage-dependent Ca2+ channels.
S. X. Takahashi, J. Miriyala, and H. M. Colecraft (2004)
PNAS 101, 7193-7198
   Abstract »    Full Text »    PDF »
Molecular heterogeneity of calcium channel {beta}-subunits in canine and human heart: evidence for differential subcellular localization.
J. D. Foell, R. C. Balijepalli, B. P. Delisle, A. M. R. Yunker, S. L. Robia, J. W. Walker, M. W. McEnery, C. T. January, and T. J. Kamp (2004)
Physiol Genomics 17, 183-200
   Abstract »    Full Text »    PDF »
Modulation of Cardiac Ca2+ Channel by Gq-activating Neurotransmitters Reconstituted in Xenopus Oocytes.
S. Weiss, T. Doan, K. E. Bernstein, and N. Dascal (2004)
J. Biol. Chem. 279, 12503-12510
   Abstract »    Full Text »    PDF »
The impact of splice isoforms on voltage-gated calcium channel {alpha}1 subunits.
K. Jurkat-Rott and F. Lehmann-Horn (2004)
J. Physiol. 554, 609-619
   Abstract »    Full Text »    PDF »
The Voltage-dependent Calcium Channel {beta} Subunit Contains Two Stable Interacting Domains.
Y. Opatowsky, O. Chomsky-Hecht, M.-G. Kang, K. P. Campbell, and J. A. Hirsch (2003)
J. Biol. Chem. 278, 52323-52332
   Abstract »    Full Text »    PDF »
G Protein Modulation of Voltage-Gated Calcium Channels.
A. C. Dolphin (2003)
Pharmacol. Rev. 55, 607-627
   Abstract »    Full Text »    PDF »
Modified Cardiovascular L-type Channels in Mice Lacking the Voltage-dependent Ca2+ Channel {beta}3 Subunit.
M. Murakami, H. Yamamura, T. Suzuki, M.-G. Kang, S. Ohya, A. Murakami, I. Miyoshi, H. Sasano, K. Muraki, T. Hano, et al. (2003)
J. Biol. Chem. 278, 43261-43267
   Abstract »    Full Text »    PDF »
Syntaxin 1A Modulates the Voltage-gated L-type Calcium Channel (Cav1.2) in a Cooperative Manner.
H. Arien, O. Wiser, I. T. Arkin, H. Leonov, and D. Atlas (2003)
J. Biol. Chem. 278, 29231-29239
   Abstract »    Full Text »    PDF »
{gamma} Subunit of Voltage-activated Calcium Channels.
M.-G. Kang and K. P. Campbell (2003)
J. Biol. Chem. 278, 21315-21318
   Full Text »    PDF »
Down-regulation of Voltage-gated Ca2+ Channels by Neuronal Calcium Sensor-1 Is beta Subunit-specific.
M. Rousset, T. Cens, S. Gavarini, A. Jeromin, and P. Charnet (2003)
J. Biol. Chem. 278, 7019-7026
   Abstract »    Full Text »    PDF »
Voltage-gated Mobility of the Ca2+ Channel Cytoplasmic Tails and Its Regulatory Role.
E. Kobrinsky, E. Schwartz, D. R. Abernethy, and N. M. Soldatov (2003)
J. Biol. Chem. 278, 5021-5028
   Abstract »    Full Text »    PDF »
gamma 1 Subunit Interactions within the Skeletal Muscle L-type Voltage-gated Calcium Channels.
J. Arikkath, C.-C. Chen, C. Ahern, V. Allamand, J. D. Flanagan, R. Coronado, R. G. Gregg, and K. P. Campbell (2003)
J. Biol. Chem. 278, 1212-1219
   Abstract »    Full Text »    PDF »
Novel functional properties of Ca2+ channel {beta} subunits revealed by their expression in adult rat heart cells.
H. M Colecraft, B. Alseikhan, S. X Takahashi, D. Chaudhuri, S. Mittman, V. Yegnasubramanian, R. S Alvania, D. C Johns, E. Marban, and D. T Yue (2002)
J. Physiol. 541, 435-452
   Abstract »    Full Text »    PDF »
Alternative Splicing of the beta 4 Subunit Has alpha 1 Subunit Subtype-Specific Effects on Ca2+ Channel Gating.
