Science 12 July 1991: Vol. 253. no. 5016, pp. 157 - 163 DOI: 10.1126/science.1853200

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Articles

Structure and Functional Studies of the CS Domain of the Essential H/ACA Ribonucleoparticle Assembly Protein SHQ1.

M. Singh, F. A. Gonzales, D. Cascio, N. Heckmann, G. Chanfreau, and J. Feigon (2009)
J. Biol. Chem. 284, 1906-1916
 |  Abstract »  |  Full Text »  |  PDF »

Insect small nuclear RNA gene promoters evolve rapidly yet retain conserved features involved in determining promoter activity and RNA polymerase specificity.

G. Hernandez Jr, F. Valafar, and W. E. Stumph (2007)
Nucleic Acids Res. 35, 21-34
 |  Abstract »  |  Full Text »  |  PDF »

The architecture of pre-mRNAs affects mechanisms of splice-site pairing.

K. L. Fox-Walsh, Y. Dou, B. J. Lam, S.-p. Hung, P. F. Baldi, and K. J. Hertel (2005)
PNAS 102, 16176-16181
 |  Abstract »  |  Full Text »  |  PDF »

Insights into the mechanisms of splicing: more lessons from the ribosome.

M. M. Konarska and C. C. Query (2005)
Genes & Dev. 19, 2255-2260
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Serine-Arginine-rich Protein p30 Directs Alternative Splicing of Glucocorticoid Receptor Pre-mRNA to Glucocorticoid Receptor {beta} in Neutrophils.

Q. Xu, D. Y. M. Leung, and K. O. Kisich (2003)
J. Biol. Chem. 278, 27112-27118
 |  Abstract »  |  Full Text »  |  PDF »

Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins.

R. Lemaire, J. Prasad, T. Kashima, J. Gustafson, J. L. Manley, and R. Lafyatis (2002)
Genes & Dev. 16, 594-607
 |  Abstract »  |  Full Text »  |  PDF »

Functional and physical interactions between components of the Prp19p-associated complex.

C.-H. Chen, W.-C. Yu, T. Y. Tsao, L.-Y. Wang, H.-R. Chen, J.-Y. Lin, W.-Y. Tsai, and S.-C. Cheng (2002)
Nucleic Acids Res. 30, 1029-1037
 |  Abstract »  |  Full Text »  |  PDF »

Novel Human Secreted Phospholipase A2 with Homology to the Group III Bee Venom Enzyme.

E. Valentin, F. Ghomashchi, M. H. Gelb, M. Lazdunski, and G. Lambeau (2000)
J. Biol. Chem. 275, 7492-7496
 |  Abstract »  |  Full Text »  |  PDF »

Extensive Genetic Interactions Between PRP8 and PRP17/CDC40, Two Yeast Genes Involved in Pre-mRNA Splicing and Cell Cycle Progression.

S. Ben-Yehuda, C. S. Russell, I. Dix, J. D. Beggs, and M. Kupiec (2000)
Genetics 154, 61-71
 |  Abstract »  |  Full Text »

An SC35-like Protein and a Novel Serine/Arginine-rich Protein Interact with Arabidopsis U1-70K Protein.

M. Golovkin and A. S. N. Reddy (1999)
J. Biol. Chem. 274, 36428-36438
 |  Abstract »  |  Full Text »  |  PDF »

A Mutation in a Methionine tRNA Gene Suppresses the prp2-1 Ts Mutation and Causes a Pre-mRNA Splicing Defect in Saccharomyces cerevisiae.

D.-H. Kim, G. Edwalds-Gilbert, C. Ren, and R.-J. Lin (1999)
Genetics 153, 1105-1115
 |  Abstract »  |  Full Text »

spp42, Identified as a Classical Suppressor of prp4-73, Which Encodes a Kinase Involved in Pre-mRNA Splicing in Fission Yeast, Is a Homologue of the Splicing Factor Prp8p.

H. Schmidt, K. Richert, R. A. Drakas, and N. F. Käufer (1999)
Genetics 153, 1183-1191
 |  Abstract »  |  Full Text »

Snt309p modulates interactions of Prp19p with its associated components to stabilize the Prp19p-associated complex essential for pre-mRNA splicing.

