Science 9 August 1991: Vol. 253. no. 5020, pp. 665 - 669 DOI: 10.1126/science.1651563

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Articles

Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition.

P. Zhou, X. Fang, B. A. McNally, P. Yu, M. Zhu, Y.-X. Fu, L. Wang, Y. Liu, and P. Zheng (2009)
PNAS 106, 17134-17139
 |  Abstract »  |  Full Text »  |  PDF »

Down-regulation of Tip60 Gene as a Potential Marker for the Malignancy of Colorectal Cancer.

K. SAKURABA, T. YASUDA, M. SAKATA, Y.-H. KITAMURA, A. SHIRAHATA, T. GOTO, H. MIZUKAMI, M. SAITO, K. ISHIBASHI, G. KIGAWA, et al. (2009)
Anticancer Res 29, 3953-3955
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Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.

K. Kawajiri, Y. Kobayashi, F. Ohtake, T. Ikuta, Y. Matsushima, J. Mimura, S. Pettersson, R. S. Pollenz, T. Sakaki, T. Hirokawa, et al. (2009)
PNAS 106, 13481-13486
 |  Abstract »  |  Full Text »  |  PDF »

Demethylation of the CDH3 Gene Is Frequently Detected in Advanced Colorectal Cancer.

K. HIBI, T. GOTO, H. MIZUKAMI, Y.-H. KITAMURA, K. SAKURABA, M. SAKATA, M. SAITO, K. ISHIBASHI, G. KIGAWA, H. NEMOTO, et al. (2009)
Anticancer Res 29, 2215-2217
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Demethylation of the CD133 Gene Is Frequently Detected in Advanced Colorectal Cancer.

K. HIBI, M. SAKATA, Y.-H. KITAMURA, K. SAKURABA, A. SHIRAHATA, T. GOTO, H. MIZUKAMI, M. SAITO, K. ISHIBASHI, G. KIGAWA, et al. (2009)
Anticancer Res 29, 2235-2237
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Oncogenic Adenomatous Polyposis Coli Mutants Impair the Mitotic Checkpoint through Direct Interaction with Mad2.

J. Zhang, R. Neisa, and Y. Mao (2009)
Mol. Biol. Cell 20, 2381-2388
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Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine.

S. Fre, S. K. Pallavi, M. Huyghe, M. Lae, K.-P. Janssen, S. Robine, S. Artavanis-Tsakonas, and D. Louvard (2009)
PNAS 106, 6309-6314
 |  Abstract »  |  Full Text »  |  PDF »

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer.

V. Rodilla, A. Villanueva, A. Obrador-Hevia, A. Robert-Moreno, V. Fernandez-Majada, A. Grilli, N. Lopez-Bigas, N. Bellora, M. M. Alba, F. Torres, et al. (2009)
PNAS 106, 6315-6320
 |  Abstract »  |  Full Text »  |  PDF »

Landmarks in the History of Cancer Epidemiology.

P. Greenwald and B. K. Dunn (2009)
Cancer Res. 69, 2151-2162
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Aberrant Methylation of the UNC5C Gene is Frequently Detected in Advanced Colorectal Cancer.

K. HIBI, H. MIZUKAMI, A. SHIRAHATA, T. GOTO, M. SAKATA, M. SAITO, K. ISHIBASHI, G. KIGAWA, H. NEMOTO, and Y. SANADA (2009)
Anticancer Res 29, 271-273
 |  Abstract »  |  Full Text »  |  PDF »

Aberrant Methylation of the p16 Gene Is Frequently Detected in Advanced Colorectal Cancer.

T. GOTO, H. MIZUKAMI, A. SHIRAHATA, M. SAKATA, M. SAITO, K. ISHIBASHI, G. KIGAWA, H. NEMOTO, Y. SANADA, and K. HIBI (2009)
Anticancer Res 29, 275-277
 |  Abstract »  |  Full Text »  |  PDF »

Vimentin Methylation as a Marker for Advanced Colorectal Carcinoma.

A. SHIRAHATA, M. SAKATA, K. SAKURABA, T. GOTO, H. MIZUKAMI, M. SAITO, K. ISHIBASHI, G. KIGAWA, H. NEMOTO, Y. SANADA, et al. (2009)
Anticancer Res 29, 279-281
 |  Abstract »  |  Full Text »  |  PDF »

c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/{beta}-catenin signaling through GSK3{beta} pathway.

