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Science 23 August 1991:
Vol. 253. no. 5022, pp. 912 - 914
DOI: 10.1126/science.1715095
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Articles

Science, Vol 253, Issue 5022, 912-914
Copyright © 1991 by American Association for the Advancement of Science

articles

Stimulation of protein tyrosine phosphorylation by NMDA receptor activation

H Bading and ME Greenberg

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.

The N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptors, plays a key role in synaptic plasticity in the nervous system. After NMDA receptor activation, calcium entry into the postsynaptic neuron is a critical initial event. However, the subsequent mechanisms by which the NMDA receptor signal is processed are incompletely understood. Stimulation of cultured rat hippocampal cells with glutamate resulted in the rapid and transient tyrosine phosphorylation of a 39-kilodalton protein (p39). Tyrosine phosphorylation of p39 was triggered by the NMDA receptor and required an influx of Ca2+ from the extracellular medium. Because p39 was found to be highly related or identical to the microtubule-associated protein 2 kinase, the NMDA receptor signal may be processed by a sequential activation of protein kinases.


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J. Neurosci. 17, 117-124
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Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation.
J. D. English and J. D. Sweatt (1996)
J. Biol. Chem. 271, 24329-24332
   Abstract »    Full Text »    PDF »
Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism.
Z. Xia, H. Dudek, C. K. Miranti, and M. E. Greenberg (1996)
J. Neurosci. 16, 5425-5436
   Abstract »    Full Text »    PDF »
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Y. Wang and J. P. Durkin (1995)
J. Biol. Chem. 270, 22783-22787
   Abstract »    Full Text »    PDF »
A Novel Mitogen-activated Protein Kinase Phosphatase.
A. Misra-Press, C. S. Rim, H. Yao, M. S. Roberson, and P. J. S. Stork (1995)
J. Biol. Chem. 270, 14587-14596
   Abstract »    Full Text »    PDF »
Calcium signaling in neurons: molecular mechanisms and cellular consequences.
A Ghosh and M. Greenberg (1995)
Science 268, 239-247
   Abstract »    PDF »
Requirement for BDNF in activity-dependent survival of cortical neurons.
A Ghosh, J Carnahan, and M. Greenberg (1994)
Science 263, 1618-1623
   Abstract »    PDF »
Temporal and spatial regulation of the expression of BAD2, a MAP kinase phosphatase, during seizure, kindling, and long-term potentiation..
Z Qian, M Gilbert, and E R Kandel (1994)
Learn. Mem. 1, 180-188
   Abstract »    PDF »
Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.
H Bading, D. Ginty, and M. Greenberg (1993)
Science 260, 181-186
   Abstract »    PDF »
Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.
D. Ginty, J. Kornhauser, M. Thompson, H Bading, K. Mayo, J. Takahashi, and M. Greenberg (1993)
Science 260, 238-241
   Abstract »    PDF »
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.
S. Grant, T. O'Dell, K. Karl, P. Stein, P Soriano, and E. Kandel (1992)
Science 258, 1903-1910
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Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Activation in Somatodendritic Compartments: Roles of Action Potentials, Frequency, and Mode of Calcium Entry.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)