Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 6 September 1991:
Vol. 253. no. 5024, pp. 1135 - 1138
DOI: 10.1126/science.1716001
Prev | Table of Contents | Next

Articles

Science, Vol 253, Issue 5024, 1135-1138
Copyright © 1991 by American Association for the Advancement of Science

articles

Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons

P Greengard, J Jen, AC Nairn, and CF Stevens

Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021.

Receptor channels activated by glutamate, an excitatory neurotransmitter in the mammalian brain, are involved in processes such as long-term potentiation and excitotoxicity. Studies of glutamate receptor channels expressed in cultured hippocampal pyramidal neurons reveal that these channels are subject to neuromodulatory regulation through the adenylate cyclase cascade. The whole-cell current response to glutamate and kainate [a non-NMDA (N-methyl-D-aspartate) receptor agonist] was enhanced by forskolin, an activator of adenylate cyclase. Single-channel analysis revealed that an adenosine 3',5'-monophosphate-dependent protein kinase (PKA) increases the opening frequency and the mean open time of the non-NMDA-type glutamate receptor channels. Analysis of synaptic events indicated that forskolin, acting through PKA, increased the amplitude and decay time of spontaneous excitatory postsynaptic currents.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Specific Role for Ca2+-Dependent Adenylyl Cyclases in Recovery from Adaptive Presynaptic Silencing.
K. L. Moulder, X. Jiang, C. Chang, A. A. Taylor, A. M. Benz, A. C. Conti, L. J. Muglia, and S. Mennerick (2008)
J. Neurosci. 28, 5159-5168
   Abstract »    Full Text »    PDF »
Desensitization Properties of AMPA Receptors at the Cerebellar Mossy Fiber Granule Cell Synapse.
D. A. DiGregorio, J. S. Rothman, T. A. Nielsen, and R. A. Silver (2007)
J. Neurosci. 27, 8344-8357
   Abstract »    Full Text »    PDF »
Nefiracetam Potentiates N-Methyl-D-aspartate (NMDA) Receptor Function via Protein Kinase C Activation and Reduces Magnesium Block of NMDA Receptor.
S. Moriguchi, N. Shioda, H. Maejima, X. Zhao, W. Marszalec, J. Z. Yeh, K. Fukunaga, and T. Narahashi (2007)
Mol. Pharmacol. 71, 580-587
   Abstract »    Full Text »    PDF »
Acute Injury to Superficial Cortex Leads to a Decrease in Synaptic Inhibition and Increase in Excitation in Neocortical Layer V Pyramidal Cells.
L. Yang, L. S. Benardo, H. Valsamis, and D. S. F. Ling (2007)
J Neurophysiol 97, 178-187
   Abstract »    Full Text »    PDF »
Intracortical Circuits in Rat Anterior Cingulate Cortex Are Activated by Nociceptive Inputs Mediated by Medial Thalamus.
J.-W. Yang, H.-C. Shih, and B.-C. Shyu (2006)
J Neurophysiol 96, 3409-3422
   Abstract »    Full Text »    PDF »
Postsynaptic Mechanisms Are Essential for Forskolin-Induced Potentiation of Synaptic Transmission.
I. V. Sokolova, H. A. Lester, and N. Davidson (2006)
J Neurophysiol 95, 2570-2579
   Abstract »    Full Text »    PDF »
Protein-Protein Coupling/Uncoupling Enables Dopamine D2 Receptor Regulation of AMPA Receptor-Mediated Excitotoxicity.
S. Zou, L. Li, L. Pei, B. Vukusic, H. H. M. Van Tol, F. J. S. Lee, Q. Wan, and F. Liu (2005)
J. Neurosci. 25, 4385-4395
   Abstract »    Full Text »    PDF »
cAMP-Mediated Mechanisms for Pain Sensitization during Opioid Withdrawal.
