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Science 27 September 1991: Vol. 253. no. 5027, pp. 1553 - 1557 DOI: 10.1126/science.1716787
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Articles
Science, Vol 253, Issue 5027, 1553-1557
Copyright © 1991 by American Association for the Advancement of Science
The roles of the subunits in the function of the calcium channel
D Singer,
M Biel,
I Lotan,
V Flockerzi,
F Hofmann,
and
N Dascal
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Dihydropyridine-sensitive voltage-dependent L-type calcium channels are critical to excitation-secretion and excitation-contraction coupling. The channel molecule is a complex of the main, pore-forming subunit alpha 1 and four additional subunits: alpha 2, delta, beta, and gamma (alpha 2 and delta are encoded by a single messenger RNA). The alpha 1 subunit messenger RNA alone directs expression of functional calcium channels in Xenopus oocytes, and coexpression of the alpha 2/delta and beta subunits enhances the amplitude of the current. The alpha 2, delta, and gamma subunits also have pronounced effects on its macroscopic characteristics, such as kinetics, voltage dependence of activation and inactivation, and enhancement by a dihydropyridine agonist. In some cases, specific modulatory functions can be assigned to individual subunits, whereas in other cases the different subunits appear to act in concert to modulate the properties of the channel.
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| Full Text »
| PDF »
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| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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| Abstract »
| Full Text »
| PDF »
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- T. D. Helton and W. A. Horne (2002)
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22, 1573-1582
| Abstract »
| Full Text »
| PDF »
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- C. Shi and N. M. Soldatov (2002)
J. Biol. Chem.
277, 6813-6821
| Abstract »
| Full Text »
| PDF »
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- Y. Blumenstein, N. Kanevsky, G. Sahar, R. Barzilai, T. Ivanina, and N. Dascal (2002)
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277, 3419-3423
| Abstract »
| Full Text »
| PDF »
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- Y. Yamada, M. Nagashima, M. Tsutsuura, T. Kobayashi, S. Seki, N. Makita, Y. Horio, and N. Tohse (2001)
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276, 47163-47170
| Abstract »
| Full Text »
| PDF »
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534, 669-689
| Abstract »
| Full Text »
| PDF »
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- A. Scholze, T. D. Plant, A. C. Dolphin, and B. Nurnberg (2001)
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15, 1211-1221
| Abstract »
| Full Text »
| PDF »
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- W. Chang, S. A. Pratt, T.-H. Chen, C.-L. Tu, G. Mikala, A. Schwartz, and D. Shoback (2001)
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| Abstract »
| Full Text »
| PDF »
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- D Ursu, S Sebille, B Dietze, D Freise, V Flockerzi, and W Melzer (2001)
J. Physiol.
533, 367-377
| Abstract »
| Full Text »
| PDF »
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- P J Green, R Warre, P D Hayes, N C L McNaughton, A D Medhurst, M Pangalos, D M Duckworth, and A D Randall (2001)
J. Physiol.
533, 467-478
| Abstract »
| Full Text »
| PDF »
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- M Rousset, T Cens, S Restituito, C Barrere, J L Black III, M W McEnery, and P Charnet (2001)
J. Physiol.
532, 583-593
| Abstract »
| Full Text »
| PDF »
- Calcium Channel alpha 2delta Subunits---Structure and Gabapentin Binding.
- E. Marais, N. Klugbauer, and F. Hofmann (2001)
Mol. Pharmacol.
59, 1243-1248
| Abstract »
| Full Text »
- Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase C.
- T. J. Kamp and J. W. Hell (2000)
Circ. Res.
87, 1095-1102
| Abstract »
| Full Text »
| PDF »
- Absence of the gamma Subunit of the Skeletal Muscle Dihydropyridine Receptor Increases L-type Ca2+ Currents and Alters Channel Inactivation Properties.
- D. Freise, B. Held, U. Wissenbach, A. Pfeifer, C. Trost, N. Himmerkus, U. Schweig, M. Freichel, M. Biel, F. Hofmann, et al. (2000)
J. Biol. Chem.
275, 14476-14481
| Abstract »
| Full Text »
| PDF »
- Functional Properties of a New Voltage-dependent Calcium Channel alpha 2delta Auxiliary Subunit Gene (CACNA2D2).
