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Science 16 August 1991:
Vol. 253. no. 5021, pp. 797 - 799
DOI: 10.1126/science.1652154
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Articles
Science, Vol 253, Issue 5021, 797-799
Copyright © 1991 by American Association for the Advancement of Science
Similar neuronal alterations induced by axonal injury and learning in Aplysia
ET Walters,
H Alizadeh,
and
GA Castro
Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225.
Learning in the marine mollusk Aplysia has been associated with enhanced sensory function, expressed in mechanosensory neurons as (i) decreases in action potential threshold, accommodation, and afterhyperpolarization, and (ii) increases in action potential duration, afterdischarge, and synaptic transmission. These alterations also occur, with a delay, after sensory axons are injured under conditions in which synaptic transmission is severely reduced. The latency and specificity of injury-induced alterations indicate that induction signals are generated at the site of injury and conveyed centrally by axonal transport. Similarities in neuronal modifications support the hypothesis that some memory mechanisms evolved from mechanisms of injury-induced sensory compensation and repair.
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