D. Hu, W. Fang, A. Han, L. Gallagher, R. J. Davis, B. Xiong, and W. Yang (2008)
Carcinogenesis 29, 2317-2324
 |  Abstract »  |  Full Text »  |  PDF »

Ku80 Deletion Suppresses Spontaneous Tumors and Induces a p53-Mediated DNA Damage Response.

V. B. Holcomb, F. Rodier, Y. Choi, R. A. Busuttil, H. Vogel, J. Vijg, J. Campisi, and P. Hasty (2008)
Cancer Res. 68, 9497-9502
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Muc2 and Apc on Wnt Signaling and in Intestinal Tumorigenesis: Potential Role of Chronic Inflammation.

K. Yang, N. V. Popova, W. C. Yang, I. Lozonschi, S. Tadesse, S. Kent, L. Bancroft, I. Matise, R. T. Cormier, S. J. Scherer, et al. (2008)
Cancer Res. 68, 7313-7322
 |  Abstract »  |  Full Text »  |  PDF »

The Pleiotropic Phenotype of Apc Mutations in the Mouse: Allele Specificity and Effects of the Genetic Background.

R. B. Halberg, X. Chen, J. M. Amos-Landgraf, A. White, K. Rasmussen, L. Clipson, C. Pasch, R. Sullivan, H. C. Pitot, and W. F. Dove (2008)
Genetics 180, 601-609
 |  Abstract »  |  Full Text »  |  PDF »

Cross-Species Comparison of Human and Mouse Intestinal Polyps Reveals Conserved Mechanisms in Adenomatous Polyposis Coli (APC)-Driven Tumorigenesis.

C. Gaspar, J. Cardoso, P. Franken, L. Molenaar, H. Morreau, G. Moslein, J. Sampson, J. M. Boer, R. X. de Menezes, and R. Fodde (2008)
Am. J. Pathol. 172, 1363-1380
 |  Abstract »  |  Full Text »  |  PDF »

Dacarbazine-Doxorubicin Therapy Ameliorated an Extremely Aggressive Mesenteric Desmoid Tumor Associated with Familial Adenomatous Polyposis: Report of a Case.

K. Ezumi, H. Yamamoto, I. Takemasa, M. Nomura, M. Ikeda, M. Sekimoto, and M. Monden (2008)
Jpn. J. Clin. Oncol. 38, 222-226
 |  Abstract »  |  Full Text »  |  PDF »

Further upregulation of {beta}-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice.

T. Oyama, Y. Yamada, K. Hata, H. Tomita, A. Hirata, H. Sheng, A. Hara, H. Aoki, T. Kunisada, S. Yamashita, et al. (2008)
Carcinogenesis 29, 666-672
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Novel Modifier Loci of ApcMin Affecting Mammary Tumor Development.

H. Wang, D. Teske, A. Tess, R. Kohlhepp, Y. Choi, C. Kendziorski, and A. R. Moser (2007)
Cancer Res. 67, 11226-11233
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Intestinal Polyposis with Reduced Angiogenesis in ApcMin/+ Mice Due to Decreases in c-Myc Expression.

K. Yekkala and T. A. Baudino (2007)
Mol. Cancer Res. 5, 1296-1303
 |  Abstract »  |  Full Text »  |  PDF »

Sox17 and Sox4 Differentially Regulate {beta}-Catenin/T-Cell Factor Activity and Proliferation of Colon Carcinoma Cells.

D. Sinner, J. J. Kordich, J. R. Spence, R. Opoka, S. Rankin, S.-C. J. Lin, D. Jonatan, A. M. Zorn, and J. M. Wells (2007)
Mol. Cell. Biol. 27, 7802-7815
 |  Abstract »  |  Full Text »  |  PDF »

{alpha}-Catenin is essential in intestinal adenoma formation.

H. Shibata, H. Takano, M. Ito, H. Shioya, M. Hirota, H. Matsumoto, Y. Kakudo, C. Ishioka, T. Akiyama, Y. Kanegae, et al. (2007)
PNAS 104, 18199-18204
 |  Abstract »  |  Full Text »  |  PDF »

The genetics of hereditary colon cancer.