T. D. Helton and W. A. Horne (2002)
J. Neurosci. 22, 1573-1582
   Abstract »    Full Text »    PDF »
Molecular Determinants of Voltage-dependent Slow Inactivation of the Ca2+ Channel.
C. Shi and N. M. Soldatov (2002)
J. Biol. Chem. 277, 6813-6821
   Abstract »    Full Text »    PDF »
A Novel Long N-terminal Isoform of Human L-type Ca2+ Channel Is Up-regulated by Protein Kinase C.
Y. Blumenstein, N. Kanevsky, G. Sahar, R. Barzilai, T. Ivanina, and N. Dascal (2002)
J. Biol. Chem. 277, 3419-3423
   Abstract »    Full Text »    PDF »
Cloning of a Functional Splice Variant of L-type Calcium Channel beta 2 Subunit from Rat Heart.
Y. Yamada, M. Nagashima, M. Tsutsuura, T. Kobayashi, S. Seki, N. Makita, Y. Horio, and N. Tohse (2001)
J. Biol. Chem. 276, 47163-47170
   Abstract »    Full Text »    PDF »
Direct measurement of single-channel Ca2+ currents in bullfrog hair cells reveals two distinct channel subtypes.
A. Rodriguez-Contreras and E. N Yamoah (2001)
J. Physiol. 534, 669-689
   Abstract »    Full Text »    PDF »
Functional Expression and Characterization of a Voltage-Gated CaV1.3 ({{alpha}}1D) Calcium Channel Subunit from an Insulin-Secreting Cell Line.
A. Scholze, T. D. Plant, A. C. Dolphin, and B. Nurnberg (2001)
Mol. Endocrinol. 15, 1211-1221
   Abstract »    Full Text »    PDF »
Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits.
W. Chang, S. A. Pratt, T.-H. Chen, C.-L. Tu, G. Mikala, A. Schwartz, and D. Shoback (2001)
Am J Physiol Endocrinol Metab 281, E180-E189
   Abstract »    Full Text »    PDF »
Excitation-contraction coupling in skeletal muscle of a mouse lacking the dihydropyridine receptor subunit {gamma}1.
D Ursu, S Sebille, B Dietze, D Freise, V Flockerzi, and W Melzer (2001)
J. Physiol. 533, 367-377
   Abstract »    Full Text »    PDF »
Kinetic modification of the {alpha}1I subunit-mediated T-type Ca2+ channel by a human neuronal Ca2+ channel {gamma} subunit.
P J Green, R Warre, P D Hayes, N C L McNaughton, A D Medhurst, M Pangalos, D M Duckworth, and A D Randall (2001)
J. Physiol. 533, 467-478
   Abstract »    Full Text »    PDF »
Functional roles of {gamma}2, {gamma}3 and {gamma}4, three new Ca2+ channel subunits, in P/Q-type Ca2+ channel expressed in Xenopus oocytes.
M Rousset, T Cens, S Restituito, C Barrere, J L Black III, M W McEnery, and P Charnet (2001)
J. Physiol. 532, 583-593
   Abstract »    Full Text »    PDF »
Calcium Channel alpha 2delta Subunits---Structure and Gabapentin Binding.
E. Marais, N. Klugbauer, and F. Hofmann (2001)
Mol. Pharmacol. 59, 1243-1248
   Abstract »    Full Text »
Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase C.
T. J. Kamp and J. W. Hell (2000)
Circ. Res. 87, 1095-1102
   Abstract »    Full Text »    PDF »
Absence of the gamma Subunit of the Skeletal Muscle Dihydropyridine Receptor Increases L-type Ca2+ Currents and Alters Channel Inactivation Properties.
D. Freise, B. Held, U. Wissenbach, A. Pfeifer, C. Trost, N. Himmerkus, U. Schweig, M. Freichel, M. Biel, F. Hofmann, et al. (2000)
J. Biol. Chem. 275, 14476-14481
   Abstract »    Full Text »    PDF »
Functional Properties of a New Voltage-dependent Calcium Channel alpha 2delta Auxiliary Subunit Gene (CACNA2D2).