- B. Gao, Y. Sekido, A. Maximov, M. Saad, E. Forgacs, F. Latif, M. H. Wei, M. Lerman, J.-H. Lee, E. Perez-Reyes, et al. (2000)
J. Biol. Chem.
275, 12237-12242
| Abstract »
| Full Text »
| PDF »
- Voltage-Gated Calcium Currents in Axotomized Adult Rat Cutaneous Afferent Neurons.
- M. L. Baccei and J. D. Kocsis (2000)
J Neurophysiol
83, 2227-2238
| Abstract »
| Full Text »
| PDF »
- Ribozyme Ablation Demonstrates That the Cardiac Subtype of the Voltage-sensitive Calcium Channel Is the Molecular Transducer of 1,25-Dihydroxyvitamin D3-stimulated Calcium Influx in Osteoblastic Cells.
- R. Liu, W. Li, N. J. Karin, J. J. Bergh, K. Adler-Storthz, and M. C. Farach-Carson (2000)
J. Biol. Chem.
275, 8711-8718
| Abstract »
| Full Text »
| PDF »
- Regulation of Cloned Cardiac L-type Calcium Channels by cGMP-dependent Protein Kinase.
- L. H. Jiang, D. J. Gawler, N. Hodson, C. J. Milligan, H. A. Pearson, V. Porter, and D. Wray (2000)
J. Biol. Chem.
275, 6135-6143
| Abstract »
| Full Text »
| PDF »
- The molecular biology of invertebrate voltage-gated Ca(2+) channels.
- M. Jeziorski, R. Greenberg, and P. Anderson (2000)
J. Exp. Biol.
203, 841-856
| Abstract »
| PDF »
- Voltage-dependent facilitation of cardiac L-type Ca channels expressed in HEK-293 cells requires beta -subunit.
- T. J. Kamp, H. Hu, and E. Marban (2000)
Am J Physiol Heart Circ Physiol
278, H126-H136
| Abstract »
| Full Text »
| PDF »
- Identification of Three Novel Ca2+ Channel gamma Subunit Genes Reveals Molecular Diversification by Tandem and Chromosome Duplication.
- D. L. Burgess, C. F. Davis, L. A. Gefrides, and J. L. Noebels (1999)
Genome Res.
9, 1204-1213
| Abstract »
| Full Text »
- Voltage-Gated Ion Channels and Hereditary Disease.
- F. Lehmann-Horn and K. Jurkat-Rott (1999)
Physiol Rev
79, 1317-1372
| Abstract »
| Full Text »
| PDF »
- Subunit Expression of the Cardiac L-Type Calcium Channel Is Differentially Regulated in Diastolic Heart Failure of the Cardiac Allograft.
- R. Hullin, F. Asmus, A. Ludwig, J. Hersel, and P. Boekstegers (1999)
Circulation
100, 155-163
| Abstract »
| Full Text »
| PDF »
- Auxiliary subunits operate as a molecular switch in determining gating behaviour of the unitary N-type Ca2+ channel current in Xenopus oocytes.
- M. Wakamori, G. Mikala, and Y. Mori (1999)
J. Physiol.
517, 659-672
| Abstract »
| Full Text »
| PDF »
- Absence of modulation of the expressed calcium channel {alpha}1G subunit by {alpha}2{delta} subunits.
- L Lacinova, N Klugbauer, and F Hofmann (1999)
J. Physiol.
516, 639-645
| Abstract »
| Full Text »
| PDF »
- Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release.
- D. M Bers and E. Perez-Reyes (1999)
Cardiovasc Res
42, 339-360
| Abstract »
| Full Text »
| PDF »
- A New beta Subtype-specific Interaction in alpha 1A Subunit Controls P/Q-type Ca2+ Channel Activation.
- D. Walker, D. Bichet, S. Geib, E. Mori, V. Cornet, T. P. Snutch, Y. Mori, and M. De Waard (1999)
J. Biol. Chem.
274, 12383-12390
| Abstract »
| Full Text »
| PDF »
- Molecular Mechanisms Underlying Ionic Remodeling in a Dog Model of Atrial Fibrillation.
