Science 5 July 1991: Vol. 253. no. 5015, pp. 79 - 82 DOI: 10.1126/science.1676542

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Articles

Prognostic and oncogenic relevance of TLX1/HOX11 expression level in T-ALLs.

J. Bergeron, E. Clappier, I. Radford, A. Buzyn, C. Millien, G. Soler, P. Ballerini, X. Thomas, J. Soulier, H. Dombret, et al. (2007)
Blood 110, 2324-2330
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Molecular Genetics of Acute Lymphoblastic Leukemia.

S. A. Armstrong and A. T. Look (2005)
J. Clin. Oncol. 23, 6306-6315
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T Cell Leukemia-1 Modulates TCR Signal Strength and IFN-{gamma} Levels through Phosphatidylinositol 3-Kinase and Protein Kinase C Pathway Activation.

K. K. Hoyer, M. Herling, K. Bagrintseva, D. W. Dawson, S. W. French, M. Renard, J. G. Weinger, D. Jones, and M. A. Teitell (2005)
J. Immunol. 175, 864-873
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Diabetes and Stem Cell Researchers Turn to the Lowly Spleen.

S. Kodama, M. Davis, and D. L. Faustman (2005)
Sci. Aging Knowl. Environ. 2005, pe2
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Age-related phenotypic and oncogenic differences in T-cell acute lymphoblastic leukemias may reflect thymic atrophy.

V. Asnafi, K. Beldjord, M. Libura, P. Villarese, C. Millien, P. Ballerini, E. Kuhlein, M. Lafage-Pochitaloff, E. Delabesse, O. Bernard, et al. (2004)
Blood 104, 4173-4180
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Pbx3 Deficiency Results in Central Hypoventilation.

J. W. Rhee, A. Arata, L. Selleri, Y. Jacobs, S. Arata, H. Onimaru, and M. L. Cleary (2004)
Am. J. Pathol. 165, 1343-1350
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Activation of the T-Cell Oncogene LMO2 after Gene Therapy for X-Linked Severe Combined Immunodeficiency.

M. P. McCormack and T. H. Rabbitts (2004)
N. Engl. J. Med. 350, 913-922
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Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.

H. Cave, S. Suciu, C. Preudhomme, B. Poppe, A. Robert, A. Uyttebroeck, M. Malet, P. Boutard, Y. Benoit, L. Mauvieux, et al. (2004)
Blood 103, 442-450
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A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24.

X. J. de Mollerat, F. Gurrieri, C. T. Morgan, E. Sangiorgi, D. B. Everman, P. Gaspari, J. Amiel, M. J. Bamshad, R. Lyle, J.-L. Blouin, et al. (2003)
Hum. Mol. Genet. 12, 1959-1971
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Specific homeodomain-DNA interactions are required for HOX11-mediated transformation.

B. M. Owens, Y.-X. Zhu, T.-C. Suen, P.-X. Wang, J. F. Greenblatt, P. E. Goss, and R. G. Hawley (2003)
Blood 101, 4966-4974
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Homeobox Protein, Hmx3, in Postnatally Developing Rat Submandibular Glands.

P. A. Shaw, X. Zhang, A. F. Russo, B. A. Amendt, S. Henderson, and V. Williams (2003)
J. Histochem. Cytochem. 51, 385-396
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Immortalization of yolk sac-derived precursor cells.

W.-M. Yu, T. S. Hawley, R. G. Hawley, and C.-K. Qu (2002)
Blood 100, 3828-3831
 |  Abstract »  |  Full Text »  |  PDF »

HOX and Non-HOX Homeobox Genes in Leukemic Hematopoiesis.

B. M. Owens and R. G. Hawley (2002)
Stem Cells 20, 364-379
 |  Abstract »  |  Full Text »  |  PDF »

Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1.

Y. Qian, S. Shirasawa, C.-L. Chen, L. Cheng, and Q. Ma (2002)
Genes & Dev. 16, 1220-1233
 |  Abstract »  |  Full Text »  |  PDF »

Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3.

Y. Qian, B. Fritzsch, S. Shirasawa, C.-L. Chen, Y. Choi, and Q. Ma (2001)
Genes & Dev. 15, 2533-2545
 |  Abstract »  |  Full Text »  |  PDF »

The HoxB1 hexapeptide is a prefolded domain: Implications for the Pbx1/Hox interaction.

