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Science 2 August 1991:
Vol. 253. no. 5019, pp. 568 - 571
DOI: 10.1126/science.1907026
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Articles

Science, Vol 253, Issue 5019, 568-571
Copyright © 1991 by American Association for the Advancement of Science

articles

Visual motion commands for pursuit eye movements in the cerebellum

RJ Krauzlis and SG Lisberger

Department of Physiology, W. M. Keck Foundation Center for Integrative Neurosciences, University of California, San Francisco 94143.

Eye movements that follow a target (pursuit eye movements) facilitate high acuity visual perception of moving targets by transforming visual motion inputs into motor commands that match eye motion to target motion. The performance of pursuit eye movements requires the cerebellar flocculus, which processes both visual motion and oculomotor signals. Electrophysiological recordings from floccular Purkinje cells have allowed the identification of their firing patterns during generation of the image velocity and image acceleration signals used for pursuit. Analysis with a method based on a behavioral model converted the time-varying spike trains of floccular Purkinje cells into a description of the firing rate contributed by three visual motion signals and one oculomotor input. The flocculus encodes all the signals needed to guide pursuit.


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Recasting the Smooth Pursuit Eye Movement System.
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J Neurophysiol 91, 591-603
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Spatial Generalization of Learning in Smooth Pursuit Eye Movements: Implications for the Coordinate Frame and Sites of Learning.
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Gaze-, Eye-, and Head-Movement Dynamics During Closed- and Open-Loop Gaze Pursuit.
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Experimental and Computational Analysis of Monkey Smooth Pursuit Eye Movements.
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Changes in the Responses of Purkinje Cells in the Floccular Complex of Monkeys After Motor Learning in Smooth Pursuit Eye Movements.
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J Neurophysiol 84, 2945-2960
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Deficits of smooth pursuit initiation in patients with degenerative cerebellar lesions.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)