B. Gao, Y. Sekido, A. Maximov, M. Saad, E. Forgacs, F. Latif, M. H. Wei, M. Lerman, J.-H. Lee, E. Perez-Reyes, et al. (2000)
J. Biol. Chem. 275, 12237-12242
   Abstract »    Full Text »    PDF »
Voltage-Gated Calcium Currents in Axotomized Adult Rat Cutaneous Afferent Neurons.
M. L. Baccei and J. D. Kocsis (2000)
J Neurophysiol 83, 2227-2238
   Abstract »    Full Text »    PDF »
Ribozyme Ablation Demonstrates That the Cardiac Subtype of the Voltage-sensitive Calcium Channel Is the Molecular Transducer of 1,25-Dihydroxyvitamin D3-stimulated Calcium Influx in Osteoblastic Cells.
R. Liu, W. Li, N. J. Karin, J. J. Bergh, K. Adler-Storthz, and M. C. Farach-Carson (2000)
J. Biol. Chem. 275, 8711-8718
   Abstract »    Full Text »    PDF »
Regulation of Cloned Cardiac L-type Calcium Channels by cGMP-dependent Protein Kinase.
L. H. Jiang, D. J. Gawler, N. Hodson, C. J. Milligan, H. A. Pearson, V. Porter, and D. Wray (2000)
J. Biol. Chem. 275, 6135-6143
   Abstract »    Full Text »    PDF »
The molecular biology of invertebrate voltage-gated Ca(2+) channels.
M. Jeziorski, R. Greenberg, and P. Anderson (2000)
J. Exp. Biol. 203, 841-856
   Abstract »    PDF »
Voltage-dependent facilitation of cardiac L-type Ca channels expressed in HEK-293 cells requires beta -subunit.
T. J. Kamp, H. Hu, and E. Marban (2000)
Am J Physiol Heart Circ Physiol 278, H126-H136
   Abstract »    Full Text »    PDF »
Identification of Three Novel Ca2+ Channel gamma Subunit Genes Reveals Molecular Diversification by Tandem and Chromosome Duplication.
D. L. Burgess, C. F. Davis, L. A. Gefrides, and J. L. Noebels (1999)
Genome Res. 9, 1204-1213
   Abstract »    Full Text »
Voltage-Gated Ion Channels and Hereditary Disease.
F. Lehmann-Horn and K. Jurkat-Rott (1999)
Physiol Rev 79, 1317-1372
   Abstract »    Full Text »    PDF »
Subunit Expression of the Cardiac L-Type Calcium Channel Is Differentially Regulated in Diastolic Heart Failure of the Cardiac Allograft.
R. Hullin, F. Asmus, A. Ludwig, J. Hersel, and P. Boekstegers (1999)
Circulation 100, 155-163
   Abstract »    Full Text »    PDF »
Auxiliary subunits operate as a molecular switch in determining gating behaviour of the unitary N-type Ca2+ channel current in Xenopus oocytes.
M. Wakamori, G. Mikala, and Y. Mori (1999)
J. Physiol. 517, 659-672
   Abstract »    Full Text »    PDF »
Absence of modulation of the expressed calcium channel {alpha}1G subunit by {alpha}2{delta} subunits.
L Lacinova, N Klugbauer, and F Hofmann (1999)
J. Physiol. 516, 639-645
   Abstract »    Full Text »    PDF »
Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release.
D. M Bers and E. Perez-Reyes (1999)
Cardiovasc Res 42, 339-360
   Abstract »    Full Text »    PDF »
A New beta  Subtype-specific Interaction in alpha 1A Subunit Controls P/Q-type Ca2+ Channel Activation.
D. Walker, D. Bichet, S. Geib, E. Mori, V. Cornet, T. P. Snutch, Y. Mori, and M. De Waard (1999)
J. Biol. Chem. 274, 12383-12390
   Abstract »    Full Text »    PDF »
Molecular Mechanisms Underlying Ionic Remodeling in a Dog Model of Atrial Fibrillation.
