Related Content
Search Google Scholar for:
|
|
Science 16 August 1991:
Vol. 253. no. 5021, pp. 786 - 789
DOI: 10.1126/science.1652153
|
|
Articles
Science, Vol 253, Issue 5021, 786-789
Copyright © 1991 by American Association for the Advancement of Science
Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements
MS Kapiloff,
Y Farkash,
M Wegner,
and
MG Rosenfeld
Eukaryotic Regulatory Biology Program, School of Medicine, University of California, San Diego, La Jolla 92093-0648.
Pit-1, a tissue-specific POU domain transcription factor, is required for the activation of the prolactin, growth hormone, and Pit-1 promoters that confer regulation by epidermal growth factor, adenosine 3',5'-monophosphate (cAMP), and phorbol esters. Pit-1 is phosphorylated in pituitary cells at two distinct sites in response to phorbol esters and cAMP. Phosphorylation of Pit-1 modifies its conformation on DNA recognition elements and results in increased binding at certain sites and decreased binding at other sites, dependent on DNA sequences adjacent to the core Pit-1 binding motif. One residue (Thr220), located in the POU homeodomain within a sequence conserved throughout the POU-domain family, confers these responses.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Cell-cycle-specific nestin expression coordinates with morphological changes in embryonic cortical neural progenitors.
- T. Sunabori, A. Tokunaga, T. Nagai, K. Sawamoto, M. Okabe, A. Miyawaki, Y. Matsuzaki, T. Miyata, and H. Okano (2008)
J. Cell Sci.
121, 1204-1212
| Abstract »
| Full Text »
| PDF »
- The Protein Kinase C Pathway Acts through Multiple Transcription Factors to Repress Gonadotropin-Releasing Hormone Gene Expression in Hypothalamic GT1-7 Neuronal Cells.
- Q. Tang, M. Mazur, and P. L. Mellon (2005)
Mol. Endocrinol.
19, 2769-2779
| Abstract »
| Full Text »
| PDF »
- Repression of the prolactin promoter: a functional consequence of the heterodimerization between Pit-1 and Pit-1 {beta}.
- R A Sporici, J S Hodskins, D M Locasto, L B Meszaros, A L Ferry, A M Weidner, C A Rinehart, J C Bailey, I M Mains, and S E Diamond (2005)
J. Mol. Endocrinol.
35, 317-331
| Abstract »
| Full Text »
| PDF »
- Ras Signaling and Transcriptional Synergy at a Flexible Ets-1/Pit-1 Composite DNA Element Is Defined by the Assembly of Selective Activation Domains.
- D. L. Duval, A. Jean, and A. Gutierrez-Hartmann (2003)
J. Biol. Chem.
278, 39684-39696
| Abstract »
| Full Text »
| PDF »
- Novel Function of the Transactivation Domain of a Pituitary-specific Transcription Factor, Pit-1.
- M. Kishimoto, Y. Okimura, K. Yagita, G. Iguchi, M. Fumoto, K. Iida, H. Kaji, H. Okamura, and K. Chihara (2002)
J. Biol. Chem.
277, 45141-45148
| Abstract »
| Full Text »
| PDF »
- Structural characterization of the PIT-1/ETS-1 interaction: PIT-1 phosphorylation regulates PIT-1/ETS-1 binding.
- K. D. Augustijn, D. L. Duval, R. Wechselberger, R. Kaptein, A. Gutierrez-Hartmann, and P. C. van der Vliet (2002)
PNAS
99, 12657-12662
| Abstract »
| Full Text »
| PDF »
- Analysis of the Role of the Mitogen-Activated Protein Kinase in Mediating Cyclic-Adenosine 3',5'-Monophosphate Effects on Prolactin Promoter Activity.
- P. Kievit, J. D. Lauten, and R. A. Maurer (2001)
Mol. Endocrinol.
15, 614-624
| Abstract »
| Full Text »
- POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease.
- B. Andersen and M. G. Rosenfeld (2001)
Endocr. Rev.
22, 2-35
| Abstract »
| Full Text »
- The LIM/Homeodomain Protein Islet-1 Modulates Estrogen Receptor Functions.
- F. Gay, I. Anglade, Z. Gong, and G. Salbert (2000)
Mol. Endocrinol.
14, 1627-1648
| Abstract »
| Full Text »
- The Pit-1 Homeodomain and beta -Domain Interact with Ets-1 and Modulate Synergistic Activation of the Rat Prolactin Promoter.
- A. P. Bradford, K. S. Brodsky, S. E. Diamond, L. C. Kuhn, Y. Liu, and A. Gutierrez-Hartmann (2000)
J. Biol. Chem.
275, 3100-3106
| Abstract »
| Full Text »
| PDF »
- Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance.