B. Bie, Y. Peng, Y. Zhang, and Z. Z. Pan (2005)
J. Neurosci. 25, 3824-3832
   Abstract »    Full Text »    PDF »
Regulation of the NMDA Receptor Complex and Trafficking by Activity-Dependent Phosphorylation of the NR2B Subunit PDZ Ligand.
H. J. Chung, Y. H. Huang, L.-F. Lau, and R. L. Huganir (2004)
J. Neurosci. 24, 10248-10259
   Abstract »    Full Text »    PDF »
Effects of PKA-Mediated Phosphorylation of Snapin on Synaptic Transmission in Cultured Hippocampal Neurons.
P. Thakur, D. R. Stevens, Z.-H. Sheng, and J. Rettig (2004)
J. Neurosci. 24, 6476-6481
   Abstract »    Full Text »    PDF »
Localized Effects of cAMP Mediated by Distinct Routes of Protein Kinase A.
K. TASKEN and E. M. AANDAHL (2004)
Physiol Rev 84, 137-167
   Abstract »    Full Text »    PDF »
PKA and PKC Enhance Excitatory Synaptic Transmission in Human Dentate Gyrus.
H.-X. Chen and S. N. Roper (2003)
J Neurophysiol 89, 2482-2488
   Abstract »    Full Text »    PDF »
Dynamic Modulation of Inspiratory Drive Currents by Protein Kinase A and Protein Phosphatases in Functionally Active Motoneurons.
C. M. Bocchiaro, S. A. Saywell, and J. L. Feldman (2003)
J. Neurosci. 23, 1099-1103
   Abstract »    Full Text »    PDF »
Postsynaptic Application of a Peptide Inhibitor of cAMP-Dependent Protein Kinase Blocks Expression of Long-Lasting Synaptic Potentiation in Hippocampal Neurons.
S. N. Duffy and P. V. Nguyen (2003)
J. Neurosci. 23, 1142-1150
   Abstract »    Full Text »    PDF »
Serotonin 5-HT1A Receptors Regulate AMPA Receptor Channels through Inhibiting Ca2+/Calmodulin-dependent Kinase II in Prefrontal Cortical Pyramidal Neurons.
X. Cai, Z. Gu, P. Zhong, Y. Ren, and Z. Yan (2002)
J. Biol. Chem. 277, 36553-36562
   Abstract »    Full Text »    PDF »
Differential Modulation of Nucleus Accumbens Synapses.
J. M. Brundege and J. T. Williams (2002)
J Neurophysiol 88, 142-151
   Abstract »    Full Text »    PDF »
Long-Term Potentiation Alters the Modulator Pharmacology of AMPA-Type Glutamate Receptors.
B. Lin, F. A. Brucher, L. L. Colgin, and G. Lynch (2002)
J Neurophysiol 87, 2790-2800
   Abstract »    Full Text »    PDF »
Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac).
P. Svenningsson, E. T. Tzavara, J. M. Witkin, A. A. Fienberg, G. G. Nomikos, and P. Greengard (2002)
PNAS 99, 3182-3187
   Abstract »    Full Text »    PDF »
A Role of the Ubiquitin-Proteasome System in Neuropathic Pain.
A. Moss, G. Blackburn-Munro, E. M. Garry, J. A. Blakemore, T. Dickinson, R. Rosie, R. Mitchell, and S. M. Fleetwood-Walker (2002)
J. Neurosci. 22, 1363-1372
   Abstract »    Full Text »    PDF »
Characterization of the Mechanism Underlying the Reversal of Long Term Potentiation by Low Frequency Stimulation at Hippocampal CA1 Synapses.
C.-C. Huang, Y.-C. Liang, and K.-S. Hsu (2001)
J. Biol. Chem. 276, 48108-48117
   Abstract »    Full Text »    PDF »
Distance-Dependent Increase in AMPA Receptor Number in the Dendrites of Adult Hippocampal CA1 Pyramidal Neurons.