A. K. Rustgi (2007)
Genes & Dev. 21, 2525-2538
 |  Abstract »  |  Full Text »  |  PDF »

WNT Signaling Pathway and Stem Cell Signaling Network.

M. Katoh and M. Katoh (2007)
Clin. Cancer Res. 13, 4042-4045
 |  Abstract »  |  Full Text »  |  PDF »

Development of Gastric Tumors in ApcMin/+ Mice by the Activation of the {beta}-Catenin/Tcf Signaling Pathway.

H. Tomita, Y. Yamada, T. Oyama, K. Hata, Y. Hirose, A. Hara, T. Kunisada, Y. Sugiyama, Y. Adachi, H. Linhart, et al. (2007)
Cancer Res. 67, 4079-4087
 |  Abstract »  |  Full Text »  |  PDF »

Absence of Stabilizing Mutations of {beta}-Catenin Encoded by CTNNB1 Exon 3 in a Large Series of Sporadic Parathyroid Adenomas.

J. Costa-Guda and A. Arnold (2007)
J. Clin. Endocrinol. Metab. 92, 1564-1566
 |  Abstract »  |  Full Text »  |  PDF »

LZTS2 Is a Novel {beta}-Catenin-Interacting Protein and Regulates the Nuclear Export of {beta}-Catenin.

G. Thyssen, T.-H. Li, L. Lehmann, M. Zhuo, M. Sharma, and Z. Sun (2006)
Mol. Cell. Biol. 26, 8857-8867
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast Cancer..

G. Wu, Z. Guo, A. Chatterjee, X. Huang, E. Rubin, F. Wu, E. Mambo, X. Chang, M. Osada, M. Sook Kim, et al. (2006)
Cancer Res. 66, 9829-9836
 |  Abstract »  |  Full Text »  |  PDF »

Assessment of Endostatin Gene Therapy for Familial Adenomatous Polyposis-Related Desmoid Tumors.

S. C.M. Martinico, S. Jezzard, N. J. H. Sturt, G. Michils, S. Tejpar, R. K. Phillips, and G. Vassaux (2006)
Cancer Res. 66, 8233-8240
 |  Abstract »  |  Full Text »  |  PDF »

Hedgehog Wnteraction in colorectal cancer.

G R van den Brink and J C H Hardwick (2006)
Gut 55, 912-914
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Diagnostic Approach and Management of Lynch Syndrome (Hereditary Nonpolyposis Colorectal Carcinoma): A Guide for Clinicians.

Y. M.C. Hendriks, A. E. de Jong, H. Morreau, C. M.J. Tops, H. F. Vasen, J. Th. Wijnen, M. H. Breuning, and A. H.J.T. Brocker-Vriends (2006)
CA Cancer J Clin 56, 213-225
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous Polyposis Coli (APC) Differentially Regulates beta-Catenin Phosphorylation and Ubiquitination in Colon Cancer Cells.

J. Yang, W. Zhang, P. M. Evans, X. Chen, X. He, and C. Liu (2006)
J. Biol. Chem. 281, 17751-17757
 |  Abstract »  |  Full Text »  |  PDF »

CANCER STEM CELLS: Redefining the Paradigm of Cancer Treatment Strategies.

M. Dean (2006)
Mol. Interv. 6, 140-148
 |  Abstract »  |  Full Text »  |  PDF »

Disparities in Genetic Testing: Thinking Outside the BRCA Box.

M. J. Hall and O. I. Olopade (2006)
J. Clin. Oncol. 24, 2197-2203
 |  Abstract »  |  Full Text »  |  PDF »

No exit strategy? No problem: APC inhibits beta-catenin inside the nucleus..

Y. Xiong and Y. Kotake (2006)
Genes & Dev. 20, 637-642
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APC inhibits ERK pathway activation and cellular proliferation induced by RAS.