- L. Yue, P. Melnyk, R. Gaspo, Z. Wang, and S. Nattel (1999)
Circ. Res.
84, 776-784
| Abstract »
| Full Text »
| PDF »
- Farnesol Blocks the L-Type Ca2+ Channel by Targeting the {alpha}1C Subunit.
- U. C. Luft, R. Bychkov, M. Gollasch, V. Gross, J.-B. Roullet, D. A. McCarron, C. Ried, F. Hofmann, Y. Yagil, C. Yagil, et al. (1999)
Arterioscler. Thromb. Vasc. Biol.
19, 959-966
| Abstract »
| Full Text »
| PDF »
- Kinetics of inactivation and restoration from inactivation of the L-type calcium current in human myotubes.
- C. Harasztosi, I Sipos, L Kovacs, and W Melzer (1999)
J. Physiol.
516, 129-138
| Abstract »
| Full Text »
| PDF »
- Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line.
- N. L Brice and A. C Dolphin (1999)
J. Physiol.
515, 685-694
| Abstract »
| Full Text »
| PDF »
- Voltage and Calcium Use the Same Molecular Determinants to Inactivate Calcium Channels.
- T. Cens, S. Restituito, S. Galas, and P. Charnet (1999)
J. Biol. Chem.
274, 5483-5490
| Abstract »
| Full Text »
| PDF »
- Complexes of the alpha 1C and beta Subunits Generate the Necessary Signal for Membrane Targeting of Class C L-type Calcium Channels.
- T. Gao, A. J. Chien, and M. M. Hosey (1999)
J. Biol. Chem.
274, 2137-2144
| Abstract »
| Full Text »
| PDF »
- Molecular Diversity of the Calcium Channel alpha 2delta Subunit.
- N. Klugbauer, L. Lacinova, E. Marais, M. Hobom, and F. Hofmann (1999)
J. Neurosci.
19, 684-691
| Abstract »
| Full Text »
| PDF »
- The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery.
- O. Wiser, M. Trus, A. Hernandez, E. Renstrom, S. Barg, P. Rorsman, and D. Atlas (1999)
PNAS
96, 248-253
| Abstract »
| Full Text »
| PDF »
- Functional Coupling of Human L-Type Ca2+ Channels and Angiotensin AT1A Receptors Coexpressed in Xenopus laevis Oocytes: Involvement of the Carboxyl-Terminal Ca2+ Sensors.
- M. Oz, M. T. Melia, N. M. Soldatov, D. R. Abernethy, and M. Morad (1998)
Mol. Pharmacol.
54, 1106-1112
| Abstract »
| Full Text »
- Cloning and Deletion Mutagenesis of the alpha 2delta Calcium Channel Subunit from Porcine Cerebral Cortex. EXPRESSION OF A SOLUBLE FORM OF THE PROTEIN THAT RETAINS [3H]GABAPENTIN BINDING ACTIVITY.
- J. P. Brown and N. S. Gee (1998)
J. Biol. Chem.
273, 25458-25465
| Abstract »
| Full Text »
| PDF »
- Membrane Targeting of L-type Calcium Channels. ROLE OF PALMITOYLATION IN THE SUBCELLULAR LOCALIZATION OF THE beta 2a SUBUNIT.
- A. J. Chien, T. Gao, E. Perez-Reyes, and M. M. Hosey (1998)
J. Biol. Chem.
273, 23590-23597
| Abstract »
| Full Text »
| PDF »
- Multiple Modulation Pathways of Calcium Channel Activity by a beta Subunit. DIRECT EVIDENCE OF beta SUBUNIT PARTICIPATION IN MEMBRANE TRAFFICKING OF THE alpha 1C SUBUNIT.
- H. Yamaguchi, M. Hara, M. Strobeck, K. Fukasawa, A. Schwartz, and G. Varadi (1998)
J. Biol. Chem.
273, 19348-19356
| Abstract »
| Full Text »
| PDF »
- Crucial Role of N Terminus in Function of Cardiac L-type Ca2+ Channel and Its Modulation by Protein Kinase C.