B. K. Andrasfalvy and J. C. Magee (2001)
J. Neurosci. 21, 9151-9159
   Abstract »    Full Text »    PDF »
The Neurobiology of Slow Synaptic Transmission.
P. Greengard (2001)
Science 294, 1024-1030
   Abstract »    Full Text »    PDF »
Cellular and Synaptic Adaptations Mediating Opioid Dependence.
J. T. Williams, M. J. Christie, and O. Manzoni (2001)
Physiol Rev 81, 299-343
   Abstract »    Full Text »    PDF »
Differential cAMP Gating of Glutamatergic Signaling Regulates Long-Term State Changes in the Suprachiasmatic Circadian Clock.
S. A. Tischkau, E. A. Gallman, G. F. Buchanan, and M. U. Gillette (2000)
J. Neurosci. 20, 7830-7837
   Abstract »    Full Text »    PDF »
Expression and Channel Properties of alpha -Bungarotoxin-Sensitive Acetylcholine Receptors on Chick Ciliary and Choroid Neurons.
M. E. McNerney, D. Pardi, P. C. Pugh, Q. Nai, and J. F. Margiotta (2000)
J Neurophysiol 84, 1314-1329
   Abstract »    Full Text »    PDF »
Regulation of Phosphorylation of the GluR1 AMPA Receptor in the Neostriatum by Dopamine and Psychostimulants In Vivo.
G. L. Snyder, P. B. Allen, A. A. Fienberg, C. G. Valle, R. L. Huganir, A. C. Nairn, and P. Greengard (2000)
J. Neurosci. 20, 4480-4488
   Abstract »    Full Text »    PDF »
Synaptic Control of Motoneuronal Excitability.
J. C. Rekling, G. D. Funk, D. A. Bayliss, X.-W. Dong, and J. L. Feldman (2000)
Physiol Rev 80, 767-852
   Abstract »    Full Text »    PDF »
Control of GluR1 AMPA Receptor Function by cAMP-Dependent Protein Kinase.
T. G. Banke, D. Bowie, H.-K. Lee, R. L. Huganir, A. Schousboe, and S. F. Traynelis (2000)
J. Neurosci. 20, 89-102
   Abstract »    Full Text »    PDF »
Platelet-derived Growth Factor Receptor-induced Feed-forward Inhibition of Excitatory Transmission between Hippocampal Pyramidal Neurons.
S. Lei, W.-Y. Lu, Z.-G. Xiong, B. A. Orser, C. F. Valenzuela, and J. F. MacDonald (1999)
J. Biol. Chem. 274, 30617-30623
   Abstract »    Full Text »    PDF »
Enhancement of AMPA-Mediated Current after Traumatic Injury in Cortical Neurons.
P. B. Goforth, E. F. Ellis, and L. S. Satin (1999)
J. Neurosci. 19, 7367-7374
   Abstract »    Full Text »    PDF »
Characterization of Phosphorylation Sites on the Glutamate Receptor 4 Subunit of the AMPA Receptors.
A. L. Carvalho, K. Kameyama, and R. L. Huganir (1999)
J. Neurosci. 19, 4748-4754
   Abstract »    Full Text »    PDF »
Ca2+/calmodulin-kinase II enhances channel conductance of alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors.
V. Derkach, A. Barria, and T. R. Soderling (1999)
PNAS 96, 3269-3274
   Abstract »    Full Text »    PDF »
The Glutamate Receptor Ion Channels.
R. Dingledine, K. Borges, D. Bowie, and S. F. Traynelis (1999)
Pharmacol. Rev. 51, 7-62
   Abstract »    Full Text »    PDF »
Plasticity of First-Order Sensory Synapses: Interactions between Homosynaptic Long-Term Potentiation and Heterosynaptically Evoked Dopaminergic Potentiation.
S. S. Kumar and D. S. Faber (1999)
J. Neurosci. 19, 1620-1635
   Abstract »    Full Text »    PDF »
Long-Term Desensitization of Nicotinic Acetylcholine Receptors Is Regulated via Protein Kinase A-Mediated Phosphorylation.