- K. Takeda, C. Takemoto, I. Kobayashi, A. Watanabe, Y. Nobukuni, D. E. Fisher, and M. Tachibana (2000)
Hum. Mol. Genet.
9, 125-132
| Abstract »
| Full Text »
| PDF »
- The Tissue-Specific Transcription Factor Pit-1/GHF-1 Binds to the c-fos Serum Response Element and Activates c-fos Transcription.
- C. Gaiddon, M. de Tapia, and J.-P. Loeffler (1999)
Mol. Endocrinol.
13, 742-751
| Abstract »
| Full Text »
- Expression Cloning and Characterization of PREB (Prolactin Regulatory Element Binding), a Novel WD Motif DNA-Binding Protein with a Capacity to Regulate Prolactin Promoter Activity.
- M. S. Fliss, P. M. Hinkle, and C. Bancroft (1999)
Mol. Endocrinol.
13, 644-657
| Abstract »
| Full Text »
- Defective Retinoic Acid Regulation of the Pit-1 Gene Enhancer: A Novel Mechanism of Combined Pituitary Hormone Deficiency.
- L. E. Cohen, K. Zanger, T. Brue, F. E. Wondisford, and S. Radovick (1999)
Mol. Endocrinol.
13, 476-484
| Abstract »
| Full Text »
- Reconstitution of the Protein Kinase A Response of the Rat Prolactin Promoter: Differential Effects of Distinct Pit-1 Isoforms and Functional Interaction with Oct-1.
- S. E. Diamond, M. Chiono, and A. Gutierrez-Hartmann (1999)
Mol. Endocrinol.
13, 228-238
| Abstract »
| Full Text »
- A Novel Mechanism for Cyclic Adenosine 3',5'-Monophosphate Regulation of Gene Expression by CREB-Binding Protein.
- K. Zanger, L. E. Cohen, K. Hashimoto, S. Radovick, and F. E. Wondisford (1999)
Mol. Endocrinol.
13, 268-275
| Abstract »
| Full Text »
- Identification of the In Vivo Casein Kinase II Phosphorylation Site within the Homeodomain of the Cardiac Tisue-Specifying Homeobox Gene Product Csx/Nkx2.5.
- H. Kasahara and S. Izumo (1999)
Mol. Cell. Biol.
19, 526-536
| Abstract »
| Full Text »
| PDF »
- Targeted Disruption of the Murine Galanin Gene.
- D. WYNICK, C. J. SMALL, S. R. BLOOM, and V. PACHNIS (1998)
Ann. N.Y. Acad. Sci.
863, 22-47
| Abstract »
| Full Text »
| PDF »
- Selective Inhibition of Prolactin Gene Transcription by the ETS-2 Repressor Factor.
- R. N. Day, J. Liu, V. Sundmark, M. Kawecki, D. Berry, and H. P. Elsholtz (1998)
J. Biol. Chem.
273, 31909-31915
| Abstract »
| Full Text »
| PDF »
- Transcription Factor AP1 Is Involved in Basal and Okadaic Acid-Stimulated Activity of the Human PRL Promoter.
- L. Caccavelli, I. Manfroid, J. A. Martial, and M. Muller (1998)
Mol. Endocrinol.
12, 1215-1227
| Abstract »
| Full Text »
- New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2.
- V. Botquin, H. Hess, G. Fuhrmann, C. Anastassiadis, M. K. Gross, G. Vriend, and H. R. Schöler (1998)
Genes & Dev.
12, 2073-2090
| Abstract »
| Full Text »
- Antioxidant-induced Nuclear Translocation of CCAAT/Enhancer-binding Protein beta . A CRITICAL ROLE FOR PROTEIN KINASE A-MEDIATED PHOSPHORYLATION OF Ser299.
- R. Chinery, J. A. Brockman, D. T. Dransfield, and R. J. Coffey (1997)
J. Biol. Chem.
272, 30356-30361
| Abstract »
| Full Text »
| PDF »
- A Novel Proximal Element Mediates the Regulation of Mouse Ren-1C Promoter by Retinoblastoma Protein in Cultured Cells.
- K. Tamura, S. Umemura, N. Nyui, S. Yamaguchi, T. Ishigami, K. Hibi, M. Yabana, M. Kihara, A. Fukamizu, K. Murakami, et al. (1997)
J. Biol. Chem.
272, 16845-16851
| Abstract »
| Full Text »
| PDF »
- Mitogenic stimulation of resting T cells causes rapid phosphorylation of the transcription factor LSF and increased DNA-binding activity..
- J L Volker, L E Rameh, Q Zhu, J DeCaprio, and U Hansen (1997)
Genes & Dev.
11, 1435-1446
| Abstract »
| PDF »
- POU domain family values: flexibility, partnerships, and developmental codes..
- A K Ryan and M G Rosenfeld (1997)
Genes & Dev.