- E. Shistik, T. Ivanina, Y. Blumenstein, and N. Dascal (1998)
J. Biol. Chem.
273, 17901-17909
| Abstract »
| Full Text »
| PDF »
- Modulation of human neuronal alpha 1E-type calcium channel by alpha 2delta -subunit.
- N. Qin, R. Olcese, E. Stefani, and L. Birnbaumer (1998)
Am J Physiol Cell Physiol
274, C1324-C1331
| Abstract »
| Full Text »
| PDF »
- Ca2+-sensitive inactivation of L-type Ca2+ channels depends on multiple cytoplasmic amino acid sequences of the alpha 1C subunit.
- R. D. Zuhlke and H. Reuter (1998)
PNAS
95, 3287-3294
| Abstract »
| Full Text »
| PDF »
- Facilitation by the {beta}2a subunit of pore openings in cardiac Ca2+ channels.
- J. Costantin, F. Noceti, N. Qin, X. Wei, L. Birnbaumer, and E. Stefani (1998)
J. Physiol.
507, 93-103
| Abstract »
| Full Text »
| PDF »
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- N. M. Soldatov, M. Oz, K. A. O'Brien, D. R. Abernethy, and M. Morad (1998)
J. Biol. Chem.
273, 957-963
| Abstract »
| Full Text »
| PDF »
- Direct Inhibition of Expressed Cardiac L-Type Ca2+ Channels by S-Nitrosothiol Nitric Oxide Donors.
- H. Hu Nipavan Chiamvimonvat Toshio Yamagishi Eduardo (1997)
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81, 742-752
| Abstract »
| Full Text »
- Dissection of Functional Domains of the Voltage-Dependent Ca2+ Channel alpha 2delta Subunit.
- R. Felix, C. A. Gurnett, M. De Waard, and K. P. Campbell (1997)
J. Neurosci.
17, 6884-6891
| Abstract »
| Full Text »
| PDF »
- Functional Expression and Characterization of Skeletal Muscle Dihydropyridine Receptors in Xenopus Oocytes.
- D. Ren and L. M. Hall (1997)
J. Biol. Chem.
272, 22393-22396
| Abstract »
| Full Text »
| PDF »
- beta Subunit Heterogeneity in Neuronal L-type Ca2+ Channels.
- M. Pichler, T. N. Cassidy, D. Reimer, H. Haase, R. Kraus, D. Ostler, and J. Striessnig (1997)
J. Biol. Chem.
272, 13877-13882
| Abstract »
| Full Text »
| PDF »
- A Xenopus oocyte beta subunit: Evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit.
- E. Tareilus, M. Roux, N. Qin, R. Olcese, J. Zhou, E. Stefani, and L. Birnbaumer (1997)
PNAS
94, 1703-1708
| Abstract »
| Full Text »
| PDF »
- Regional Expression and Cellular Localization of the alpha 1 and beta Subunit of High Voltage-Activated Calcium Channels in Rat Brain.
- A. Ludwig, V. Flockerzi, and F. Hofmann (1997)
J. Neurosci.
17, 1339-1349
| Abstract »
| Full Text »
| PDF »
- Molecular Structures Involved in L-type Calcium Channel Inactivation. ROLE OF THE CARBOXYL-TERMINAL REGION ENCODED BY EXONS 40-42 IN alpha 1C SUBUNIT IN THE KINETICS AND Ca2+ DEPENDENCE OF INACTIVATION.
- N. M. Soldatov, R. D. Zuhlke, A. Bouron, and H. Reuter (1997)
J. Biol. Chem.
272, 3560-3566
| Abstract »
| Full Text »
| PDF »
- Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling.
- R. G. Gregg, A. Messing, C. Strube, M. Beurg, R. Moss, M. Behan, M. Sukhareva, S. Haynes, J. A. Powell, R. Coronado, et al. (1996)
PNAS
93, 13961-13966
| Abstract »
| Full Text »
| PDF »
- Roles of a Membrane-localized beta Subunit in the Formation and Targeting of Functional L-type Ca[IMAGE] Channels.