K.-S. Park, S. H. Jeon, S.-E. Kim, Y.-Y. Bahk, S. L. Holmen, B. O. Williams, K.-C. Chung, Y.-J. Surh, and K.-Y. Choi (2006)
J. Cell Sci. 119, 819-827
 |  Abstract »  |  Full Text »  |  PDF »

Successful Chemotherapeutic Modality of Doxorubicin Plus Dacarbazine for the Treatment of Desmoid Tumors in Association With Familial Adenomatous Polyposis.

M. Gega, H. Yanagi, R. Yoshikawa, M. Noda, H. Ikeuchi, K. Tsukamoto, T. Oshima, Y. Fujiwara, N. Gondo, K. Tamura, et al. (2006)
J. Clin. Oncol. 24, 102-105
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Peptidyl-Prolyl Isomerase-Like 1 Is Associated with the Growth of Colon Cancer Cells.

K. Obama, T. Kato, S. Hasegawa, S. Satoh, Y. Nakamura, and Y. Furukawa (2006)
Clin. Cancer Res. 12, 70-76
 |  Abstract »  |  Full Text »  |  PDF »

The Ubiquitin-Proteasome Pathway and Its Role in Cancer.

A. Mani and E. P. Gelmann (2005)
J. Clin. Oncol. 23, 4776-4789
 |  Abstract »  |  Full Text »  |  PDF »

DRO1, a Gene Down-regulated by Oncogenes, Mediates Growth Inhibition in Colon and Pancreatic Cancer Cells.

G. T. Bommer, C. Jager, E.-M. Durr, S. Baehs, S. T. Eichhorst, T. Brabletz, G. Hu, T. Frohlich, G. Arnold, D. C. Kress, et al. (2005)
J. Biol. Chem. 280, 7962-7975
 |  Abstract »  |  Full Text »  |  PDF »

Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation.

K. Schoonjans, L. Dubuquoy, J. Mebis, E. Fayard, O. Wendling, C. Haby, K. Geboes, and J. Auwerx (2005)
PNAS 102, 2058-2062
 |  Abstract »  |  Full Text »  |  PDF »

Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis.

J. Chen, C. Rocken, C. Lofton-Day, H.-U. Schulz, O. Muller, N. Kutzner, P. Malfertheiner, and M. P.A. Ebert (2005)
Carcinogenesis 26, 37-43
 |  Abstract »  |  Full Text »  |  PDF »

Cellular FLIP Inhibits {beta}-Catenin Ubiquitylation and Enhances Wnt Signaling.

M. Naito, R. Katayama, T. Ishioka, A. Suga, K. Takubo, M. Nanjo, C. Hashimoto, M. Taira, S. Takada, R. Takada, et al. (2004)
Mol. Cell. Biol. 24, 8418-8427
 |  Abstract »  |  Full Text »  |  PDF »

Wnt11 Signaling Promotes Proliferation, Transformation, and Migration of IEC6 Intestinal Epithelial Cells.

L. Ouko, T. R. Ziegler, L. H. Gu, L. M. Eisenberg, and V. W. Yang (2004)
J. Biol. Chem. 279, 26707-26715
 |  Abstract »  |  Full Text »  |  PDF »

New Chemotherapeutic Advances in Pancreatic, Colorectal, and Gastric Cancers.

E. Diaz-Rubio (2004)
Oncologist 9, 282-294
 |  Abstract »  |  Full Text »  |  PDF »

Epstein-Barr Virus-Positive Gastric Carcinoma Has a Distinct Protein Expression Profile in Comparison with Epstein-Barr Virus-Negative Carcinoma.

H. S. Lee, M. S. Chang, H.-K. Yang, B. L. Lee, and W. H. Kim (2004)
Clin. Cancer Res. 10, 1698-1705
 |  Abstract »  |  Full Text »  |  PDF »

Prognostic and Diagnostic Significance of {beta}-Catenin Nuclear Immunostaining in Colorectal Cancer.

S. C. C. Wong, E. S. F. Lo, K. C. Lee, J. K. C. Chan, and W. L. W. Hsiao (2004)
Clin. Cancer Res. 10, 1401-1408
 |  Abstract »  |  Full Text »  |  PDF »

The Correlation of Microsatellite Instability and Tumor-infiltrating Lymphocytes in Hereditary Non-polyposis Colorectal Cancer (HNPCC) and Sporadic Colorectal Cancers: the Significance of Different Types of Lymphocyte Infiltration.