L. Yue, P. Melnyk, R. Gaspo, Z. Wang, and S. Nattel (1999)
Circ. Res. 84, 776-784
   Abstract »    Full Text »    PDF »
Farnesol Blocks the L-Type Ca2+ Channel by Targeting the {alpha}1C Subunit.
U. C. Luft, R. Bychkov, M. Gollasch, V. Gross, J.-B. Roullet, D. A. McCarron, C. Ried, F. Hofmann, Y. Yagil, C. Yagil, et al. (1999)
Arterioscler. Thromb. Vasc. Biol. 19, 959-966
   Abstract »    Full Text »    PDF »
Kinetics of inactivation and restoration from inactivation of the L-type calcium current in human myotubes.
C. Harasztosi, I Sipos, L Kovacs, and W Melzer (1999)
J. Physiol. 516, 129-138
   Abstract »    Full Text »    PDF »
Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line.
N. L Brice and A. C Dolphin (1999)
J. Physiol. 515, 685-694
   Abstract »    Full Text »    PDF »
Voltage and Calcium Use the Same Molecular Determinants to Inactivate Calcium Channels.
T. Cens, S. Restituito, S. Galas, and P. Charnet (1999)
J. Biol. Chem. 274, 5483-5490
   Abstract »    Full Text »    PDF »
Complexes of the alpha 1C and beta  Subunits Generate the Necessary Signal for Membrane Targeting of Class C L-type Calcium Channels.
T. Gao, A. J. Chien, and M. M. Hosey (1999)
J. Biol. Chem. 274, 2137-2144
   Abstract »    Full Text »    PDF »
Molecular Diversity of the Calcium Channel alpha 2delta Subunit.
N. Klugbauer, L. Lacinova, E. Marais, M. Hobom, and F. Hofmann (1999)
J. Neurosci. 19, 684-691
   Abstract »    Full Text »    PDF »
The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery.
O. Wiser, M. Trus, A. Hernandez, E. Renstrom, S. Barg, P. Rorsman, and D. Atlas (1999)
PNAS 96, 248-253
   Abstract »    Full Text »    PDF »
Functional Coupling of Human L-Type Ca2+ Channels and Angiotensin AT1A Receptors Coexpressed in Xenopus laevis Oocytes: Involvement of the Carboxyl-Terminal Ca2+ Sensors.
M. Oz, M. T. Melia, N. M. Soldatov, D. R. Abernethy, and M. Morad (1998)
Mol. Pharmacol. 54, 1106-1112
   Abstract »    Full Text »
Cloning and Deletion Mutagenesis of the alpha 2delta Calcium Channel Subunit from Porcine Cerebral Cortex. EXPRESSION OF A SOLUBLE FORM OF THE PROTEIN THAT RETAINS [3H]GABAPENTIN BINDING ACTIVITY.
J. P. Brown and N. S. Gee (1998)
J. Biol. Chem. 273, 25458-25465
   Abstract »    Full Text »    PDF »
Membrane Targeting of L-type Calcium Channels. ROLE OF PALMITOYLATION IN THE SUBCELLULAR LOCALIZATION OF THE beta 2a SUBUNIT.
A. J. Chien, T. Gao, E. Perez-Reyes, and M. M. Hosey (1998)
J. Biol. Chem. 273, 23590-23597
   Abstract »    Full Text »    PDF »
Multiple Modulation Pathways of Calcium Channel Activity by a beta  Subunit. DIRECT EVIDENCE OF beta  SUBUNIT PARTICIPATION IN MEMBRANE TRAFFICKING OF THE alpha 1C SUBUNIT.
H. Yamaguchi, M. Hara, M. Strobeck, K. Fukasawa, A. Schwartz, and G. Varadi (1998)
J. Biol. Chem. 273, 19348-19356
   Abstract »    Full Text »    PDF »
Crucial Role of N Terminus in Function of Cardiac L-type Ca2+ Channel and Its Modulation by Protein Kinase C.
