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Science 13 September 1991:
Vol. 253. no. 5025, pp. 1286 - 1289
DOI: 10.1126/science.1653970
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Articles

Science, Vol 253, Issue 5025, 1286-1289
Copyright © 1991 by American Association for the Advancement of Science

articles

Modulation of cardiac sodium channels by cAMP receptors on the myocyte surface

LA Sorbera and M Morad

Department of Physiology, University of Pennsylvania, Philadelphia 19104.

The phosphorylation of the cardiac sodium channel by adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase A leads to its inactivation. It was shown that extracellular cAMP can also modulate the sodium channel of rat, guinea pig, and frog ventricular myocytes in a rapid (less than 50 milliseconds), reversible, and dose-dependent manner. The decrease in the sodium current was accompanied by a 10- to 15-millivolt shift in the steady-state availability of the sodium channel toward more negative potentials and was inhibited by guanosine-5'-O-(2-thiodiphosphate) or pertussis toxin, suggesting that the extracellular modulation of the sodium channel by cAMP is mediated by a membrane-delimited mechanism that includes a pertussis toxin-sensitive G protein.


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