N. Takemoto, F. Konishi, K. Yamashita, M. Kojima, T. Furukawa, Y. Miyakura, K. Shitoh, and H. Nagai (2004)
Jpn. J. Clin. Oncol. 34, 90-98
 |  Abstract »  |  Full Text »  |  PDF »

Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion.

M. C. Faux, J. L. Ross, C. Meeker, T. Johns, H. Ji, R. J. Simpson, M. J. Layton, and A. W. Burgess (2004)
J. Cell Sci. 117, 427-439
 |  Abstract »  |  Full Text »  |  PDF »

Reconstructed {beta}-Catenin/TCF4 Signaling in Yeast Applicable to Functional Evaluation of APC Mutations.

H. Yamada, K. Furuuchi, T. Aoyama, A. Kataoka, J.-i. Hamada, M. Tada, S. Okushiba, S. Kondo, T. Moriuchi, and H. Katoh (2003)
Am. J. Pathol. 163, 2201-2209
 |  Abstract »  |  Full Text »

Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse.

N. F. Paoni, M. W. Feldman, L. S. Gutierrez, V. A. Ploplis, and F. J. Castellino (2003)
Physiol Genomics 15, 228-235
 |  Abstract »  |  Full Text »  |  PDF »

A Randomized, Double-Blind, Placebo-Controlled Trial of the Effects of Rofecoxib, a Selective Cyclooxygenase-2 Inhibitor, on Rectal Polyps in Familial Adenomatous Polyposis Patients.

T. Higuchi, T. Iwama, K. Yoshinaga, M. Toyooka, M. M. Taketo, and K. Sugihara (2003)
Clin. Cancer Res. 9, 4756-4760
 |  Abstract »  |  Full Text »  |  PDF »

Proportion and Phenotype of MYH-Associated Colorectal Neoplasia in a Population-Based Series of Finnish Colorectal Cancer Patients.

S. Enholm, T. Hienonen, A. Suomalainen, L. Lipton, I. Tomlinson, V. Karja, M. Eskelinen, J.-P. Mecklin, A. Karhu, H. J. Jarvinen, et al. (2003)
Am. J. Pathol. 163, 827-832
 |  Abstract »  |  Full Text »  |  PDF »

Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene.

M. E. Martinez, T. G. O'Brien, K. E. Fultz, N. Babbar, H. Yerushalmi, N. Qu, Y. Guo, D. Boorman, J. Einspahr, D. S. Alberts, et al. (2003)
PNAS 100, 7859-7864
 |  Abstract »  |  Full Text »  |  PDF »

Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization.

T. Husoy, V. Cruciani, H. K. Knutsen, S.-O. Mikalsen, H. B. Olstorn, and J. Alexander (2003)
Carcinogenesis 24, 643-650
 |  Abstract »  |  Full Text »  |  PDF »

A Cancer-prone Case with a Background of Methylation of p16 Tumor Suppressor Gene.

K. Hibi, M. Koike, H. Nakayama, S. Fujitake, Y. Kasai, K. Ito, S. Akiyama, and A. Nakao (2003)
Clin. Cancer Res. 9, 1053-1056
 |  Abstract »  |  Full Text »  |  PDF »

Microadenomatous Lesions Involving Loss of Apc Heterozygosity in the Colon of Adult ApcMin/+ Mice.

Y. Yamada, K. Hata, Y. Hirose, A. Hara, S. Sugie, T. Kuno, N. Yoshimi, T. Tanaka, and H. Mori (2002)
Cancer Res. 62, 6367-6370
 |  Abstract »  |  Full Text »  |  PDF »

Compound Disruption of Smad2 Accelerates Malignant Progression of Intestinal Tumors in Apc Knockout Mice.

T. Hamamoto, H. Beppu, H. Okada, M. Kawabata, T. Kitamura, K. Miyazono, and M. Kato (2002)
Cancer Res. 62, 5955-5961
 |  Abstract »  |  Full Text »  |  PDF »

A novel aberrant splice site mutation in the APC gene.