E. Shistik, T. Ivanina, Y. Blumenstein, and N. Dascal (1998)
J. Biol. Chem. 273, 17901-17909
   Abstract »    Full Text »    PDF »
Modulation of human neuronal alpha 1E-type calcium channel by alpha 2delta -subunit.
N. Qin, R. Olcese, E. Stefani, and L. Birnbaumer (1998)
Am J Physiol Cell Physiol 274, C1324-C1331
   Abstract »    Full Text »    PDF »
Ca2+-sensitive inactivation of L-type Ca2+ channels depends on multiple cytoplasmic amino acid sequences of the alpha 1C subunit.
R. D. Zuhlke and H. Reuter (1998)
PNAS 95, 3287-3294
   Abstract »    Full Text »    PDF »
Facilitation by the {beta}2a subunit of pore openings in cardiac Ca2+ channels.
J. Costantin, F. Noceti, N. Qin, X. Wei, L. Birnbaumer, and E. Stefani (1998)
J. Physiol. 507, 93-103
   Abstract »    Full Text »    PDF »
Molecular Determinants of L-type Ca2+ Channel Inactivation. SEGMENT EXCHANGE ANALYSIS OF THE CARBOXYL-TERMINAL CYTOPLASMIC MOTIF ENCODED BY EXONS 40-42 OF THE HUMAN alpha 1C SUBUNIT GENE.
N. M. Soldatov, M. Oz, K. A. O'Brien, D. R. Abernethy, and M. Morad (1998)
J. Biol. Chem. 273, 957-963
   Abstract »    Full Text »    PDF »
Direct Inhibition of Expressed Cardiac L-Type Ca2+ Channels by S-Nitrosothiol Nitric Oxide Donors.
H. Hu Nipavan Chiamvimonvat Toshio Yamagishi Eduardo (1997)
Circ. Res. 81, 742-752
   Abstract »    Full Text »
Dissection of Functional Domains of the Voltage-Dependent Ca2+ Channel alpha 2delta Subunit.
R. Felix, C. A. Gurnett, M. De Waard, and K. P. Campbell (1997)
J. Neurosci. 17, 6884-6891
   Abstract »    Full Text »    PDF »
Functional Expression and Characterization of Skeletal Muscle Dihydropyridine Receptors in Xenopus Oocytes.
D. Ren and L. M. Hall (1997)
J. Biol. Chem. 272, 22393-22396
   Abstract »    Full Text »    PDF »
beta Subunit Heterogeneity in Neuronal L-type Ca2+ Channels.
M. Pichler, T. N. Cassidy, D. Reimer, H. Haase, R. Kraus, D. Ostler, and J. Striessnig (1997)
J. Biol. Chem. 272, 13877-13882
   Abstract »    Full Text »    PDF »
A Xenopus oocyte beta  subunit: Evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit.
E. Tareilus, M. Roux, N. Qin, R. Olcese, J. Zhou, E. Stefani, and L. Birnbaumer (1997)
PNAS 94, 1703-1708
   Abstract »    Full Text »    PDF »
Regional Expression and Cellular Localization of the alpha 1 and beta  Subunit of High Voltage-Activated Calcium Channels in Rat Brain.
A. Ludwig, V. Flockerzi, and F. Hofmann (1997)
J. Neurosci. 17, 1339-1349
   Abstract »    Full Text »    PDF »
Molecular Structures Involved in L-type Calcium Channel Inactivation. ROLE OF THE CARBOXYL-TERMINAL REGION ENCODED BY EXONS 40-42 IN alpha 1C SUBUNIT IN THE KINETICS AND Ca2+ DEPENDENCE OF INACTIVATION.
N. M. Soldatov, R. D. Zuhlke, A. Bouron, and H. Reuter (1997)
J. Biol. Chem. 272, 3560-3566
   Abstract »    Full Text »    PDF »
Absence of the beta  subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling.
R. G. Gregg, A. Messing, C. Strube, M. Beurg, R. Moss, M. Behan, M. Sukhareva, S. Haynes, J. A. Powell, R. Coronado, et al. (1996)
PNAS 93, 13961-13966
   Abstract »    Full Text »    PDF »
Roles of a Membrane-localized beta Subunit in the Formation and Targeting of Functional L-type Ca[IMAGE] Channels.