H.-R. Chen, T. Y. Tsao, C.-H. Chen, W.-Y. Tsai, L.-S. Her, M. M.-T. Hsu, and S.-C. Cheng (1999)
PNAS 96, 5406-5411
 |  Abstract »  |  Full Text »  |  PDF »

Cef1p Is a Component of the Prp19p-associated Complex and Essential for Pre-mRNA Splicing.

W.-Y. Tsai, Y-T. Chow, H.-R. Chen, K.-T. Huang, R.-I Hong, S.-P. Jan, N.-Y. Kuo, T. Y. Tsao, C.-H. Chen, and S.-C. Cheng (1999)
J. Biol. Chem. 274, 9455-9462
 |  Abstract »  |  Full Text »  |  PDF »

Pseudouridine Mapping in the Saccharomyces cerevisiae Spliceosomal U Small Nuclear RNAs (snRNAs) Reveals that Pseudouridine Synthase Pus1p Exhibits a Dual Substrate Specificity for U2 snRNA and tRNA.

S. Massenet, Y. Motorin, D. L. J. Lafontaine, E. C. Hurt, H. Grosjean, and C. Branlant (1999)
Mol. Cell. Biol. 19, 2142-2154
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Isoform of the Mitochondrial Outer Membrane Protein VDAC3 via Alternative Splicing of a 3-Base Exon. FUNCTIONAL CHARACTERISTICS AND SUBCELLULAR LOCALIZATION.

M. J. Sampson, L. Ross, W. K. Decker, and W. J. Craigen (1998)
J. Biol. Chem. 273, 30482-30486
 |  Abstract »  |  Full Text »  |  PDF »

The Plant U1 Small Nuclear Ribonucleoprotein Particle 70K Protein Interacts with Two Novel Serine/Arginine –Rich Proteins.

M. Golovkin and A. S. N. Reddy (1998)
PLANT CELL 10, 1637-1648
 |  Abstract »  |  Full Text »

Isolation, Structural Characterization, and Chromosomal Mapping of the Mouse Vascular Adhesion Protein-1 Gene and Promoter.

P. Bono, M. Salmi, D. J. Smith, I. Leppanen, N. Horelli-Kuitunen, A. Palotie, and S. Jalkanen (1998)
J. Immunol. 161, 2953-2960
 |  Abstract »  |  Full Text »  |  PDF »

NS1-Binding Protein (NS1-BP): a Novel Human Protein That Interacts with the Influenza A Virus Nonstructural NS1 Protein Is Relocalized in the Nuclei of Infected Cells.

T. Wolff, R. E. O'Neill, and P. Palese (1998)
J. Virol. 72, 7170-7180
 |  Abstract »  |  Full Text »  |  PDF »

A Role for SRp54 during Intron Bridging of Small Introns with Pyrimidine Tracts Upstream of the Branch Point.

C. F. Kennedy, A. Krämer, and S. M. Berget (1998)
Mol. Cell. Biol. 18, 5425-5434
 |  Abstract »  |  Full Text »

Snt309p, a Component of the Prp19p-Associated Complex That Interacts with Prp19p and Associates with the Spliceosome Simultaneously with or Immediately after Dissociation of U4 in the Same Manner as Prp19p.

H.-R. Chen, S.-P. Jan, T. Y. Tsao, Y.-J. Sheu, J. Banroques, and S.-C. Cheng (1998)
Mol. Cell. Biol. 18, 2196-2204
 |  Abstract »  |  Full Text »

Sip1, a Novel RS Domain-Containing Protein Essential for Pre-mRNA Splicing.

W.-J. Zhang and J. Y. Wu (1998)
Mol. Cell. Biol. 18, 676-684
 |  Abstract »  |  Full Text »

Yeast Pre-mRNA Splicing Requires a Pair of U1 snRNP-Associated Tetratricopeptide Repeat Proteins.

M. R. McLean and B. C. Rymond (1998)
Mol. Cell. Biol. 18, 353-360
 |  Abstract »  |  Full Text »

U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction..

