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Science 13 September 1991:
Vol. 253. no. 5025, pp. 1271 - 1275
DOI: 10.1126/science.1653969
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Articles
Science, Vol 253, Issue 5025, 1271-1275
Copyright © 1991 by American Association for the Advancement of Science
Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A
A Giordano,
JH Lee,
JA Scheppler,
C Herrmann,
E Harlow,
U Deuschle,
D Beach,
and
BR Franza Jr
Freeman Laboratory of Cancer Cell Biology, Cold Spring Harbor Laboratory, NY 11724.
Several cellular proteins form stable complexes with the proteins encoded by the adenovirus early region 1A (E1A) gene in extracts derived from adenovirus infected or transformed cells. Two of the cellular proteins that bind to E1A have been identified; one, a 105-kilodalton protein (pRb), is the product of the retinoblastoma gene, and the other, a 60-kilodalton protein, is a human cyclin A. Two other proteins that bind E1A have now been shown to be related to p34cdc2. This E1A complex displayed histone H1-specific kinase activity; the kinase activity was modulated during the cell division cycle, and association of pRb with E1A apparently was not required for this activity.
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- A link between cyclin A expression and adhesion-dependent cell cycle progression.
- T. Guadagno, M Ohtsubo, J. Roberts, and R. Assoian (1993)
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- Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.
- A Koff, A Giordano, D Desai, K Yamashita, J. Harper, S Elledge, T Nishimoto, D. Morgan, B. Franza, and J. Roberts (1992)
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