G S Charames, H Cheng, C A Gilpin, A G W Hunter, T Berk, and B Bapat (2002)
J. Med. Genet. 39, 754-757
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The food mutagen 2-amino-9H-pyrido[2,3-b]indole (A{alpha}C) but not its methylated form (MeA{alpha}C) increases intestinal tumorigenesis in neonatally exposed multiple intestinal neoplasia mice.

I.-L. Steffensen, J. E. Paulsen, and J. Alexander (2002)
Carcinogenesis 23, 1373-1378
 |  Abstract »  |  Full Text »  |  PDF »

Gene Expression in Colorectal Cancer.

K. Birkenkamp-Demtroder, L. L. Christensen, S. H. Olesen, C. M. Frederiksen, P. Laiho, L. A. Aaltonen, S. Laurberg, F. B. Sorensen, R. Hagemann, and T. F. Orntoft (2002)
Cancer Res. 62, 4352-4363
 |  Abstract »  |  Full Text »  |  PDF »

Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.

M. Kucherlapati, K. Yang, M. Kuraguchi, J. Zhao, M. Lia, J. Heyer, M. F. Kane, K. Fan, R. Russell, A. M. C. Brown, et al. (2002)
PNAS 99, 9924-9929
 |  Abstract »  |  Full Text »  |  PDF »

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the {beta}-catenin signaling cascade.

C. Albuquerque, C. Breukel, R. van der Luijt, P. Fidalgo, P. Lage, F. J.M. Slors, C. N. Leitao, R. Fodde, and R. Smits (2002)
Hum. Mol. Genet. 11, 1549-1560
 |  Abstract »  |  Full Text »  |  PDF »

Protection against Anoikis and Down-regulation of Cadherin Expression by a Regulatable beta -Catenin Protein.

Z. Weng, M. Xin, L. Pablo, D. Grueneberg, M. Hagel, G. Bain, T. Muller, and J. Papkoff (2002)
J. Biol. Chem. 277, 18677-18686
 |  Abstract »  |  Full Text »  |  PDF »

Primary Chemoprevention of Familial Adenomatous Polyposis with Sulindac.

F. M. Giardiello, V. W. Yang, L. M. Hylind, A. J. Krush, G. M. Petersen, J. D. Trimbath, S. Piantadosi, E. Garrett, D. E. Geiman, W. Hubbard, et al. (2002)
N. Engl. J. Med. 346, 1054-1059
 |  Abstract »  |  Full Text »  |  PDF »

Selenium-Enriched Broccoli Decreases Intestinal Tumorigenesis in Multiple Intestinal Neoplasia Mice.

C. D. Davis, H. Zeng, and J. W. Finley (2002)
J. Nutr. 132, 307-309
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the Modifier of Min 2 (Mom2) Locus, a New Mutation That Influences Apc-Induced Intestinal Neoplasia.

K. A. Silverman, R. Koratkar, L. D. Siracusa, and A. M. Buchberg (2002)
Genome Res. 12, 88-97
 |  Abstract »  |  Full Text »  |  PDF »

Different Combinations of Biallelic APC Mutation Confer Different Growth Advantages in Colorectal Tumours.

J. P. Cheadle, M. Krawczak, M. W. Thomas, A. K. Hodges, N. Al-Tassan, N. Fleming, and J. R. Sampson (2002)
Cancer Res. 62, 363-366
 |  Abstract »  |  Full Text »  |  PDF »

PGP9.5 as a Marker for Invasive Colorectal Cancer.

T. Yamazaki, K. Hibi, T. Takase, E. Tezel, H. Nakayama, Y. Kasai, K. Ito, S. Akiyama, T. Nagasaka, and A. Nakao (2002)
Clin. Cancer Res. 8, 192-195
 |  Abstract »  |  Full Text »  |  PDF »

Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein.

F. Zhang, R. L. White, and K. L. Neufeld (2001)
Mol. Cell. Biol. 21, 8143-8156
 |  Abstract »  |  Full Text »  |  PDF »

Intestinal Tumorigenesis in Multiple Intestinal Neoplasia Mice Induced by the Food Mutagen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: Perinatal Susceptibility, Regional Variation, and Correlation with DNA Adducts.