C. M. Slupsky, D. B. Sykes, G. L. Gay, and B. D. Sykes (2001)
Protein Sci. 10, 1244-1253
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Altered HOX and WNT7A expression in human lung cancer.

R. Calvo, J. West, W. Franklin, P. Erickson, L. Bemis, E. Li, B. Helfrich, P. Bunn, J. Roche, E. Brambilla, et al. (2000)
PNAS 97, 12776-12781
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Diagnostic Approach to Non-Hodgkin's Lymphoma.

D. A. Arber (2000)
J. Mol. Diagn. 2, 178-190
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Hoxa9 Immortalizes a Granulocyte-Macrophage Colony-Stimulating Factor-Dependent Promyelocyte Capable of Biphenotypic Differentiation to Neutrophils or Macrophages, Independent of Enforced Meis Expression.

K. R. Calvo, D. B. Sykes, M. Pasillas, and M. P. Kamps (2000)
Mol. Cell. Biol. 20, 3274-3285
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An Enhancer Element for Expression of the Ncx (Enx, Hox11L1) Gene in Neural Crest-derived Cells.

Y. Iitsuka, H. Shimizu, M. M. Kang, K. Sasagawa, S. Sekiya, T. Tokuhisa, and M. Hatano (1999)
J. Biol. Chem. 274, 24401-24407
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Constitutive HOXA5 Expression Inhibits Erythropoiesis and Increases Myelopoiesis From Human Hematopoietic Progenitors.

G. M. Crooks, J. Fuller, D. Petersen, P. Izadi, P. Malik, P. K. Pattengale, D. B. Kohn, and J. C. Gasson (1999)
Blood 94, 519-528
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NUP98 Is Fused to PMX1 Homeobox Gene in Human Acute Myelogenous Leukemia With Chromosome Translocation t(1;11)(q23;p15).

T. Nakamura, Y. Yamazaki, Y. Hatano, and I. Miura (1999)
Blood 94, 741-747
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Fusion of ETV6 to the Caudal-Related Homeobox Gene CDX2 in Acute Myeloid Leukemia With the t(12;13)(p13;q12).

A. Chase, A. Reiter, L. Burci, G. Cazzaniga, A. Biondi, J. Pickard, I. A.G. Roberts, J. M. Goldman, and N. C.P. Cross (1999)
Blood 93, 1025-1031
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The T-Cell Oncogenic Protein HOX11 Activates Aldh1 Expression in NIH 3T3 Cells but Represses Its Expression in Mouse Spleen Development.

W. K. Greene, S. Bahn, N. Masson, and T. H. Rabbitts (1998)
Mol. Cell. Biol. 18, 7030-7037
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A model for spontaneous B-lineage lymphomas in IgHµ-HOX11 transgenic mice.

M. R. Hough, M. D. Reis, R. Singaraja, D. M. Bryce, S. Kamel-Reid, I. Dardick, M. L. Breitman, and I. D. Dube (1998)
PNAS 95, 13853-13858
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Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: A possible mechanism of breast carcinogenesis.

H. L. Ford, E. N. Kabingu, E. A. Bump, G. L. Mutter, and A. B. Pardee (1998)
PNAS 95, 12608-12613
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Association of the TLX-2 Homeodomain and 14-3-3eta Signaling Proteins.

S. J. Tang, T.-C. Suen, R. R. McInnes, and M. Buchwald (1998)
J. Biol. Chem. 273, 25356-25363
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LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes.

T. H. Rabbitts (1998)
Genes & Dev. 12, 2651-2657
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Tlx-1 and Tlx-3 Homeobox Gene Expression in Cranial Sensory Ganglia and Hindbrain of the Chick Embryo: Markers of Patterned Connectivity.

C. Logan, R. J. T. Wingate, I. J. McKay, and A. Lumsden (1998)
J. Neurosci. 18, 5389-5402
 |  Abstract »  |  Full Text »  |  PDF »

Multiplex Reverse Transcription-Polymerase Chain Reaction for Simultaneous Screening of 29 Translocations and Chromosomal Aberrations in Acute Leukemia.

