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Science 2 August 1991:
Vol. 253. no. 5019, pp. 551 - 555
DOI: 10.1126/science.1857984
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Articles

Science, Vol 253, Issue 5019, 551-555
Copyright © 1991 by American Association for the Advancement of Science

articles

A component of calcium-activated potassium channels encoded by the Drosophila slo locus

NS Atkinson, GA Robertson, and B Ganetzky

Laboratory of Genetics, University of Wisconsin, Madison 53706.

Calcium-activated potassium channels mediate many biologically important functions in electrically excitable cells. Despite recent progress in the molecular analysis of voltage-activated K+ channels, Ca(2+)-activated K+ channels have not been similarly characterized. The Drosophila slowpoke (slo) locus, mutations of which specifically abolish a Ca(2+)-activated K+ current in muscles and neurons, provides an opportunity for molecular characterization of these channels. Genomic and complementary DNA clones from the slo locus were isolated and sequenced. The polypeptide predicted by slo is similar to voltage-activated K+ channel polypeptides in discrete domains known to be essential for function. Thus, these results indicate that slo encodes a structural component of Ca(2+)-activated K+ channels.


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J. Gen. Physiol. 113, 295-320
   Abstract »    Full Text »    PDF »
Role of the S4 Segment in a Voltage-dependent Calcium-sensitive Potassium (hSlo) Channel.
L. Diaz, P. Meera, J. Amigo, E. Stefani, O. Alvarez, L. Toro, and R. Latorre (1998)
J. Biol. Chem. 273, 32430-32436
   Abstract »    Full Text »    PDF »
Voltage-dependent Gating of Single Wild-Type and S4 Mutant KAT1 Inward Rectifier Potassium Channels.
P. C. Zei and R. W. Aldrich (1998)
J. Gen. Physiol. 112, 679-713
   Abstract »    Full Text »    PDF »
Modulation of a calcium-sensitive nonspecific cation channel by closely associated protein kinase and phosphatase activities.
G. F. Wilson, N. S. Magoski, and L. K. Kaczmarek (1998)
PNAS 95, 10938-10943
   Abstract »    Full Text »    PDF »
Ion channels in microglia (brain macrophages).
C. Eder (1998)
Am J Physiol Cell Physiol 275, C327-C342
   Abstract »    Full Text »    PDF »
Glomerular Mesangial Cells: Electrophysiology and Regulation of Contraction.
J. D. STOCKAND and S. C. SANSOM (1998)
Physiol Rev 78, 723-744
   Abstract »    Full Text »    PDF »
Courtship and Visual Defects of cacophony Mutants Reveal Functional Complexity of a Calcium-Channel {alpha}1 Subunit in Drosophila.
L. A. Smith, A. A. Peixoto, E. M. Kramer, A. Villella, and J. C. Hall (1998)
Genetics 149, 1407-1426
   Abstract »    Full Text »    PDF »
Reconstitution of beta -Adrenergic Modulation of Large Conductance, Calcium-activated Potassium (Maxi-K) Channels in Xenopus Oocytes. IDENTIFICATION OF THE cAMP-DEPENDENT PROTEIN KINASE PHOSPHORYLATION SITE.
M. Nara, P. D. K. Dhulipala, Y.-X. Wang, and M. I. Kotlikoff (1998)
J. Biol. Chem. 273, 14920-14924
   Abstract »    Full Text »    PDF »


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