J Fleckner, M Zhang, J Valcarcel, and M R Green (1997)
Genes & Dev. 11, 1864-1872
 |  Abstract »  |  PDF »

Dynamics of the U1 Small Nuclear Ribonucleoprotein during Yeast Spliceosome Assembly.

S. W. Ruby (1997)
J. Biol. Chem. 272, 17333-17341
 |  Abstract »  |  Full Text »  |  PDF »

Cloning of Human 2H9 Heterogeneous Nuclear Ribonucleoproteins. RELATION WITH SPLICING AND EARLY HEAT SHOCK-INDUCED SPLICING ARREST.

D. Mahe, P. Mahl, R. Gattoni, N. Fischer, M.-G. Mattei, J. Stevenin, and J.-P. Fuchs (1997)
J. Biol. Chem. 272, 1827-1836
 |  Abstract »  |  Full Text »  |  PDF »

SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract.

A. M. MacMillan, P. S. McCaw, J. D. Crispino, and P. A. Sharp (1997)
PNAS 94, 133-136
 |  Abstract »  |  Full Text »  |  PDF »

Architectural limits on split genes.

D. A. Sterner, T. Carlo, and S. M. Berget (1996)
PNAS 93, 15081-15085
 |  Abstract »  |  Full Text »  |  PDF »

The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20, the small subunit of the nuclear cap-binding complex..

H V Colot, F Stutz, and M Rosbash (1996)
Genes & Dev. 10, 1699-1708
 |  Abstract »  |  PDF »

Evidence of Post-transcriptional Regulation of U6 Small Nuclear RNA.

S. B. Noonberg, G. K. Scott, and C. C. Benz (1996)
J. Biol. Chem. 271, 10477-10481
 |  Abstract »  |  Full Text »  |  PDF »

A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome..

M Ohno and Y Shimura (1996)
Genes & Dev. 10, 997-1007
 |  Abstract »  |  PDF »

Functionally redundant interactions between U2 and U6 spliceosomal snRNAs..

D J Field and J D Friesen (1996)
Genes & Dev. 10, 489-501
 |  Abstract »  |  PDF »

In Vitro Splicing Deficiency Induced by a C to T Mutation at Position -3 in the Intron 10 Acceptor Site of the Phenylalanine Hydroxylase Gene in a Patient with Phenylketonuria.

J. Jaruzelska, V. Abadie, Y. d'Aubenton-Carafa, E. Brody, A. Munnich, and J.ël. Marie (1995)
J. Biol. Chem. 270, 20370-20375
 |  Abstract »  |  Full Text »  |  PDF »

A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing..

J S Sun and J L Manley (1995)
Genes & Dev. 9, 843-854
 |  Abstract »  |  PDF »

A novel role for a U5 snRNP protein in 3' splice site selection..

J G Umen and C Guthrie (1995)
Genes & Dev. 9, 855-868
 |  Abstract »  |  PDF »

Exon Recognition in Vertebrate Splicing.

S. M. Berget and S. M. Berget (1995)
J. Biol. Chem. 270, 2411-2414
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Dynamic association of proteins with the pre-mRNA branch region..

A M MacMillan, C C Query, C R Allerson, S Chen, G L Verdine, and P A Sharp (1994)
Genes & Dev. 8, 3008-3020
 |  Abstract »  |  PDF »

The stereochemical course of group II intron self-splicing.

R. Padgett, M Podar, S. Boulanger, and P. Perlman (1994)
Science 266, 1685-1688
 |  Abstract »  |  PDF »

SR proteins can compensate for the loss of U1 snRNP functions in vitro..

W Y Tarn and J A Steitz (1994)
Genes & Dev. 8, 2704-2717
 |  Abstract »  |  PDF »

Chromosome end games.

T. Cech (1994)
Science 266, 387-388
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Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP.

J. Crispino, B. Blencowe, and P. Sharp (1994)
Science 265, 1866-1869
 |  Abstract »  |  PDF »

Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing..