A. J. Chien, X. Zhao, R. E. Shirokov, T. S. Puri, C. F. Chang, D. Sun, E. Rios, and M. M. Hosey (1995)
J. Biol. Chem. 270, 30036-30044
   Abstract »    Full Text »    PDF »
Molecular Determinants of Cardiac Ca[IMAGE] Channel Pharmacology.
X. Wei, S. Pan, W. Lang, H. Kim, T. Schneider, E. Perez-Reyes, and L. Birnbaumer (1995)
J. Biol. Chem. 270, 27106-27111
   Abstract »    Full Text »    PDF »
Regulation of Dihydropyridine and Ryanodine Receptor Gene Expression in Skeletal Muscle.
A. Ray, J. Kyselovic, J. J. Leddy, J. T. Wigle, B. J. Jasmin, and B. S. Tuana (1995)
J. Biol. Chem. 270, 25837-25844
   Abstract »    Full Text »    PDF »
Immunochemical Identification and Differential Phosphorylation of Alternatively Spliced Forms of the alpha[IMAGE] Subunit of Brain Calcium Channels.
T. Sakurai, J. W. Hell, A. Woppmann, G. P. Miljanich, and W. A. Catterall (1995)
J. Biol. Chem. 270, 21234-21242
   Abstract »    Full Text »    PDF »
Association of Native Ca[IMAGE] Channel [IMAGE] Subunits with the [IMAGE][IMAGE] Subunit Interaction Domain.
D. R. Witcher, M. D. Waard, H. Liu, M. Pragnell, and K. P. Campbell (1995)
J. Biol. Chem. 270, 18088-18093
   Abstract »    Full Text »    PDF »
Properties of the [IMAGE][IMAGE]-[IMAGE] Anchoring Site in Voltage-dependent Ca[IMAGE] Channels.
M. D. Waard, D. R. Witcher, M. Pragnell, H. Liu, and K. P. Campbell (1995)
J. Biol. Chem. 270, 12056-12064
   Abstract »    Full Text »    PDF »
Different Voltage-dependent Inhibition by Dihydropyridines of Human Ca[IMAGE] Channel Splice Variants.
N. M. Soldatov, A. Bouron, and H. Reuter (1995)
J. Biol. Chem. 270, 10540-10543
   Abstract »    Full Text »    PDF »
Stable Expression and Coupling of Cardiac L-Type Ca2+ Channels With ß1-Adrenoceptors.
A. Yatani, M. Wakamori, T. Niidome, S. Yamamoto, I. Tanaka, Y. Mori, K. Katayama, and S. Green (1995)
Circ. Res. 76, 335-342
   Abstract »    Full Text »
Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channels.
A Mastrogiacomo, S. Parsons, G. Zampighi, D. Jenden, J. Umbach, and C. Gundersen (1994)
Science 263, 981-982
   Abstract »    PDF »
Co-localization of 1,4-dihydropyridine receptor alpha 2/delta subunit and N-CAM during early myogenesis in vitro.
S. Vandaele and F Rieger (1994)
J. Cell Sci. 107, 1217-1227
   Abstract »    PDF »
Potentiation by the beta subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel.
A Neely, X Wei, R Olcese, L Birnbaumer, and E Stefani (1993)
Science 262, 575-578
   Abstract »    PDF »
A putative ATP-activated Na+ channel involved in sperm-induced fertilization.
Y Kupitz and D Atlas (1993)
Science 261, 484-486
   Abstract »    PDF »
Structure and functional expression of a member of the low voltage-activated calcium channel family.
T. Soong, A Stea, C. Hodson, S. Dubel, Vincent SR, and T. Snutch (1993)
Science 260, 1133-1136
   Abstract »    PDF »
Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel.
L. Isom, K. De Jongh, D. Patton, B. Reber, J Offord, H Charbonneau, K Walsh, A. Goldin, and W. Catterall (1992)
Science 256, 839-842
   Abstract »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)