I.-L. Steffensen, H. A. J. Schut, J. E. Paulsen, A. Andreassen, and J. Alexander (2001)
Cancer Res. 61, 8689-8696
 |  Abstract »  |  Full Text »  |  PDF »

A silent mutation in exon 14 of the APC gene is associated with exon skipping in a FAP family.

M. Montera, F. Piaggio, C. Marchese, V. Gismondi, A. Stella, N. Resta, L. Varesco, G. Guanti, and C. Mareni (2001)
J. Med. Genet. 38, 863-867
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Polymorphic insertion of additional repeat within an area of direct 8 bp tandem repeats in the 5'-untranslated region of the p53R2 gene and cancer risk.

J. Smeds, R. Kumar, and K. Hemminki (2001)
Mutagenesis 16, 547-550
 |  Abstract »  |  Full Text »  |  PDF »

Genetic alterations and growth pattern in biliary duct carcinomas: loss of heterozygosity at chromosome 5q bears a close relation with polypoid growth.

E Hidaka, A Yanagisawa, M Seki, T Setoguchi, and Y Kato (2001)
Gut 48, 656-659
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Alterations of Gene Expression during Colorectal Carcinogenesis Revealed by cDNA Microarrays after Laser-Capture Microdissection of Tumor Tissues and Normal Epithelia.

O. Kitahara, Y. Furukawa, T. Tanaka, C. Kihara, K. Ono, R. Yanagawa, M. E. Nita, T. Takagi, Y. Nakamura, and T. Tsunoda (2001)
Cancer Res. 61, 3544-3549
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Familial adenomatous polyposis: more evidence for disease diversity and genetic heterogeneity.

R J Scott, C Meldrum, R Crooks, A D Spigelman, J Kirk, K Tucker, D Koorey, and t. H. F. C. Service (2001)
Gut 48, 508-514
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Down-Regulation of {beta}-Catenin TCF Signaling Is Linked to Colonic Epithelial Cell Differentiation.

J. M. Mariadason, M. Bordonaro, F. Aslam, L. Shi, M. Kuraguchi, A. Velcich, and L. H. Augenlicht (2001)
Cancer Res. 61, 3465-3471
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A distinct splice form of APC is highly expressed in neurones but not commonly mutated in neuroepithelial tumours.

K. STEIGERWALD, I. M SANTORO, J. J KORDICH, V. GISMONDI, C. TRZEPACZ, M. BADIALI, F GIANGASPERO, M G. BALKO, J. S GRAHAM, N. RATNER, et al. (2001)
J. Med. Genet. 38, 257-262
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Stabilized {beta}-Catenin Immortalizes Colonic Epithelial Cells.

R. A. Wagenaar, H. C. Crawford, and L. M. Matrisian (2001)
Cancer Res. 61, 2097-2104
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Restoration of Epithelial Cell Polarity in a Colorectal Cancer Cell Line by Suppression of {beta}-catenin/T-Cell Factor 4-mediated Gene Transactivation.

Y. Naishiro, T. Yamada, A. S. Takaoka, R. Hayashi, F. Hasegawa, K. Imai, and S. Hirohashi (2001)
Cancer Res. 61, 2751-2758
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A Mammalian Two-Hybrid System for Adenomatous Polyposis Coli-Mutated Colon Cancer Therapeutics.

K. Wakita, O. Tetsu, and F. McCormick (2001)
Cancer Res. 61, 854-858
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Mammary Tumor Induction and Premature Ovarian Failure in ApcMin Mice Are Not Enhanced by Brca2 Defi ciency.

L. M. Bennett, K. A. Mcallister, T. Ward, J. Malphurs, N. K. Collins, J. C. Seely, B. J. Davis, and R. W. Wiseman (2001)
Toxicol Pathol 29, 117-125
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Differential Genetic Alterations in von Hippel-Lindau Syndrome-Associated and Sporadic Pheochromocytomas.

B. U. Bender, M. Gutsche, S. Gläsker, B. Müller, G. Kirste, C. Eng, and H. P. H. Neumann (2000)
J. Clin. Endocrinol. Metab. 85, 4568-4574
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Organizing Cancer Genetics Programs: The Swiss Model.

G. Pichert and R. A. Stahel (2000)
J. Clin. Oncol. 18, 65s-69
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Transactivation of the Multidrug Resistance 1 Gene by T-Cell Factor 4/{beta}-Catenin Complex in Early Colorectal Carcinogenesis.

