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Science 12 July 1991:
Vol. 253. no. 5016, pp. 194 - 196
DOI: 10.1126/science.1677215

Articles

Science, Vol 253, Issue 5016, 194-196
Copyright © 1991 by American Association for the Advancement of Science


articles

Organizer-specific homeobox genes in Xenopus laevis embryos

B Blumberg, CV Wright, EM De Robertis, and KW Cho

Department of Biological Chemistry, University of California, Los Angeles 90024.

The dorsal blastopore lip of the early Xenopus laevis gastrula can organize a complete secondary body axis when transplanted to another embryo. A search for potential gene regulatory components specifically expressed in the organizer was undertaken that resulted in the identification of four types of complementary DNAs from homeobox-containing genes that fulfill this criterion. The most abundant of these encodes a DNA-binding specificity similar to that of the Drosophila melanogaster anterior morphogen bicoid. The other three are also homologous to developmentally significant Drosophila genes. These four genes may participate in the regulation of the developmental potential of the organizer.


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   Abstract »    PDF »
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P. Crossley and G. Martin (1995)
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Vertebrate embryonic induction: mesodermal and neural patterning.
D. Kessler and D. Melton (1994)
Science 266, 596-604
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Heparan sulfate proteoglycans are required for mesoderm formation in Xenopus embryos.
K. Itoh and S. Y. Sokol (1994)
Development 120, 2703-2711
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Conversion of a mesodermalizing molecule, the Xenopus Brachyury gene, into a neuralizing factor..
Y Rao (1994)
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Mesodermal patterning by a gradient of the vertebrate homeobox gene goosecoid.
C Niehrs, H Steinbeisser, and E. De Robertis (1994)
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Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern.
J. Green, J. Smith, and J. Gerhart (1994)
Development 120, 2271-2278
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Morphological differences in Xenopus embryonic mesodermal cells are specified as an early response to distinct threshold concentrations of activin.
K Symes, C Yordan, and M Mercola (1994)
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The cleavage stage origin of Spemann's Organizer: analysis of the movements of blastomere clones before and during gastrulation in Xenopus.
D. Bauer, S Huang, and S. Moody (1994)
Development 120, 1179-1189
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Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos.
S Schulte-Merker, M Hammerschmidt, D Beuchle, K. Cho, E. De Robertis, and C Nusslein-Volhard (1994)
Development 120, 843-852
   Abstract »    PDF »
Activin-mediated mesoderm induction requires FGF.
R. Cornell and D Kimelman (1994)
Development 120, 453-462
   Abstract »    PDF »
Primitive streak mesoderm-like cell lines expressing Pax-3 and Hox gene autoinducing activities.
S. Pruitt (1994)
Development 120, 37-47
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Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos.
C. Thisse, B. Thisse, T. F. Schilling, and J. H. Postlethwait (1993)
Development 119, 1203-1215
   Abstract »    PDF »
Cooperative dimerization of paired class homeo domains on DNA..
D Wilson, G Sheng, T Lecuit, N Dostatni, and C Desplan (1993)
Genes & Dev. 7, 2120-2134
   Abstract »    PDF »
Neural induction by the secreted polypeptide noggin.
T. Lamb, A. Knecht, W. Smith, S. Stachel, A. Economides, N Stahl, G. Yancopolous, and R. Harland (1993)
Science 262, 713-718
   Abstract »    PDF »
Later embryogenesis: regulatory circuitry in morphogenetic fields.
E. Davidson (1993)
Development 118, 665-690
   Abstract »    PDF »
Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs.
H Steinbeisser, E. De Robertis, M Ku, D. Kessler, and D. Melton (1993)
Development 118, 499-507
   Abstract »    PDF »
The chicken CdxA homeobox gene and axial positioning during gastrulation.
A Frumkin, R Haffner, E Shapira, N Tarcic, Y Gruenbaum, and A Fainsod (1993)
Development 118, 553-562
   Abstract »    PDF »
Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.
H Sasaki and B. Hogan (1993)
Development 118, 47-59
   Abstract »    PDF »
Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall.
S. Gaunt, M Blum, and E. De Robertis (1993)
Development 117, 769-778
   Abstract »    PDF »
The frog prince-ss: a molecular formula for dorsoventral patterning in Xenopus..
H L Sive (1993)
Genes & Dev. 7, 1-12
   PDF »
Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus..
J L Christian and R T Moon (1993)
Genes & Dev. 7, 13-28
   Abstract »    PDF »
Mouse Cdx-1 expression during gastrulation.
B. I. Meyer and P. Gruss (1993)
Development 117, 191-203
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Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor.
D. A. Grueneberg, S. Natesan, C. Alexandre, and M. Z. Gilman (1992)
Science 257, 1089-1095
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A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain..
M L Dirksen and M Jamrich (1992)
Genes & Dev. 6, 599-608
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The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos..
M Taira, M Jamrich, P J Good, and I B Dawid (1992)
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Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis.
A Ruiz i Altaba and T. Jessell (1992)
Development 116, 81-93
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A Gene Expression Screen in Zebrafish Embryogenesis.
T. Kudoh, M. Tsang, N. A. Hukriede, X. Chen, M. Dedekian, C. J. Clarke, A. Kiang, S. Schultz, J. A. Epstein, R. Toyama, et al. (2001)
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