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Science 19 July 1991:
Vol. 253. no. 5017, pp. 317 - 320
DOI: 10.1126/science.1857968
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Articles

Science, Vol 253, Issue 5017, 317-320
Copyright © 1991 by American Association for the Advancement of Science

articles

Deleted HTLV-I provirus in blood and cutaneous lesions of patients with mycosis fungoides

WW Hall, CR Liu, O Schneewind, H Takahashi, MH Kaplan, G Roupe, and A Vahlne

Division of Infectious Disease, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030.

Mycosis fungoides, a rare form of cutaneous T cell leukemia/lymphoma, is suspected of having a viral etiology on the basis of certain similarities to adult T cell leukemia, which is associated with human T cell leukemia/lymphoma virus type I (HTLV-I) infection. Cell lines were established from peripheral blood mononuclear cells (PBMC) of an HTLV-I-seronegative patient with mycosis fungoides. DNA hybridization analysis revealed the presence of HTLV-I-related sequences with unusual restriction endonuclease sites. Sequence analysis of subcloned fragments demonstrated the presence of a monoclonally integrated provirus with a 5.5-kilobase deletion involving large regions of gag and env and all of pol. Additional evidence for the presence of deleted proviruses was found by polymerase chain reaction (PCR) amplification of DNA from cutaneous lesions of five other HTLV-I-seronegative patients. The findings suggest that HTLV-I infection may be involved in the etiology of at least certain cases of mycosis fungoides.


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Response.
W. W. Hall (1993)
Science 259, 1471
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