11, 1207-1225
| PDF »
- Target-dependent Effect of Phosphorylation on the DNA Binding Activity of the TAL1/SCL Oncoprotein.
- K. S.S. Prasad and S. J. Brandt (1997)
J. Biol. Chem.
272, 11457-11462
| Abstract »
| Full Text »
| PDF »
- Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility..
- E M Jacobson, P Li, A Leon-del-Rio, M G Rosenfeld, and A K Aggarwal (1997)
Genes & Dev.
11, 198-212
| Abstract »
| PDF »
- AP-1 and Oct-1 Transcription Factors Down-regulate the Expression of the Human PIT1/GHF1 Gene.
- M. Delhase, J.-L. Castrillo, M. de la Hoya, F. Rajas, and E. L. Hooghe-Peters (1996)
J. Biol. Chem.
271, 32349-32358
| Abstract »
| Full Text »
| PDF »
- CCAAT/Enhancer-binding Protein alpha Activation of the Rat Growth Hormone Promoter in Pituitary Progenitor GHFT1-5 Cells.
- F. Schaufele and F. Schaufele (1996)
J. Biol. Chem.
271, 21484-21489
| Abstract »
| Full Text »
| PDF »
- An Activation Function in Pit-1 Required Selectively for Synergistic Transcription.
- W. Chang, W. Zhou, L. E. Theill, J. D. Baxter, and F. Schaufele (1996)
J. Biol. Chem.
271, 17733-17738
| Abstract »
| Full Text »
| PDF »
- Identification of the Nuclear Localization Signal of the POU Domain Protein Tst-1/Oct6.
- E. Sock, J. Enderich, M. G. Rosenfeld, and M. Wegner (1996)
J. Biol. Chem.
271, 17512-17518
| Abstract »
| Full Text »
| PDF »
- Regulation of Human Involucrin Promoter Activity by POU Domain Proteins.
- J. F. Welter, H. Gali, J. F. Crish, and R. L. Eckert (1996)
J. Biol. Chem.
271, 14727-14733
| Abstract »
| Full Text »
| PDF »
- Activin Increases Phosphorylation and Decreases Stability of the Transcription Factor Pit-1 in MtTW15 Somatotrope Cells.
- D. Gaddy-Kurten and W. W. Vale (1995)
J. Biol. Chem.
270, 28733-28739
| Abstract »
| Full Text »
| PDF »
- In Vivo Mutational Analysis of the DNA Binding Domain of the Tissue-specific Transcription Factor, Pit-1.
- J. Liang, S. Moye-Rowley, and R. A. Maurer (1995)
J. Biol. Chem.
270, 25520-25525
| Abstract »
| Full Text »
| PDF »
- A Composite Ets/Pit-1 Binding Site in the Prolactin Gene Can Mediate Transcriptional Responses to Multiple Signal Transduction Pathways.
- P. W. Howard and R. A. Maurer (1995)
J. Biol. Chem.
270, 20930-20936
| Abstract »
| Full Text »
| PDF »
- The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain..
- W Herr and M A Cleary (1995)
Genes & Dev.
9, 1679-1693
| PDF »
- An Inactivating Point Mutation Demonstrates That Interaction of cAMP Response Element Binding Protein (CREB) with the CREB Binding Protein Is Not Sufficient for Transcriptional Activation.
- P. Sun and R. A. Maurer (1995)
J. Biol. Chem.
270, 7041-7044
| Abstract »
| Full Text »
| PDF »
- A Dopamine-responsive Domain in the N-terminal Sequence of Pit-1.
- A. M. Lew and H. P. Elsholtz (1995)
J. Biol. Chem.
270, 7156-7160
| Abstract »
| Full Text »
| PDF »
- Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope.
- S. Lin, S Li, D. Drolet, and M. Rosenfeld (1994)
Development
120, 515-522
| Abstract »
| PDF »
- Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPbeta.
- M. Wegner, Z. Cao, and M. G. Rosenfeld (1992)
Science
256, 370-373
| Abstract »
| PDF »
- PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors.
- A Poleev, H Fickenscher, S Mundlos, A Winterpacht, B Zabel, A Fidler, P Gruss, and D Plachov (1992)
Development
116, 611-623
| Abstract »
| PDF »
- Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity.
- N Segil, S. Roberts, and N Heintz (1991)
Science
254, 1814-1816
| Abstract »
| PDF »
- cAMP Response Element-binding Protein-binding Protein Mediates Thyrotropin-releasing Hormone Signaling on Thyrotropin Subunit Genes.
- K. Hashimoto, K. Zanger, A. N. Hollenberg, L. E. Cohen, S. Radovick, and F. E. Wondisford (2000)
J. Biol. Chem.
275, 33365-33372
| Abstract »
| Full Text »
| PDF »
|
|
