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Science 20 September 1991:
Vol. 253. no. 5026, pp. 1411 - 1415
DOI: 10.1126/science.1716785
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Articles

Science, Vol 253, Issue 5026, 1411-1415
Copyright © 1991 by American Association for the Advancement of Science

articles

Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes

SP Balk, EC Ebert, RL Blumenthal, FV McDermott, KW Wucherpfennig, SB Landau, and RS Blumberg

Hematology-Oncology Division, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215.

A human intestinal intraepithelial lymphocyte (IEL) T cell line was established from jejunum to characterize the structure and function of the alpha beta T cell antigen receptors (TCRs) expressed by this population. Single-sided polymerase chain reaction (PCR) amplification cloning and quantitative PCR amplification of the TCR chains from the cell line and from fresh IELs demonstrated that IELs were oligoclonal. The IEL T cell line exhibited CD1-specific cytotoxicity and a dominant IEL T cell clone was CD1c-specific. Thus, human jejunal intraepithelial lymphocytes are oligoclonal and recognize members of the CD1 gene family.


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