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Science 23 August 1991:
Vol. 253. no. 5022, pp. 903 - 905
DOI: 10.1126/science.1831565
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Articles

Science, Vol 253, Issue 5022, 903-905
Copyright © 1991 by American Association for the Advancement of Science

articles

Requirement for positive selection of gamma delta receptor-bearing T cells

FB Wells, SJ Gahm, SM Hedrick, JA Bluestone, A Dent, and LA Matis

Biological Carcinogenesis and Development Program, Program Resources, Inc./DynCorp, NCI-Frederick Cancer Research and Development Center, MD 21701-0201.

The alpha beta and gamma delta T cell receptors for antigen (TCR) delineate distinct T cell populations. TCR alpha beta-bearing thymocytes must be positively selected by binding of the TCR to major histocompatibility complex (MHC) molecules on thymic epithelium. To examine the requirement for positive selection of TCR gamma delta T cells, mice bearing a class I MHC-specific gamma delta transgene (Tg) were crossed to mice with disrupted beta 2 microglobulin (beta 2M) genes. The Tg+beta 2M- (class I MHC-) offspring had Tg+ thymocytes that did not proliferate to antigen or Tg-specific monoclonal antibody and few peripheral Tg+ cells. This is evidence for positive selection within the gamma delta T cell subset.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Allelic Exclusion at the TCR{delta} Locus and Commitment to {gamma}{delta} Lineage: Different Modalities Apply to Distinct Human {gamma}{delta} Subsets.
C. Couedel, E. Lippert, K. Bernardeau, M. Bonneville, and F. Davodeau (2004)
J. Immunol. 172, 5544-5552
   Abstract »    Full Text »    PDF »
T Cell Receptor-{gamma} Allele-Specific Selection of V{gamma}1/V{delta}4 Cells in the Intestinal Epithelium.
K. Grigoriadou, L. Boucontet, and P. Pereira (2002)
J. Immunol. 169, 3736-3743
   Abstract »    Full Text »    PDF »
Deficiency in {beta}2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Faslpr Mice: An Example of Disease Regulation at the Organ Level.
O. T. M. Chan, V. Paliwal, J. M. McNiff, S.-H. Park, A. Bendelac, and M. J. Shlomchik (2001)
J. Immunol. 167, 2985-2990
   Abstract »    Full Text »    PDF »
Lifespan of gamma /delta T Cells.
D. F. Tough and J. Sprent (1998)
J. Exp. Med. 187, 357-365
   Abstract »    Full Text »    PDF »
The T cell receptor repertoire of intestinal intraepithelial gamma delta T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci.
P. Pereira, J. J. Lafaille, D. Gerber, and S. Tonegawa (1997)
PNAS 94, 5761-5766
   Abstract »    Full Text »    PDF »
Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells.
J Penninger, K Kishihara, T Molina, V. Wallace, E Timms, S. Hedrick, and T. Mak (1993)
Science 260, 358-361
   Abstract »    PDF »


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