K. Paradiso and P. Brehm (1998)
J. Neurosci. 18, 9227-9237
   Abstract »    Full Text »    PDF »
Effects of PKA and PKC on Miniature Excitatory Postsynaptic Currents in CA1 Pyramidal Cells.
R. C. Carroll, R. A. Nicoll, and R. C. Malenka (1998)
J Neurophysiol 80, 2797-2800
   Abstract »    Full Text »    PDF »
Multiple Second-Messenger System Modulation of Voltage-Activated Calcium Currents in Teleost Retinal Horizontal Cells.
C. L. Pfeiffer-Linn and E. M. Lasater (1998)
J Neurophysiol 80, 377-388
   Abstract »    Full Text »    PDF »
Activity-Dependent Regulation of [Ca2+]i in Avian Cochlear Nucleus Neurons: Roles of Protein Kinases A and C and Relation to Cell Death.
L. Zirpel, W. R. Lippe, and E. W Rubel (1998)
J Neurophysiol 79, 2288-2302
   Abstract »    Full Text »    PDF »
Galpha s-Induced Neurodegeneration in Caenorhabditis elegans.
A. J. Berger, A. C. Hart, and J. M. Kaplan (1998)
J. Neurosci. 18, 2871-2880
   Abstract »    Full Text »    PDF »
Dopaminergic Modulation of NMDA-Induced Whole Cell Currents in Neostriatal Neurons in Slices: Contribution of Calcium Conductances.
C. Cepeda, C. S. Colwell, J. N. Itri, S. H. Chandler, and M. S. Levine (1998)
J Neurophysiol 79, 82-94
   Abstract »    Full Text »    PDF »
The phosphoprotein DARPP-32 mediates cAMP-dependent potentiation of striatal N-methyl-D-aspartate responses.
T. Blank, I. Nijholt, U. Teichert, H. Kugler, H. Behrsing, A. Fienberg, P. Greengard, and J. Spiess (1997)
PNAS 94, 14859-14864
   Abstract »    Full Text »    PDF »
The Mechanism of cAMP-Mediated Enhancement at a Cerebellar Synapse.
C. Chen and W. G. Regehr (1997)
J. Neurosci. 17, 8687-8694
   Abstract »    Full Text »    PDF »
NMDA-Independent LTP by Adenosine A2 Receptor-Mediated Postsynaptic AMPA Potentiation in Hippocampus.
K. Kessey and D. J. Mogul (1997)
J Neurophysiol 78, 1965-1972
   Abstract »    Full Text »    PDF »
Dopaminergic Modulation of Excitatory Postsynaptic Currents in Rat Neostriatal Neurons.
M. Umemiya and L. A. Raymond (1997)
J Neurophysiol 78, 1248-1255
   Abstract »    Full Text »    PDF »
Involvement of cAMP-Dependent Protein Kinase in µ-Opioid Modulation of NMDA-Mediated Synaptic Currents.
C.-W. Xie and D. V. Lewis (1997)
J Neurophysiol 78, 759-766
   Abstract »    Full Text »    PDF »
Site-Specific and Sensory Neuron-Dependent Increases in Postsynaptic Glutamate Sensitivity Accompany Serotonin-Induced Long-Term Facilitation at Aplysia Sensorimotor Synapses.
H. Zhu, F. Wu, and S. Schacher (1997)
J. Neurosci. 17, 4976-4986
   Abstract »    Full Text »    PDF »
cAMP-Dependent Protein Kinase Modulates Expiratory Neurons In Vivo.
P. M. Lalley, O. Pierrefiche, A. M. Bischoff, and D. W. Richter (1997)
J Neurophysiol 77, 1119-1131
   Abstract »    Full Text »    PDF »
Arg-Gly-Asp-Ser-Selective Adhesion and the Stabilization of Long-Term Potentiation: Pharmacological Studies and the Characterization of a Candidate Matrix Receptor.