T. Yamada, A. S. Takaoka, Y. Naishiro, R. Hayashi, K. Maruyama, C. Maesawa, A. Ochiai, and S. Hirohashi (2000)
Cancer Res. 60, 4761-4766
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Somatic Mutations of the APC Gene in Primary Breast Cancers.

K. Furuuchi, M. Tada, H. Yamada, A. Kataoka, N. Furuuchi, J.-i. Hamada, M. Takahashi, S. Todo, and T. Moriuchi (2000)
Am. J. Pathol. 156, 1997-2005
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Biology of the Adenomatous Polyposis Coli Tumor Suppressor.

K. H. Goss and J. Groden (2000)
J. Clin. Oncol. 18, 1967-1979
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A Novel Non-pathogenetic Polymorphism of the APC Gene in a Patient with Familial Adenomatous Polyposis Coli.

Y. Ogiso, I. Ueno, M. Fujimori, Y. Fukushima, and T. Katsuyama (2000)
Jpn. J. Clin. Oncol. 30, 204-206
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The Relationship Between Frequencies of Extracolonic Manifestations and the Position of APC Germline Mutation in Patients with Familial Adenomatous Polyposis.

M. Enomoto, M. Konishi, T. Iwama, J. Utsunomiya, K.-i. Sugihara, and M. Miyaki (2000)
Jpn. J. Clin. Oncol. 30, 82-88
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Germline Mutations of the APC Gene in Patients with Familial Adenomatous Polyposis-Associated Thyroid Carcinoma: Results from a European Cooperative Study.

F. Cetta, G. Montalto, M. Gori, M. C. Curia, A. Cama, and S. Olschwang (2000)
J. Clin. Endocrinol. Metab. 85, 286-292
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Molecular Genetics of the Hair Follicle: The State of the Art.

M. A. M. van Steensel, R. Happle, and P. M. Steijlen (2000)
Experimental Biology and Medicine 223, 1-7
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APCL, a Central Nervous System-specific Homologue of Adenomatous Polyposis Coli Tumor Suppressor, Binds to p53-binding Protein 2 and Translocates it to the Perinucleus.

H. Nakagawa, K. Koyama, Y. Murata, M. Morito, T. Akiyama, and Y. Nakamura (2000)
Cancer Res. 60, 101-105
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Phase I Trial of Exisulind (Sulindac Sulfone, FGN-1) as a Chemopreventive Agent in Patients with Familial Adenomatous Polyposis.

R. van Stolk, G. Stoner, W. L. Hayton, K. Chan, B. DeYoung, L. Kresty, B. H. Kemmenoe, P. Elson, L. Rybicki, J. Church, et al. (2000)
Clin. Cancer Res. 6, 78-89
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Differential expression of cyclooxygenase 2 in human colorectal cancer.

J Dimberg, A Samuelsson, A Hugander, and P Soderkvist (1999)
Gut 45, 730-732
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A missense mutation in both hMSH2 and APC in an Ashkenazi Jewish HNPCC kindred: implications for clinical screening.

Z. Q. YUAN, N. WONG, W. D FOULKES, L. ALPERT, F. MANGANARO, C. ANDREUTTI-ZAUGG, R. IGGO, K. ANTHONY, E. HSIEH, M. REDSTON, et al. (1999)
J. Med. Genet. 36, 792-793
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Synergy Between Tumor Suppressor APC and the -Catenin-Tcf4 Target Tcf1.

J. Roose, G. Huls, M. v. Beest, P. Moerer, K. v. d. Horn, R. Goldschmeding, T. Logtenberg, and H. Clevers (1999)
Science 285, 1923-1926
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Localization of MCC (Mutated in Colorectal Cancer) in Various Tissues of Mice and Its Involvement in Cell Differentiation.

T. Senda, A. Matsumine, H. Yanai, and T. Akiyama (1999)
J. Histochem. Cytochem. 47, 1149-1158
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Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice.

J. E. Paulsen, I.-L. Steffensen, A. Andreassen, R. Vikse, and J. Alexander (1999)
Carcinogenesis 20, 1277-1282
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