J A Epstein, T Glaser, J Cai, L Jepeal, D S Walton, and R L Maas (1994)
Genes & Dev. 8, 2022-2034
 |  Abstract »  |  PDF »

U4/U5/U6 snRNP recognizes the 5' splice site in the absence of U2 snRNP..

B B Konforti and M M Konarska (1994)
Genes & Dev. 8, 1962-1973
 |  Abstract »  |  PDF »

Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI..

C W Siebel, R Kanaar, and D C Rio (1994)
Genes & Dev. 8, 1713-1725
 |  Abstract »  |  PDF »

A group III intron is formed from domains of two individual group II introns..

L Hong and R B Hallick (1994)
Genes & Dev. 8, 1589-1599
 |  Abstract »  |  PDF »

A tertiary interaction in the Tetrahymena intron contributes to selection of the 5' splice site..

W D Downs and T R Cech (1994)
Genes & Dev. 8, 1198-1211
 |  Abstract »  |  PDF »

Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome..

H D Madhani and C Guthrie (1994)
Genes & Dev. 8, 1071-1086
 |  Abstract »  |  PDF »

Isolation of S. cerevisiae snRNPs: comparison of U1 and U4/U6.U5 to their human counterparts.

P Fabrizio, S Esser, B Kastner, and R Luhrmann (1994)
Science 264, 261-265
 |  Abstract »  |  PDF »

The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP addition..

N Abovich, X C Liao, and M Rosbash (1994)
Genes & Dev. 8, 843-854
 |  Abstract »  |  PDF »

Branch nucleophile selection in pre-mRNA splicing: evidence for the bulged duplex model..

C C Query, M J Moore, and P A Sharp (1994)
Genes & Dev. 8, 587-597
 |  Abstract »  |  PDF »

Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation..

D Nesic and L E Maquat (1994)
Genes & Dev. 8, 363-375
 |  Abstract »  |  PDF »

A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing..

D M Fortner, R G Troy, and D A Brow (1994)
Genes & Dev. 8, 221-233
 |  Abstract »  |  PDF »

Alternative pre-mRNA splicing: factors involved in splice site selection.

P. Norton (1994)
J. Cell Sci. 107, 1-7
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Mutations in U6 snRNA that alter splice site specificity: implications for the active site.

C. Lesser and C Guthrie (1993)
Science 262, 1982-1988
 |  Abstract »  |  PDF »

The U5 and U6 small nuclear RNAs as active site components of the spliceosome.

E. Sontheimer and J. Steitz (1993)
Science 262, 1989-1996
 |  Abstract »  |  PDF »

Involvement of U6 snRNA in 5' splice site selection.

S Kandels-Lewis and B Seraphin (1993)
Science 262, 2035-2039
 |  Abstract »  |  PDF »

A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding..

A Lavigueur, H La Branche, A R Kornblihtt, and B Chabot (1993)
Genes & Dev. 7, 2405-2417
 |  Abstract »  |  PDF »

The conserved pre-mRNA splicing factor U2AF from Drosophila: requirement for viability.

R Kanaar, S. Roche, E. Beall, M. Green, and D. Rio (1993)
Science 262, 569-573
 |  Abstract »  |  PDF »

Four yeast spliceosomal proteins (PRP5, PRP9, PRP11, and PRP21) interact to promote U2 snRNP binding to pre-mRNA..

S W Ruby, T H Chang, and J Abelson (1993)
Genes & Dev. 7, 1909-1925
 |  Abstract »  |  PDF »

Conformational changes of U6 RNA during the spliceosome cycle: an intramolecular helix is essential both for initiating the U4-U6 interaction and for the first step of slicing..

T Wolff and A Bindereif (1993)
Genes & Dev. 7, 1377-1389
 |  Abstract »  |  PDF »

Interactions between PRP9 and SPP91 splicing factors identify a protein complex required in prespliceosome assembly..

P Legrain, C Chapon, and F Galisson (1993)
Genes & Dev. 7, 1390-1399
 |  Abstract »  |  PDF »

A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals..

