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Science 13 September 1991:
Vol. 253. no. 5025, pp. 1275 - 1277
DOI: 10.1126/science.1891715
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Articles

Science, Vol 253, Issue 5025, 1275-1277
Copyright © 1991 by American Association for the Advancement of Science

articles

Requirement of microfilaments in sorting of actin messenger RNA

CL Sundell and RH Singer

Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655.

Specific messenger RNAs (mRNAs) can be sequestered within distinct cellular locations, but little is known about how this is accomplished. The participation of the three major cellular filaments in the localization of actin mRNA was studied in chicken embryo fibroblasts. Movement of actin mRNA to the cell periphery and maintenance of that regionalization required intact microfilaments (composed of actin) but not microtubules or intermediate filaments. The results presented here suggest that actin-binding proteins may participate in mRNA sorting.


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