B. A. Bahr, U. Staubli, P. Xiao, D. Chun, Z.-X. Ji, E. T. Esteban, and G. Lynch (1997)
J. Neurosci. 17, 1320-1329
   Abstract »    Full Text »    PDF »
Transient Activation of Cyclic AMP-dependent Protein Kinase during Hippocampal Long-term Potentiation.
E. D. Roberson and J. D. Sweatt (1996)
J. Biol. Chem. 271, 30436-30441
   Abstract »    Full Text »    PDF »
cAMP-dependent Facilitation of Glutamate Release by beta -Adrenergic Receptors in Cerebrocortical Nerve Terminals.
I. Herrero and J. Sanchez-Prieto (1996)
J. Biol. Chem. 271, 30554-30560
   Abstract »    Full Text »    PDF »
Induction of Hippocampal Long-Term Depression Requires Release of Ca2+ from Separate Presynaptic and Postsynaptic Intracellular Stores.
M. Reyes and P. K. Stanton (1996)
J. Neurosci. 16, 5951-5960
   Abstract »    Full Text »    PDF »
17beta -Estradiol Potentiates Kainate-Induced Currents via Activation of the cAMP Cascade.
Q. Gu and R. L. Moss (1996)
J. Neurosci. 16, 3620-3629
   Abstract »    Full Text »    PDF »
Promoter Sequences in the RIbeta Subunit Gene of cAMP-dependent Protein Kinase Required for Transgene Expression in Mouse Brain.
C. H. Clegg, H. S. Haugen, and L. F. Boring (1996)
J. Biol. Chem. 271, 1638-1644
   Abstract »    Full Text »    PDF »
Effects of a conditional Drosophila PKA mutant on olfactory learning and memory..
W Li, T Tully, and D Kalderon (1996)
Learn. Mem. 2, 320-333
   Abstract »    PDF »
Long-lasting forms of synaptic potentiation in the mammalian hippocampus..
Y Y Huang, P V Nguyen, T Abel, and E R Kandel (1996)
Learn. Mem. 3, 74-85
   PDF »
Proactive and retrograde effects on LTP produced by theta pulse stimulation: mechanisms and characteristics of LTP reversal in vitro..
U Staubli and D Chun (1996)
Learn. Mem. 3, 96-105
   Abstract »    PDF »
Mutagenesis of the Regulatory Subunit (RIIbeta) of cAMP-dependent Protein Kinase IIbeta Reveals Hydrophobic Amino Acids That Are Essential for RIIbeta Dimerization and/or Anchoring RIIbeta to the Cytoskeleton.
Y. Li and C. S. Rubin (1995)
J. Biol. Chem. 270, 1935-1944
   Abstract »    Full Text »    PDF »
A critical period of protein kinase activity after tetanic stimulation is required for the induction of long-term potentiation..
K M Huber, M D Mauk, C Thompson, and P T Kelly (1995)
Learn. Mem. 2, 81-100
   Abstract »    PDF »
Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization..
Y Y Huang and E R Kandel (1994)
Learn. Mem. 1, 74-82
   Abstract »    PDF »
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons.
U Frey, Y. Huang, and E. Kandel (1993)
Science 260, 1661-1664
   Abstract »    PDF »
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons.
B. Bacskai, B Hochner, M Mahaut-Smith, Adams SR, B. Kaang, E. Kandel, and R. Tsien (1993)
Science 260, 222-226
   Abstract »    PDF »
Phosphorylation and modulation of a kainate receptor (GluR6) by cAMP-dependent protein kinase.
L. Wang, F. Taverna, X. Huang, J. MacDonald, and D. Hampson (1993)
Science 259, 1173-1175
   Abstract »    PDF »
Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons.
J. K. Seamans, D. Durstewitz, B. R. Christie, C. F. Stevens, and T. J. Sejnowski (2001)
PNAS 98, 301-306
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)