N. Pallisgaard, P. Hokland, D. C. Riishoj, B. Pedersen, and P. Jorgensen (1998)
Blood 92, 574-588
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BAZF, a Novel Bcl6 Homolog, Functions as a Transcriptional Repressor.

S. Okabe, T. Fukuda, K. Ishibashi, S. Kojima, S. Okada, M. Hatano, M. Ebara, H. Saisho, and T. Tokuhisa (1998)
Mol. Cell. Biol. 18, 4235-4244
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Optimal Activation of an Endogenous Gene by HOX11 Requires the NH2-Terminal 50 Amino Acids.

N. Masson, W. K. Greene, and T. H. Rabbitts (1998)
Mol. Cell. Biol. 18, 3502-3508
 |  Abstract »  |  Full Text »

Clinical Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia.

S. Faderl, H. M. Kantarjian, M. Talpaz, and Z. Estrov (1998)
Blood 91, 3995-4019
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A Conserved C-terminal Domain in PBX Increases DNA Binding by the PBX Homeodomain and Is Not a Primary Site of Contact for the YPWM Motif of HOXA1.

N. C. Green, I. Rambaldi, J. Teakles, and M. S. Featherstone (1998)
J. Biol. Chem. 273, 13273-13279
 |  Abstract »  |  Full Text »  |  PDF »

Biology and Treatment of Childhood T-Lineage Acute Lymphoblastic Leukemia.

F. M. Uckun, M. G. Sensel, L. Sun, P. G. Steinherz, M. E. Trigg, N. A. Heerema, H. N. Sather, G. H. Reaman, and P. S. Gaynon (1998)
Blood 91, 735-746
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The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development.

S. Tang, P. Hoodless, Z Lu, M. Breitman, R. McInnes, J. Wrana, and M Buchwald (1998)
Development 125, 1877-1887
 |  Abstract »  |  PDF »

HRX Leukemic Fusion Proteins Form a Heterocomplex with the Leukemia-associated Protein SET and Protein Phosphatase 2A.

H. T. Adler, F. S. Nallaseth, G. Walter, and D. C. Tkachuk (1997)
J. Biol. Chem. 272, 28407-28414
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c-myc genes and apoptosis.

T. Shimamoto, S. Nakamura, J. Bollekens, F. H. Ruddle, and K. Takeshita (1997)
PNAS 94, 3245-3249
 |  Abstract »  |  Full Text »  |  PDF »

Non-Hodgkin's Lymphoma in Childhood.

J. T. Sandlund, J. R. Downing, and W. M. Crist (1996)
N. Engl. J. Med. 334, 1238-1248
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The role of HOX homeobox genes in normal and leukemic hematopoiesis.

H. Lawrence, G Sauvageau, R. Humphries, and C Largman (1996)
Stem Cells 14, 281-291
 |  Abstract »

Transcription-Factor Mutations and Disease.

D. S. Latchman (1996)
N. Engl. J. Med. 334, 28-33
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The Hox11 gene is essential for cell survival during spleen development.

T. Dear, W. Colledge, M. Carlton, I Lavenir, T Larson, A. Smith, A. Warren, M. Evans, M. Sofroniew, and T. Rabbitts (1995)
Development 121, 2909-2915
 |  Abstract »  |  PDF »

The Molecular Basis of Leukemia.

M. J. Cline (1994)
N. Engl. J. Med. 330, 328-336
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Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.

T. Lints, L. Parsons, L Hartley, I Lyons, and R. Harvey (1993)
Development 119, 419-431
 |  Abstract »  |  PDF »

Chromosome aberrations and cancer.

E Solomon, J Borrow, and A. Goddard (1991)
Science 254, 1153-1160
 |  Abstract »  |  PDF »

Analysis of the V(D)J Recombination Efficiency at Lymphoid Chromosomal Translocation Breakpoints.

S. C. Raghavan, I. R. Kirsch, and M. R. Lieber (2001)
J. Biol. Chem. 276, 29126-29133
 |  Abstract »  |  Full Text »  |  PDF »

Induction of tolerance to immunogenic tumor antigens associated with lymphomagenesis in HOX11 transgenic mice.

S. Rosic-Kablar, K. Chan, M. D. Reis, I. D. Dube, and M. R. Hough (2000)
PNAS 97, 13300-13305
 |  Abstract »  |  Full Text »  |  PDF »

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