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Science 20 September 1991:
Vol. 253. no. 5026, pp. 1420 - 1423
DOI: 10.1126/science.1654594
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Articles

Science, Vol 253, Issue 5026, 1420-1423
Copyright © 1991 by American Association for the Advancement of Science

articles

Excitatory synaptic responses mediated by GABAA receptors in the hippocampus

HB Michelson and RK Wong

Department of Pharmacology, State University of New York, Brooklyn 11203.

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the cortex. Activation of postsynaptic GABAA receptors hyperpolarizes cells and inhibits neuronal activity. Synaptic responses mediated by GABAA receptors also strongly excited hippocampal neurons. This excitatory response was recorded in morphologically identified interneurons in the presence of 4-aminopyridine or after elevation of extracellular potassium concentrations. The synaptic excitation sustained by GABAA receptors synchronized the activity of inhibitory interneurons. This synchronized discharge of interneurons in turn elicited large-amplitude inhibitory postsynaptic potentials in pyramidal and granule cells. Excitatory synaptic responses mediated by GABAA receptors may thus provide a mechanism for the recruitment of GABAergic interneurons through their recurrent connections.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)