- A. J. Chien, X. Zhao, R. E. Shirokov, T. S. Puri, C. F. Chang, D. Sun, E. Rios, and M. M. Hosey (1995)
J. Biol. Chem.
270, 30036-30044
| Abstract »
| Full Text »
| PDF »
- Molecular Determinants of Cardiac Ca[IMAGE] Channel Pharmacology.
- X. Wei, S. Pan, W. Lang, H. Kim, T. Schneider, E. Perez-Reyes, and L. Birnbaumer (1995)
J. Biol. Chem.
270, 27106-27111
| Abstract »
| Full Text »
| PDF »
- Regulation of Dihydropyridine and Ryanodine Receptor Gene Expression in Skeletal Muscle.
- A. Ray, J. Kyselovic, J. J. Leddy, J. T. Wigle, B. J. Jasmin, and B. S. Tuana (1995)
J. Biol. Chem.
270, 25837-25844
| Abstract »
| Full Text »
| PDF »
- Immunochemical Identification and Differential Phosphorylation of Alternatively Spliced Forms of the alpha[IMAGE] Subunit of Brain Calcium Channels.
- T. Sakurai, J. W. Hell, A. Woppmann, G. P. Miljanich, and W. A. Catterall (1995)
J. Biol. Chem.
270, 21234-21242
| Abstract »
| Full Text »
| PDF »
- Association of Native Ca[IMAGE] Channel [IMAGE] Subunits with the [IMAGE][IMAGE] Subunit Interaction Domain.
- D. R. Witcher, M. D. Waard, H. Liu, M. Pragnell, and K. P. Campbell (1995)
J. Biol. Chem.
270, 18088-18093
| Abstract »
| Full Text »
| PDF »
- Properties of the [IMAGE][IMAGE]-[IMAGE] Anchoring Site in Voltage-dependent Ca[IMAGE] Channels.
- M. D. Waard, D. R. Witcher, M. Pragnell, H. Liu, and K. P. Campbell (1995)
J. Biol. Chem.
270, 12056-12064
| Abstract »
| Full Text »
| PDF »
- Different Voltage-dependent Inhibition by Dihydropyridines of Human Ca[IMAGE] Channel Splice Variants.
- N. M. Soldatov, A. Bouron, and H. Reuter (1995)
J. Biol. Chem.
270, 10540-10543
| Abstract »
| Full Text »
| PDF »
- Stable Expression and Coupling of Cardiac L-Type Ca2+ Channels With ß1-Adrenoceptors.
- A. Yatani, M. Wakamori, T. Niidome, S. Yamamoto, I. Tanaka, Y. Mori, K. Katayama, and S. Green (1995)
Circ. Res.
76, 335-342
| Abstract »
| Full Text »
- Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channels.
- A Mastrogiacomo, S. Parsons, G. Zampighi, D. Jenden, J. Umbach, and C. Gundersen (1994)
Science
263, 981-982
| Abstract »
| PDF »
- Co-localization of 1,4-dihydropyridine receptor alpha 2/delta subunit and N-CAM during early myogenesis in vitro.
- S. Vandaele and F Rieger (1994)
J. Cell Sci.
107, 1217-1227
| Abstract »
| PDF »
- Potentiation by the beta subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel.
- A Neely, X Wei, R Olcese, L Birnbaumer, and E Stefani (1993)
Science
262, 575-578
| Abstract »
| PDF »
- A putative ATP-activated Na+ channel involved in sperm-induced fertilization.
- Y Kupitz and D Atlas (1993)
Science
261, 484-486
| Abstract »
| PDF »
- Structure and functional expression of a member of the low voltage-activated calcium channel family.
- T. Soong, A Stea, C. Hodson, S. Dubel, Vincent SR, and T. Snutch (1993)
Science
260, 1133-1136
| Abstract »
| PDF »
- Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel.
- L. Isom, K. De Jongh, D. Patton, B. Reber, J Offord, H Charbonneau, K Walsh, A. Goldin, and W. Catterall (1992)
Science
256, 839-842
| Abstract »
| PDF »
|
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