S Michaud and R Reed (1993)
Genes & Dev. 7, 1008-1020
 |  Abstract »  |  PDF »

Movement of the guide sequence during RNA catalysis by a group I ribozyme.

J. Wang, W. Downs, and T. Cech (1993)
Science 260, 504-508
 |  Abstract »  |  PDF »

Association with terminal exons in pre-mRNAs: a new role for the U1 snRNP?.

K M Wassarman and J A Steitz (1993)
Genes & Dev. 7, 647-659
 |  Abstract »  |  PDF »

Cloning and characterization of PSF, a novel pre-mRNA splicing factor..

J G Patton, E B Porro, J Galceran, P Tempst, and B Nadal-Ginard (1993)
Genes & Dev. 7, 393-406
 |  Abstract »  |  PDF »

An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing..

X C Liao, J Tang, and M Rosbash (1993)
Genes & Dev. 7, 419-428
 |  Abstract »  |  PDF »

Stages in the second reaction of pre-mRNA splicing: the final step is ATP independent..

D S Horowitz and J Abelson (1993)
Genes & Dev. 7, 320-329
 |  Abstract »  |  PDF »

Interaction of U6 snRNA with a sequence required for function of the nematode SL RNA in trans-splicing.

G. Hannon, P. Maroney, Y. Yu, G. Hannon, and T. Nilsen (1992)
Science 258, 1775-1780
 |  Abstract »  |  PDF »

Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing..

J R Wyatt, E J Sontheimer, and J A Steitz (1992)
Genes & Dev. 6, 2542-2553
 |  Abstract »  |  PDF »

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon..

B E Hoffman and P J Grabowski (1992)
Genes & Dev. 6, 2554-2568
 |  Abstract »  |  PDF »

An essential splicing factor, SLU7, mediates 3' splice site choice in yeast..

D Frank and C Guthrie (1992)
Genes & Dev. 6, 2112-2124
 |  Abstract »  |  PDF »

Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure..

W Forrester, F Stutz, M Rosbash, and M Wickens (1992)
Genes & Dev. 6, 1914-1926
 |  Abstract »  |  PDF »

Protein components specifically associated with prespliceosome and spliceosome complexes..

M Bennett, S Michaud, J Kingston, and R Reed (1992)
Genes & Dev. 6, 1986-2000
 |  Abstract »  |  PDF »

Splicing takes a holliday.

J. Steitz (1992)
Science 257, 888-889
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Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites.

M. Moore and P. Sharp (1992)
Science 256, 992-997
 |  Abstract »  |  PDF »

A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation..

C F Hardy, L Sussel, and D Shore (1992)
Genes & Dev. 6, 801-814
 |  Abstract »  |  PDF »

A splicing factor that is inactivated during in vivo heat shock is functionally equivalent to the [U4/U6.U5] triple snRNP-specific proteins..

U Utans, S E Behrens, R Luhrmann, R Kole, and A Kramer (1992)
Genes & Dev. 6, 631-641
 |  Abstract »  |  PDF »

Cyclic 2',3'-phosphates and nontemplated nucleotides at the 3' end of spliceosomal U6 small nuclear RNA's.

E Lund and J. Dahlberg (1992)
Science 255, 327-330
 |  Abstract »  |  PDF »

Efficient association of U2 snRNPs with pre-mRNA requires an essential U2 RNA structural element..

M I Zavanelli and M Ares (1991)
Genes & Dev. 5, 2521-2533
 |  Abstract »  |  PDF »

Identification and Characterization of Two Novel Components of The Prp19p-associated Complex, Ntc30p and Ntc20p.

C.-H. Chen, W.-Y. Tsai, H.-R. Chen, C.-H. Wang, and S.-C. Cheng (2001)
J. Biol. Chem. 276, 488-494
 |  Abstract »  |  Full Text »  |  PDF »

New Roles for the Snp1 and Exo84 Proteins in Yeast Pre-mRNA Splicing.

S. Awasthi, R. Palmer, M. Castro, C. D. Mobarak, and S. W. Ruby (2001)
J. Biol. Chem. 276, 31004-31015
 |  Abstract »  |  Full Text »  |  PDF »

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